ATE215078T1 - Verbessertes verfahren zum herstellen von geschützten 3,4-dihydroxybuttersäure estern - Google Patents
Verbessertes verfahren zum herstellen von geschützten 3,4-dihydroxybuttersäure esternInfo
- Publication number
- ATE215078T1 ATE215078T1 AT97931557T AT97931557T ATE215078T1 AT E215078 T1 ATE215078 T1 AT E215078T1 AT 97931557 T AT97931557 T AT 97931557T AT 97931557 T AT97931557 T AT 97931557T AT E215078 T1 ATE215078 T1 AT E215078T1
- Authority
- AT
- Austria
- Prior art keywords
- dihydroxybuturic
- acid esters
- improved method
- pct
- producing protected
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
- C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D317/30—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
- C07D317/32—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C67/00—Preparation of carboxylic acid esters
- C07C67/03—Preparation of carboxylic acid esters by reacting an ester group with a hydroxy group
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
- C07D317/32—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D317/34—Oxygen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Pyrane Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US2236996P | 1996-07-29 | 1996-07-29 | |
| PCT/US1997/011654 WO1998004543A1 (en) | 1996-07-29 | 1997-07-01 | Improved process for the synthesis of protected esters of (s)-3,4-dihydroxybutyric acid |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE215078T1 true ATE215078T1 (de) | 2002-04-15 |
Family
ID=21809241
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT97931557T ATE215078T1 (de) | 1996-07-29 | 1997-07-01 | Verbessertes verfahren zum herstellen von geschützten 3,4-dihydroxybuttersäure estern |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US5998633A (de) |
| EP (1) | EP0915866B1 (de) |
| JP (1) | JP2000515882A (de) |
| KR (1) | KR100447370B1 (de) |
| CN (1) | CN1093126C (de) |
| AT (1) | ATE215078T1 (de) |
| AU (1) | AU3515497A (de) |
| CO (1) | CO4950542A1 (de) |
| DE (1) | DE69711391T2 (de) |
| DK (1) | DK0915866T3 (de) |
| ES (1) | ES2176756T3 (de) |
| HK (1) | HK1020728A1 (de) |
| HU (1) | HU226465B1 (de) |
| IL (1) | IL127058A (de) |
| PT (1) | PT915866E (de) |
| TR (1) | TR199900191T2 (de) |
| WO (1) | WO1998004543A1 (de) |
| ZA (1) | ZA976705B (de) |
Families Citing this family (49)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TR199900191T2 (xx) * | 1996-07-29 | 1999-04-21 | Warner-Lambert Company | (S)-3,4-Dihidroksibutirik asitin korumal� esterlerinin sentezi i�in geli�tirilmi� proses. |
| KR100332703B1 (ko) * | 1998-07-24 | 2002-08-27 | 삼성정밀화학 주식회사 | 광학활성을갖는(s)-3,4-에폭시부티르산염의제조방법 |
| US6713290B2 (en) | 1998-07-24 | 2004-03-30 | Samsung Fine Chemicals Co., Ltd. | Process for preparing optically pure (S)-3-hydroxy-γ-butyrolactone |
| ES2183584T3 (es) | 1998-07-24 | 2003-03-16 | Samsung Fine Chemicals Co Ltd | Procedimiento para la preparacion de (s) -3-hidroxi-gamma-butirolactona opticamente pura. |
| US6235930B1 (en) * | 1999-03-31 | 2001-05-22 | Board Of Trustees Operating Michigan State University | Process for the preparation of 3,4-dihydroxybutanoic acid and derivatives thereof from substituted pentose sugars |
