BR0314243A - Derivados de 4-(3,5-dicianofenoxi)pirazolo para uso como moduladores da transcriptase reversa no tratamento da i.a hiv - Google Patents
Derivados de 4-(3,5-dicianofenoxi)pirazolo para uso como moduladores da transcriptase reversa no tratamento da i.a hivInfo
- Publication number
- BR0314243A BR0314243A BR0314243-4A BR0314243A BR0314243A BR 0314243 A BR0314243 A BR 0314243A BR 0314243 A BR0314243 A BR 0314243A BR 0314243 A BR0314243 A BR 0314243A
- Authority
- BR
- Brazil
- Prior art keywords
- hiv
- reverse transcriptase
- modulators
- treatment
- derivatives
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D231/18—One oxygen or sulfur atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
- C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C255/54—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and etherified hydroxy groups bound to the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/004—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reaction with organometalhalides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
- C07C45/63—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by introduction of halogen; by substitution of halogen atoms by other halogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
- C07C49/29—Saturated compounds containing keto groups bound to rings
- C07C49/293—Saturated compounds containing keto groups bound to rings to a three- or four-membered ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
- C07C49/29—Saturated compounds containing keto groups bound to rings
- C07C49/327—Saturated compounds containing keto groups bound to rings containing halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Virology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- AIDS & HIV (AREA)
- Tropical Medicine & Parasitology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
"DERIVADOS DE 4-(3,5-DICIANOFENOXI)PIRAZOLO PARA USO COMO MODULADORES DA TRANSCRIPTASE REVERSA NO TRATAMENTO DA I.A HIV". Esta invenção diz respeito aos derivados de pirazolo de fórmula (I) e sais, solvatos ou derivados farmaceuticamente aceitáveis destes, a sua utilização em medicina, às formulações que os contém, aos processos para a sua preparação e aos intermediários utilizados nestes processos. Os compostos da invenção ligam-se à enzima transcriptase reversa e são moduladores, em especial inibidores, desta. A transcriptase reversa está envolvida no ciclo de vida infeccioso do Vírus da Imunodeficiência Humana (HIV). Os compostos que interferem com a função desta enzima têm mostrado utilidade no tratamento de condições provocadas pelo HIV e por retrovírus geneticamente relacionados, tal como a Síndrome da Imunodeficiência Adquirida (SIDA).
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB0221477.3A GB0221477D0 (en) | 2002-09-16 | 2002-09-16 | Chemical compounds |
GBGB0223354.2A GB0223354D0 (en) | 2002-09-16 | 2002-10-08 | Chemical compounds |
PCT/IB2003/003946 WO2004024147A1 (en) | 2002-09-16 | 2003-09-08 | 4-(3,5-dicyanophenoxy) pyrazole derivatives for use as transcriptase modulators in the treatment of i.a. hiv |
Publications (1)
Publication Number | Publication Date |
---|---|
BR0314243A true BR0314243A (pt) | 2005-07-26 |
Family
ID=31995706
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR0314243-4A BR0314243A (pt) | 2002-09-16 | 2003-09-08 | Derivados de 4-(3,5-dicianofenoxi)pirazolo para uso como moduladores da transcriptase reversa no tratamento da i.a hiv |
Country Status (20)
Country | Link |
---|---|
EP (1) | EP1542679B1 (pt) |
JP (1) | JP2006504792A (pt) |
KR (1) | KR20050043962A (pt) |
CN (1) | CN1681494A (pt) |
AP (1) | AP2005003248A0 (pt) |
AU (1) | AU2003263422A1 (pt) |
BR (1) | BR0314243A (pt) |
CA (1) | CA2496315A1 (pt) |
DE (1) | DE60311284T2 (pt) |
EA (1) | EA200500287A1 (pt) |
EC (1) | ECSP055673A (pt) |
GB (2) | GB0221477D0 (pt) |
HR (1) | HRP20050222A2 (pt) |
IS (1) | IS7705A (pt) |
