KR930700494A - 신규한 옥사디논 유도체 - Google Patents

신규한 옥사디논 유도체

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Publication number
KR930700494A
KR930700494A KR1019920703171A KR920703171A KR930700494A KR 930700494 A KR930700494 A KR 930700494A KR 1019920703171 A KR1019920703171 A KR 1019920703171A KR 920703171 A KR920703171 A KR 920703171A KR 930700494 A KR930700494 A KR 930700494A
Authority
KR
South Korea
Prior art keywords
group
alkyl group
lower alkyl
hydrogen atom
atom
Prior art date
Application number
KR1019920703171A
Other languages
English (en)
Inventor
고지 고바야시
슈니치 마나베
요시히로 와타나베
가주히데 하야카와
잇츠오 우치다
Original Assignee
시게루 미즈노
재팬-타바코 인코퍼레이티드
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 시게루 미즈노, 재팬-타바코 인코퍼레이티드 filed Critical 시게루 미즈노
Publication of KR930700494A publication Critical patent/KR930700494A/ko

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/04—1,3-Oxazines; Hydrogenated 1,3-oxazines
    • C07D265/12—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems
    • C07D265/14—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D265/20—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring with hetero atoms directly attached in position 4
    • C07D265/22—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

내용 없음.

Description

신규한 옥사디논 유도체
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (12)

  1. 하기 일반식[Ⅰ]으로 표시되는 신규한 옥사디논유도체 또는 약학적으로 허용되는 그것 들의 산부가염.
  3. 단, 식 중의 R1∼R4, A, X, Y 및 Z는 각각 다음의 의미를 갖는다. (R1) : 수소원자, 저급알킬기 또는 저급아실기; (R, R2) : 동일 또는 상이하며, 각각 수소원자, 저급알킬기 또는 저급알킬티오저급알킬기이다. 또는 R 및 R2가 함께되어서 알킬사슬로 이루어진 고리를 형성하여도 좋다; (R3) : 수소원자, 불소로 치환되어도 좋은 저급알킬기, 저급알콕시기 또는 할로겐원자; (R4) : 수소원자, 저급알킬기, 수산기, 할로겐원자, 저급알콕시기, 저급알콕시카르보닐기, 카르복실기, 저급알킬티오기, 니트로기, 저급아실록시기 또는 -NR5R6(R5및 R6은 동일 또는 상이하며 수소원자, 저급알킬기 또는 저급아실기이거나 또는 인접하는 질소원자와 함께 되어서 치환기를 갖고 있어서 좋은 헤테고리를 형성하여도 좋다);
  5. 이다. 단, * W는 단일결합, -O-,-S-, -CH=CH- 또는 -NR9-(R9는 수소원자, 저급알킬기 또는 저급아실기)이다; * U는 -CH- 또는 질소원자이다; * V1은 -O-, -S-, -CO-, -CHR10-(R10은 수소원자, 저급알킬기 또는 저급아실기) 또는 -NR11-(R11는 수소원자, 저급알킬기 또는 저급아실기)이다. 여기서 U가 질소원자일때는 V1은 -CO-, -CHR10-(R10은 상기와 같다) 또는 -NR11-(R11은 상기와 같다)이다; * T는 =CH- 또는 =N-이다; * R7및 R8은 동일 또는 상이하며, 각각 수소원자, 불소로 치환되어도 좋은 저급알킬기, 저급아실기, 할로겐원자, 수산기, 저급알콕시기, 저급아시록시기, 카르복실기, 또는 -NR13R14(R13및 R14는 동일 또는 상이하며, 각각 수소원자, 저급알킬기 또는 저급아실기를 의미한다)이다; * m, n은 독립하여 0 내지 2의 정수를 의미한다. (단, m+n＜2); * D는 2개 이하의 치환기를 갖고 있어도 좋고, 또 복수의 헤테로원자를 함유하여도 좋은 5 내지 7원의 방향환 또는 치환이다. (Y) : 단일결합, -O-, -S-, -CO- 또는 -NR15-(R15는 수소원자, 저급알킬기 또는 저급아실기이다); (X) : 단일결합, -O-, -CH=CH- 또는 -NR16-(R16는 수소원자, 저급알킬기 또는 저급아실기이다); (Z) : -CH2- 또는 -CO-(단 Z가 -CH2-인 경우는 Y는 단일결합이다); (1) : 0 내지 4의 정수.
  6. 제1항에 있어서, D가
  8. 단 R17및 R18은 동일, 또는 상이하며, 각각 수소원자, 불소로 치환되어도 좋은 저급알킬기, 저급아실기, 할로겐원자, 수산기, 저급알콕시기, 저급아실록시, 카르복실기 또는 -NR19R20(R19및 R20은 동일 또는 상이하며, 각각 소수원자, 저급알킬기 또는 저급아실기를 의미한다)이다. 인 신규한 옥시디논유도체 또는 약학적으로 허용되는 그것들의 산부가염.
  9. 의약으로서 적당한 담체와 항염증작용적 유효량의 청구의 범위 제1항 또는 제2항 기재의 화합물을 함유하여 이루어지는 항염증제.
  10. 의약으로서 적당한 담체와 호중구 침윤억제작용적유효량의 청구의 범위 제1항 또는 제2항 기재의 화합물을 함유하여 이루어지는 호중구침윤억제제.
  11. 의약으로서 적당한 담체와, 세린프로테아제 저해작용적 유효량의 청구의 범위 제1항 또는 제2항 기재의 화합물을 함유하여 이루어지는 세린프로테아제저해제.
  12. ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019920703171A 1990-04-10 1992-04-09 신규한 옥사디논 유도체 KR930700494A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP91-164060 1990-04-10
JP16406091 1991-04-10
PCT/JP1992/000444 WO1992018488A1 (fr) 1991-04-10 1992-04-09 Nouveau derive d'oxazinone

