EA199800931A1 - Способ получения ингибиторов фосфодиэстеразы iv - Google Patents

Способ получения ингибиторов фосфодиэстеразы iv

Info

Publication number
EA199800931A1
EA199800931A1 EA199800931A EA199800931A EA199800931A1 EA 199800931 A1 EA199800931 A1 EA 199800931A1 EA 199800931 A EA199800931 A EA 199800931A EA 199800931 A EA199800931 A EA 199800931A EA 199800931 A1 EA199800931 A1 EA 199800931A1
Authority
EA
Eurasian Patent Office
Prior art keywords
obtaining
phosphodystrase
inhibitors
compound
phenyl
Prior art date
Application number
EA199800931A
Other languages
English (en)
Other versions
EA000877B1 (ru
Inventor
Иоаннис Хоупис
Одри Молина
Ральф П. Волант
Original Assignee
Мерк Энд Ко., Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9612083.7A external-priority patent/GB9612083D0/en
Application filed by Мерк Энд Ко., Инк. filed Critical Мерк Энд Ко., Инк.
Publication of EA199800931A1 publication Critical patent/EA199800931A1/ru
Publication of EA000877B1 publication Critical patent/EA000877B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
    • C07D213/32—Sulfur atoms
    • C07D213/34—Sulfur atoms to which a second hetero atom is attached
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pulmonology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

Способ получения соединения структурной формулы (I), где Rобозначает алкил, алкенил, фенил или замещенный фенил, который включает присоединение Rк промежуточному соединению (2) путем обработки соединения (2) соединением (R)М с последующим восстановительным удалением сульфинильной группы.Международная заявка была опубликована вместе с отчетом о международном поиске.
EA199800931A 1996-04-17 1997-04-14 Способ получения ингибиторов фосфодиэстеразы iv EA000877B1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US1568796P 1996-04-17 1996-04-17
GBGB9612083.7A GB9612083D0 (en) 1996-06-10 1996-06-10 Method of preparing phosphodiesterase IV inhibitors
PCT/US1997/006131 WO1997038976A1 (en) 1996-04-17 1997-04-14 Method of preparing phosphodiesterase iv inhibitors

Publications (2)

Publication Number Publication Date
EA199800931A1 true EA199800931A1 (ru) 1999-04-29
EA000877B1 EA000877B1 (ru) 2000-06-26

Family

ID=26309476

Family Applications (1)

Application Number Title Priority Date Filing Date
EA199800931A EA000877B1 (ru) 1996-04-17 1997-04-14 Способ получения ингибиторов фосфодиэстеразы iv

Country Status (10)

Country Link
EP (1) EP0898564A1 (ru)
CN (1) CN1216532A (ru)
AR (1) AR006550A1 (ru)
AU (1) AU2459297A (ru)
BR (1) BR9708684A (ru)
CZ (1) CZ333298A3 (ru)
EA (1) EA000877B1 (ru)
SK (1) SK143198A3 (ru)
TW (1) TW426669B (ru)
WO (1) WO1997038976A1 (ru)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998012178A1 (en) * 1996-09-17 1998-03-26 Merck & Co., Inc. Method of preparing phosphodiesterase iv inhibitors
TW508353B (en) * 1996-09-17 2002-11-01 Merck & Co Inc Method of preparing phosphodiesterase IV inhibitors

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW263495B (ru) * 1992-12-23 1995-11-21 Celltech Ltd
GB9326173D0 (en) * 1993-12-22 1994-02-23 Celltech Ltd Chemical compounds and process

Also Published As

Publication number Publication date
EA000877B1 (ru) 2000-06-26
EP0898564A1 (en) 1999-03-03
AU2459297A (en) 1997-11-07
AR006550A1 (es) 1999-09-08
CN1216532A (zh) 1999-05-12
CZ333298A3 (cs) 1999-03-17
SK143198A3 (en) 1999-06-11
BR9708684A (pt) 1999-08-03
WO1997038976A1 (en) 1997-10-23
TW426669B (en) 2001-03-21

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Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM

MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): RU