PT1122245E - 2-amino-benzoxazinonas para o tratamento de infeccoes virais - Google Patents
2-amino-benzoxazinonas para o tratamento de infeccoes viraisInfo
- Publication number
- PT1122245E PT1122245E PT01110048T PT01110048T PT1122245E PT 1122245 E PT1122245 E PT 1122245E PT 01110048 T PT01110048 T PT 01110048T PT 01110048 T PT01110048 T PT 01110048T PT 1122245 E PT1122245 E PT 1122245E
- Authority
- PT
- Portugal
- Prior art keywords
- treatment
- viral infections
- benzoxazinones
- amino
- compounds
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D265/04—1,3-Oxazines; Hydrogenated 1,3-oxazines
- C07D265/12—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems
- C07D265/14—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D265/24—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring with hetero atoms directly attached in positions 2 and 4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Virology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/448,795 US5985872A (en) | 1995-05-24 | 1995-05-24 | 2-amino-benzoxazinones for the treatment of viral infections |
US95262498A | 1998-05-15 | 1998-05-15 | |
US09/502,038 US6380189B1 (en) | 1995-05-24 | 2000-02-11 | 2-amino benzoxazinones for the treatment of viral infections |
US10/035,433 US6683077B2 (en) | 1995-05-24 | 2002-01-04 | 2-Amino-benzoxazinones for the treatment of viral infections |
Publications (1)
Publication Number | Publication Date |
---|---|
PT1122245E true PT1122245E (pt) | 2004-11-30 |
Family
ID=37772666
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PT01110048T PT1122245E (pt) | 1995-05-24 | 1996-05-23 | 2-amino-benzoxazinonas para o tratamento de infeccoes virais |
PT96914762T PT828721E (pt) | 1995-05-24 | 1996-05-23 | 2-amino-benxoxazinonas para o tratamento de infeccoes virais |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PT96914762T PT828721E (pt) | 1995-05-24 | 1996-05-23 | 2-amino-benxoxazinonas para o tratamento de infeccoes virais |
Country Status (15)
Country | Link |
---|---|
US (3) | US5985872A (pt) |
EP (1) | EP0828721B1 (pt) |
JP (1) | JPH11505849A (pt) |
CN (1) | CN1070480C (pt) |
AT (2) | ATE208765T1 (pt) |
AU (1) | AU711174B2 (pt) |
BR (1) | BR9608506A (pt) |
CA (1) | CA2222034A1 (pt) |
DE (2) | DE69617005T2 (pt) |
DK (1) | DK0828721T3 (pt) |
ES (2) | ES2225339T3 (pt) |
NZ (1) | NZ308398A (pt) |
PT (2) | PT1122245E (pt) |
TW (1) | TW455583B (pt) |
WO (1) | WO1996037485A1 (pt) |
Families Citing this family (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5985872A (en) | 1995-05-24 | 1999-11-16 | G.D. Searle & Co. | 2-amino-benzoxazinones for the treatment of viral infections |
MX9709016A (es) * | 1995-05-24 | 1998-04-30 | Searle & Co | 2-amino-benzoxazinonas, composiciones que las contienen y uso de las mismas. |
AU3339797A (en) * | 1996-06-20 | 1998-01-07 | Smithkline Beecham Plc | 4h-3,1-benzoxazin-4-one derivatives and analogs as antiviral agents |
GB9710928D0 (en) * | 1997-05-29 | 1997-07-23 | Smithkline Beecham Plc | Pharmaceuticals |
GB9900416D0 (en) * | 1999-01-08 | 1999-02-24 | Alizyme Therapeutics Ltd | Inhibitors |
AR022204A1 (es) * | 1999-01-08 | 2002-09-04 | Norgine Bv | Compuesto, proceso para su preparacion, composicion farmaceutica y producto comestible que lo comprende. |
