JPS6450819A - Antidementia agent - Google Patents

Antidementia agent

Info

Publication number
JPS6450819A
JPS6450819A JP62207330A JP20733087A JPS6450819A JP S6450819 A JPS6450819 A JP S6450819A JP 62207330 A JP62207330 A JP 62207330A JP 20733087 A JP20733087 A JP 20733087A JP S6450819 A JPS6450819 A JP S6450819A
Authority
JP
Japan
Prior art keywords
compound
formula
agent
administration
active component
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP62207330A
Other languages
Japanese (ja)
Other versions
JPH0699307B2 (en
Inventor
Hiroshi Kaneto
Yukiyoshi Ajisawa
Seiichi Ikeguchi
Yukihiko Kinoshita
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kissei Pharmaceutical Co Ltd
Original Assignee
Kissei Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kissei Pharmaceutical Co Ltd filed Critical Kissei Pharmaceutical Co Ltd
Priority to JP62207330A priority Critical patent/JPH0699307B2/en
Priority to US07/233,487 priority patent/US4933354A/en
Priority to EP19880307637 priority patent/EP0314275A3/en
Publication of JPS6450819A publication Critical patent/JPS6450819A/en
Publication of JPH0699307B2 publication Critical patent/JPH0699307B2/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24—Oxygen or sulfur atoms
    • C07D207/26—2-Pyrrolidones
    • C07D207/273—2-Pyrrolidones with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to other ring carbon atoms
    • C07D207/277—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D207/28—2-Pyrrolidone-5- carboxylic acids; Functional derivatives thereof, e.g. esters, nitriles

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrrole Compounds (AREA)

Abstract

PURPOSE:To provide a safe and excellent antidementia agent containing a 2-pyrrolidone-5-carboxylic acid derivative as an active component, exhibiting anti-amnestic effect by oral administration and having low toxicity. CONSTITUTION:The objective agent contains a compound of formula I (A is phenyl or pyridyl which may have halogen as a nucleus substituent; n is 1-4; Y is -O- or -NH-) as an active component. The compound is mixed with various drug additives such as excipient, disintegrant, condensation agent or lubricant and used in various forms such as tablet or powder. The daily rate of administration for adult is 50-1,000mg in the case of oral administration and 1-500mg for parenteral administration. The compound of formula I can be synthesized e.g. by reacting the compound of formula II with the compound of formula III preferably in the presence of a condensation agent (e.g. N,N'- dicyclohexylcarbodiimide).
JP62207330A 1987-08-20 1987-08-20 Anti-dementia agent Expired - Lifetime JPH0699307B2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
JP62207330A JPH0699307B2 (en) 1987-08-20 1987-08-20 Anti-dementia agent
US07/233,487 US4933354A (en) 1987-08-20 1988-08-17 2-pyrrolidone-5-carboxylic acid compounds useful for the treatment of mental disorders
EP19880307637 EP0314275A3 (en) 1987-08-20 1988-08-18 2-pyrrolidone-5-carboxylic acid compounds

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP62207330A JPH0699307B2 (en) 1987-08-20 1987-08-20 Anti-dementia agent

Publications (2)

Publication Number Publication Date
JPS6450819A true JPS6450819A (en) 1989-02-27
JPH0699307B2 JPH0699307B2 (en) 1994-12-07

Family

ID=16537965

Family Applications (1)

Application Number Title Priority Date Filing Date
JP62207330A Expired - Lifetime JPH0699307B2 (en) 1987-08-20 1987-08-20 Anti-dementia agent

Country Status (3)

Country Link
US (1) US4933354A (en)
EP (1) EP0314275A3 (en)
JP (1) JPH0699307B2 (en)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1984002907A1 (en) * 1983-01-21 1984-08-02 Alkaloida Vegyeszeti Gyar New alkyl diamine derivatives
US4994472A (en) * 1989-08-02 1991-02-19 Hoechst-Roussel Pharmaceuticals Incorporated 1-(pyridinylamino)-2-pyrrolidinones as pain relievers
IT1242043B (en) * 1990-12-21 1994-02-02 Sigma Tau Ind Farmaceuti DERIVATIVES OF 1,2,3,4, -TETRAIDRONAFTILAMINA WITH NOOTROPIC ACTIVITY AND PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM.
IT1244548B (en) * 1991-02-06 1994-07-15 Poli Ind Chimica Spa 5-OXO-L-PROLIN DERIVATIVES AND THEIR PHARMACEUTICAL APPLICATIONS
IT1244507B (en) * 1991-04-11 1994-07-15 Sigma Tau Ind Farmaceuti PYROGLUTAMIC ACID DERIVATIVES AS ACTIVATORS OF LEARNING PROCESSES AND MEMORY AND PHARMACEUTICAL COMPOSITIONS INCLUDING SUCH COMPOUNDS
CA2067614C (en) * 1991-05-02 2002-07-30 Eiichi Otomo Agent for improving dementia
WO1995025101A1 (en) * 1994-03-14 1995-09-21 Merck & Co., Inc. Pyridil ethylation of lactams
AU2002320251A1 (en) * 2001-07-05 2003-01-21 Vital Basics, Inc. Compositions for improving mental performance
US6951658B1 (en) * 2003-07-08 2005-10-04 Pearson Research & Development Limited Emu-based compositions for mental well-being and method of use
ITMI20040244A1 (en) * 2004-02-13 2004-05-13 Vama Farmacosmetica S R L BACTERIOSTATIC SUBSTANCE FOR PREPARATIONS FOR TOPICAL USE, IN PARTICULAR FOR DERMOPHARMACEUTICAL AND COSMETIC USE AND PREPARATIONS INCLUDING THIS SUBSTANCE
EA016076B1 (en) * 2006-07-06 2012-01-30 Глэксо Груп Лимитед Substituted n-phenylmethyl -5-oxo-proline-2-amides as p2x7-receptor antagonists and their methods of use

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2651639A (en) * 1951-08-22 1953-09-08 American Cyanamid Co 2-pyrrolidone-5-carboxamide derivatives and methods of preparing the same
US3051722A (en) * 1960-10-21 1962-08-28 Lakeside Lab Inc 5-pyrrolidone-2-carboxamides
FR2172906A1 (en) * 1972-02-25 1973-10-05 Fabre Sa Pierre Salts of 3-pyridyl methanol derivs - vasodilators
FR2207707A1 (en) * 1972-11-27 1974-06-21 Fabre Sa Pierre 2-Pyrrolidone-5-carboxylic acid esters and amides - with sedative and hypnotic activity
DE2456634A1 (en) * 1974-11-29 1976-08-12 Thomae Gmbh Dr K Pyroglutamic acid aralkyl esters - prepd e.g. by esterifying pyroglutamic acid with an aralkanol

Also Published As

Publication number Publication date
EP0314275A2 (en) 1989-05-03
US4933354A (en) 1990-06-12
JPH0699307B2 (en) 1994-12-07
EP0314275A3 (en) 1991-07-31

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