BR9711160A - Composições farmacêuticas para neutralizar danosss a células ou tecido, prcoessos para o tratamento de indivìduo para neutralizar danos a células, tecido ou órgão e para a conservação ex vivo de 'rogão, tecido ou células, e, composto. - Google Patents
Composições farmacêuticas para neutralizar danosss a células ou tecido, prcoessos para o tratamento de indivìduo para neutralizar danos a células, tecido ou órgão e para a conservação ex vivo de 'rogão, tecido ou células, e, composto.Info
- Publication number
- BR9711160A BR9711160A BR9711160-0A BR9711160A BR9711160A BR 9711160 A BR9711160 A BR 9711160A BR 9711160 A BR9711160 A BR 9711160A BR 9711160 A BR9711160 A BR 9711160A
- Authority
- BR
- Brazil
- Prior art keywords
- tissue
- cells
- damage
- neutralize
- organ
- Prior art date
Links
- 210000000056 organ Anatomy 0.000 title abstract 4
- 150000001875 compounds Chemical class 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 235000013339 cereals Nutrition 0.000 abstract 3
- 230000003472 neutralizing effect Effects 0.000 abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000005344 pyridylmethyl group Chemical group [H]C1=C([H])C([H])=C([H])C(=N1)C([H])([H])* 0.000 abstract 1
- 231100000331 toxic Toxicity 0.000 abstract 1
- 230000002588 toxic effect Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/275—Nitriles; Isonitriles
- A61K31/277—Nitriles; Isonitriles having a ring, e.g. verapamil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4406—Non condensed pyridines; Hydrogenated derivatives thereof only substituted in position 3, e.g. zimeldine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
Landscapes
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Toxicology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
"COMPOSIçõES FARMACêUTICAS PARA NEUTRALIZAR DANOS A CéLULAS OU TECIDO, PROCESSOS PARA O TRATAMENTO DE UM INDIVìDUO PARA NEUTRALIZAR DANOS A CéLULAS, TECIDO OU óRGãO E PARA A CONSERVAçãO EX VIVO DE óRGãO, TECIDO OU CéLULAS, E, COMPOSTO". Compostos úteis para neutralizar efeitos tóxicos indesejados em células, tecidos ou órgãos, apresentando a fórmula (I) em que: Ar é um grupo de fórmulas (i) ou (ii), n é O ou, quando Ar tem a fórmula (i), acima, então n também pode ser 1, R é CN, -C(S)NH~ 2~, -C(S)NH~ 2~, -C(O)NHR~ 3~ ou, quando R~ 1~ é 4-NO~ 2~ e R~ 2~ é ou 3-OH, então R também pode ser um grupo de fórmulas (iii), (iv), (v), (vi) em que R~ 3~ é H, fenila, fenila(alquila inferior) ou piridilmetila; R~ 1~ e R~ 2~ são, cada um, independentemente, H, OH, NO~ 2~ ou, quando R é CN, também CH~ 3~, F ou CF~ 3~, desde que ambos, R~ 1~ e R~ 2~, sejam simultaneamente H.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IL11906996A IL119069A0 (en) | 1996-08-14 | 1996-08-14 | Pharmaceutical composition comprising tyrphostins |
PCT/IL1997/000276 WO1998006391A1 (en) | 1996-08-14 | 1997-08-14 | Pharmaceutical compositions comprising tyrphostins |
Publications (1)
Publication Number | Publication Date |
---|---|
BR9711160A true BR9711160A (pt) | 2000-01-11 |
Family
ID=11069189
