NO20022456L - Pyrazolo[1,5-d][1,2,4]triazinerderivater for forbedring av kognisjon - Google Patents
Pyrazolo[1,5-d][1,2,4]triazinerderivater for forbedring av kognisjonInfo
- Publication number
- NO20022456L NO20022456L NO20022456A NO20022456A NO20022456L NO 20022456 L NO20022456 L NO 20022456L NO 20022456 A NO20022456 A NO 20022456A NO 20022456 A NO20022456 A NO 20022456A NO 20022456 L NO20022456 L NO 20022456L
- Authority
- NO
- Norway
- Prior art keywords
- optionally substituted
- alkyl
- compounds
- membered
- group
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- General Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Psychiatry (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Hospice & Palliative Care (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
Forbindelser med formel (I), og salter derav, hvor R1 betegner halogen eller d-s-alkyl, C3_7-sykloalkyl, C4.7-sykloal- kenyl, C6-s-bisykloalkyl, C6-i0-aryl, C3.7- heterosykloalkyl, heteroaryl eller di- (d-s) alkylamino, idet en hvilken som helst av disse grupper eventuelt er substituert; L er O, S eller NR", hvor R" er H, d-e-alkyl eller C3-6-sykloalkyl; W er d-6-alkyl, d-«-alkenyl eller C2.s- alkynyl, hvilke eventuelt er substitu- ert; X er NR4R5, eller X er en 5-leddet eller 6-leddet heteroaromatisk ring som eventuelt er kondensert med en benzen- eller pyridinring og eventuelt er sub- stituert; Y er eventuelt forgrenet d-4- alkylen som eventuelt er substituert med en oksogruppe, eller Y er en gruppe (CH2)jO hvor oksygenatomet står nærmest gruppen X, og j er 2, 3 eller 4; og Z betegner en 5-leddet eller 6-leddet heteroaromatisk ring som eventuelt er substituert; samt farmasøytiske prepa- rater inneholdende disse forbindelser, deres anvendelse ved behandlingsmeto- -Y-X (D der, og deres anvendelse for fremstil- ling av preparater for forbedring av kognisjonen, spesielt ved Alzheimers sykdom, og tilsvarende behandlingsme- toder. Forbindelsene er ligander og invers-agonister for GABAA-a5-reseptor- subtypen.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB9927874.9A GB9927874D0 (en) | 1999-11-25 | 1999-11-25 | Therapeutic agents |
GB0009602A GB0009602D0 (en) | 2000-04-18 | 2000-04-18 | Therapeutic agents |
GB0018651A GB0018651D0 (en) | 2000-07-28 | 2000-07-28 | Therapeutic agents |
PCT/GB2000/004450 WO2001038331A2 (en) | 1999-11-25 | 2000-11-22 | Pyrazolo[1,5-d][1,2,4]triazines for enhancing cognition |
Publications (2)
Publication Number | Publication Date |
---|---|
NO20022456D0 NO20022456D0 (no) | 2002-05-24 |
NO20022456L true NO20022456L (no) | 2002-05-24 |
Family
ID=27255677
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO20022456A NO20022456L (no) | 1999-11-25 | 2002-05-24 | Pyrazolo[1,5-d][1,2,4]triazinerderivater for forbedring av kognisjon |
Country Status (20)
Country | Link |
---|---|
US (1) | US6355638B1 (no) |
EP (1) | EP1235829A2 (no) |
JP (1) | JP2003514909A (no) |
KR (1) | KR20020053091A (no) |
CN (1) | CN1391574A (no) |
AU (1) | AU1533001A (no) |
BG (1) | BG106734A (no) |
BR (1) | BR0015126A (no) |
CA (1) | CA2391103A1 (no) |
CZ (1) | CZ20021813A3 (no) |
EA (1) | EA200200599A1 (no) |
EE (1) | EE200200260A (no) |
HK (1) | HK1046406A1 (no) |
HU (1) | HUP0203579A3 (no) |
IL (1) | IL149051A0 (no) |
MX (1) | MXPA02005233A (no) |
NO (1) | NO20022456L (no) |
PL (1) | PL355637A1 (no) |
SK (1) | SK8952002A3 (no) |
WO (1) | WO2001038331A2 (no) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB0128499D0 (en) * | 2001-11-28 | 2002-01-23 | Merck Sharp & Dohme | Therapeutic agents |
EP2298296A1 (en) * | 2009-08-25 | 2011-03-23 | CNRS Centre National De La Recherche Scientifique | Composition and method for treating cognitive impairments in down syndrome subjects |
EP3318561B1 (en) * | 2010-05-26 | 2021-12-22 | Sunovion Pharmaceuticals Inc. | Heteroaryl compounds and methods of use thereof |
