KR970707108A - 항염증제로 유용한, 복소환부를 갖는 디-t-부틸페놀 화합물(DI-TERT-BUTYLPHENOL COMPOUNDS WITH HETEROCYCLIC MOIETY, USEFUL AS ANTI-INFLAMMATORY AGENTS) - Google Patents

항염증제로 유용한, 복소환부를 갖는 디-t-부틸페놀 화합물(DI-TERT-BUTYLPHENOL COMPOUNDS WITH HETEROCYCLIC MOIETY, USEFUL AS ANTI-INFLAMMATORY AGENTS)

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Publication number
KR970707108A
KR970707108A KR1019970702584A KR19970702584A KR970707108A KR 970707108 A KR970707108 A KR 970707108A KR 1019970702584 A KR1019970702584 A KR 1019970702584A KR 19970702584 A KR19970702584 A KR 19970702584A KR 970707108 A KR970707108 A KR 970707108A
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KR
South Korea
Prior art keywords
compound
hydrogen
unsubstituted
methyl
group
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KR1019970702584A
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English (en)
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KR100226509B1 (ko
Inventor
미카엘 비어드 쉐르쯔
스타니슬라브 피쿨
Original Assignee
레이셔 야코버스 코넬리스
더 프록터 앤드 갬블 캄파니
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Publication of KR970707108A publication Critical patent/KR970707108A/ko
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/06—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/06—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D231/08—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with oxygen or sulfur atoms directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
    • C07D261/04—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pain & Pain Management (AREA)
  • Epidemiology (AREA)
  • Rheumatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

본 발명은 하기 화학식(Ⅰ)의 구조를 갖는 화합물에 관한 것이다:
[식 중, a) 각각의 R은 독립적으로 탄소수 1 내지 7의 알킬이고; b) Z는 0 또는 N-X이고; c) X는 수소, 탄소수 1 내지 7의 알킬; C(O)Y, C(S)Y, 및 SO2Y이고;d) Y는 R', OR' 및 NR'2로부터 선택되고; e) 각각의 R'은 수소, 탄소수 1 내지 7의 알킬, 및 페닐로부터 선택된다].
또한 본 발명의 목적은 상기 화합물을 이용하여 염증 및/또는 통증을 치료하는 방법에 관한 것이다.

Description

항염증제로 유용한, 복소환부를 갖는 디-t-부틸페놀 화합물(DI-TERT-BUTYLPHENOL COMPOUNDS WITH HETEROCYCLIC MOIETY, USEFUL AS ANTI-INFLAMMATORY AGENTS)
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (14)

  1. 하기 화학식(Ⅰ)의 화합물:
    [식 중, a) 각각의 R은 독립적으로 탄소수 1 내지 7의 알킬이고; b) Z는 0 또는 N-X이고; c) X는 수소, 탄소수 1 내지 7의 알킬, C(O)Y, C(S)Y, 및 SO2Y로 구성된 군으로부터 선택되고; d) Y는 R', OR' 및 NR'2구성된 군으로부터 선택되고; e) R'은 수소, 탄소수 1 내지 7의 알킬, 및 페닐로 구성된 군으로부터 선택된다].
  2. 제1항에 있어서, Z가 산소인 화합물.
  3. 제1항에 있어서, 각각의 R이 비치환된 C1-C3알카닐인 화합물.
  4. 제3항에 있어서, Z가 산소인 화합물.
  5. 제3항에 있어서, 양 R이 동일부인 화합물.
  6. 제5항에 있어서, 양 R이 메틸이고, Z가 산소인 화합물.
  7. 제3항에 있어서, Z가 N-X인 화합물.
  8. 제7항에 있어서, X가 수소 또는 비치환된 C1-C3알카닐이고, 양 R이 동일부인 화합물.
  9. 제7항에 있어서, X가 C(O)Y, C(S)Y, 및 SO2Y로 구성된 군으로부터 선택되고; R'은 수소 또는 비치환된 C1-C3알카닐이고; 양 R이 동일부인 화합물.
  10. 제9항에 있어서, X가 SO2Y이고 Y가 비치환된 C1-C3알카닐인 화합물.
  11. 제10항에 있어서, Y가 메틸이고, 양 R이 메틸인 화합물.
  12. 제8항에 있어서, 양 R이 메틸인 화합물.
  13. 하기를 함유하는 약제학적 조성물: (a) 안전 및 유효량의 청구항 1, 4, 6, 8 또는 9의 화합물; 및 (b) 약제학적으로 허용가능한 담체.
  14. 청구항 1, 4, 6, 8 또는 9의 화합물의 안전 및 유효량을 경구 투여하는 것으로 이루어진, 염증 및 통증의 치료방법.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019970702584A 1994-10-20 1995-10-18 항염증제로 유용한, 복소환부를 갖는 디-t-부틸페놀 화합물 KR100226509B1 (ko)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US8/326619 1994-10-20
US08/326,619 US5510361A (en) 1994-10-20 1994-10-20 Di-tert-butylphenol compounds with heterocyclic moiety, useful as anti-inflammatory agents
US08/326619 1994-10-20
PCT/US1995/012878 WO1996012710A1 (en) 1994-10-20 1995-10-18 Di-tert-butylphenol compounds with heterocyclic moiety, useful as anti-inflammatory agents

Publications (2)

Publication Number Publication Date
KR970707108A true KR970707108A (ko) 1997-12-01
KR100226509B1 KR100226509B1 (ko) 1999-10-15

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Family Applications (1)

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KR1019970702584A KR100226509B1 (ko) 1994-10-20 1995-10-18 항염증제로 유용한, 복소환부를 갖는 디-t-부틸페놀 화합물

Country Status (8)

Country Link
US (1) US5510361A (ko)
EP (1) EP0787130A1 (ko)
JP (1) JPH10507754A (ko)
KR (1) KR100226509B1 (ko)
AU (1) AU705645B2 (ko)
FI (1) FI971674A0 (ko)
NO (1) NO971789L (ko)
WO (1) WO1996012710A1 (ko)

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Also Published As

Publication number Publication date
NO971789D0 (no) 1997-04-18
AU705645B2 (en) 1999-05-27
MX9702941A (es) 1997-07-31
US5510361A (en) 1996-04-23
AU3859895A (en) 1996-05-15
KR100226509B1 (ko) 1999-10-15
FI971674A (fi) 1997-04-18
EP0787130A1 (en) 1997-08-06
JPH10507754A (ja) 1998-07-28
NO971789L (no) 1997-06-19
FI971674A0 (fi) 1997-04-18
WO1996012710A1 (en) 1996-05-02

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