MA (1) | MA27435A1 (pt) |
MX (1) | MXPA05002963A (pt) |
NO (1) | NO20051833L (pt) |
OA (1) | OA12920A (pt) |
PL (1) | PL375976A1 (pt) |
WO (1) | WO2004024147A1 (pt) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2005100322A1 (en) * | 2004-04-14 | 2005-10-27 | Pfizer Limited | Sulphur-linked imidazole compounds for the treament of hiv |
DE102008015032A1 (de) | 2008-03-17 | 2009-09-24 | Aicuris Gmbh & Co. Kg | Substituierte Pyrazolamide und ihre Verwendung |
DE102008015033A1 (de) | 2008-03-17 | 2009-09-24 | Aicuris Gmbh & Co. Kg | Substituierte (Pyrazolyl-carbonyl)imidazolidinone und ihre Verwendung |
DE102008062863A1 (de) | 2008-12-17 | 2010-06-24 | Aicuris Gmbh & Co. Kg | Substituierte (Thiophenyl-carbonyl)imidazolidinone und ihre Verwendung |
DE102008062878A1 (de) | 2008-12-17 | 2010-06-24 | Aicuris Gmbh & Co. Kg | Substituierte Furancarboxamide und ihre Verwendung |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3303200A (en) * | 1963-11-05 | 1967-02-07 | American Home Prod | Pyrazole-1-ethanol derivatives |
GB0016787D0 (en) * | 2000-07-07 | 2000-08-30 | Pfizer Ltd | Compounds useful in therapy |
EP1377556B1 (en) * | 2001-04-10 | 2007-04-04 | Pfizer Limited | Pyrazole derivatives for treating hiv |
-
2002
- 2002-09-16 GB GBGB0221477.3A patent/GB0221477D0/en not_active Ceased
- 2002-10-08 GB GBGB0223354.2A patent/GB0223354D0/en not_active Ceased
-
2003
- 2003-09-08 KR KR1020057004426A patent/KR20050043962A/ko not_active Application Discontinuation
- 2003-09-08 BR BR0314243-4A patent/BR0314243A/pt not_active IP Right Cessation
- 2003-09-08 MX MXPA05002963A patent/MXPA05002963A/es unknown
- 2003-09-08 PL PL03375976A patent/PL375976A1/xx not_active Application Discontinuation
- 2003-09-08 CN CNA038219603A patent/CN1681494A/zh active Pending
- 2003-09-08 AP AP2005003248A patent/AP2005003248A0/xx unknown
- 2003-09-08 AU AU2003263422A patent/AU2003263422A1/en not_active Abandoned
- 2003-09-08 DE DE60311284T patent/DE60311284T2/de not_active Expired - Fee Related
- 2003-09-08 CA CA002496315A patent/CA2496315A1/en not_active Abandoned
- 2003-09-08 JP JP2004571926A patent/JP2006504792A/ja not_active Withdrawn
- 2003-09-08 EA EA200500287A patent/EA200500287A1/ru unknown
- 2003-09-08 EP EP03795160A patent/EP1542679B1/en not_active Expired - Lifetime
- 2003-09-08 WO PCT/IB2003/003946 patent/WO2004024147A1/en active IP Right Grant
- 2003-09-08 OA OA1200500067A patent/OA12920A/en unknown
-
2005
- 2005-02-21 IS IS7705A patent/IS7705A/is unknown
- 2005-03-08 HR HR20050222A patent/HRP20050222A2/hr not_active Application Discontinuation
- 2005-03-14 EC EC2005005673A patent/ECSP055673A/es unknown
- 2005-03-16 MA MA28148A patent/MA27435A1/fr unknown
- 2005-04-15 NO NO20051833A patent/NO20051833L/no unknown
Also Published As
Publication number | Publication date |
---|---|
OA12920A (en) | 2006-10-13 |
WO2004024147A1 (en) | 2004-03-25 |
JP2006504792A (ja) | 2006-02-09 |
ECSP055673A (es) | 2005-07-06 |
EP1542679A1 (en) | 2005-06-22 |
KR20050043962A (ko) | 2005-05-11 |
MA27435A1 (fr) | 2005-07-01 |
GB0223354D0 (en) | 2002-11-13 |
PL375976A1 (en) | 2005-12-12 |
AU2003263422A1 (en) | 2004-04-30 |
CN1681494A (zh) | 2005-10-12 |
DE60311284T2 (de) | 2007-06-21 |
IS7705A (is) | 2005-02-21 |
GB0221477D0 (en) | 2002-10-23 |
EA200500287A1 (ru) | 2005-10-27 |
CA2496315A1 (en) | 2004-03-25 |
DE60311284D1 (de) | 2007-03-08 |
NO20051833L (no) | 2005-06-14 |
MXPA05002963A (es) | 2005-05-27 |
EP1542679B1 (en) | 2007-01-17 |
AP2005003248A0 (en) | 2005-03-31 |
HRP20050222A2 (en) | 2005-10-31 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 4A , 5A , 6A E 7A ANUIDADES. |
|
B08J | Incorrect entry in the gazette republished [chapter 8.10 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 DA RPI 2069 DE 31/08/2010. TEXTO CORRETO: REFERENTE A 5A, 6A E 7A ANUIDADES. |
|
B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AOS DESPACHOS PUBLICADOS NA RPI 2069 DE 31/08/2010 E RPI 2090 DE 25/01/2011. |