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR9711160-0A BR9711160A (pt) | 1996-08-14 | 1997-08-14 | Composições farmacêuticas para neutralizar danosss a células ou tecido, prcoessos para o tratamento de indivìduo para neutralizar danos a células, tecido ou órgão e para a conservação ex vivo de 'rogão, tecido ou células, e, composto. |
Country Status (11)
Country | Link |
---|---|
US (2) | US6426366B1 (pt) |
EP (1) | EP0923371B1 (pt) |
JP (1) | JP2001504085A (pt) |
CN (1) | CN1232392A (pt) |
AT (1) | ATE266398T1 (pt) |
AU (1) | AU728672B2 (pt) |
BR (1) | BR9711160A (pt) |
CA (1) | CA2263325A1 (pt) |
DE (1) | DE69729104D1 (pt) |
IL (1) | IL119069A0 (pt) |
WO (1) | WO1998006391A1 (pt) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2003525862A (ja) * | 1999-01-27 | 2003-09-02 | ザ ユニヴァーシティー オブ サウス フロリダ | ヒト癌の治療のためのstat3シグナル伝達の阻害 |
ATE462423T1 (de) * | 1999-10-12 | 2010-04-15 | Univ Temple | Ungesättigte arylsulfone zum schutz von normalen zellen gegen die zytotoxische wirkung von chemotherapeutika |
US20040052762A1 (en) * | 2001-09-10 | 2004-03-18 | Hua Yu | Stat3 agonists and antagonists and therapeutic uses thereof |
WO2003065971A2 (en) * | 2001-06-14 | 2003-08-14 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Non-myeloablative tolerogenic treatment with tyrphostins |
US6433018B1 (en) | 2001-08-31 | 2002-08-13 | The Research Foundation Of State University Of New York | Method for reducing hypertrophy and ischemia |
US7638122B2 (en) * | 2003-03-07 | 2009-12-29 | University Of South Florida | Stat3 antagonists and their use as vaccines against cancer |
EP1701941B1 (en) * | 2003-12-11 | 2012-05-30 | Board of Regents, The University of Texas System | Compounds for treatment of cell proliferative diseases |
EP1737493B1 (en) * | 2004-02-25 | 2011-06-29 | Dana-Farber Cancer Institute, Inc. | Inhibitors of insulin-like growth factor receptor -1 for inhibiting tumor cell growth |
RU2456265C2 (ru) * | 2006-03-31 | 2012-07-20 | Дзе Борд Оф Риджентс Оф Дзе Юниверсити Оф Техас Систем | Биологически доступная для перорального применения кофейная кислота, относящаяся к противоопухолевым лекарственным средствам |
US20100292229A1 (en) * | 2006-06-30 | 2010-11-18 | The Board Of Regents Of The University Of Texas System | Tryphostin-analogs for the treatment of cell proliferative diseases |
EP2282739A2 (en) * | 2008-05-05 | 2011-02-16 | Schering Corporation | Sequential administration of chemotherapeutic agents for treatment of cancer |
KR20110033922A (ko) | 2008-07-08 | 2011-04-01 | 더 보드 오브 리전츠 오브 더 유니버시티 오브 텍사스 시스템 | 전사의 신호 변환자 및 활성제(stats)의 증식 및 활성화의 신규한 억제제 |
WO2011080261A1 (en) | 2009-12-28 | 2011-07-07 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Method for improved cardiomyogenic differentiation of pluripotent cells |
AU2018366270B2 (en) | 2017-11-10 | 2023-04-20 | Board Of Regents, The University Of Texas System | Caffeic acid derivatives for treating hyperproliferative diseases |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CH484603A (de) | 1966-03-21 | 1970-01-31 | Ciba Geigy | Schädlingsbekämpfungsmittel, enthaltend bestimmte Malodinitrile |
US3551573A (en) | 1967-11-08 | 1970-12-29 | Monsanto Co | Insecticidal composition and method containing anilinomethylene malonitriles |
US3726662A (en) * | 1970-01-14 | 1973-04-10 | Monsanto Co | Herbicidal anilinomethylene-malononitriles |
