ES2169242T3 - 2-amino-benzoxazinonas para el tratamiento de infecciones virales. - Google Patents

2-amino-benzoxazinonas para el tratamiento de infecciones virales.

Info

Publication number
ES2169242T3
ES2169242T3 ES96914762T ES96914762T ES2169242T3 ES 2169242 T3 ES2169242 T3 ES 2169242T3 ES 96914762 T ES96914762 T ES 96914762T ES 96914762 T ES96914762 T ES 96914762T ES 2169242 T3 ES2169242 T3 ES 2169242T3
Authority
ES
Spain
Prior art keywords
treatment
viral infections
benzoxazinones
amino
compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES96914762T
Other languages
English (en)
Inventor
Norman Abood
Daniel L Flynn
Daniel P Becker
Brian M Bax
Hui Li
Roger A Nosal
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
GD Searle LLC
Original Assignee
GD Searle LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by GD Searle LLC filed Critical GD Searle LLC
Priority claimed from US09/502,038 external-priority patent/US6380189B1/en
Application granted granted Critical
Publication of ES2169242T3 publication Critical patent/ES2169242T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/04—1,3-Oxazines; Hydrogenated 1,3-oxazines
    • C07D265/12—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems
    • C07D265/14—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D265/24—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring with hetero atoms directly attached in positions 2 and 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Virology (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

SE DESCUBRE UNA CLASE DE COMPUESTOS PARA EL TRATAMIENTO DE INFECCIONES VIRALES. LOS COMPUESTOS DE INTERES PARTICULAR SE DEFINEN POR LA FORMULA (I), EN LA QUE R -R SUP,4} SON COMO SE DEFINE AQUI, O SALES FARMACEUTICAMENTE ACEPTABLES DE LOS MISMOS.
ES96914762T 1995-05-24 1996-05-23 2-amino-benzoxazinonas para el tratamiento de infecciones virales. Expired - Lifetime ES2169242T3 (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US08/448,795 US5985872A (en) 1995-05-24 1995-05-24 2-amino-benzoxazinones for the treatment of viral infections
US95262498A 1998-05-15 1998-05-15
US09/502,038 US6380189B1 (en) 1995-05-24 2000-02-11 2-amino benzoxazinones for the treatment of viral infections
US10/035,433 US6683077B2 (en) 1995-05-24 2002-01-04 2-Amino-benzoxazinones for the treatment of viral infections

Publications (1)

Publication Number Publication Date
ES2169242T3 true ES2169242T3 (es) 2002-07-01

Family

ID=37772666

Family Applications (2)

Application Number Title Priority Date Filing Date
ES96914762T Expired - Lifetime ES2169242T3 (es) 1995-05-24 1996-05-23 2-amino-benzoxazinonas para el tratamiento de infecciones virales.
ES01110048T Expired - Lifetime ES2225339T3 (es) 1995-05-24 1996-05-23 2-amino-benzoxazinonas para el tratamiento de infecciones virales.

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES01110048T Expired - Lifetime ES2225339T3 (es) 1995-05-24 1996-05-23 2-amino-benzoxazinonas para el tratamiento de infecciones virales.

Country Status (15)

Country Link
US (3) US5985872A (es)
EP (1) EP0828721B1 (es)
JP (1) JPH11505849A (es)
CN (1) CN1070480C (es)
AT (2) ATE270667T1 (es)
AU (1) AU711174B2 (es)
BR (1) BR9608506A (es)
CA (1) CA2222034A1 (es)
DE (2) DE69632876T2 (es)
DK (1) DK0828721T3 (es)
ES (2) ES2169242T3 (es)
NZ (1) NZ308398A (es)
PT (2) PT828721E (es)
TW (1) TW455583B (es)
WO (1) WO1996037485A1 (es)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100460932B1 (ko) * 1995-05-24 2005-02-28 지.디. 썰 엘엘씨 바이러스감염치료용2-아미노-벤조옥사진온
US5985872A (en) 1995-05-24 1999-11-16 G.D. Searle & Co. 2-amino-benzoxazinones for the treatment of viral infections
AU3339797A (en) * 1996-06-20 1998-01-07 Smithkline Beecham Plc 4h-3,1-benzoxazin-4-one derivatives and analogs as antiviral agents
GB9710928D0 (en) * 1997-05-29 1997-07-23 Smithkline Beecham Plc Pharmaceuticals
GB9900416D0 (en) * 1999-01-08 1999-02-24 Alizyme Therapeutics Ltd Inhibitors
AR022204A1 (es) * 1999-01-08 2002-09-04 Norgine Bv Compuesto, proceso para su preparacion, composicion farmaceutica y producto comestible que lo comprende.
US6806269B1 (en) 1999-07-12 2004-10-19 G. D. Searle & Cop 2-Amino-benzoxazinones for the treatment of herpes simplex virus
CN1481245A (zh) * 1999-07-12 2004-03-10 G.D.瑟尔及两合公司 用于治疗单纯疱疹病毒的2－氨基苯并噁嗪酮
DE10036184A1 (de) * 2000-07-24 2002-02-14 Aventis Cropscience Gmbh Substituierte Sulfonylaminomethylbenzoesäure(derivate) und Verfahren zu ihrer Herstellung
WO2003002558A1 (fr) * 2001-06-13 2003-01-09 Asahi Kasei Pharma Corporation Remede pour maladies infectieuses virales
MXPA05005409A (es) * 2002-11-21 2005-08-03 Neurosearch As Derivados de arilureido y su uso medico.
US7192471B2 (en) * 2004-09-24 2007-03-20 Honeywell International Inc. Aryl-ureido benzoxazinone compounds
EP2103601B1 (en) * 2006-11-22 2012-03-14 Ajinomoto Co., Inc. Process for production of phenylalanine derivatives having quinazolinedione skeletons and intermediates for the production
EP2144870A2 (en) * 2007-04-27 2010-01-20 Paratek Pharmaceuticals, Inc. Methods for synthesizing and purifying aminoalkyl tetracycline compounds
US8356971B2 (en) * 2009-12-17 2013-01-22 Detch John W Disc turbine with streamlined hub vanes and co-axial exhaust tube
CN115109006A (zh) * 2022-05-20 2022-09-27 上海大学 一种3-取代-1,2-苯并噁嗪-4-酮类化合物及其制备方法