Publications (1)

Publication Number Publication Date
KR930700494A true KR930700494A (ko) 1993-03-15

Family

ID=15786023

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019920703171A KR930700494A (ko) 1990-04-10 1992-04-09 신규한 옥사디논 유도체

Country Status (5)

Country Link
US (1) US5332734A (ko)
EP (1) EP0533951A4 (ko)
KR (1) KR930700494A (ko)
CA (1) CA2084997A1 (ko)
WO (1) WO1992018488A1 (ko)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH05148249A (ja) * 1991-11-28 1993-06-15 Japan Tobacco Inc ベンゾオキサジノン誘導体
US5985872A (en) * 1995-05-24 1999-11-16 G.D. Searle & Co. 2-amino-benzoxazinones for the treatment of viral infections
WO1997027200A1 (en) * 1996-01-26 1997-07-31 Smithkline Beecham Plc Thienoxazinone derivatives useful as antiviral agents
US8022058B2 (en) 2000-05-10 2011-09-20 The Trustees Of Columbia University In The City Of New York Agents for preventing and treating disorders involving modulation of the RyR receptors
US7393652B2 (en) 2000-05-10 2008-07-01 The Trustees Of Columbia University In The City Of New York Methods for identifying a chemical compound that directly enhances binding of FKBP12.6 to PKA-phosphorylated type 2 ryanodine receptor (RyR2)
US7718644B2 (en) 2004-01-22 2010-05-18 The Trustees Of Columbia University In The City Of New York Anti-arrhythmic and heart failure drugs that target the leak in the ryanodine receptor (RyR2) and uses thereof
US7879840B2 (en) 2005-08-25 2011-02-01 The Trustees Of Columbia University In The City Of New York Agents for preventing and treating disorders involving modulation of the RyR receptors
US7544678B2 (en) 2002-11-05 2009-06-09 The Trustees Of Columbia University In The City Of New York Anti-arrythmic and heart failure drugs that target the leak in the ryanodine receptor (RyR2)
JP2007525165A (ja) 2003-03-07 2007-09-06 トラスティーズ・オブ・コロンビア・ユニバーシティ・イン・ザ・シティ・オブ・ニューヨーク タイプ１ライアノジン受容体に基づく方法
US8710045B2 (en) 2004-01-22 2014-04-29 The Trustees Of Columbia University In The City Of New York Agents for preventing and treating disorders involving modulation of the ryanodine receptors
EP1738176A1 (en) * 2004-04-08 2007-01-03 Janssen Pharmaceutica N.V. Immunohistochemical detection method of collagen in a tissue sample
US7704990B2 (en) 2005-08-25 2010-04-27 The Trustees Of Columbia University In The City Of New York Agents for preventing and treating disorders involving modulation of the RyR receptors
US7879846B2 (en) * 2006-09-21 2011-02-01 Kyorin Pharmaceutical Co.., Ltd. Serine hydrolase inhibitors

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4013665A (en) * 1973-10-01 1977-03-22 Bristol-Myers Company Antiviral, substituted 1,3-dimethyl-1h-pyrazolo(3,4b)quinolines
JPS5749620A (en) * 1980-09-11 1982-03-23 Teijin Ltd Improvement of polyester
CA1309556C (en) * 1987-06-09 1992-10-27 Masayuki Kokubo 4h-3,1-benzoxazin-4-one compounds and pharmaceutical composition thereoffor the inhibition of serine proteases
JP2765001B2 (ja) * 1988-02-23 1998-06-11 武田薬品工業株式会社 プロテアーゼ阻害剤
IL89835A0 (en) * 1988-04-11 1989-12-15 Merck & Co Inc Substituted azetidinones,their preparation and pharmaceutical compositions containing them
US5204462A (en) * 1990-03-30 1993-04-20 Japan Tobacco, Inc. 4h-3,1-benzoxazin-4-one derivative
FR2663633B1 (fr) * 1990-06-22 1994-06-17 Adir Nouvelles chalcones, leur procede de preparation et les compositions pharmaceutiques qui les contiennent.

Also Published As

Publication number Publication date
EP0533951A4 (en) 1993-09-01
CA2084997A1 (en) 1992-10-11
US5332734A (en) 1994-07-26
EP0533951A1 (en) 1993-03-31
WO1992018488A1 (fr) 1992-10-29

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