EA200201083A1 - Противоопухолевые производные эктейнасцидина - Google Patents

Противоопухолевые производные эктейнасцидина

Info

Publication number
EA200201083A1
EA200201083A1 EA200201083A EA200201083A EA200201083A1 EA 200201083 A1 EA200201083 A1 EA 200201083A1 EA 200201083 A EA200201083 A EA 200201083A EA 200201083 A EA200201083 A EA 200201083A EA 200201083 A1 EA200201083 A1 EA 200201083A1
Authority
EA
Eurasian Patent Office
Prior art keywords
ekteynascidine
derivatives
bridge
compounds
tumor derivatives
Prior art date
Application number
EA200201083A
Other languages
English (en)
Other versions
EA006206B1 (ru
Inventor
Мария Флорес
Андрес Франсесч
Пилар Гальего
Хосе Луис Чичарро
Мария Сарсуэло
Каролина Фернандес
Игнасио Мансанарес
Original Assignee
Фарма Мар, С.А.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0009043A external-priority patent/GB0009043D0/en
Priority claimed from PCT/GB2000/001852 external-priority patent/WO2000069862A2/en
Priority claimed from GB0022644A external-priority patent/GB0022644D0/en
Application filed by Фарма Мар, С.А. filed Critical Фарма Мар, С.А.
Publication of EA200201083A1 publication Critical patent/EA200201083A1/ru
Publication of EA006206B1 publication Critical patent/EA006206B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D515/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D515/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains four or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Abstract

Раскрыты соединения, обладающие, конденсированной системой эктейнасцидина из пяти колец с 1,4-мостиком, имеющим структуру формулы (VIa или VIb), а также их производные по -NHили -ОН группе 1,4-мостика. Такие соединения пригодны для лечения опухолей.Международная заявка была опубликована вместе с отчетом о международном поиске.
EA200201083A 2000-04-12 2001-04-12 Противоопухолевые производные эктейнасцидина EA006206B1 (ru)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB0009043A GB0009043D0 (en) 2000-04-12 2000-04-12 New autitumoural derivatives of ET-743
PCT/GB2000/001852 WO2000069862A2 (en) 1999-05-14 2000-05-15 Hemisynthetic method and intermediates thereof
GB0022644A GB0022644D0 (en) 2000-09-14 2000-09-14 Antitumoral derivatives of ET-743
PCT/GB2001/001667 WO2001077115A1 (en) 2000-04-12 2001-04-12 Antitumoral ecteinascidin derivatives

Publications (2)

Publication Number Publication Date
EA200201083A1 true EA200201083A1 (ru) 2003-04-24
EA006206B1 EA006206B1 (ru) 2005-10-27

Family

ID=26244092

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200201083A EA006206B1 (ru) 2000-04-12 2001-04-12 Противоопухолевые производные эктейнасцидина

Country Status (27)

