KR910016697A - 테트라히드로피리딘 유도체 - Google Patents

테트라히드로피리딘 유도체 Download PDF

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Publication number
KR910016697A
KR910016697A KR1019910003560A KR910003560A KR910016697A KR 910016697 A KR910016697 A KR 910016697A KR 1019910003560 A KR1019910003560 A KR 1019910003560A KR 910003560 A KR910003560 A KR 910003560A KR 910016697 A KR910016697 A KR 910016697A
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KR
South Korea
Prior art keywords
lower alkyl
hydroxy
halogen
substituted
hydrogen
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KR1019910003560A
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English (en)
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KR0167782B1 (ko
Inventor
히로무 마쓰무라
도시사다 야노
히로시 하시즈메
아끼라 마쓰시따
마사미 에이교
Original Assignee
요시또시 가즈오
시오노기세이야꾸가부시끼가이샤
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Application filed by 요시또시 가즈오, 시오노기세이야꾸가부시끼가이샤 filed Critical 요시또시 가즈오
Publication of KR910016697A publication Critical patent/KR910016697A/ko
Application granted granted Critical
Publication of KR0167782B1 publication Critical patent/KR0167782B1/ko

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D211/70—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D211/72—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D211/74—Oxygen atoms
    • C07D211/76—Oxygen atoms attached in position 2 or 6
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

내용 없음

Description

테트라히드로피리딘 유도체
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (2)

  1. 하기 일반식의 화합물 또는 그의 약제학적으로 허용하가능한 산부가염.
    [상기식에서, Ar은 저급 알킬, 저급 알콕시, 할로겐, 치환 또는 비치환 페닐, 트리플루오로메틸 및 히드록시로 구성된 군으로 부터 선택된 동일하거나 상이한 하나 또는 두개의 치환체로 치환될 수 있는 페닐 또는 티에닐이며, n은 2~6의 정수이고, R은 히드록시 또는 일반식, R2R3N(CO)P(NR1)q-, 또는
    (상기식에서, R1은 수소 또는 저급 알킬이고; R2및 R3는 각각 수소 또는 저급 알킬이거나, 인접한 질소원자와 함께 벤젠고리와 축합할 수 있는 5- 또는 6-원 헤테로고리기를 형성할 수 있는데, 이 헤테로고리기는 저급알킬, 할로겐, 옥소, 피리미딘 및 치환 또는 비치환 페닐로 구성된 군으로부터 선택된 동일하거나 상이한 1~3개의 치환체를 가질 수 있으며; R4은 NH, O 또는 단일결합이며; X1및 X2는 각각 수소, 저급 알킬, 할로겐 또는 히드록시이며; p와 q는 각각 0 또는 1의 정수인데, 단 q가 1일때 p는 0이다)의 기이다〕
  2. 활성성분으로서 제1항에 청구된 화합물을 함유하는 향정신약.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019910003560A 1990-03-05 1991-03-05 테트라히드로피리딘 유도체 KR0167782B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP54220/1990 1990-03-05
JP5422090 1990-03-05

Publications (2)

Publication Number Publication Date
KR910016697A true KR910016697A (ko) 1991-11-05
KR0167782B1 KR0167782B1 (ko) 1999-01-15

Family

ID=12964460

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019910003560A KR0167782B1 (ko) 1990-03-05 1991-03-05 테트라히드로피리딘 유도체

Country Status (5)

Country Link
US (3) US5149817A (ko)
EP (2) EP0861832A1 (ko)
KR (1) KR0167782B1 (ko)
AU (1) AU643258B2 (ko)
CA (1) CA2037566A1 (ko)

