KR920000755A - 축합 헤테로사이클릭 화합물 및 이를 함유하는 정신약제 조성물 - Google Patents

축합 헤테로사이클릭 화합물 및 이를 함유하는 정신약제 조성물 Download PDF

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KR920000755A
KR920000755A KR1019910010753A KR910010753A KR920000755A KR 920000755 A KR920000755 A KR 920000755A KR 1019910010753 A KR1019910010753 A KR 1019910010753A KR 910010753 A KR910010753 A KR 910010753A KR 920000755 A KR920000755 A KR 920000755A
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South Korea
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group
condensed heterocyclic
compound
heterocyclic compound
psychopharmaceutical
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KR1019910010753A
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도시오 다츠오카
가요코 노무라
마코토 시바타
마사노리 가와이
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도리이 신이치로
산토리 가부시키가이샤
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Application filed by 도리이 신이치로, 산토리 가부시키가이샤 filed Critical 도리이 신이치로
Publication of KR920000755A publication Critical patent/KR920000755A/ko

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

내용 없음

Description

축합 헤테로사이클릭 화합물 및 이를 함유하는 정신약제 조성물
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (6)

  1. 일반식(I)을 갖는 축합 헤테로사이클릭 화합물 도는 이의 염.
    상기식에서, A 및 B는 모두 카보닐 그룹이거나 이중 하나가 메틸렌 그룹을 나타내고 그 나머지가 카보닐 그룹을 나타내며, Z는 산소원자, 황원자, 비치환 또는 치환된 이니노 그룹, 또는 메틸렌 그룹을 나타내고, n은 2내지 6의 정수를 나타내며 R은 다음 일반식을 갖는 그룹을 나타낸다:
    [상기식에서, R1은 수소원자 또는 하이드록실 그룹을 나타내고 R2는 할로겐 원자에 의해 치환될 수 있는 페닐 그룹 또는 피리딜 그룹을 나타낸다.]
  2. 제1항에 있어서, Z중의 치환된 이미노 그룹이 C1-C5알킬아미노 그룹인 축합 헤테로사이클릭 화합물.
  3. 제1항에 있어서, A가 카보닐 그룹을 나타내고 B가 카보닐 그룹 또는 메틸렌 그룹을 나타내는 축합 헤테로사이클릭 화합물.
  4. 제1항에 있어서, R이 다음 일반식인 축합 헤테로사이클릭 화합물.
    상기식에서, X는 수소원자 또는 할로겐 원자를 나타낸다.
  5. 유효성분으로서, 제1항 내지 제4항중 어느 한 항에 따른 일반식(I)의 화합물 또는 이의 약학적으로 허용가능한 염 및 이의 담체를 포함하는 정신약제 조성물.
  6. 제5항에 있어서, 화합물이 4-(4-(4-페닐)-1-피페리디닐)부틸-2,3,4,5-테트라하이드로-1,4-벤조디아제핀-3,5-디온, 4-(5-(4-페닐)-1-피페리디닐)펜틸-2,3,4,5-테트라하이드로-1,4-벤족사제핀-5-온 및 2-(5-(4-(4-클로로페닐)-1-피페리디닐)펜틸-1,3,4,5-테트라하이드로-2-벤즈아제핀-1,3-디온으로 구성된 그룹으로부터 선택된 적어도 하나의 화합물인 정신약제 조성물.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019910010753A 1990-06-28 1991-06-27 축합 헤테로사이클릭 화합물 및 이를 함유하는 정신약제 조성물 KR920000755A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP90-168555 1990-06-28
JP2168555A JP2935541B2 (ja) 1990-06-28 1990-06-28 縮合複素環化合物

Publications (1)

Publication Number Publication Date
KR920000755A true KR920000755A (ko) 1992-01-29

Family

ID=15870200

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019910010753A KR920000755A (ko) 1990-06-28 1991-06-27 축합 헤테로사이클릭 화합물 및 이를 함유하는 정신약제 조성물

Country Status (7)