WO2001003697A1 (en) * | 1999-07-12 | 2001-01-18 | G.D. Searle & Co. | 2-amino-benzoxazinones for the treatment of herpes simplex virus |
US6806269B1 (en) * | 1999-07-12 | 2004-10-19 | G. D. Searle & Cop | 2-Amino-benzoxazinones for the treatment of herpes simplex virus |
DE10036184A1 (de) * | 2000-07-24 | 2002-02-14 | Aventis Cropscience Gmbh | Substituierte Sulfonylaminomethylbenzoesäure(derivate) und Verfahren zu ihrer Herstellung |
EP1403269A1 (en) * | 2001-06-13 | 2004-03-31 | Asahi Kasei Pharma Corporation | Remedial agent for viral infectious disease |
CA2502705A1 (en) * | 2002-11-21 | 2004-06-03 | Jon Valgeirsson | Aryl ureido derivatives and their medical use |
US7192471B2 (en) * | 2004-09-24 | 2007-03-20 | Honeywell International Inc. | Aryl-ureido benzoxazinone compounds |
RU2469028C2 (ru) | 2006-11-22 | 2012-12-10 | Адзиномото Ко., Инк. | Способ получения производных фенилаланина с хиназолиндионовым скелетом и промежуточных соединений, применяемых при получении таких производных |
JP2010525069A (ja) * | 2007-04-27 | 2010-07-22 | パラテック ファーマシューティカルズ インコーポレイテッド | アミノアルキルテトラサイクリン化合物の合成方法および精製方法 |
US8356971B2 (en) * | 2009-12-17 | 2013-01-22 | Detch John W | Disc turbine with streamlined hub vanes and co-axial exhaust tube |
CN115109006A (zh) * | 2022-05-20 | 2022-09-27 | 上海大学 | 一种3-取代-1,2-苯并噁嗪-4-酮类化合物及其制备方法 |
Family Cites Families (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3297755A (en) * | 1960-12-02 | 1967-01-10 | Hoffmann La Roche | 2-chloro-5-trifluoromethylbenzo-phenone compounds |
US3450700A (en) * | 1966-12-20 | 1969-06-17 | Upjohn Co | 2-tertiary amino-4h-3,1-benzoxazin-4-ones |
DE2218302A1 (de) * | 1972-04-15 | 1973-10-25 | Bayer Ag | Verfahren zur herstellung von trifluormethylimino-derivaten von benzoxazinonen |
DE2315303A1 (de) * | 1973-03-27 | 1974-10-17 | Bayer Ag | Verfahren zur herstellung von n-substituierten 2-amino-3,1-benzoxazin-4-onen |
US4657893A (en) * | 1984-05-09 | 1987-04-14 | Syntex (U.S.A.) Inc. | 4H-3,1-benzoxazin-4-ones and related compounds and use as enzyme inhibitors |
NZ210669A (en) * | 1983-12-27 | 1988-05-30 | Syntex Inc | Benzoxazin-4-one derivatives and pharmaceutical compositions |
US4665070A (en) * | 1985-06-25 | 1987-05-12 | Syntex (U.S.A.) Inc. | 2-oxy-4H-3,1-benzoxazin-4-ones and pharmaceutical use |
US4745116A (en) * | 1985-06-25 | 1988-05-17 | Syntex (U.S.A.) Inc. | 2-oxy-4H-3,1-benzoxazin-4-ones and related compounds and pharmaceutical use |
CA1309556C (en) * | 1987-06-09 | 1992-10-27 | Masayuki Kokubo | 4h-3,1-benzoxazin-4-one compounds and pharmaceutical composition thereoffor the inhibition of serine proteases |
WO1991012245A1 (fr) * | 1990-02-15 | 1991-08-22 | Teijin Limited | Compose de 4h-3,1-benzoxazine-4-one et composition inhibitrice d'elastase le renfermant |
US5332734A (en) * | 1991-04-10 | 1994-07-26 | Japan Tobacco, Incorporated | Oxazinone derivative |
NZ242739A (en) * | 1991-05-24 | 1994-12-22 | Arch Dev Corp | Identification and purification of herpes protease nucleic acid segments and their use in the production of this protease |
US5434074A (en) * | 1991-07-05 | 1995-07-18 | Gibson; D. Wade | Cytomegalovirus proteinase |
