OA12920A - 4-(3,5-dicyanophenoxy)pyrazole derivatives for useas reverse transcriptase modulators in the treatment of I.A H.I.V. - Google Patents

4-(3,5-dicyanophenoxy)pyrazole derivatives for useas reverse transcriptase modulators in the treatment of I.A H.I.V. Download PDF

Info

Publication number
OA12920A
OA12920A OA1200500067A OA1200500067A OA12920A OA 12920 A OA12920 A OA 12920A OA 1200500067 A OA1200500067 A OA 1200500067A OA 1200500067 A OA1200500067 A OA 1200500067A OA 12920 A OA12920 A OA 12920A
Authority
OA
OAPI
Prior art keywords
compound
formula
dérivative
pharmaceutically acceptable
pharmaceutical composition
Prior art date
Application number
OA1200500067A
Other languages
English (en)
Inventor
Charles Eric Mowbray
David Anthony Price
Matthew Duncan Selby
Paul Anthony Stupple
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of OA12920A publication Critical patent/OA12920A/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D231/00Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D231/18One oxygen or sulfur atom
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4151,2-Diazoles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • A61P31/18Antivirals for RNA viruses for HIV
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00Carboxylic acid nitriles
    • C07C255/49Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C255/54Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and etherified hydroxy groups bound to the carbon skeleton
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/004Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reaction with organometalhalides
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/63Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by introduction of halogen; by substitution of halogen atoms by other halogen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/29Saturated compounds containing keto groups bound to rings
    • C07C49/293Saturated compounds containing keto groups bound to rings to a three- or four-membered ring
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/29Saturated compounds containing keto groups bound to rings
    • C07C49/327Saturated compounds containing keto groups bound to rings containing halogen
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00Systems containing only non-condensed rings
    • C07C2601/02Systems containing only non-condensed rings with a three-membered ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Virology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
OA1200500067A 2002-09-16 2003-09-08 4-(3,5-dicyanophenoxy)pyrazole derivatives for useas reverse transcriptase modulators in the treatment of I.A H.I.V. OA12920A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0221477.3A GB0221477D0 (en) 2002-09-16 2002-09-16 Chemical compounds
GBGB0223354.2A GB0223354D0 (en) 2002-09-16 2002-10-08 Chemical compounds

Publications (1)

Publication Number Publication Date
OA12920A true OA12920A (en) 2006-10-13

Family

ID=31995706

Family Applications (1)

Application Number Title Priority Date Filing Date
OA1200500067A OA12920A (en) 2002-09-16 2003-09-08 4-(3,5-dicyanophenoxy)pyrazole derivatives for useas reverse transcriptase modulators in the treatment of I.A H.I.V.

Country Status (20)

Country Link
EP (1) EP1542679B1 (no)
JP (1) JP2006504792A (no)
KR (1) KR20050043962A (no)
CN (1) CN1681494A (no)
AP (1) AP2005003248A0 (no)
AU (1) AU2003263422A1 (no)
BR (1) BR0314243A (no)
CA (1) CA2496315A1 (no)
DE (1) DE60311284T2 (no)
EA (1) EA200500287A1 (no)
EC (1) ECSP055673A (no)
GB (2) GB0221477D0 (no)
HR (1) HRP20050222A2 (no)
IS (1) IS7705A (no)
MA (1) MA27435A1 (no)
MX (1) MXPA05002963A (no)
NO (1) NO20051833L (no)
OA (1) OA12920A (no)
PL (1) PL375976A1 (no)
WO (1) WO2004024147A1 (no)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005100322A1 (en) * 2004-04-14 2005-10-27 Pfizer Limited Sulphur-linked imidazole compounds for the treament of hiv
DE102008015033A1 (de) * 2008-03-17 2009-09-24 Aicuris Gmbh & Co. Kg Substituierte (Pyrazolyl-carbonyl)imidazolidinone und ihre Verwendung
DE102008015032A1 (de) 2008-03-17 2009-09-24 Aicuris Gmbh & Co. Kg Substituierte Pyrazolamide und ihre Verwendung
DE102008062863A1 (de) 2008-12-17 2010-06-24 Aicuris Gmbh & Co. Kg Substituierte (Thiophenyl-carbonyl)imidazolidinone und ihre Verwendung
DE102008062878A1 (de) 2008-12-17 2010-06-24 Aicuris Gmbh & Co. Kg Substituierte Furancarboxamide und ihre Verwendung

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3303200A (en) * 1963-11-05 1967-02-07 American Home Prod Pyrazole-1-ethanol derivatives
GB0016787D0 (en) * 2000-07-07 2000-08-30 Pfizer Ltd Compounds useful in therapy
DK1377556T3 (da) * 2001-04-10 2007-07-16 Pfizer Pyrazolderivater til behandling af HIV

Also Published As

Publication number Publication date
AU2003263422A1 (en) 2004-04-30
IS7705A (is) 2005-02-21
WO2004024147A1 (en) 2004-03-25
NO20051833L (no) 2005-06-14
MXPA05002963A (es) 2005-05-27
EA200500287A1 (ru) 2005-10-27
KR20050043962A (ko) 2005-05-11
MA27435A1 (fr) 2005-07-01
BR0314243A (pt) 2005-07-26
PL375976A1 (en) 2005-12-12
ECSP055673A (es) 2005-07-06
CA2496315A1 (en) 2004-03-25
AP2005003248A0 (en) 2005-03-31
EP1542679B1 (en) 2007-01-17
JP2006504792A (ja) 2006-02-09
DE60311284D1 (de) 2007-03-08
EP1542679A1 (en) 2005-06-22
CN1681494A (zh) 2005-10-12
HRP20050222A2 (en) 2005-10-31
GB0223354D0 (en) 2002-11-13
DE60311284T2 (de) 2007-06-21
GB0221477D0 (en) 2002-10-23

Similar Documents

Publication Publication Date Title
EP1762567B1 (en) Pyrazole derivatives for treating HIV
US6750230B2 (en) Pyrazole derivatives
US6933312B2 (en) Pyrazole derivatives
EP1551828B1 (en) Pyrazole derivatives
HRP20050222A2 (en) 4-(3,5-dicyanophenoxy) pyrazole derivatives for use as reverse transcriptase modulators in the treatment of i.a. hiv
US7220772B2 (en) Pyrazole derivatives
WO2004029042A1 (en) Pyrazole derivatives as reverse transcriptase inhibitors
US20050004129A1 (en) Pyrazole derivatives
EP1556359B1 (en) Pyrazole derivatives and their use as therapeutic agents for hiv mediated diseases
US20040132793A1 (en) Pyrazole derivatives
US7230025B2 (en) Pyrazole derivatives