| HU227840B1 (en) * | 1999-05-06 | 2012-05-02 | Egis Gyogyszergyar Nyilvanosan M Kod Ruszvunytarsasag | Intermediates of atorvastatin synthesis and process for producing them |
| ATE309985T1 (de) | 1999-12-17 | 2005-12-15 | Pfizer Science & Tech Ltd | Herstellungsverfahren auf industrieller basis von atorvastatin trihydrat hemi-kalziumsalz in kristalliner form |
| MXPA02004082A (es) * | 1999-12-17 | 2002-10-11 | Warner Lambert Res & Dev | Un proceso para producir calcio de atorvastatin cristalino. |
| JP4598917B2 (ja) * | 2000-04-28 | 2010-12-15 | ダイセル化学工業株式会社 | ラクトンの製造方法 |
| KR100645665B1 (ko) | 2000-07-27 | 2006-11-13 | 에스케이 주식회사 | (ｓ)-베타-하이드록시-감마-부티로락톤의 연속 제조방법 |
| US6476235B2 (en) * | 2001-01-09 | 2002-11-05 | Warner-Lambert Company | Process for the synthesis of 5-(4-fluorophenyl)-1-[2-((2R,4R)-4-hydroxy-6-oxo-tetrahydro-pyran-2-yl)-ethyl]-2-isopropyl-4-phenyl-1H-pyrrole-3-carboxylic acid phenylamide |
| EP1734034A3 (de) | 2001-01-09 | 2007-01-03 | Warner-Lambert Company LLC | Carbonsäuresalze von beta-Alaninestern oder -Amiden |
| WO2002057229A1 (en) * | 2001-01-19 | 2002-07-25 | Biocon India Limited | FORM V CRYSTALLINE [R-(R*,R*)]-2-(4-FLUOROPHENYL)-ß,$G(D)-DIHYDROXY-5-(1-METHYLETHYL)-3-PHENYL-4-[(PHENYLAMINO)CARBONYL]-1H-PYRROLE-1- HEPTANOIC ACID HEMI CALCIUM SALT. (ATORVASTATIN) |
| WO2003004470A1 (en) | 2001-06-29 | 2003-01-16 | Warner-Lambert Company Llc | Crystalline forms of 'r-(r*,r*)!-2-(4-fluorophenyl)-beta, delta-dihydroxy-5-(1-methylethyl)-3-phenyl-4-'phenylamino)carbonyl!-1h-pyrrole-1-heptanoic acid calcium salt (2:1) (atorvastatin) |
| PL366610A1 (en) * | 2001-07-06 | 2005-02-07 | Teva Pharmaceutical Industries Ltd. | Process for the preparation of 7-amino syn 3,5-dihydroxy heptanoic acid derivatives via 6-cyano syn 3,5-dihydroxy hexanoic acid derivatives |
| AU2002241235B2 (en) * | 2002-02-25 | 2009-04-23 | Biocon Limited | Novel boronate esters |
| GB0211716D0 (en) | 2002-05-22 | 2002-07-03 | Phoenix Chemicals Ltd | Process |
| ES2287549T3 (es) * | 2002-08-06 | 2007-12-16 | Warner-Lambert Company Llc | Procedimiento para preparar la fenilamida del acido 5-(4-fluorofenil)-1-(2-((2r,4r)-4-hidroxi-6-oxo-tetrahidropiran-2-il)etil)-2-isopropil-4-fenil-1h-pirrol-3-carboxilico. |
| EP1558597B1 (de) * | 2002-09-18 | 2008-05-07 | SK Holdings Co., Ltd. | Kontinuierliches verfahren zur herstellung von optisch reinem (s)-beta hydroxy- gamma-butyrolacton |
| AU2003263031A1 (en) * | 2002-09-20 | 2004-04-08 | Diversa Corporation | Chemoenzymatic methods for the synthesis of statins and stain intermediates |
| US6713639B1 (en) | 2002-10-28 | 2004-03-30 | Council Of Scientific And Industrial Research | Process for preparing enantiomerically pure (S)-3-hydroxy-gamma-butyrolactone |
| RU2337905C2 (ru) * | 2003-04-14 | 2008-11-10 | Уорнер-Ламберт Компани Ллс | Способ получения фениламида 5-(4-фторфенил)-1-[2-((2r,4r)-4-гидрокси-6-оксотетрагидропиран-2-ил)этил]-2-изопропил-4-фенил-1h-пиррол-3-карбоновой кислоты |
| ES2323366T3 (es) * | 2003-04-22 | 2009-07-14 | Biocon Limited | Procedimiento novedoso para la reduccion estereoselectiva de beta-cetoesteres. |
