PT828721E - 2-amino-benxoxazinonas para o tratamento de infeccoes virais - Google Patents

2-amino-benxoxazinonas para o tratamento de infeccoes virais

Info

Publication number
PT828721E
PT828721E PT96914762T PT96914762T PT828721E PT 828721 E PT828721 E PT 828721E PT 96914762 T PT96914762 T PT 96914762T PT 96914762 T PT96914762 T PT 96914762T PT 828721 E PT828721 E PT 828721E
Authority
PT
Portugal
Prior art keywords
treatment
viral infections
benxoxazinones
amino
compounds
Prior art date
Application number
PT96914762T
Other languages
English (en)
Inventor
Clara I Villamil
Daniel Lee Flynn
Norman Anthony Abood
Lori Ann Schretzman
Daniel P Becker
Brian M Bax
Hui Li
Roger A Nosal
Michael J Bennett
John L Bedell
Kenneth Williams
Original Assignee
Searle & Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Searle & Co filed Critical Searle & Co
Priority claimed from US09/502,038 external-priority patent/US6380189B1/en
Publication of PT828721E publication Critical patent/PT828721E/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/04—1,3-Oxazines; Hydrogenated 1,3-oxazines
    • C07D265/12—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems
    • C07D265/14—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D265/24—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring with hetero atoms directly attached in positions 2 and 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Virology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
PT96914762T 1995-05-24 1996-05-23 2-amino-benxoxazinonas para o tratamento de infeccoes virais PT828721E (pt)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US08/448,795 US5985872A (en) 1995-05-24 1995-05-24 2-amino-benzoxazinones for the treatment of viral infections
US95262498A 1998-05-15 1998-05-15
US09/502,038 US6380189B1 (en) 1995-05-24 2000-02-11 2-amino benzoxazinones for the treatment of viral infections
US10/035,433 US6683077B2 (en) 1995-05-24 2002-01-04 2-Amino-benzoxazinones for the treatment of viral infections

Publications (1)

Publication Number Publication Date
PT828721E true PT828721E (pt) 2002-04-29

Family

ID=37772666

Family Applications (2)

Application Number Title Priority Date Filing Date
PT01110048T PT1122245E (pt) 1995-05-24 1996-05-23 2-amino-benzoxazinonas para o tratamento de infeccoes virais
PT96914762T PT828721E (pt) 1995-05-24 1996-05-23 2-amino-benxoxazinonas para o tratamento de infeccoes virais

Family Applications Before (1)

Application Number Title Priority Date Filing Date
PT01110048T PT1122245E (pt) 1995-05-24 1996-05-23 2-amino-benzoxazinonas para o tratamento de infeccoes virais

Country Status (15)

Country Link
US (3) US5985872A (pt)
EP (1) EP0828721B1 (pt)
JP (1) JPH11505849A (pt)
CN (1) CN1070480C (pt)
AT (2) ATE270667T1 (pt)
AU (1) AU711174B2 (pt)
BR (1) BR9608506A (pt)
CA (1) CA2222034A1 (pt)
DE (2) DE69617005T2 (pt)
DK (1) DK0828721T3 (pt)
ES (2) ES2225339T3 (pt)
NZ (1) NZ308398A (pt)
PT (2) PT1122245E (pt)
TW (1) TW455583B (pt)
WO (1) WO1996037485A1 (pt)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5985872A (en) 1995-05-24 1999-11-16 G.D. Searle & Co. 2-amino-benzoxazinones for the treatment of viral infections
KR100460932B1 (ko) * 1995-05-24 2005-02-28 지.디. 썰 엘엘씨 바이러스감염치료용2-아미노-벤조옥사진온
WO1997048707A1 (en) * 1996-06-20 1997-12-24 Smithkline Beecham Plc 4h-3,1-benzoxazin-4-one derivatives and analogs as antiviral agents
GB9710928D0 (en) * 1997-05-29 1997-07-23 Smithkline Beecham Plc Pharmaceuticals
GB9900416D0 (en) * 1999-01-08 1999-02-24 Alizyme Therapeutics Ltd Inhibitors
AR022204A1 (es) * 1999-01-08 2002-09-04 Norgine Bv Compuesto, proceso para su preparacion, composicion farmaceutica y producto comestible que lo comprende.
CA2378014A1 (en) * 1999-07-12 2001-01-18 G.D. Searle & Co. 2-amino-benzoxazinones for the treatment of herpes simplex virus
US6806269B1 (en) * 1999-07-12 2004-10-19 G. D. Searle & Cop 2-Amino-benzoxazinones for the treatment of herpes simplex virus
DE10036184A1 (de) * 2000-07-24 2002-02-14 Aventis Cropscience Gmbh Substituierte Sulfonylaminomethylbenzoesäure(derivate) und Verfahren zu ihrer Herstellung
US20040116420A1 (en) * 2001-06-13 2004-06-17 Wataru Takahashi Remedial agent for viral infectious disease
ATE431335T1 (de) * 2002-11-21 2009-05-15 Neurosearch As Diarylureidoderivate und deren medizinische verwendung
US7192471B2 (en) * 2004-09-24 2007-03-20 Honeywell International Inc. Aryl-ureido benzoxazinone compounds
MX297306B (es) 2006-11-22 2012-03-22 Ajinomoto Kk Procedimiento para la produccion de derivados de fenilalanina que tienen estructuras de base de quinazolinodiona e intermediarios para la produccion.
AU2008246119A1 (en) * 2007-04-27 2008-11-06 Paratek Pharmaceuticals, Inc. Methods for synthesizing and purifying aminoalkyl tetracycline compounds
US8356971B2 (en) * 2009-12-17 2013-01-22 Detch John W Disc turbine with streamlined hub vanes and co-axial exhaust tube
CN115109006A (zh) * 2022-05-20 2022-09-27 上海大学 一种3-取代-1,2-苯并噁嗪-4-酮类化合物及其制备方法