Country Link
US (1) US5158947A (ko)
EP (1) EP0463810B1 (ko)
JP (1) JP2935541B2 (ko)
KR (1) KR920000755A (ko)
CA (1) CA2045453C (ko)
DE (1) DE69116242T2 (ko)
HU (1) HU213615B (ko)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100716592B1 (ko) * 1999-11-30 2007-05-09 오시카 코포레이션 알데히드 소취제 조성물

Families Citing this family (17)

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JP2703408B2 (ja) * 1990-12-28 1998-01-26 麒麟麦酒株式会社 １，４‐ベンゾチアゼピン誘導体
ES2074946B1 (es) * 1993-07-19 1996-06-16 Ferrer Int Nuevos compuestos derivados de la 1,2-etanodiamina-n,n,n',n'-tetrasustituida.
US5597922A (en) * 1994-07-29 1997-01-28 State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education, Acting For And On Behalf Of The Oregon Health Sciences University And The University Of Oregon Glycine receptor antagonist pharmacophore
EP0777657A1 (en) * 1994-08-22 1997-06-11 Smithkline Beecham Corporation Bicyclic compounds
WO1996024594A1 (fr) 1995-02-10 1996-08-15 Suntory Limited Derives de benzodiazepines, sels issus de ces derives, et medicaments a base de ces derives et sels
JP2001501951A (ja) * 1996-10-07 2001-02-13 スミスクライン・ビーチャム・コーポレイション 骨形成刺激方法
SE0003476D0 (sv) * 2000-09-28 2000-09-28 Astrazeneca Ab Compounds
KR101589551B1 (ko) 2005-07-15 2016-02-02 알바니 몰레큘라 리써치, 인크. 아릴- 및 헤테로아릴-치환된 테트라히드로벤자제핀, 및 노르에피네프린, 도파민 및 세로토닌의 재흡수를 차단하기 위한 용도
AU2006304787A1 (en) 2005-10-21 2007-04-26 Braincells, Inc. Modulation of neurogenesis by PDE inhibition
CA2625210A1 (en) 2005-10-31 2007-05-10 Braincells, Inc. Gaba receptor mediated modulation of neurogenesis
US20100216734A1 (en) 2006-03-08 2010-08-26 Braincells, Inc. Modulation of neurogenesis by nootropic agents
AU2007249399A1 (en) 2006-05-09 2007-11-22 Braincells, Inc. Neurogenesis by modulating angiotensin
US7678808B2 (en) 2006-05-09 2010-03-16 Braincells, Inc. 5 HT receptor mediated neurogenesis
EP2068872A1 (en) 2006-09-08 2009-06-17 Braincells, Inc. Combinations containing a 4-acylaminopyridine derivative
US20100184806A1 (en) 2006-09-19 2010-07-22 Braincells, Inc. Modulation of neurogenesis by ppar agents
DE102008035596A1 (de) * 2008-07-31 2010-02-04 Westfälische Wilhelms-Universität Münster Körperschaft des öffentlichen Rechts Derivate benzoannelierter Stickstoff-Heterocyclen
WO2010099217A1 (en) 2009-02-25 2010-09-02 Braincells, Inc. Modulation of neurogenesis using d-cycloserine combinations

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5071845A (en) * 1988-12-28 1991-12-10 Suntory Limited Benzoxazepine derivative

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100716592B1 (ko) * 1999-11-30 2007-05-09 오시카 코포레이션 알데히드 소취제 조성물

Also Published As

Publication number Publication date
HU912193D0 (en) 1991-12-30
EP0463810A1 (en) 1992-01-02
CA2045453C (en) 2000-04-25
CA2045453A1 (en) 1991-12-29
EP0463810B1 (en) 1996-01-10
JPH0459775A (ja) 1992-02-26
DE69116242D1 (de) 1996-02-22
DE69116242T2 (de) 1996-06-13
HU213615B (en) 1997-08-28
US5158947A (en) 1992-10-27
HUT60486A (en) 1992-09-28
JP2935541B2 (ja) 1999-08-16

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