DK1533304T3 - Amidderivat - Google Patents
AmidderivatInfo
- Publication number
- DK1533304T3 DK1533304T3 DK03738555.6T DK03738555T DK1533304T3 DK 1533304 T3 DK1533304 T3 DK 1533304T3 DK 03738555 T DK03738555 T DK 03738555T DK 1533304 T3 DK1533304 T3 DK 1533304T3
- Authority
- DK
- Denmark
- Prior art keywords
- amide derivative
- het
- halogen
- present
- formula
- Prior art date
Links
- 150000001408 amides Chemical class 0.000 title abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 150000002367 halogens Chemical class 0.000 abstract 2
- 229940124290 BCR-ABL tyrosine kinase inhibitor Drugs 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000003277 amino group Chemical group 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000004122 cyclic group Chemical group 0.000 abstract 1
- 125000001188 haloalkyl group Chemical group 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 125000004076 pyridyl group Chemical group 0.000 abstract 1
- 125000000714 pyrimidinyl group Chemical group 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/42—One nitrogen atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyridine Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2002189269 | 2002-06-28 | ||
| JP2002305146 | 2002-10-18 | ||
| JP2002377937 | 2002-12-26 | ||
| PCT/JP2003/008192 WO2004002963A1 (ja) | 2002-06-28 | 2003-06-27 | アミド誘導体及び医薬 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1533304T3 true DK1533304T3 (da) | 2010-03-22 |
Family
ID=30003594
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK03738555.6T DK1533304T3 (da) | 2002-06-28 | 2003-06-27 | Amidderivat |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US7494997B2 (da) |
| EP (1) | EP1533304B1 (da) |
| JP (1) | JP4552650B2 (da) |
| CN (1) | CN100343237C (da) |
| AT (1) | ATE447560T1 (da) |
| AU (1) | AU2003246100A1 (da) |
| BR (1) | BRPI0312288B8 (da) |
| CA (1) | CA2490907C (da) |
| DE (1) | DE60329918D1 (da) |
| DK (1) | DK1533304T3 (da) |
| ES (1) | ES2337995T3 (da) |
| MX (1) | MXPA04012845A (da) |
| PT (1) | PT1533304E (da) |
| RU (1) | RU2315043C2 (da) |
| WO (1) | WO2004002963A1 (da) |
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0215676D0 (en) * | 2002-07-05 | 2002-08-14 | Novartis Ag | Organic compounds |
| US7375175B2 (en) | 2002-08-19 | 2008-05-20 | National Starch And Chemical Investment Holding Corporation | Dispersions containing living radicals |
| EP1585723A2 (en) * | 2003-01-17 | 2005-10-19 | Wisconsin Alumni Research Foundation | Modified retinoid compounds and their uses |
| GB2400101A (en) * | 2003-03-28 | 2004-10-06 | Biofocus Discovery Ltd | Compounds capable of binding to the active site of protein kinases |
| CA2529090A1 (en) * | 2003-06-13 | 2004-12-23 | Novartis Ag | 2-aminopyrimidine derivatives as raf kinase inhibitors |
| EP1661904A1 (en) | 2003-08-22 | 2006-05-31 | Meiji Seika Kaisha Ltd. | Novel azalide and azalactam derivatives and process for the production of the same |
| HUE034712T2 (hu) * | 2003-12-25 | 2018-02-28 | Nippon Shinyaku Co Ltd | Amidszármazék és gyógyszer |
| US8735415B2 (en) | 2004-09-09 | 2014-05-27 | Natco Pharma Limited | Acid addition salts of (3,5-Bis trifluoromethyl)-N-[4-methyl-3-(4-pyridin-3yl-pyrimidin-2ylamino)-phenyl]-benzamide |
| EP1786799B1 (en) * | 2004-09-09 | 2012-07-04 | Natco Pharma Limited | Novel phenylaminopyrimidine derivatives as inhibitors of bcr-abl kinase |
| GB0512091D0 (en) * | 2005-06-14 | 2005-07-20 | Novartis Ag | Organic compounds |
| KR100674813B1 (ko) * | 2005-08-05 | 2007-01-29 | 일양약품주식회사 | Ｎ-페닐-2-피리미딘-아민 유도체 및 그의 제조방법 |
| US20100048597A1 (en) * | 2006-12-22 | 2010-02-25 | Novartis Ag | Organic Compounds and Their Uses |
| JP5559043B2 (ja) | 2007-06-07 | 2014-07-23 | イントラ−セルラー・セラピーズ・インコーポレイテッド | 新規ヘテロ環化合物およびその使用 |
| JP5710251B2 (ja) | 2007-06-07 | 2015-04-30 | イントラ−セルラー・セラピーズ・インコーポレイテッドＩｎｔｒａ−Ｃｅｌｌｕｌａｒ Ｔｈｅｒａｐｉｅｓ， Ｉｎｃ． | 新規ヘテロ環化合物およびその使用 |
| US8415358B2 (en) | 2007-09-17 | 2013-04-09 | Neurosearch A/S | Pyrazine derivatives and their use as potassium channel modulators |
| WO2009124037A1 (en) * | 2008-03-31 | 2009-10-08 | Teva Pharmaceutical Industries Ltd. | Processes for preparing sunitinib and salts thereof |