| US7790197B2 (en) * | 2003-06-09 | 2010-09-07 | Warner-Lambert Company Llc | Pharmaceutical compositions of atorvastatin |
| US7655692B2 (en) * | 2003-06-12 | 2010-02-02 | Pfizer Inc. | Process for forming amorphous atorvastatin |
| US20050271717A1 (en) * | 2003-06-12 | 2005-12-08 | Alfred Berchielli | Pharmaceutical compositions of atorvastatin |
| US20040253305A1 (en) * | 2003-06-12 | 2004-12-16 | Luner Paul E. | Pharmaceutical compositions of atorvastatin |
| EP1663969A1 (de) * | 2003-09-17 | 2006-06-07 | Warner-Lambert Company LLC | Kristalline formen von [r-(r*,r*)]-2-(4-fluorphenyl)-beta,delta-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1h-pyrrol-1-heptansäure |
| WO2005068642A2 (en) | 2003-10-01 | 2005-07-28 | Board Of Trustees Operating Michigan State University | Bacterial synthesis of 1,2,4-butanetriol enantiomers |
| CA2562844A1 (en) * | 2004-04-16 | 2005-10-27 | Pfizer Products Inc. | Process for forming amorphous atorvastatin calcium |
| CA2649054A1 (en) | 2004-05-05 | 2005-11-10 | Pfizer Products Inc. | Salt forms of [r-(r*,r*)]-2-(4-fluorophenyl)-.beta., .delta.-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1h-pyrrole-1-heptanoic acid |
| US8026376B2 (en) | 2004-07-20 | 2011-09-27 | Pfizer, Inc. | Forms of [R-(R*,R*)]-2-(4-fluorophenyl)-β,δ-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrole-1-heptanoicacid calcium salt (2:1) |
| CN101048141A (zh) * | 2004-10-28 | 2007-10-03 | 沃尼尔·朗伯有限责任公司 | 形成非晶形的阿托伐他汀的方法 |
| US20090088465A1 (en) * | 2004-12-02 | 2009-04-02 | Stephen Craig Dyar | Pharmaceutical Compositions of Amorphous Atorvastatin and Process for Preparing Same |
| WO2006129649A1 (ja) * | 2005-05-31 | 2006-12-07 | Kowa Co., Ltd. | 光学活性ｐｐａｒ活性化化合物及びその製造中間体の製造法 |
| CA2547216A1 (en) | 2005-09-21 | 2007-03-21 | Renuka D. Reddy | Process for annealing amorphous atorvastatin |
| DE602006014193D1 (de) | 2005-11-21 | 2010-06-17 | Warner Lambert Co | Neue formen von är-(r*,r*)ü-2-(4-fluorphenyl)-b,d-dihydroxy-5-(1-methylethyl)-3-phenyl-4-ä(phenylamino)carbonylü-1h-pyrrol-1-heptansäure-magnesium |
| US20110165641A1 (en) * | 2006-03-31 | 2011-07-07 | The Board Of Trustees Of Michigan State University | Synthesis of 1,2,4-Butanetriol Enantiomers from Carbohydrates |
| CN101512004A (zh) * | 2006-07-19 | 2009-08-19 | 密歇根州州立大学托管委员会 | D-1,2,4-丁三醇的微生物合成 |
| KR100850558B1 (ko) | 2008-01-02 | 2008-08-06 | 조동옥 | 아토르바스타틴의 효율적인 제조방법 |
| JP2009256316A (ja) | 2008-03-28 | 2009-11-05 | Daicel Chem Ind Ltd | β−ヒドロキシ−γ−ブチロラクトンの製造方法 |
| CN101337906B (zh) * | 2008-08-15 | 2012-06-27 | 河南豫辰精细化工有限公司 | 一种4-甲基-3-氧代-n-苯基戊酰胺的制备方法 |
| EP2327682A1 (de) | 2009-10-29 | 2011-06-01 | KRKA, D.D., Novo Mesto | Verwendung von amphiphilen Verbindungen zur gesteuerten Kristallisation von Statinen und Statin Zwischenprodukte. |
| SI2373609T1 (sl) | 2008-12-19 | 2013-12-31 | Krka, D.D., Novo Mesto | Uporaba amfifilnih spojin za kontrolirano kristalizacijo statinov in intermediatov statinov |
| MX2013015272A (es) | 2011-07-01 | 2014-04-14 | Dsm Sinochem Pharm Nl Bv | Cristales micronizados. |
| CN106397241A (zh) * | 2016-08-23 | 2017-02-15 | 杨锋 | 一种4‑甲基‑3‑氧代‑n‑苯基戊酰胺的绿色环保后处理方法 |
