EA200400893A1 - N-арил-2-оксазолидинон-5-карбоксамиды, их производные и их применение в качестве антибактериальных средств - Google Patents

N-арил-2-оксазолидинон-5-карбоксамиды, их производные и их применение в качестве антибактериальных средств

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Publication number
EA200400893A1
EA200400893A1 EA200400893A EA200400893A EA200400893A1 EA 200400893 A1 EA200400893 A1 EA 200400893A1 EA 200400893 A EA200400893 A EA 200400893A EA 200400893 A EA200400893 A EA 200400893A EA 200400893 A1 EA200400893 A1 EA 200400893A1
Authority
EA
Eurasian Patent Office
Prior art keywords
aryl
oxazolidinone
carboxamides
derivatives
antibacterial drugs
Prior art date
Application number
EA200400893A
Other languages
English (en)
Other versions
EA007490B1 (ru
Inventor
Ричард К. Томас
Тони-Джо Пол
Михаил Р. Барбачин
Михаил Ф. Гордеев
Гэри У. Люр
Адам Ренсло
Апиндер Сингх
Original Assignee
Фармация Энд Апджон Компани
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Фармация Энд Апджон Компани filed Critical Фармация Энд Апджон Компани
Publication of EA200400893A1 publication Critical patent/EA200400893A1/ru
Publication of EA007490B1 publication Critical patent/EA007490B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D263/18—Oxygen atoms
    • C07D263/20—Oxygen atoms attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
    • C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
    • C07D261/10—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D261/12—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
    • C07D263/54—Benzoxazoles; Hydrogenated benzoxazoles
    • C07D263/58—Benzoxazoles; Hydrogenated benzoxazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
    • C07F9/65583—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system each of the hetero rings containing nitrogen as ring hetero atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

Соединения формулы B-C-A-CO-NH-R, причем A представляет собой структуру i, ii или iii формулы (I), (II), (III), C обозначает возможно замещенный арил или гетероарил, а B представляет собой специфическую циклическую группировку или C и B совместно представляют собой гетероциклическую группировку. Полезны в качестве антибактериальных агентов.Отчет о международном поиске был опубликован 2004.08.12.
EA200400893A 2002-02-25 2003-02-24 N-арил-2-оксазолидинон-5-карбоксамиды, их производные и их применение в качестве антибактериальных средств EA007490B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US35949502P 2002-02-25 2002-02-25
PCT/US2003/003125 WO2003072553A1 (en) 2002-02-25 2003-02-24 N-aryl-2-oxazolidinone-5-carboxamides and their derivates and their use as antibacterials

Publications (2)

Publication Number Publication Date
EA200400893A1 true EA200400893A1 (ru) 2005-02-24
EA007490B1 EA007490B1 (ru) 2006-10-27

Family

ID=27766097

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200400893A EA007490B1 (ru) 2002-02-25 2003-02-24 N-арил-2-оксазолидинон-5-карбоксамиды, их производные и их применение в качестве антибактериальных средств

Country Status (36)

Country Link
US (1) US6919329B2 (ru)
EP (1) EP1478629B1 (ru)
JP (1) JP2005524660A (ru)
KR (1) KR100613532B1 (ru)
CN (1) CN1639135A (ru)
AP (1) AP1902A (ru)
AR (1) AR038536A1 (ru)
AT (1) ATE342258T1 (ru)
AU (1) AU2003210807A1 (ru)
BR (1) BR0307924A (ru)
CA (1) CA2476038A1 (ru)
CO (1) CO5611128A2 (ru)
CY (1) CY1105797T1 (ru)
DE (1) DE60308998T2 (ru)
DK (1) DK1478629T3 (ru)
EA (1) EA007490B1 (ru)
EC (1) ECSP045245A (ru)
ES (1) ES2271615T3 (ru)
GE (1) GEP20074198B (ru)
HR (1) HRP20040717A2 (ru)
IS (1) IS7376A (ru)
MA (1) MA27180A1 (ru)
MX (1) MXPA04008205A (ru)
MY (1) MY135233A (ru)
NO (1) NO20044062L (ru)
NZ (1) NZ534521A (ru)
OA (1) OA12779A (ru)
PL (1) PL372461A1 (ru)
PT (1) PT1478629E (ru)
SI (1) SI1478629T1 (ru)
TN (1) TNSN04163A1 (ru)
TW (1) TW200305568A (ru)
UA (1) UA80112C2 (ru)
WO (1) WO2003072553A1 (ru)
YU (1) YU72804A (ru)
ZA (1) ZA200406362B (ru)

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KR20040091668A (ko) 2004-10-28
EP1478629B1 (en) 2006-10-11
AR038536A1 (es) 2005-01-19
KR100613532B1 (ko) 2006-08-16
WO2003072553A8 (en) 2004-09-16
CA2476038A1 (en) 2003-09-04
AP1902A (en) 2008-10-15
UA80112C2 (en) 2007-08-27
JP2005524660A (ja) 2005-08-18
DK1478629T3 (da) 2007-01-29
MY135233A (en) 2008-03-31
CN1639135A (zh) 2005-07-13
PT1478629E (pt) 2007-01-31
HRP20040717A2 (en) 2005-02-28
TNSN04163A1 (fr) 2007-03-12
CO5611128A2 (es) 2006-02-28
DE60308998T2 (de) 2007-03-01
TW200305568A (en) 2003-11-01
YU72804A (sh) 2006-08-17
US6919329B2 (en) 2005-07-19
OA12779A (en) 2006-07-06
EA007490B1 (ru) 2006-10-27
ECSP045245A (es) 2004-09-28
MXPA04008205A (es) 2004-11-26
GEP20074198B (en) 2007-09-25
NO20044062L (no) 2004-10-26
BR0307924A (pt) 2004-12-07
US20040044052A1 (en) 2004-03-04
NZ534521A (en) 2007-02-23
ES2271615T3 (es) 2007-04-16
WO2003072553A1 (en) 2003-09-04
ZA200406362B (en) 2006-02-22
DE60308998D1 (de) 2006-11-23
PL372461A1 (en) 2005-07-25
AU2003210807A1 (en) 2003-09-09
AP2004003110A0 (en) 2004-09-30
EP1478629A1 (en) 2004-11-24
CY1105797T1 (el) 2011-02-02
SI1478629T1 (sl) 2007-02-28
IS7376A (is) 2004-07-29
ATE342258T1 (de) 2006-11-15

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