US20150374705A1 (en) | 2012-02-14 | 2015-12-31 | Shanghai Institues for Biological Sciences | Substances for treatment or relief of pain |
CN107344938B (zh) * | 2016-05-06 | 2022-05-06 | 上海赛默罗生物科技有限公司 | 吡唑-三嗪类衍生物、其制备方法、药物组合物和用途 |
CN107344936B (zh) * | 2016-05-06 | 2022-06-03 | 上海赛默罗生物科技有限公司 | 三唑哒嗪类衍生物、其制备方法、药物组合物和用途 |
CA3143334A1 (en) * | 2019-06-19 | 2020-12-24 | Biomarin Pharmaceutical Inc. | Glycolate oxidase inhibitors for the treatment of disease |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BR9710729A (pt) * | 1996-07-25 | 1999-08-17 | Merck Sharp & Dohme | Composto composi-Æo farmac-utica utiliza-Æo de um composto e processo para o tratamento e/ou a preven-Æo da ansiedade e de convuls{es para a triagem de compostos ansioliticos nÆo-sedativos e para a prepara-Æo de um composto |
GB9715977D0 (en) * | 1997-07-29 | 1997-10-01 | Merck Sharp & Dohme | Therapeutic agents |
WO1999036423A1 (en) * | 1998-01-14 | 1999-07-22 | Merck Sharp & Dohme Limited | Triazolo-pyridazine derivatives as ligands for gaba receptors |
GB9806102D0 (en) * | 1998-03-20 | 1998-05-20 | Merck Sharp & Dohme | Therapeutic agents |
AU755855B2 (en) * | 1998-06-16 | 2002-12-19 | Merck Sharp & Dohme Limited | Triazolo-pyridine derivatives as ligands for GABA receptors |
WO2000023449A1 (en) * | 1998-10-16 | 2000-04-27 | Merck Sharp & Dohme Limited | Pyrazolo-triazine derivatives as ligands for gaba receptors |
-
2000
- 2000-11-21 US US09/717,423 patent/US6355638B1/en not_active Expired - Lifetime
- 2000-11-22 CZ CZ20021813A patent/CZ20021813A3/cs unknown
- 2000-11-22 KR KR1020027006672A patent/KR20020053091A/ko not_active Application Discontinuation
- 2000-11-22 CN CN00816013A patent/CN1391574A/zh active Pending
- 2000-11-22 EE EEP200200260A patent/EE200200260A/xx unknown
- 2000-11-22 CA CA002391103A patent/CA2391103A1/en not_active Abandoned
- 2000-11-22 EA EA200200599A patent/EA200200599A1/ru unknown
- 2000-11-22 HU HU0203579A patent/HUP0203579A3/hu unknown
- 2000-11-22 IL IL14905100A patent/IL149051A0/xx unknown
- 2000-11-22 JP JP2001540094A patent/JP2003514909A/ja not_active Withdrawn
- 2000-11-22 EP EP00977692A patent/EP1235829A2/en not_active Withdrawn
- 2000-11-22 MX MXPA02005233A patent/MXPA02005233A/es not_active Application Discontinuation
- 2000-11-22 SK SK895-2002A patent/SK8952002A3/sk unknown
- 2000-11-22 BR BR0015126-2A patent/BR0015126A/pt not_active Application Discontinuation
- 2000-11-22 AU AU15330/01A patent/AU1533001A/en not_active Abandoned
- 2000-11-22 WO PCT/GB2000/004450 patent/WO2001038331A2/en not_active Application Discontinuation
- 2000-11-22 PL PL00355637A patent/PL355637A1/xx not_active Application Discontinuation
-
2002
- 2002-05-22 BG BG106734A patent/BG106734A/xx unknown
- 2002-05-24 NO NO20022456A patent/NO20022456L/no not_active Application Discontinuation
- 2002-10-29 HK HK02107821.8A patent/HK1046406A1/zh unknown
Also Published As
Publication number | Publication date |
---|---|
CZ20021813A3 (cs) | 2002-08-14 |
EP1235829A2 (en) | 2002-09-04 |
PL355637A1 (en) | 2004-05-04 |
MXPA02005233A (es) | 2002-11-07 |
BR0015126A (pt) | 2002-07-02 |
HUP0203579A3 (en) | 2003-07-28 |
US6355638B1 (en) | 2002-03-12 |
EE200200260A (et) | 2003-06-16 |
NO20022456D0 (no) | 2002-05-24 |
CN1391574A (zh) | 2003-01-15 |
BG106734A (en) | 2003-02-28 |
IL149051A0 (en) | 2002-11-10 |
KR20020053091A (ko) | 2002-07-04 |
EA200200599A1 (ru) | 2002-12-26 |
CA2391103A1 (en) | 2001-05-31 |
AU1533001A (en) | 2001-06-04 |
WO2001038331A2 (en) | 2001-05-31 |
JP2003514909A (ja) | 2003-04-22 |
HUP0203579A2 (hu) | 2003-03-28 |
SK8952002A3 (en) | 2002-10-08 |
WO2001038331A3 (en) | 2001-11-08 |
HK1046406A1 (zh) | 2003-01-10 |
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Legal Events
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FC2A | Withdrawal, rejection or dismissal of laid open patent application |