US5428021A (en) * | 1994-01-27 | 1995-06-27 | Sri International | Human leukocyte elastase (HLE) inhibitors, and related pharmaceutical compositions and methods of use |
US5652237A (en) * | 1994-09-09 | 1997-07-29 | Warner-Lambert Company | 2-substituted-4H-3, 1-benzoxazin-4-ones and benzthiazin-4-ones as inhibitors of complement C1r protease for the treatment of inflammatory processes |
US5985872A (en) | 1995-05-24 | 1999-11-16 | G.D. Searle & Co. | 2-amino-benzoxazinones for the treatment of viral infections |
MX9709016A (es) * | 1995-05-24 | 1998-04-30 | Searle & Co | 2-amino-benzoxazinonas, composiciones que las contienen y uso de las mismas. |
-
1995
- 1995-05-24 US US08/448,795 patent/US5985872A/en not_active Expired - Fee Related
-
1996
- 1996-05-23 PT PT01110048T patent/PT1122245E/pt unknown
- 1996-05-23 WO PCT/US1996/007526 patent/WO1996037485A1/en active IP Right Grant
- 1996-05-23 AT AT96914762T patent/ATE208765T1/de not_active IP Right Cessation
- 1996-05-23 BR BR9608506A patent/BR9608506A/pt not_active Application Discontinuation
- 1996-05-23 DK DK96914762T patent/DK0828721T3/da active
- 1996-05-23 ES ES01110048T patent/ES2225339T3/es not_active Expired - Lifetime
- 1996-05-23 DE DE69617005T patent/DE69617005T2/de not_active Expired - Fee Related
- 1996-05-23 NZ NZ308398A patent/NZ308398A/xx unknown
- 1996-05-23 PT PT96914762T patent/PT828721E/pt unknown
- 1996-05-23 DE DE69632876T patent/DE69632876T2/de not_active Expired - Fee Related
- 1996-05-23 AT AT01110048T patent/ATE270667T1/de not_active IP Right Cessation
- 1996-05-23 AU AU58030/96A patent/AU711174B2/en not_active Ceased
- 1996-05-23 JP JP8535869A patent/JPH11505849A/ja not_active Abandoned
- 1996-05-23 ES ES96914762T patent/ES2169242T3/es not_active Expired - Lifetime
- 1996-05-23 EP EP96914762A patent/EP0828721B1/en not_active Expired - Lifetime
- 1996-05-23 CA CA002222034A patent/CA2222034A1/en not_active Abandoned
- 1996-05-23 CN CN96195622A patent/CN1070480C/zh not_active Expired - Fee Related
- 1996-10-08 TW TW085112293A patent/TW455583B/zh not_active IP Right Cessation
-
2002
- 2002-01-04 US US10/035,433 patent/US6683077B2/en not_active Expired - Fee Related
-
2003
- 2003-12-08 US US10/728,946 patent/US20050032793A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
TW455583B (en) | 2001-09-21 |
EP0828721B1 (en) | 2001-11-14 |
CA2222034A1 (en) | 1996-11-28 |
ES2225339T3 (es) | 2005-03-16 |
US20030022895A1 (en) | 2003-01-30 |
DE69632876D1 (de) | 2004-08-12 |
WO1996037485A1 (en) | 1996-11-28 |
CN1190963A (zh) | 1998-08-19 |
ES2169242T3 (es) | 2002-07-01 |
ATE270667T1 (de) | 2004-07-15 |
DE69617005T2 (de) | 2002-07-04 |
PT828721E (pt) | 2002-04-29 |
ATE208765T1 (de) | 2001-11-15 |
US20050032793A1 (en) | 2005-02-10 |
JPH11505849A (ja) | 1999-05-25 |
US5985872A (en) | 1999-11-16 |
EP0828721A1 (en) | 1998-03-18 |
BR9608506A (pt) | 1999-06-15 |
DK0828721T3 (da) | 2002-03-04 |
DE69632876T2 (de) | 2005-03-03 |
AU5803096A (en) | 1996-12-11 |
DE69617005D1 (de) | 2001-12-20 |
US6683077B2 (en) | 2004-01-27 |
AU711174B2 (en) | 1999-10-07 |
NZ308398A (en) | 1999-06-29 |
CN1070480C (zh) | 2001-09-05 |
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