MX2016002367A - Compuestos de carboxamida de furo y tienopiridina utiles como inhibidores de cinasas pim. - Google Patents

Compuestos de carboxamida de furo y tienopiridina utiles como inhibidores de cinasas pim.

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Publication number
MX2016002367A
MX2016002367A MX2016002367A MX2016002367A MX2016002367A MX 2016002367 A MX2016002367 A MX 2016002367A MX 2016002367 A MX2016002367 A MX 2016002367A MX 2016002367 A MX2016002367 A MX 2016002367A MX 2016002367 A MX2016002367 A MX 2016002367A
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MX
Mexico
Prior art keywords
membered
furo
thieno
cyb
cya
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MX2016002367A
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English (en)
Inventor
M Burns David
Li Yun-Long
Mei Song
Zhu Wenyu
Rafalski Maria
Xue Chu-Biao
Feng Hao
Pan Jun
Wang Anlai
Huang Taisheng
Vechorkin Oleg
- Fen Ye Hai
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Incyte Corp
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Publication of MX2016002367A publication Critical patent/MX2016002367A/es

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    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • C07D491/048—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being five-membered

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  • Health & Medical Sciences (AREA)
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  • Animal Behavior & Ethology (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Pulmonology (AREA)
  • Hematology (AREA)
  • Dermatology (AREA)
  • Oncology (AREA)
  • Urology & Nephrology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
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  • Obesity (AREA)
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  • Transplantation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Epidemiology (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

La presente descripción describe compuestos de carboxamida de furo y tienopiridina de la Fórmula (I) o una sal farmacéuticamente aceptable de estos, donde: X es S u O; A5 es N o C-R5. CyA es un grupo heteroarilo monocíclico de 5 a 6 miembros, donde los átomos del anillo del grupo heteroarilo que forman CyA consisten en átomos de carbono y 1, 2 o 3 heteroátomos seleccionados de N, O y S, y donde el grupo heteroarilo monocíclico de 5 a 6 miembros que forma CyA está no sustituido o sustituido con 1, 2 o 3 RA, CyB es arilo C6-10, cicloalquilo C3-7, heteriarilo de 5-10 miembros o heterocicloalquilo de 4-10 miembros, donde los átomos del anillo de los átomos del anillo del heteroarilo o heterocicloalquilo que forman CyB consisten en átomos de carbono y 1, 2 o 3 heteroátomos seleccionados de O, N y S, y donde cada uno de el arilo C6-10, cicloalquilo C3-7, heteriarilo de 5-10 miembros o heterocicloalquilo de 4-10 miembros que forma CyB está no sustituido o sustituido con 1, 2, 3, 4 o 5 RB; R2 es H, halógeno o NH2 y R5, R6 y R7 son como se define en la reivindicación 1; Los compuestos inhiben la actividad de las cinasa Pim y son útiles en el tratamiento de enferemedades relacionadas con la actividad de cinasas Pim, inclusive, p. ej., cáncer y otras enfermedades.
MX2016002367A 2013-08-23 2014-08-22 Compuestos de carboxamida de furo y tienopiridina utiles como inhibidores de cinasas pim. MX2016002367A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361869442P 2013-08-23 2013-08-23
PCT/US2014/052214 WO2015027124A1 (en) 2013-08-23 2014-08-22 Furo- and thieno-pyridine carboxamide compounds useful as pim kinase inhibitors

Publications (1)

Publication Number Publication Date
MX2016002367A true MX2016002367A (es) 2016-10-28

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MX2016002367A MX2016002367A (es) 2013-08-23 2014-08-22 Compuestos de carboxamida de furo y tienopiridina utiles como inhibidores de cinasas pim.

Country Status (18)

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US (2) US9556197B2 (es)
EP (1) EP3036238A1 (es)
JP (1) JP2016528298A (es)
KR (1) KR20160056896A (es)
CN (1) CN105658653A (es)
AR (1) AR097431A1 (es)
AU (2) AU2014308703A1 (es)
CA (1) CA2921959A1 (es)
CL (1) CL2016000398A1 (es)
CR (1) CR20160135A (es)
EA (1) EA201690458A1 (es)
IL (1) IL244224A0 (es)
MX (1) MX2016002367A (es)
PE (1) PE20160532A1 (es)
PH (1) PH12016500359A1 (es)
SG (1) SG11201601259YA (es)
TW (1) TW201605866A (es)
WO (1) WO2015027124A1 (es)

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KR20160056896A (ko) 2016-05-20
PE20160532A1 (es) 2016-05-21
SG11201601259YA (en) 2016-03-30
PH12016500359A1 (en) 2016-05-16
JP2016528298A (ja) 2016-09-15
AU2014308703A1 (en) 2016-03-24
CA2921959A1 (en) 2015-02-26
US10000507B2 (en) 2018-06-19
WO2015027124A1 (en) 2015-02-26
US9556197B2 (en) 2017-01-31
US20170190716A1 (en) 2017-07-06
US20150057265A1 (en) 2015-02-26
EA201690458A1 (ru) 2016-07-29
IL244224A0 (en) 2016-04-21
EP3036238A1 (en) 2016-06-29
CR20160135A (es) 2016-08-05
CL2016000398A1 (es) 2016-09-23
AU2018278928A1 (en) 2019-01-17

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