EA200201210A1 - Синтетический способ получения соединения эктеинасцидина - Google Patents

Синтетический способ получения соединения эктеинасцидина

Info

Publication number
EA200201210A1
EA200201210A1 EA200201210A EA200201210A EA200201210A1 EA 200201210 A1 EA200201210 A1 EA 200201210A1 EA 200201210 A EA200201210 A EA 200201210A EA 200201210 A EA200201210 A EA 200201210A EA 200201210 A1 EA200201210 A1 EA 200201210A1
Authority
EA
Eurasian Patent Office
Prior art keywords
compound
ekteinascidine
obtaining
bridge
synthetic method
Prior art date
Application number
EA200201210A
Other languages
English (en)
Other versions
EA006369B1 (ru
Inventor
Кармен Куэвас
Марта Перес
Андрес Франсесч
Каролина Фернандес
Хосе Луис Чичарро
Пилар Гальего
Мария Сарсуэло
Игнасио Мансанарес
Мария Хесус Мартин
Саймон Мант
Original Assignee
Фарма Мар, С.А.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/GB2000/001852 external-priority patent/WO2000069862A2/en
Application filed by Фарма Мар, С.А. filed Critical Фарма Мар, С.А.
Publication of EA200201210A1 publication Critical patent/EA200201210A1/ru
Publication of EA006369B1 publication Critical patent/EA006369B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/08—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/18—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/22—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed systems contains four or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D497/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having oxygen and sulfur atoms as the only ring hetero atoms
    • C07D497/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having oxygen and sulfur atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D515/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D515/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains four or more hetero rings
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Saccharide Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyrane Compounds (AREA)
  • Discharging, Photosensitive Material Shape In Electrophotography (AREA)
  • Instruments For Viewing The Inside Of Hollow Bodies (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

Описан способ получения соединений с конденсированной циклической структурой формулы (XIV). Указанными продуктами являются эктеинасцидины, которые имеют спироамин-1,4-мостик. Указанный способ включает образование 1,4-мостика с использованием (1-лабильный)-10-гидрокси-(18-защищенный гидрокси)-ди-6,8-ен-5-он-конденсированного циклического соединения. После образования 1,4-мостика, С-18-защиту удаляют перед введением спироамина.Международная заявка была опубликована вместе с отчетом о международном поиске.
EA200201210A 2000-05-15 2001-05-15 Синтетический способ получения соединения эктеинасцидина EA006369B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
PCT/GB2000/001852 WO2000069862A2 (en) 1999-05-14 2000-05-15 Hemisynthetic method and intermediates thereof
PCT/GB2001/002120 WO2001087895A1 (en) 1999-05-14 2001-05-15 Synthetic process for the manufacture of an ecteinaschidin compound

Publications (2)

Publication Number Publication Date
EA200201210A1 true EA200201210A1 (ru) 2003-04-24
EA006369B1 EA006369B1 (ru) 2005-12-29

Family

ID=34855248

Family Applications (2)

Application Number Title Priority Date Filing Date
EA200201209A EA006070B1 (ru) 2000-05-15 2001-05-15 Противоопухолевые аналоги ет-743
EA200201210A EA006369B1 (ru) 2000-05-15 2001-05-15 Синтетический способ получения соединения эктеинасцидина

Family Applications Before (1)

Application Number Title Priority Date Filing Date
EA200201209A EA006070B1 (ru) 2000-05-15 2001-05-15 Противоопухолевые аналоги ет-743

Country Status (17)

