KR970706000A - 자궁내막 유사분열의 저해 방법(methods of inihibiting endometrial mitoses) - Google Patents

자궁내막 유사분열의 저해 방법(methods of inihibiting endometrial mitoses)

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Publication number
KR970706000A
KR970706000A KR1019970701826A KR19970701826A KR970706000A KR 970706000 A KR970706000 A KR 970706000A KR 1019970701826 A KR1019970701826 A KR 1019970701826A KR 19970701826 A KR19970701826 A KR 19970701826A KR 970706000 A KR970706000 A KR 970706000A
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KR
South Korea
Prior art keywords
compound
rti
group
methods
mitogenesis
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Application number
KR1019970701826A
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English (en)
Inventor
수잔 마가렛 보스
Original Assignee
스트링거 피터 지
일라이 릴리 앤드 캄파니
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by 스트링거 피터 지, 일라이 릴리 앤드 캄파니 filed Critical 스트링거 피터 지
Publication of KR970706000A publication Critical patent/KR970706000A/ko

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4535—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a heterocyclic ring having sulfur as a ring hetero atom, e.g. pizotifen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/4025—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cosmetics (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

본 발명은 자궁내막 유사분열을 저해시킬 필요가 있는 인간에게 하기 화학식(Ⅰ)의 화합물 및 그의 약학적으로 허용가능한 염 및 용매화물을 자궁내막 유사분열 저해효과량으로 투여함을 포함하는 자궁내막 유사분열 저해 방법에 관한 것이다 :
상기식에서, R1및 R3는 독립적으로 수소,또는이고(Ar은 임으로 치환된 페닐이다). R2는 피롤리딘, 헥사메틸렌이미노, 및 피페리디노로 이루어진 그룹으로부터 선택된다.

Description

자궁내막 유사분열의 저해방법(METHODS OF INHIBITING ENDOMETRIAL MITOSES)
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (4)

  1. 자궁내막 유사분열을 저해시킬 필요가 있는 인간에게 하기 화학식(Ⅰ)의 화합물, 또는 그의 약학적으로 허용가능한 염 또는 용매화합물을 자궁내막 유사분열 저해효과량으로 투여함을 포함하는 자궁내막 유사분열의 저해방법:
    상기식에서, R1및 R3는 독립적으로 수소,또는이고(Ar은 임으로 치환된 페닐이다), R2는 피롤리딘, 헥사메틸렌이미노, 및 피페리디노로 이루어진 그룹으로부터 선택된다.
  2. 제1항에 있어서, 상기 화합물이 그의 염산염인 방법.
  3. 제1항에 있어서, 상기 투여가 예방 투여인 방법.
  4. 제1항에 있어서, 상기 화합물이 하기의 화합물 또는 그의 염산염인 방법 :
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019970701826A 1994-09-22 1995-09-20 자궁내막 유사분열의 저해 방법(methods of inihibiting endometrial mitoses) KR970706000A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/310,292 US5843964A (en) 1994-09-22 1994-09-22 Methods of inhibiting endometrial mitoses
US08/310,292 1994-09-22
PCT/US1995/011926 WO1996009050A1 (en) 1994-09-22 1995-09-20 Methods of inhibiting endometrial mitoses

Publications (1)

Publication Number Publication Date
KR970706000A true KR970706000A (ko) 1997-11-03

Family

ID=23201835

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019970701826A KR970706000A (ko) 1994-09-22 1995-09-20 자궁내막 유사분열의 저해 방법(methods of inihibiting endometrial mitoses)

Country Status (16)

Country Link
US (1) US5843964A (ko)
EP (1) EP0782446A4 (ko)
JP (1) JPH10506108A (ko)
KR (1) KR970706000A (ko)
CN (1) CN1158086A (ko)
AU (1) AU692309B2 (ko)
CA (1) CA2200451A1 (ko)
CZ (1) CZ83997A3 (ko)
FI (1) FI971197A (ko)
HU (1) HUT76828A (ko)
IL (1) IL115383A0 (ko)
MX (1) MX9702148A (ko)
NO (1) NO971029L (ko)
NZ (1) NZ294123A (ko)
WO (1) WO1996009050A1 (ko)
ZA (1) ZA957949B (ko)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CZ51897A3 (en) * 1994-08-22 1997-06-11 Lilly Co Eli Inhibition method of endometrial cancer
HUP0200871A3 (en) 1999-05-04 2004-04-28 Strakan Int Ltd Androgen glycosides and androgenic activity thereof
EP2726229B1 (en) 2011-06-30 2016-05-04 Hellermanntyton Corporation Cable tie tensioning and cut-off tool
USD692738S1 (en) 2011-06-30 2013-11-05 Hellermanntyton Corporation Cable tie tensioning and cut-off tool
PL3514072T3 (pl) 2014-12-12 2021-07-12 Hellermanntyton Corporation Mechanizm do naprężania i kalibracji mechanizmu do naprężania i odcinania opasek

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4133814A (en) * 1975-10-28 1979-01-09 Eli Lilly And Company 2-Phenyl-3-aroylbenzothiophenes useful as antifertility agents
US4380635A (en) * 1981-04-03 1983-04-19 Eli Lilly And Company Synthesis of acylated benzothiophenes
US4418068A (en) * 1981-04-03 1983-11-29 Eli Lilly And Company Antiestrogenic and antiandrugenic benzothiophenes
US5395842A (en) * 1988-10-31 1995-03-07 Endorecherche Inc. Anti-estrogenic compounds and compositions
JP3157882B2 (ja) * 1991-11-15 2001-04-16 帝国臓器製薬株式会社 新規なベンゾチオフエン誘導体
US5461065A (en) * 1993-10-15 1995-10-24 Eli Lilly And Company Methods for inhibiting endometriosis
DK0771201T3 (da) * 1994-08-22 2001-05-07 Lilly Co Eli Anvendelse af 2-phenyl-3-aroylbenzothiophener til fremstilling af et medikament til inhibering af primær endometrisk hyperplasi

Also Published As

Publication number Publication date
AU692309B2 (en) 1998-06-04
FI971197A0 (fi) 1997-03-21
EP0782446A1 (en) 1997-07-09
NO971029D0 (no) 1997-03-06
CZ83997A3 (en) 1997-07-16
HUT76828A (en) 1997-11-28
NO971029L (no) 1997-03-06
CN1158086A (zh) 1997-08-27
AU3678895A (en) 1996-04-09
FI971197A (fi) 1997-03-21
US5843964A (en) 1998-12-01
MX9702148A (es) 1997-06-28
CA2200451A1 (en) 1996-03-28
NZ294123A (en) 1999-09-29
ZA957949B (en) 1997-03-20
EP0782446A4 (en) 1999-01-07
JPH10506108A (ja) 1998-06-16
IL115383A0 (en) 1995-12-31
WO1996009050A1 (en) 1996-03-28

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