Country Link
US (1) US7202361B2 (ru)
EP (1) EP1280809B1 (ru)
JP (1) JP5219323B2 (ru)
KR (1) KR100886496B1 (ru)
CN (1) CN1436191B (ru)
AR (1) AR032879A1 (ru)
AT (1) ATE299146T1 (ru)
AU (1) AU784249C (ru)
BG (1) BG65987B1 (ru)
BR (1) BRPI0110024B8 (ru)
CA (1) CA2406080C (ru)
CZ (1) CZ304749B6 (ru)
DE (1) DE60111845T2 (ru)
DK (1) DK1280809T3 (ru)
EA (1) EA006206B1 (ru)
ES (1) ES2244598T3 (ru)
HK (1) HK1049005B (ru)
HU (1) HU230918B1 (ru)
IL (1) IL152094A (ru)
MX (1) MXPA02010088A (ru)
NO (1) NO329125B1 (ru)
NZ (1) NZ521550A (ru)
PL (1) PL210703B1 (ru)
PT (1) PT1280809E (ru)
SI (1) SI1280809T1 (ru)
SK (1) SK288017B6 (ru)
WO (1) WO2001077115A1 (ru)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SK285069B6 (sk) * 1998-05-11 2006-05-04 Pharma Mar, S. A. Zlúčeniny, ktoré sú metabolitmi ekteinascidínu 743, farmaceutické prostriedky s ich obsahom a ich použitie
MY164077A (en) 1999-05-13 2017-11-30 Pharma Mar Sa Compositions and uses of et743 for treating cancer
MY130271A (en) * 1999-05-14 2007-06-29 Pharma Mar Sa Hemisynthetic method and new compounds
US7919493B2 (en) 2000-04-12 2011-04-05 Pharma Mar, S.A. Anititumoral ecteinascidin derivatives
US7420051B2 (en) 2000-05-15 2008-09-02 Pharma Mar, S.A. Synthetic process for the manufacture of an ecteinaschidin compound
MXPA02011319A (es) * 2000-05-15 2003-06-06 Pharma Mar Sa Analogos antitumorales de ecteinascidina 743.
GB0117402D0 (en) 2001-07-17 2001-09-05 Pharma Mar Sa New antitumoral derivatives of et-743
GB0119243D0 (en) * 2001-08-07 2001-10-03 Pharma Mar Sa Antitumoral analogs of ET-743
WO2003039571A1 (en) * 2001-10-19 2003-05-15 Pharmamar S.A. Improved use of antitumoral compound in cancer therapy
JP4208469B2 (ja) * 2002-01-29 2009-01-14 独立行政法人科学技術振興機構 エクテナサイジン類の全合成方法、エクテナサイジン類に類縁構造を持つ前記全合成用中間体化合物類、及び該中間体化合物類の合成方法
GB0202544D0 (en) * 2002-02-04 2002-03-20 Pharma Mar Sa The synthesis of naturally occuring ecteinascidins and related compounds
RS50692B (sr) 2003-11-13 2010-06-30 Pharma Mar S.A.U. Kombinacija et-743 sa prolekovima 5-fluorouracila za lečenje kancera
JP2008514688A (ja) * 2004-09-29 2008-05-08 ファルマ・マル・エス・アー， ソシエダッド・ユニペルソナル 抗炎症剤としてのエクテイナシジン化合物
BRPI0517238B1 (pt) 2004-10-29 2021-11-09 Pharma Mar, S.A. Composições que compreendem ecteinascidina e um dissacarídeo, método para produzir um frasco que contém a referida composição e para preparar uma solução para infusão intravenosa e uso da referida solução
US8067462B2 (en) * 2004-12-20 2011-11-29 The Trustees Of Columbia University In The City Of New York Processes of making sesquiterpenoid tashironin, its analogs and their uses
US20090131498A1 (en) * 2005-01-18 2009-05-21 Danishefsky Samuel J Enantioselective Synthesis of Merrilactone and Its Analogs
GB0522082D0 (en) 2005-10-31 2005-12-07 Pharma Mar Sa Formulations
WO2007087220A2 (en) * 2006-01-25 2007-08-02 The Trustees Of Columbia University In The City Of New York The total synthesis of ecteinascidin 743 and derivatives thereof
FR2936951B1 (fr) * 2008-10-10 2010-12-03 Novexel Nouvelles combinaisons de composes heterocycliques azotes antibacteriens avec d'autres composes antibacteriens et leur utilisation comme medicaments
CN103038240A (zh) 2010-05-25 2013-04-10 法马马有限公司 制备海鞘素化合物的合成方法
KR20170096065A (ko) 2010-11-12 2017-08-23 파르마 마르 에스.에이. 항종양 알칼로이드를 이용한 병용요법
JOP20190254A1 (ar) 2017-04-27 2019-10-27 Pharma Mar Sa مركبات مضادة للأورام
CN112679513B (zh) * 2019-10-18 2023-08-25 南通诺泰生物医药技术有限公司 一种制备曲贝替定的关键中间体的方法
CN114940682A (zh) * 2022-05-18 2022-08-26 博瑞制药(苏州)有限公司 芦比替定的晶型及其制备方法和用途
CN115677728A (zh) * 2022-11-02 2023-02-03 成都科岭源医药技术有限公司 一种海鞘素类化合物中间体的制备方法

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS59225189A (ja) 1983-06-03 1984-12-18 Shionogi & Co Ltd キノナミン誘導体およびその製造法
JPS6084288A (ja) 1983-10-13 1985-05-13 Shionogi & Co Ltd シアノキノナミンアセテ−ト類およびその製造法
US5089273A (en) 1986-06-09 1992-02-18 Board Of Trustees Of The University Of Illinois Ecteinascidins 729, 743, 745, 759A, 759B and 770
US5149804A (en) 1990-11-30 1992-09-22 The Board Of Trustees Of The University Of Illinois Ecteinascidins 736 and 722
EP0309477B1 (en) 1986-06-09 1991-11-06 The Board Of Trustees Of The University Of Illinois Ecteinascidins 729, 743, 745, 759a, 759b and 770
US5256663A (en) 1986-06-09 1993-10-26 The Board Of Trustees Of The University Of Illinois Compositions comprising ecteinascidins and a method of treating herpes simplex virus infections therewith
US5721365A (en) * 1989-09-15 1998-02-24 Us Health N-substituted piperazine NONOates
US5478932A (en) 1993-12-02 1995-12-26 The Board Of Trustees Of The University Of Illinois Ecteinascidins
US5721362A (en) 1996-09-18 1998-02-24 President And Fellows Of Harvard College Process for producing ecteinascidin compounds
US5985876A (en) * 1997-04-15 1999-11-16 Univ Illinois Nucleophile substituted ecteinascidins and N-oxide ecteinascidins
SK285069B6 (sk) 1998-05-11 2006-05-04 Pharma Mar, S. A. Zlúčeniny, ktoré sú metabolitmi ekteinascidínu 743, farmaceutické prostriedky s ich obsahom a ich použitie
US6124292A (en) 1998-09-30 2000-09-26 President And Fellows Of Harvard College Synthetic analogs of ecteinascidin-743
MY130271A (en) 1999-05-14 2007-06-29 Pharma Mar Sa Hemisynthetic method and new compounds
US6686470B2 (en) 2000-01-19 2004-02-03 The Trustees Of Columbia University In The City Of New York Compounds of the saframycin-ecteinascidin series, uses, and synthesis thereof
MXPA02011319A (es) 2000-05-15 2003-06-06 Pharma Mar Sa Analogos antitumorales de ecteinascidina 743.