Country Link
EP (3) EP1289999B1 (ru)
KR (2) KR100830717B1 (ru)
AT (2) ATE368671T1 (ru)
AU (2) AU2001256496C1 (ru)
DE (3) DE60112286T2 (ru)
DK (3) DK1287004T3 (ru)
EA (2) EA006070B1 (ru)
ES (2) ES2290583T3 (ru)
GB (1) GB9918178D0 (ru)
HK (1) HK1050193A1 (ru)
HU (1) HU228789B1 (ru)
MX (1) MXPA02010701A (ru)
NZ (2) NZ521807A (ru)
PL (2) PL203745B1 (ru)
PT (3) PT1496060E (ru)
SI (2) SI1496060T1 (ru)
UA (1) UA75597C2 (ru)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1658848B1 (en) 2004-10-29 2007-08-01 Pharma Mar S.A., Sociedad Unipersonal Formulations comprising ecteinascidin and a disaccharide
KR100676324B1 (ko) * 2005-03-15 2007-01-30 삼성전자주식회사 디스플레이장치
KR100676325B1 (ko) * 2005-03-15 2007-01-30 삼성전자주식회사 디스플레이장치
KR100712667B1 (ko) * 2006-04-11 2007-05-02 재단법인서울대학교산학협력재단 신규한 디아자 헤테로고리 유도체 및 그의 고체상 제조방법
CN107033164A (zh) * 2010-05-25 2017-08-11 法马马有限公司 制备海鞘素化合物的合成方法
JOP20190254A1 (ar) 2017-04-27 2019-10-27 Pharma Mar Sa مركبات مضادة للأورام
WO2020105068A1 (en) * 2018-11-24 2020-05-28 Natco Pharma Limited Process for the preparation of ecteinascidin derivative and its intermediate

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS59225189A (ja) 1983-06-03 1984-12-18 Shionogi & Co Ltd キノナミン誘導体およびその製造法
WO1987007610A2 (en) * 1986-06-09 1987-12-17 University Of Illinois Ecteinascidins 729, 743, 745, 759a, 759b and 770
US5721362A (en) * 1996-09-18 1998-02-24 President And Fellows Of Harvard College Process for producing ecteinascidin compounds
US6124292A (en) * 1998-09-30 2000-09-26 President And Fellows Of Harvard College Synthetic analogs of ecteinascidin-743

Also Published As

Publication number Publication date
PL358258A1 (en) 2004-08-09
EP1287004A1 (en) 2003-03-05
SI1289999T1 (en) 2005-06-30
PT1496060E (pt) 2007-10-30
AU2001256496B2 (en) 2006-02-16
DK1496060T3 (da) 2007-12-03
EP1287004B1 (en) 2005-07-27
KR100830717B1 (ko) 2008-05-20
EA200201209A1 (ru) 2003-04-24
SI1496060T1 (sl) 2008-06-30
AU2001256496C1 (en) 2006-08-03
GB9918178D0 (en) 1999-10-06
EA006070B1 (ru) 2005-08-25
AU783563B2 (en) 2005-11-10
ES2248319T3 (es) 2006-03-16
AU5649301A (en) 2001-11-26
DE60129753T2 (de) 2008-04-30
ATE368671T1 (de) 2007-08-15
KR20030031481A (ko) 2003-04-21
DE60129753D1 (de) 2007-09-13
KR20030005308A (ko) 2003-01-17
NZ532793A (en) 2004-10-29
PT1287004E (pt) 2005-11-30
HUP0300648A3 (en) 2006-05-29
KR100777464B1 (ko) 2007-11-27
EA006369B1 (ru) 2005-12-29
HUP0300648A2 (hu) 2003-07-28
NZ521807A (en) 2004-06-25
DE60107241D1 (de) 2004-12-23
DK1287004T3 (da) 2005-11-28
EP1289999B1 (en) 2004-11-17
MXPA02010701A (es) 2003-05-14
UA75597C2 (en) 2006-05-15
DE60112286D1 (de) 2005-09-01
EP1496060B1 (en) 2007-08-01
EP1496060A1 (en) 2005-01-12
PL203745B1 (pl) 2009-11-30
EP1289999A1 (en) 2003-03-12
ATE300547T1 (de) 2005-08-15
ES2290583T3 (es) 2008-02-16
HK1050193A1 (en) 2003-06-13
DE60107241T2 (de) 2006-08-03
PT1289999E (pt) 2005-03-31
PL358143A1 (en) 2004-08-09
HU228789B1 (en) 2013-05-28
PL215769B1 (pl) 2014-01-31
DK1289999T3 (da) 2005-03-14
DE60112286T2 (de) 2006-06-01

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Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM

MK4A Patent expired

Designated state(s): RU