| CN106588689A (zh) * | 2016-12-15 | 2017-04-26 | 河南豫辰药业股份有限公司 | 一种从结晶母液废液中回收阿托伐他汀中间体m4的方法 |
| CN112939901B (zh) * | 2021-02-09 | 2023-05-09 | 中国科学院福建物质结构研究所 | 一种α-羟基-γ-丁内酯的制备方法 |
| CN114195670B (zh) * | 2021-12-31 | 2024-03-15 | 河南豫辰药业股份有限公司 | 一种阿托伐他汀母核m4的精制方法 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2710688B2 (ja) * | 1990-10-09 | 1998-02-10 | 鐘淵化学工業株式会社 | ４―ブロモ―３―ヒドロキシ酪酸エステル誘導体の製造法 |
| CA2049536C (en) * | 1991-05-13 | 1999-07-06 | Rawle I. Hollingsworth | Process for the preparation of 3,4-dihydroxybutanoic acid and salts thereof |
| JP3351563B2 (ja) * | 1992-12-03 | 2002-11-25 | 鐘淵化学工業株式会社 | ３−ヒドロキシ酪酸誘導体の製造法 |
| TR199900191T2 (xx) * | 1996-07-29 | 1999-04-21 | Warner-Lambert Company | (S)-3,4-Dihidroksibutirik asitin korumal� esterlerinin sentezi i�in geli�tirilmi� proses. |
-
1997
- 1997-07-01 TR TR1999/00191T patent/TR199900191T2/xx unknown
- 1997-07-01 DE DE69711391T patent/DE69711391T2/de not_active Expired - Fee Related
- 1997-07-01 KR KR10-1999-7000721A patent/KR100447370B1/ko not_active IP Right Cessation
- 1997-07-01 US US09/230,397 patent/US5998633A/en not_active Expired - Fee Related
- 1997-07-01 ES ES97931557T patent/ES2176756T3/es not_active Expired - Lifetime
- 1997-07-01 PT PT97931557T patent/PT915866E/pt unknown
- 1997-07-01 EP EP97931557A patent/EP0915866B1/de not_active Expired - Lifetime
- 1997-07-01 WO PCT/US1997/011654 patent/WO1998004543A1/en active IP Right Grant
- 1997-07-01 DK DK97931557T patent/DK0915866T3/da active
- 1997-07-01 AT AT97931557T patent/ATE215078T1/de not_active IP Right Cessation
- 1997-07-01 JP JP10508813A patent/JP2000515882A/ja not_active Ceased
- 1997-07-01 AU AU35154/97A patent/AU3515497A/en not_active Abandoned
- 1997-07-01 CN CN97195996A patent/CN1093126C/zh not_active Expired - Fee Related
- 1997-07-01 IL IL12705897A patent/IL127058A/en not_active IP Right Cessation
- 1997-07-01 HU HU9904348A patent/HU226465B1/hu not_active IP Right Cessation
- 1997-07-28 CO CO97042973A patent/CO4950542A1/es unknown
- 1997-07-28 ZA ZA9706705A patent/ZA976705B/xx unknown
-
1999
- 1999-12-09 HK HK99105756A patent/HK1020728A1/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| WO1998004543A1 (en) | 1998-02-05 |
| HUP9904348A2 (hu) | 2000-04-28 |
| HK1020728A1 (en) | 2000-05-19 |
| US5998633A (en) | 1999-12-07 |
| TR199900191T2 (xx) | 1999-04-21 |
| HU226465B1 (en) | 2008-12-29 |
| CN1223647A (zh) | 1999-07-21 |
| IL127058A0 (en) | 1999-09-22 |
| KR100447370B1 (ko) | 2004-09-08 |
| EP0915866B1 (de) | 2002-03-27 |
| EP0915866A1 (de) | 1999-05-19 |
| DE69711391T2 (de) | 2002-11-07 |
| KR20000029648A (ko) | 2000-05-25 |
| DE69711391D1 (de) | 2002-05-02 |
| HUP9904348A3 (en) | 2004-03-01 |
| PT915866E (pt) | 2002-07-31 |
| JP2000515882A (ja) | 2000-11-28 |
| IL127058A (en) | 2001-07-24 |
| CO4950542A1 (es) | 2000-09-01 |
| CN1093126C (zh) | 2002-10-23 |
| DK0915866T3 (da) | 2002-06-10 |
| AU3515497A (en) | 1998-02-20 |
| ES2176756T3 (es) | 2002-12-01 |
| ZA976705B (en) | 1998-02-10 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
Ref document number: 0915866 Country of ref document: EP |
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| REN | Ceased due to non-payment of the annual fee |