| MX2011009310A (es) | 2009-03-06 | 2011-10-13 | Novartis Ag | Uso de derivados de pirimidilaminobenzamida para el tratamiento de trastornos mediados por la cinasa que contiene un motivo de cierre de leucina y alfa esteril (zak). |
| SG178279A1 (en) | 2009-08-05 | 2012-03-29 | Intra Cellular Therapies Inc | Novel regulatory proteins and inhibitors |
| RU2012120901A (ru) | 2009-10-23 | 2013-12-10 | Новартис Аг | Способ лечения пролиферативных расстройств и других патологических состояний, опосредованных действием киназ bcr-abl, c-kit, ddr1, ddr2 или pdgf-r |
| JO3634B1 (ar) | 2009-11-17 | 2020-08-27 | Novartis Ag | طريقة لعلاج اضطرابات تكاثرية وحالات مرضية أخرى متوسطة بنشاط كيناز bcr-abl، c-kit، ddr1، ddr2، أو pdgf-r |
| RU2672553C2 (ru) * | 2012-03-14 | 2018-11-16 | Индиана Юниверсити Рисерч Энд Текнолоджи Корпорейшн | Соединения и способы лечения лейкемии |
| SG10201600149VA (en) | 2012-11-21 | 2016-02-26 | Ptc Therapeutics Inc | Substituted reverse pyrimidine bmi-1 inhibitors |
| CA2922657C (en) | 2013-08-30 | 2022-04-12 | Ptc Therapeutics, Inc. | Substituted pyrimidine bmi-1 inhibitors |
| WO2015076800A1 (en) | 2013-11-21 | 2015-05-28 | Ptc Therapeutics, Inc. | Substituted pyridine and pyrazine bmi-1 inhibitors |
| WO2015076801A1 (en) * | 2013-11-21 | 2015-05-28 | Ptc Therapeutics, Inc. | Substituted triazine bmi-1 inhibitors |
| US10722484B2 (en) | 2016-03-09 | 2020-07-28 | K-Gen, Inc. | Methods of cancer treatment |
| CN108602800B (zh) * | 2017-01-20 | 2019-08-27 | 深圳市塔吉瑞生物医药有限公司 | 用于抑制蛋白激酶活性的(杂)芳基酰胺类化合物 |
| CN108699039B (zh) | 2017-01-20 | 2019-12-20 | 深圳市塔吉瑞生物医药有限公司 | 用于抑制蛋白激酶活性的(杂)芳基酰胺类化合物 |
| JP2022523562A (ja) * | 2019-03-05 | 2022-04-25 | ホンイー アンド アソシエイツ エルエルシー | 神経変性疾患および癌の治療のための化合物 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW225528B (da) * | 1992-04-03 | 1994-06-21 | Ciba Geigy Ag | |
| US5521184A (en) * | 1992-04-03 | 1996-05-28 | Ciba-Geigy Corporation | Pyrimidine derivatives and processes for the preparation thereof |
| CO4940418A1 (es) * | 1997-07-18 | 2000-07-24 | Novartis Ag | Modificacion de cristal de un derivado de n-fenil-2- pirimidinamina, procesos para su fabricacion y su uso |
| GB0022438D0 (en) * | 2000-09-13 | 2000-11-01 | Novartis Ag | Organic Compounds |
-
2003
- 2003-06-27 ES ES03738555T patent/ES2337995T3/es not_active Expired - Lifetime
- 2003-06-27 CA CA2490907A patent/CA2490907C/en not_active Expired - Lifetime
- 2003-06-27 AU AU2003246100A patent/AU2003246100A1/en not_active Abandoned
- 2003-06-27 MX MXPA04012845A patent/MXPA04012845A/es active IP Right Grant
- 2003-06-27 BR BRPI0312288A patent/BRPI0312288B8/pt active IP Right Grant
- 2003-06-27 JP JP2004517313A patent/JP4552650B2/ja not_active Expired - Lifetime
- 2003-06-27 DE DE60329918T patent/DE60329918D1/de not_active Expired - Lifetime
- 2003-06-27 AT AT03738555T patent/ATE447560T1/de active
- 2003-06-27 PT PT03738555T patent/PT1533304E/pt unknown
- 2003-06-27 EP EP03738555A patent/EP1533304B1/en not_active Expired - Lifetime
- 2003-06-27 WO PCT/JP2003/008192 patent/WO2004002963A1/ja active Application Filing
- 2003-06-27 DK DK03738555.6T patent/DK1533304T3/da active
- 2003-06-27 CN CNB038201461A patent/CN100343237C/zh not_active Expired - Lifetime
- 2003-06-27 RU RU2005102098/04A patent/RU2315043C2/ru active
- 2003-06-27 US US10/519,722 patent/US7494997B2/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| EP1533304B1 (en) | 2009-11-04 |
| DE60329918D1 (de) | 2009-12-17 |
| BR0312288A (pt) | 2005-04-12 |
| JP4552650B2 (ja) | 2010-09-29 |
| ES2337995T3 (es) | 2010-05-03 |
| JPWO2004002963A1 (ja) | 2005-10-27 |
| BRPI0312288B1 (pt) | 2019-01-02 |
| RU2315043C2 (ru) | 2008-01-20 |
| US20060014742A1 (en) | 2006-01-19 |
| CA2490907C (en) | 2010-08-24 |
| EP1533304A1 (en) | 2005-05-25 |
| BRPI0312288B8 (pt) | 2021-05-25 |
| MXPA04012845A (es) | 2005-02-24 |
| US7494997B2 (en) | 2009-02-24 |
| CN1678590A (zh) | 2005-10-05 |
| AU2003246100A1 (en) | 2004-01-19 |
| RU2005102098A (ru) | 2005-09-20 |
| EP1533304A4 (en) | 2006-10-18 |
| PT1533304E (pt) | 2010-02-08 |
| CN100343237C (zh) | 2007-10-17 |
| WO2004002963A1 (ja) | 2004-01-08 |
| CA2490907A1 (en) | 2004-01-08 |
| ATE447560T1 (de) | 2009-11-15 |
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