Also Published As

Publication number Publication date
AU784249B2 (en) 2006-02-23
HK1049005A1 (en) 2003-04-25
JP5219323B2 (ja) 2013-06-26
HK1049005B (zh) 2006-01-27
HU230918B1 (hu) 2019-03-28
IL152094A0 (en) 2003-05-29
EA006206B1 (ru) 2005-10-27
BRPI0110024B8 (pt) 2021-05-25
CZ20023352A3 (cs) 2003-05-14
SI1280809T1 (sl) 2005-12-31
DK1280809T3 (da) 2005-11-07
HUP0300534A2 (hu) 2003-07-28
BG65987B1 (bg) 2010-08-31
CN1436193A (zh) 2003-08-13
ES2244598T3 (es) 2005-12-16
BR0110024A (pt) 2003-02-18
KR100886496B1 (ko) 2009-03-05
AR032879A1 (es) 2003-12-03
SK288017B6 (sk) 2012-11-05
BRPI0110024B1 (pt) 2019-07-16
CA2406080C (en) 2011-11-29
JP2003530402A (ja) 2003-10-14
NO20024906D0 (no) 2002-10-11
EP1280809B1 (en) 2005-07-06
BG107220A (en) 2003-05-30
CA2406080A1 (en) 2001-10-18
ATE299146T1 (de) 2005-07-15
CN1436191B (zh) 2011-09-14
KR20030012864A (ko) 2003-02-12
HUP0300534A3 (en) 2006-02-28
US20030216397A1 (en) 2003-11-20
AU4672901A (en) 2001-10-23
SK14352002A3 (sk) 2003-04-01
PL357574A1 (en) 2004-07-26
AU784249C (en) 2007-05-03
IL152094A (en) 2011-10-31
NZ521550A (en) 2004-10-29
DE60111845D1 (de) 2005-08-11
EP1280809A1 (en) 2003-02-05
DE60111845T2 (de) 2006-04-27
NO20024906L (no) 2002-11-27
PT1280809E (pt) 2005-11-30
WO2001077115A1 (en) 2001-10-18
US7202361B2 (en) 2007-04-10
PL210703B1 (pl) 2012-02-29
MXPA02010088A (es) 2004-08-19
NO329125B1 (no) 2010-08-30
CZ304749B6 (cs) 2014-09-24

Similar Documents

Publication Publication Date Title
EA200201083A1 (ru) Противоопухолевые производные эктейнасцидина
EA200000592A1 (ru) Азаполициклические соединения, конденсированные с арилом
EA200100412A1 (ru) Замещенные 3-цианохинолины в качестве ингибиторов протеинтирозинкиназ
EA200100411A1 (ru) Замещенные 3-цианохинолины в качестве ингибиторов протеинтирозинкиназ
ES2172864T3 (es) 2-metoxibenzofenonas fungicidas.
ES2103751T3 (es) Procedimiento para la obtencion de oxetanonas.
EA200400893A1 (ru) N-арил-2-оксазолидинон-5-карбоксамиды, их производные и их применение в качестве антибактериальных средств
TR200101969T2 (tr) Enflamasyon tedavisi için sübstitüe edilmiş benzopiran analogları.
FR2733244B1 (fr) Systeme de stabilisants a base de derives de polyalkylpiperidine
EA200300050A1 (ru) Гликопептидфосфонатные производные
ECSP034600A (es) Compuestos de lactama
CY1105387T1 (el) Υποκατεστημενα παραγωγα 2-διαλκυλαμινοαλκυλοδιφαινθλιου
EA200100983A1 (ru) Производные 13-метилэритромицина
DE69634961D1 (de) Neue zyklische depsipeptid pf1022 derivate
ES2169242T3 (es) 2-amino-benzoxazinonas para el tratamiento de infecciones virales.
EA199900163A1 (ru) Акрилоил-замещенные производные дистамицина, способы их получения и их применение в качестве противоопухолевых и противовирусных средств
TR200002932T2 (tr) Azabisayklik 5HT1 Alıcı liganolları
EA199900235A1 (ru) Аморфные бензотиофены, способы получения и способы применения
ES2101798T3 (es) Policondensados melaminicos.
DE69703115T2 (de) Zwischenprodukte um 2-imidazolin-5onederivate herzustellen.
MX9709016A (es) 2-amino-benzoxazinonas, composiciones que las contienen y uso de las mismas.
PT1140932E (pt) Derivados de 1,8-benzonaftiridina
EA200101090A1 (ru) Псевдомициновые природные продукты
EA199800931A1 (ru) Способ получения ингибиторов фосфодиэстеразы iv
DE60108242D1 (de) Herstellung von hydroxyverbindungen

Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ KZ KG MD TJ TM

MK4A Patent expired

Designated state(s): BY RU