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3297755A (en) * 1960-12-02 1967-01-10 Hoffmann La Roche 2-chloro-5-trifluoromethylbenzo-phenone compounds
US3450700A (en) * 1966-12-20 1969-06-17 Upjohn Co 2-tertiary amino-4h-3,1-benzoxazin-4-ones
DE2218302A1 (de) * 1972-04-15 1973-10-25 Bayer Ag Verfahren zur herstellung von trifluormethylimino-derivaten von benzoxazinonen
DE2315303A1 (de) * 1973-03-27 1974-10-17 Bayer Ag Verfahren zur herstellung von n-substituierten 2-amino-3,1-benzoxazin-4-onen
US4657893A (en) * 1984-05-09 1987-04-14 Syntex (U.S.A.) Inc. 4H-3,1-benzoxazin-4-ones and related compounds and use as enzyme inhibitors
NZ210669A (en) * 1983-12-27 1988-05-30 Syntex Inc Benzoxazin-4-one derivatives and pharmaceutical compositions
US4745116A (en) * 1985-06-25 1988-05-17 Syntex (U.S.A.) Inc. 2-oxy-4H-3,1-benzoxazin-4-ones and related compounds and pharmaceutical use
US4665070A (en) * 1985-06-25 1987-05-12 Syntex (U.S.A.) Inc. 2-oxy-4H-3,1-benzoxazin-4-ones and pharmaceutical use
CA1309556C (en) * 1987-06-09 1992-10-27 Masayuki Kokubo 4h-3,1-benzoxazin-4-one compounds and pharmaceutical composition thereoffor the inhibition of serine proteases
KR920701180A (ko) * 1990-02-15 1992-08-11 이다가끼 히로시 4h-3,1-벤즈옥사진-4-온 화합물 및 그의 엘라스타아제 저해용 약학조성물
KR930700494A (ko) * 1990-04-10 1993-03-15 시게루 미즈노 신규한 옥사디논 유도체
NZ242739A (en) * 1991-05-24 1994-12-22 Arch Dev Corp Identification and purification of herpes protease nucleic acid segments and their use in the production of this protease
US5434074A (en) * 1991-07-05 1995-07-18 Gibson; D. Wade Cytomegalovirus proteinase
US5428021A (en) * 1994-01-27 1995-06-27 Sri International Human leukocyte elastase (HLE) inhibitors, and related pharmaceutical compositions and methods of use
US5652237A (en) * 1994-09-09 1997-07-29 Warner-Lambert Company 2-substituted-4H-3, 1-benzoxazin-4-ones and benzthiazin-4-ones as inhibitors of complement C1r protease for the treatment of inflammatory processes
KR100460932B1 (ko) * 1995-05-24 2005-02-28 지.디. 썰 엘엘씨 바이러스감염치료용2-아미노-벤조옥사진온
US5985872A (en) 1995-05-24 1999-11-16 G.D. Searle & Co. 2-amino-benzoxazinones for the treatment of viral infections

Also Published As

Publication number Publication date
WO1996037485A1 (en) 1996-11-28
DE69617005D1 (de) 2001-12-20
US5985872A (en) 1999-11-16
ES2225339T3 (es) 2005-03-16
PT828721E (pt) 2002-04-29
DE69617005T2 (de) 2002-07-04
EP0828721B1 (en) 2001-11-14
AU711174B2 (en) 1999-10-07
AU5803096A (en) 1996-12-11
DK0828721T3 (da) 2002-03-04
US6683077B2 (en) 2004-01-27
ATE270667T1 (de) 2004-07-15
EP0828721A1 (en) 1998-03-18
CN1190963A (zh) 1998-08-19
DE69632876D1 (de) 2004-08-12
NZ308398A (en) 1999-06-29
CA2222034A1 (en) 1996-11-28
US20030022895A1 (en) 2003-01-30
CN1070480C (zh) 2001-09-05
DE69632876T2 (de) 2005-03-03
BR9608506A (pt) 1999-06-15
JPH11505849A (ja) 1999-05-25
PT1122245E (pt) 2004-11-30
ATE208765T1 (de) 2001-11-15
TW455583B (en) 2001-09-21
US20050032793A1 (en) 2005-02-10

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