ATE206409T1 - N-(1-alkyl-5-phenyl-2,3,4,5-tetrahydro-1-h- benzo(b)(1,5)-diazepin-3-yl)-acetamide - Google Patents

N-(1-alkyl-5-phenyl-2,3,4,5-tetrahydro-1-h- benzo(b)(1,5)-diazepin-3-yl)-acetamide

Info

Publication number
ATE206409T1
ATE206409T1 AT96920612T AT96920612T ATE206409T1 AT E206409 T1 ATE206409 T1 AT E206409T1 AT 96920612 T AT96920612 T AT 96920612T AT 96920612 T AT96920612 T AT 96920612T AT E206409 T1 ATE206409 T1 AT E206409T1
Authority
AT
Austria
Prior art keywords
diazepine
acetamide
benzo
tetrahydro
phenyl
Prior art date
Application number
AT96920612T
Other languages
English (en)
Inventor
David A Claremon
Nigel Liverton
Harold G Selnick
Garry R Smith
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Application granted granted Critical
Publication of ATE206409T1 publication Critical patent/ATE206409T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D243/12—1,5-Benzodiazepines; Hydrogenated 1,5-benzodiazepines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Plural Heterocyclic Compounds (AREA)
AT96920612T 1995-06-07 1996-06-03 N-(1-alkyl-5-phenyl-2,3,4,5-tetrahydro-1-h- benzo(b)(1,5)-diazepin-3-yl)-acetamide ATE206409T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US47653495A 1995-06-07 1995-06-07
PCT/US1996/008331 WO1996040653A1 (en) 1995-06-07 1996-06-03 Novel n-(1-alkyl-5-phenyl-2,3,4,5-tetrahydro-1h-benzo[b][1,4]diazepin-3-yl)-acetamides

Publications (1)

Publication Number Publication Date
ATE206409T1 true ATE206409T1 (de) 2001-10-15

Family

ID=23892257

Family Applications (1)

Application Number Title Priority Date Filing Date
AT96920612T ATE206409T1 (de) 1995-06-07 1996-06-03 N-(1-alkyl-5-phenyl-2,3,4,5-tetrahydro-1-h- benzo(b)(1,5)-diazepin-3-yl)-acetamide

Country Status (12)

Country Link
US (1) US5726171A (de)
EP (1) EP0830350B1 (de)
JP (1) JPH11506745A (de)
AT (1) ATE206409T1 (de)
AU (1) AU704592B2 (de)
CA (1) CA2222330A1 (de)
DE (1) DE69615682T2 (de)
DK (1) DK0830350T3 (de)
ES (1) ES2163638T3 (de)
GR (1) GR3036813T3 (de)
PT (1) PT830350E (de)
WO (1) WO1996040653A1 (de)

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US6774125B2 (en) 1998-06-22 2004-08-10 Elan Pharmaceuticals, Inc. Deoxyamino acid compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds
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US20100009966A1 (en) * 2001-04-11 2010-01-14 Bristol-Myers Squibb Pharma Company Substituted lactams as inhibitors of abeta protein production
WO2001077086A1 (en) 2000-04-11 2001-10-18 Dupont Pharmaceuticals Company SUBSTITUTED LACTAMS AS INHIBITORS OF Aβ PROTEIN PRODUCTION
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EP2063905B1 (de) 2006-09-18 2014-07-30 Raptor Pharmaceutical Inc Behandlungen von lebererkrankungen durch verabreichung von konjugaten aus rezeptor-assoziierten proteinen
DK2398500T3 (da) 2009-02-20 2019-05-13 2 Bbb Medicines B V Glutathion-baseret lægemiddelafgivelsessystem
SG175896A1 (en) 2009-05-06 2011-12-29 Lab Skin Care Inc Dermal delivery compositions comprising active agent-calcium phosphate particle complexes and methods of using the same
US20120077778A1 (en) 2010-09-29 2012-03-29 Andrea Bourdelais Ladder-Frame Polyether Conjugates
SG10201913587WA (en) 2016-02-05 2020-02-27 Denali Therapeutics Inc Inhibitors of receptor-interacting protein kinase 1
RS63203B1 (sr) 2016-12-09 2022-06-30 Denali Therapeutics Inc Jedinjenja korisna kao inhibitori ripk1
EP4463229A1 (de) 2022-01-12 2024-11-20 Denali Therapeutics Inc. Kristalline formen von (s)-5-benzyl-n-(5-methyl-4-oxo-2,3,4,5-tetrahydropyrido[3,2-b! [l,4)oxazepin-3-yl)-4h-1,2,4-triazol-3-carboxamid

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Also Published As

Publication number Publication date
AU5886496A (en) 1996-12-30
EP0830350B1 (de) 2001-10-04
EP0830350A1 (de) 1998-03-25
CA2222330A1 (en) 1996-12-19
GR3036813T3 (en) 2002-01-31
PT830350E (pt) 2002-02-28
DE69615682D1 (de) 2001-11-08
ES2163638T3 (es) 2002-02-01
DE69615682T2 (de) 2002-07-11
JPH11506745A (ja) 1999-06-15
DK0830350T3 (da) 2001-11-19
EP0830350A4 (de) 1998-09-30
AU704592B2 (en) 1999-04-29
US5726171A (en) 1998-03-10
WO1996040653A1 (en) 1996-12-19

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee