DE69729104D1 - Pharmazeutische zusammensetzungen enthaltend tyrphostine - Google Patents

Pharmazeutische zusammensetzungen enthaltend tyrphostine

Info

Publication number
DE69729104D1
DE69729104D1 DE69729104T DE69729104T DE69729104D1 DE 69729104 D1 DE69729104 D1 DE 69729104D1 DE 69729104 T DE69729104 T DE 69729104T DE 69729104 T DE69729104 T DE 69729104T DE 69729104 D1 DE69729104 D1 DE 69729104D1
Authority
DE
Germany
Prior art keywords
tyrphostine
pharmaceutical compositions
compositions containing
formulae
phenyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69729104T
Other languages
English (en)
Inventor
Abraham Novogrodsky
Alexander Levitzki
Aviv Gazit
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Notox Ltd
Original Assignee
Notox Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Notox Ltd filed Critical Notox Ltd
Application granted granted Critical
Publication of DE69729104D1 publication Critical patent/DE69729104D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/275—Nitriles; Isonitriles
    • A61K31/277—Nitriles; Isonitriles having a ring, e.g. verapamil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4406—Non condensed pyridines; Hydrogenated derivatives thereof only substituted in position 3, e.g. zimeldine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Toxicology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
DE69729104T 1996-08-14 1997-08-14 Pharmazeutische zusammensetzungen enthaltend tyrphostine Expired - Lifetime DE69729104D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IL11906996A IL119069A0 (en) 1996-08-14 1996-08-14 Pharmaceutical composition comprising tyrphostins
PCT/IL1997/000276 WO1998006391A1 (en) 1996-08-14 1997-08-14 Pharmaceutical compositions comprising tyrphostins

Publications (1)

Publication Number Publication Date
DE69729104D1 true DE69729104D1 (de) 2004-06-17

Family

ID=11069189

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69729104T Expired - Lifetime DE69729104D1 (de) 1996-08-14 1997-08-14 Pharmazeutische zusammensetzungen enthaltend tyrphostine

Country Status (11)

Country Link
US (2) US6426366B1 (de)
EP (1) EP0923371B1 (de)
JP (1) JP2001504085A (de)
CN (1) CN1232392A (de)
AT (1) ATE266398T1 (de)
AU (1) AU728672B2 (de)
BR (1) BR9711160A (de)
CA (1) CA2263325A1 (de)
DE (1) DE69729104D1 (de)
IL (1) IL119069A0 (de)
WO (1) WO1998006391A1 (de)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1146869A2 (de) * 1999-01-27 2001-10-24 University Of South Florida Inhibierung der stat3 signaltransduktion für krebsbehandlung
DE60044092D1 (de) * 1999-10-12 2010-05-12 Univ Temple Ungesättigte arylsulfone zum schutz von normalen zellen gegen die zytotoxische wirkung von chemotherapeutika
US20040052762A1 (en) * 2001-09-10 2004-03-18 Hua Yu Stat3 agonists and antagonists and therapeutic uses thereof
CA2450807A1 (en) * 2001-06-14 2003-08-14 Yissum Research Development Company Of The Hebrew University Of Jerusale M Non-myeloablative tolerogenic treatment with tyrphostins
US6433018B1 (en) 2001-08-31 2002-08-13 The Research Foundation Of State University Of New York Method for reducing hypertrophy and ischemia
US7638122B2 (en) * 2003-03-07 2009-12-29 University Of South Florida Stat3 antagonists and their use as vaccines against cancer
SI1701941T1 (sl) * 2003-12-11 2012-09-28 Univ Texas Spojine za zdravljenje celičnih proliferativnih bolezni
WO2005082415A2 (en) * 2004-02-25 2005-09-09 Dana Farber Cancer Institute, Inc. Inhibitors of insulin-like growth factor receptor-1 for inhibiting tumor cell growth
EP2514742B1 (de) * 2006-03-31 2014-12-31 The Board of Regents of The University of Texas System Oral bioverfügbare Antikrebsmittel in Verbindung mit Kaffeesäure
US20100292229A1 (en) * 2006-06-30 2010-11-18 The Board Of Regents Of The University Of Texas System Tryphostin-analogs for the treatment of cell proliferative diseases
MX2010012064A (es) * 2008-05-05 2010-12-06 Schering Corp Uso secuencial de agentes quimioterapeuticos citotoxicos para el tratamiento de cancer.
JP5675606B2 (ja) 2008-07-08 2015-02-25 ボード・オブ・リージエンツ，ザ・ユニバーシテイ・オブ・テキサス・システム シグナル伝達性転写因子（ｓｔａｔ）の増殖及び活性化の新規の抑制剤
WO2011080261A1 (en) 2009-12-28 2011-07-07 INSERM (Institut National de la Santé et de la Recherche Médicale) Method for improved cardiomyogenic differentiation of pluripotent cells
EA202091164A1 (ru) 2017-11-10 2020-08-03 Борд Оф Риджентс, Дзе Юниверсити Оф Техас Систем Производные кофейной кислоты и их применение