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3297755A (en) * 1960-12-02 1967-01-10 Hoffmann La Roche 2-chloro-5-trifluoromethylbenzo-phenone compounds
US3450700A (en) * 1966-12-20 1969-06-17 Upjohn Co 2-tertiary amino-4h-3,1-benzoxazin-4-ones
DE2218302A1 (de) * 1972-04-15 1973-10-25 Bayer Ag Verfahren zur herstellung von trifluormethylimino-derivaten von benzoxazinonen
DE2315303A1 (de) * 1973-03-27 1974-10-17 Bayer Ag Verfahren zur herstellung von n-substituierten 2-amino-3,1-benzoxazin-4-onen
US4657893A (en) * 1984-05-09 1987-04-14 Syntex (U.S.A.) Inc. 4H-3,1-benzoxazin-4-ones and related compounds and use as enzyme inhibitors
NZ210669A (en) * 1983-12-27 1988-05-30 Syntex Inc Benzoxazin-4-one derivatives and pharmaceutical compositions
US4745116A (en) * 1985-06-25 1988-05-17 Syntex (U.S.A.) Inc. 2-oxy-4H-3,1-benzoxazin-4-ones and related compounds and pharmaceutical use
US4665070A (en) * 1985-06-25 1987-05-12 Syntex (U.S.A.) Inc. 2-oxy-4H-3,1-benzoxazin-4-ones and pharmaceutical use
CA1309556C (en) * 1987-06-09 1992-10-27 Masayuki Kokubo 4h-3,1-benzoxazin-4-one compounds and pharmaceutical composition thereoffor the inhibition of serine proteases
JP2685648B2 (ja) * 1990-02-15 1997-12-03 帝人株式会社 ４ｈ−３．１−ベンズオキサジン−４−オン化合物
US5332734A (en) * 1991-04-10 1994-07-26 Japan Tobacco, Incorporated Oxazinone derivative
NZ242739A (en) * 1991-05-24 1994-12-22 Arch Dev Corp Identification and purification of herpes protease nucleic acid segments and their use in the production of this protease
US5434074A (en) * 1991-07-05 1995-07-18 Gibson; D. Wade Cytomegalovirus proteinase
US5428021A (en) * 1994-01-27 1995-06-27 Sri International Human leukocyte elastase (HLE) inhibitors, and related pharmaceutical compositions and methods of use
US5652237A (en) * 1994-09-09 1997-07-29 Warner-Lambert Company 2-substituted-4H-3, 1-benzoxazin-4-ones and benzthiazin-4-ones as inhibitors of complement C1r protease for the treatment of inflammatory processes
US5985872A (en) 1995-05-24 1999-11-16 G.D. Searle & Co. 2-amino-benzoxazinones for the treatment of viral infections
KR100460932B1 (ko) * 1995-05-24 2005-02-28 지.디. 썰 엘엘씨 바이러스감염치료용2-아미노-벤조옥사진온

Also Published As

Publication number Publication date
DE69617005D1 (de) 2001-12-20
US20050032793A1 (en) 2005-02-10
EP0828721B1 (en) 2001-11-14
US5985872A (en) 1999-11-16
US20030022895A1 (en) 2003-01-30
DE69632876D1 (de) 2004-08-12
DE69632876T2 (de) 2005-03-03
PT1122245E (pt) 2004-11-30
JPH11505849A (ja) 1999-05-25
DE69617005T2 (de) 2002-07-04
ATE270667T1 (de) 2004-07-15
CN1070480C (zh) 2001-09-05
AU5803096A (en) 1996-12-11
CA2222034A1 (en) 1996-11-28
AU711174B2 (en) 1999-10-07
BR9608506A (pt) 1999-06-15
DK0828721T3 (da) 2002-03-04
NZ308398A (en) 1999-06-29
WO1996037485A1 (en) 1996-11-28
US6683077B2 (en) 2004-01-27
ES2169242T3 (es) 2002-07-01
EP0828721A1 (en) 1998-03-18
ES2225339T3 (es) 2005-03-16
CN1190963A (zh) 1998-08-19
ATE208765T1 (de) 2001-11-15
TW455583B (en) 2001-09-21

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