NL7800191A (nl) * | 1977-01-10 | 1978-07-12 | Ciba Geigy | Anthelmintisch preparaat. |
AU632992B2 (en) * | 1987-12-24 | 1993-01-21 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Pharmaceutical compositions comprising benzylidene- and cinnamylidene-malononitrile derivatives for the inhibition of proliferative processes in mammalian cells, certain such novel compounds and their preparation |
RU2024514C1 (ru) | 1991-10-01 | 1994-12-15 | Иркутский институт органической химии СО РАН | Комплекс 1-этилимидазола с аскорбатом цинка, повышающий устойчивость организма к действию диоксида азота и обладающий цитопротекторным и антигипоксическим действием |
US5284868A (en) * | 1991-10-09 | 1994-02-08 | Eli Lilly And Company | Pharmaceutical compounds |
US5972598A (en) * | 1992-09-17 | 1999-10-26 | Board Of Trustess Of The University Of Illinois | Methods for preventing multidrug resistance in cancer cells |
KR960703622A (ko) | 1993-07-15 | 1996-08-31 | 수잔 포오덴 | 단백질 티로신 키나아제 억제제의 프로드러그(prodrugs of protein tyrosine kinase inhibitors) |
IL107736A (en) * | 1993-11-24 | 2001-01-11 | Yissum Res Dev Co | Pharmaceutical composition for the prevention of septic shock and for the treatment of chronic inflammatory diseases |
US5700823A (en) * | 1994-01-07 | 1997-12-23 | Sugen, Inc. | Treatment of platelet derived growth factor related disorders such as cancers |
WO1995024190A2 (en) * | 1994-03-07 | 1995-09-14 | Sugen, Inc. | Receptor tyrosine kinase inhibitors for inhibiting cell proliferative disorders and compositions thereof |
DE69634900T2 (de) * | 1995-09-11 | 2006-05-18 | Osteoarthritis Sciences, Inc., Cambridge | Proteintyrosine-kinaseinhibitoren zur behandlung der osteoarthritis |
-
1996
- 1996-08-14 IL IL11906996A patent/IL119069A0/xx unknown
-
1997
- 1997-08-14 JP JP50955898A patent/JP2001504085A/ja active Pending
- 1997-08-14 DE DE69729104T patent/DE69729104D1/de not_active Expired - Lifetime
- 1997-08-14 EP EP97934696A patent/EP0923371B1/en not_active Expired - Lifetime
- 1997-08-14 CN CN97198596A patent/CN1232392A/zh active Pending
- 1997-08-14 WO PCT/IL1997/000276 patent/WO1998006391A1/en active IP Right Grant
- 1997-08-14 BR BR9711160-0A patent/BR9711160A/pt unknown
- 1997-08-14 CA CA002263325A patent/CA2263325A1/en not_active Abandoned
- 1997-08-14 AT AT97934696T patent/ATE266398T1/de not_active IP Right Cessation
- 1997-08-14 AU AU37822/97A patent/AU728672B2/en not_active Ceased
- 1997-08-14 US US09/242,342 patent/US6426366B1/en not_active Expired - Fee Related
-
2002
- 2002-05-09 US US10/141,086 patent/US20030013748A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
US20030013748A1 (en) | 2003-01-16 |
US6426366B1 (en) | 2002-07-30 |
WO1998006391A1 (en) | 1998-02-19 |
ATE266398T1 (de) | 2004-05-15 |
AU3782297A (en) | 1998-03-06 |
DE69729104D1 (de) | 2004-06-17 |
EP0923371B1 (en) | 2004-05-12 |
CA2263325A1 (en) | 1998-02-19 |
EP0923371A1 (en) | 1999-06-23 |
CN1232392A (zh) | 1999-10-20 |
AU728672B2 (en) | 2001-01-18 |
IL119069A0 (en) | 1996-11-14 |
JP2001504085A (ja) | 2001-03-27 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B25A | Requested transfer of rights approved |
Free format text: NOTOX LTD. (IL) |
|
B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 7A E 8A ANUIDADES. |