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH484603A (de) 1966-03-21 1970-01-31 Ciba Geigy Schädlingsbekämpfungsmittel, enthaltend bestimmte Malodinitrile
US3551573A (en) 1967-11-08 1970-12-29 Monsanto Co Insecticidal composition and method containing anilinomethylene malonitriles
US3726662A (en) 1970-01-14 1973-04-10 Monsanto Co Herbicidal anilinomethylene-malononitriles
US4151298A (en) * 1977-01-10 1979-04-24 Ciba-Geigy Corporation Anthelmintic compositions
AU632992B2 (en) * 1987-12-24 1993-01-21 Yissum Research Development Company Of The Hebrew University Of Jerusalem Pharmaceutical compositions comprising benzylidene- and cinnamylidene-malononitrile derivatives for the inhibition of proliferative processes in mammalian cells, certain such novel compounds and their preparation
RU2024514C1 (ru) 1991-10-01 1994-12-15 Иркутский институт органической химии СО РАН Комплекс 1-этилимидазола с аскорбатом цинка, повышающий устойчивость организма к действию диоксида азота и обладающий цитопротекторным и антигипоксическим действием
US5284868A (en) * 1991-10-09 1994-02-08 Eli Lilly And Company Pharmaceutical compounds
US5972598A (en) 1992-09-17 1999-10-26 Board Of Trustess Of The University Of Illinois Methods for preventing multidrug resistance in cancer cells
DE69434969T2 (de) * 1993-07-15 2008-01-10 Cancer Research Campaign Technology Ltd. Verbindungen die zur herstellung von protein-tyrosin-kinase-inhibitor-prodrogen verwendet werden können
IL107736A (en) * 1993-11-24 2001-01-11 Yissum Res Dev Co Pharmaceutical composition for the prevention of septic shock and for the treatment of chronic inflammatory diseases
US5700823A (en) 1994-01-07 1997-12-23 Sugen, Inc. Treatment of platelet derived growth factor related disorders such as cancers
AU2096895A (en) 1994-03-07 1995-09-25 Sugen, Incorporated Receptor tyrosine kinase inhibitors for inhibiting cell proliferative disorders and compositions thereof
DE69634900T2 (de) * 1995-09-11 2006-05-18 Osteoarthritis Sciences, Inc., Cambridge Proteintyrosine-kinaseinhibitoren zur behandlung der osteoarthritis

Also Published As

Publication number Publication date
ATE266398T1 (de) 2004-05-15
EP0923371A1 (de) 1999-06-23
IL119069A0 (en) 1996-11-14
JP2001504085A (ja) 2001-03-27
BR9711160A (pt) 2000-01-11
WO1998006391A1 (en) 1998-02-19
EP0923371B1 (de) 2004-05-12
CN1232392A (zh) 1999-10-20
AU3782297A (en) 1998-03-06
AU728672B2 (en) 2001-01-18
US6426366B1 (en) 2002-07-30
CA2263325A1 (en) 1998-02-19
US20030013748A1 (en) 2003-01-16

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