ZA200609178B - (1,10B-dihydro-2-(aminocarbonyl-phenyl)-5H-pyrazolo[1,5-c][1,3]benzoxazin-5-yl)phenylmethanone derivatives as HIV viral replication inhibitors - Google Patents

(1,10B-dihydro-2-(aminocarbonyl-phenyl)-5H-pyrazolo[1,5-c][1,3]benzoxazin-5-yl)phenylmethanone derivatives as HIV viral replication inhibitors

Info

Publication number
ZA200609178B
ZA200609178B ZA200609178A ZA200609178A ZA200609178B ZA 200609178 B ZA200609178 B ZA 200609178B ZA 200609178 A ZA200609178 A ZA 200609178A ZA 200609178 A ZA200609178 A ZA 200609178A ZA 200609178 B ZA200609178 B ZA 200609178B
Authority
ZA
South Africa
Prior art keywords
benzoxazin
pyrazolo
aminocarbonyl
dihydro
phenyl
Prior art date
Application number
ZA200609178A
Other languages
English (en)
Inventor
Tahri Abdellah
Acker Koenraad Lodewijk August Van
Michiels Lieve Emma Jan
Surleraux Dominique Louis Nestor Ghislain
Original Assignee
Tibotec Pharm Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tibotec Pharm Ltd filed Critical Tibotec Pharm Ltd
Publication of ZA200609178B publication Critical patent/ZA200609178B/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/538—1,4-Oxazines, e.g. morpholine ortho- or peri-condensed with carbocyclic ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
ZA200609178A 2004-05-04 2006-11-03 (1,10B-dihydro-2-(aminocarbonyl-phenyl)-5H-pyrazolo[1,5-c][1,3]benzoxazin-5-yl)phenylmethanone derivatives as HIV viral replication inhibitors ZA200609178B (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP04101913 2004-05-04
US60427504P 2004-08-25 2004-08-25
PCT/EP2005/052041 WO2005105810A2 (en) 2004-05-04 2005-05-04 (1,10b-dihydro-2-(aminocarbonyl-phenyl)-5h-pyrazolo[1,5- c][1,3]benzoxazin-5-yl)phenyl methanone derivatives as hiv viral replication inhibitors

Publications (1)

Publication Number Publication Date
ZA200609178B true ZA200609178B (en) 2008-08-27

Family

ID=35058129

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA200609178A ZA200609178B (en) 2004-05-04 2006-11-03 (1,10B-dihydro-2-(aminocarbonyl-phenyl)-5H-pyrazolo[1,5-c][1,3]benzoxazin-5-yl)phenylmethanone derivatives as HIV viral replication inhibitors

Country Status (20)

Country Link
US (1) US7326703B2 (no)
EP (1) EP1778696B1 (no)
JP (1) JP4929162B2 (no)
KR (1) KR20070015547A (no)
CN (1) CN1950380B (no)
AP (1) AP2006003759A0 (no)
AR (1) AR048650A1 (no)
AT (1) ATE389660T1 (no)
AU (1) AU2005238235B2 (no)
BR (1) BRPI0510612A (no)
CA (1) CA2563959C (no)
DE (1) DE602005005490T2 (no)
ES (1) ES2303244T3 (no)
IL (1) IL178082A (no)
MX (1) MXPA06012755A (no)
NO (1) NO20065582L (no)
PL (1) PL1778696T3 (no)
RU (1) RU2382789C2 (no)
WO (1) WO2005105810A2 (no)
ZA (1) ZA200609178B (no)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7122185B2 (en) 2002-02-22 2006-10-17 Progenics Pharmaceuticals, Inc. Anti-CCR5 antibody
TW200710091A (en) * 2005-04-11 2007-03-16 Tibotec Pharm Ltd (1,10B-dihydro-2-(aminoalkyl-phenyl)-5H-pyrazolo [1,5-c][1,3]benzoxazin-5-yl)phenyl methanone derivatives as HIV viral replication inhibitors
AU2006272750B2 (en) * 2005-07-22 2011-09-29 Cytodyn, Inc. Methods for reducing viral load in HIV-1-infected patients
US20100190809A1 (en) * 2007-06-25 2010-07-29 Jody Firmin Voorspoels Combination formulations
US8592487B2 (en) * 2007-10-26 2013-11-26 Concert Pharmaceuticals, Inc. Deuterated darunavir
WO2009134401A2 (en) * 2008-04-29 2009-11-05 Progenics Pharmaceuticals, Inc. Methods of inhibiting infection by diverse subtypes of drug-resistant hiv-1

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5145684A (en) 1991-01-25 1992-09-08 Sterling Drug Inc. Surface modified drug nanoparticles
DE4210939A1 (de) * 1992-04-02 1993-10-07 Bayer Ag Verwendung von 7-Oxo-7H-pyrido[1,2,3-de][1,4]benzoxacin-6-carbonsäuren und -estern als Arzneimittel
PH30929A (en) 1992-09-03 1997-12-23 Janssen Pharmaceutica Nv Beads having a core coated with an antifungal and a polymer.
HU222355B1 (hu) 1993-10-01 2003-06-28 Astra Aktiebolag Eljárás és berendezés finom gyógyszerhatóanyag-porok kezelésére és feldolgozására
TR199801225T2 (xx) 1996-05-20 1998-11-23 Janssen Pharmaceutica N.V. Geli�tirilmi� biyolojik kullan�l�rl��a sahip antifungal bile�imler.
AU4802797A (en) 1996-10-02 1998-04-24 Du Pont Pharmaceuticals Company 4,4-disubstituted-1,4-dihydro-2h-3,1-benzoxazin-2-ones useful as hiv rever se transcriptase inhibitors and intermediates and processes for making the same
RU2218153C2 (ru) 1997-03-26 2003-12-10 Жансен Фармасетика Н.В. Драже, имеющее ядро, покрытое противогрибковым средством и полимером
BR9815899A (pt) * 1998-05-20 2001-02-20 Lilly Co Eli Compostos antivirais
WO2002085860A1 (en) * 2001-04-10 2002-10-31 Pfizer Limited Pyrazole derivatives for treating hiv

Also Published As

Publication number Publication date
US20070248624A1 (en) 2007-10-25
AR048650A1 (es) 2006-05-10
IL178082A (en) 2012-06-28
US7326703B2 (en) 2008-02-05
CN1950380A (zh) 2007-04-18
ES2303244T3 (es) 2008-08-01
WO2005105810A2 (en) 2005-11-10
ATE389660T1 (de) 2008-04-15
EP1778696B1 (en) 2008-03-19
CA2563959A1 (en) 2005-11-10
JP2007536346A (ja) 2007-12-13
PL1778696T3 (pl) 2008-08-29
IL178082A0 (en) 2006-12-31
AU2005238235B2 (en) 2011-07-07
KR20070015547A (ko) 2007-02-05
CA2563959C (en) 2014-07-15
AU2005238235A1 (en) 2005-11-10
BRPI0510612A (pt) 2007-10-30
NO20065582L (no) 2006-12-04
AP2006003759A0 (en) 2006-10-31
MXPA06012755A (es) 2007-01-16
DE602005005490T2 (de) 2009-04-23
RU2382789C2 (ru) 2010-02-27
EP1778696A2 (en) 2007-05-02
RU2006142705A (ru) 2008-06-20
WO2005105810A3 (en) 2006-03-02
DE602005005490D1 (de) 2008-04-30
JP4929162B2 (ja) 2012-05-09
CN1950380B (zh) 2010-12-08

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