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DK78692D0 (da) * 1992-06-12 1992-06-12 Lundbeck & Co As H Dimere piperidin- og piperazinderivater
CA2100641A1 (en) * 1992-07-23 1994-01-24 Hiromu Matsumura Novel piperidine derivatives and process for preparation thereof
JP3719612B2 (ja) * 1993-06-14 2005-11-24 塩野義製薬株式会社 ヘテロ環を含有する尿素誘導体
ES2074946B1 (es) * 1993-07-19 1996-06-16 Ferrer Int Nuevos compuestos derivados de la 1,2-etanodiamina-n,n,n',n'-tetrasustituida.
ES2117934B1 (es) * 1994-07-29 1999-04-01 Esteve Labor Dr Tetrahidropiridinas (0 4-hidroxipiperidinas) alquilazoles.
FR2723091B1 (fr) * 1994-07-29 1996-11-08 Esteve Labor Dr Tetrahydropyridine-(6,4-hydroxypiperidine) alkylazoles
ZA9610741B (en) 1995-12-22 1997-06-24 Warner Lambert Co 4-Substituted piperidine analogs and their use as subtype selective nmda receptor antagonists
ZA9610736B (en) 1995-12-22 1997-06-27 Warner Lambert Co 2-Substituted piperidine analogs and their use as subtypeselective nmda receptor antagonists
ZA9610745B (en) * 1995-12-22 1997-06-24 Warner Lambert Co 4-Subsituted piperidine analogs and their use as subtype selective nmda receptor antagonists
ZA9610738B (en) 1995-12-22 1997-06-24 Warner Lambert Co Subtype selective nmda receptor ligands and the use thereof
PT885004E (pt) * 1996-03-08 2002-08-30 Hoffmann La Roche Utilizacao de derivados de 4-fenil-3,6-di-hidro-2h-piridilo como bloqueadores dos subtipos dos receptores nmda
HUP9904335A3 (en) * 1996-07-22 2001-07-30 Daiichi Asubio Pharma Co Ltd Arylpiperidinol and arylpiperidine derivatives and drugs containing the same
US6727277B1 (en) 2002-11-12 2004-04-27 Kansas State University Research Foundation Compounds affecting cholesterol absorption
US7500742B2 (en) 2003-10-22 2009-03-10 Hewlett-Packard Development Company, L.P. Systems and methods for printing onto a substrate using reactive ink
GB0514615D0 (en) 2005-07-15 2005-08-24 Novartis Ag Organic compounds
EP1917255A2 (en) 2005-07-29 2008-05-07 F. Hoffmann-Roche AG Indol-3-yl-carbonyl-piperidin and piperazin derivatives
EP2377530A3 (en) 2005-10-21 2012-06-20 Braincells, Inc. Modulation of neurogenesis by PDE inhibition
WO2007053596A1 (en) 2005-10-31 2007-05-10 Braincells, Inc. Gaba receptor mediated modulation of neurogenesis
US20100216734A1 (en) 2006-03-08 2010-08-26 Braincells, Inc. Modulation of neurogenesis by nootropic agents
JP2009536669A (ja) 2006-05-09 2009-10-15 ブレインセルス，インコーポレイティド アンジオテンシン調節による神経新生
EP2026813A2 (en) 2006-05-09 2009-02-25 Braincells, Inc. 5 ht receptor mediated neurogenesis
KR20090064418A (ko) 2006-09-08 2009-06-18 브레인셀즈 인코퍼레이션 4-아실아미노피리딘 유도체 포함 조합물
US20100184806A1 (en) 2006-09-19 2010-07-22 Braincells, Inc. Modulation of neurogenesis by ppar agents
US20100216805A1 (en) 2009-02-25 2010-08-26 Braincells, Inc. Modulation of neurogenesis using d-cycloserine combinations

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US3951987A (en) * 1970-06-19 1976-04-20 Hoffmann-La Roche Inc. Tetrahydropyridine derivatives
US4006232A (en) * 1973-07-20 1977-02-01 Miles Laboratories, Inc. Therapeutic method of treating cardiac arrhythmias utilizing 3-substituted diphenylhydantoins
US4012374A (en) * 1975-09-29 1977-03-15 E. R. Squibb & Sons, Inc. 1-[[4-Phenyl-piperidinyl (or tetrahydropyridinyl)]alkyl]-2,6-piperidinedione and analogs
US4487773A (en) * 1981-03-16 1984-12-11 Mead Johnson & Company 1,2,4-Triazol-3-one antidepressants
FR2531707A1 (fr) * 1982-08-16 1984-02-17 Midy Spa Trifluoromethylphenyltetrahydropyridines substituees a activite anorexigene, un procede de preparation et compositions pharmaceutiques
US4678787A (en) * 1985-01-30 1987-07-07 Warner-Lambert Company 4H-1-benzopyran-4-ones and their sulfur containing analogs
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CA1305148C (en) * 1987-08-19 1992-07-14 Hiromu Matsumura Carbamoylpyrrolidone derivatives and drugs for senile dementia
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Also Published As

Publication number Publication date
EP0445701A1 (en) 1991-09-11
US5149817A (en) 1992-09-22
US5410058A (en) 1995-04-25
AU7203891A (en) 1991-09-05
EP0861832A1 (en) 1998-09-02
AU643258B2 (en) 1993-11-11
KR0167782B1 (ko) 1999-01-15
US5362873A (en) 1994-11-08
CA2037566A1 (en) 1991-09-06

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