ATE206409T1 - N-(1-alkyl-5-phenyl-2,3,4,5-tetrahydro-1-h- benzo(b)(1,5)-diazepin-3-yl)-acetamide - Google Patents

N-(1-alkyl-5-phenyl-2,3,4,5-tetrahydro-1-h- benzo(b)(1,5)-diazepin-3-yl)-acetamide

Info

Publication number
ATE206409T1
ATE206409T1 AT96920612T AT96920612T ATE206409T1 AT E206409 T1 ATE206409 T1 AT E206409T1 AT 96920612 T AT96920612 T AT 96920612T AT 96920612 T AT96920612 T AT 96920612T AT E206409 T1 ATE206409 T1 AT E206409T1
Authority
AT
Austria
Prior art keywords
diazepine
acetamide
benzo
tetrahydro
phenyl
Prior art date
Application number
AT96920612T
Other languages
English (en)
Inventor
David A Claremon
Nigel Liverton
Harold G Selnick
Garry R Smith
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Application granted granted Critical
Publication of ATE206409T1 publication Critical patent/ATE206409T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D243/12—1,5-Benzodiazepines; Hydrogenated 1,5-benzodiazepines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Plural Heterocyclic Compounds (AREA)
AT96920612T 1995-06-07 1996-06-03 N-(1-alkyl-5-phenyl-2,3,4,5-tetrahydro-1-h- benzo(b)(1,5)-diazepin-3-yl)-acetamide ATE206409T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US47653495A 1995-06-07 1995-06-07
PCT/US1996/008331 WO1996040653A1 (en) 1995-06-07 1996-06-03 Novel n-(1-alkyl-5-phenyl-2,3,4,5-tetrahydro-1h-benzo[b][1,4]diazepin-3-yl)-acetamides

Publications (1)

Publication Number Publication Date
ATE206409T1 true ATE206409T1 (de) 2001-10-15

Family

ID=23892257

Family Applications (1)

Application Number Title Priority Date Filing Date
AT96920612T ATE206409T1 (de) 1995-06-07 1996-06-03 N-(1-alkyl-5-phenyl-2,3,4,5-tetrahydro-1-h- benzo(b)(1,5)-diazepin-3-yl)-acetamide

Country Status (12)

Country Link
US (1) US5726171A (de)
EP (1) EP0830350B1 (de)
JP (1) JPH11506745A (de)
AT (1) ATE206409T1 (de)
AU (1) AU704592B2 (de)
CA (1) CA2222330A1 (de)
DE (1) DE69615682T2 (de)
DK (1) DK0830350T3 (de)
ES (1) ES2163638T3 (de)
GR (1) GR3036813T3 (de)
PT (1) PT830350E (de)
WO (1) WO1996040653A1 (de)

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JP4202250B2 (ja) 2001-07-25 2008-12-24 バイオマリン ファーマシューティカル インコーポレイテッド 血液脳関門輸送を調節するための組成物および方法
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US8795627B2 (en) 2007-03-21 2014-08-05 Raptor Pharmaceuticals Inc. Treatment of liver disorders by administration of RAP conjugates
ES2919563T3 (es) 2009-02-20 2022-07-27 Enhanx Biopharm Inc Sistema de administración de medicamentos a base de glutatión
CN110075069A (zh) 2009-05-06 2019-08-02 实验室护肤股份有限公司 包含活性剂-磷酸钙颗粒复合物的皮肤递送组合物及其应用
US20120077778A1 (en) 2010-09-29 2012-03-29 Andrea Bourdelais Ladder-Frame Polyether Conjugates
CN118994191A (zh) 2016-02-05 2024-11-22 戴纳立制药公司 受体相互作用蛋白激酶1的抑制剂
HRP20220636T1 (hr) 2016-12-09 2022-07-22 Denali Therapeutics Inc. Spojevi korisni kao inhibitori ripk1
AU2023206890A1 (en) 2022-01-12 2024-08-22 Denali Therapeutics Inc. Crystalline forms of (s)-5-benzyl-n-(5-methyl-4-oxo-2, 3,4,5- tetrahydropyrido [3,2-b] [l,4]oxazepin-3-yl)-4h-l,2,4-triazole-3-carboxamide

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Also Published As

Publication number Publication date
DE69615682T2 (de) 2002-07-11
AU704592B2 (en) 1999-04-29
EP0830350A4 (de) 1998-09-30
DK0830350T3 (da) 2001-11-19
EP0830350B1 (de) 2001-10-04
AU5886496A (en) 1996-12-30
US5726171A (en) 1998-03-10
JPH11506745A (ja) 1999-06-15
PT830350E (pt) 2002-02-28
CA2222330A1 (en) 1996-12-19
DE69615682D1 (de) 2001-11-08
ES2163638T3 (es) 2002-02-01
WO1996040653A1 (en) 1996-12-19
GR3036813T3 (en) 2002-01-31
EP0830350A1 (de) 1998-03-25

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee