EA199900735A1 - Соединения и способ получения замещенных 4-фенил-4-цианоциклогексановых кислот - Google Patents

Соединения и способ получения замещенных 4-фенил-4-цианоциклогексановых кислот

Info

Publication number
EA199900735A1
EA199900735A1 EA199900735A EA199900735A EA199900735A1 EA 199900735 A1 EA199900735 A1 EA 199900735A1 EA 199900735 A EA199900735 A EA 199900735A EA 199900735 A EA199900735 A EA 199900735A EA 199900735 A1 EA199900735 A1 EA 199900735A1
Authority
EA
Eurasian Patent Office
Prior art keywords
cyanocyl
phenyl
compounds
obtaining substituted
hexane
Prior art date
Application number
EA199900735A
Other languages
English (en)
Other versions
EA001783B1 (ru
Inventor
Эндрю Аллен
Энн Мари Дидерих
Ли Лиу
Уилфорд Мендельсон
Кевин Уэбб
Original Assignee
Смитклайн Бичам Корпорейшн
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Смитклайн Бичам Корпорейшн filed Critical Смитклайн Бичам Корпорейшн
Publication of EA199900735A1 publication Critical patent/EA199900735A1/ru
Publication of EA001783B1 publication Critical patent/EA001783B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00—Ethers; Compounds having groups, groups or groups
    • C07C43/02—Ethers
    • C07C43/20—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring
    • C07C43/21—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring containing rings other than six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/48—Compounds containing oxirane rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C253/00—Preparation of carboxylic acid nitriles
    • C07C253/30—Preparation of carboxylic acid nitriles by reactions not involving the formation of cyano groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
    • C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pulmonology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Catalysts (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Изобретение относится к способу получения соединения формулы (I) путем обработки соединения формулы (II) бромидом лития, бромидом магния и тому подобным.Международная заявка была опубликована вместе с отчетом о международном поиске.
EA199900735A 1997-02-12 1998-02-12 Соединения и способ получения замещенных 4-фенил-4-цианоциклогексановых кислот EA001783B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US3760897P 1997-02-12 1997-02-12
PCT/US1998/002749 WO1998034584A2 (en) 1997-02-12 1998-02-12 Compounds and method for preparing substituted 4-phenyl-4-cyanocyclohexanoic acids

Publications (2)

Publication Number Publication Date
EA199900735A1 true EA199900735A1 (ru) 2000-02-28
EA001783B1 EA001783B1 (ru) 2001-08-27

Family

ID=21895265

Family Applications (1)

Application Number Title Priority Date Filing Date
EA199900735A EA001783B1 (ru) 1997-02-12 1998-02-12 Соединения и способ получения замещенных 4-фенил-4-цианоциклогексановых кислот

Country Status (38)

Country Link
US (1) US6337408B1 (ru)
EP (1) EP1023279B8 (ru)
JP (4) JP3786971B2 (ru)
KR (1) KR100412008B1 (ru)
CN (2) CN1854131A (ru)
AP (1) AP1215A (ru)
AR (2) AR012550A1 (ru)
AT (2) ATE300517T1 (ru)
AU (1) AU725484B2 (ru)
BG (1) BG63541B1 (ru)
BR (1) BR9808637A (ru)
CA (1) CA2279951A1 (ru)
CO (1) CO4950534A1 (ru)
CY (1) CY2478B1 (ru)
DE (3) DE69831022T2 (ru)
DK (2) DK1524268T3 (ru)
DZ (1) DZ2423A1 (ru)
EA (1) EA001783B1 (ru)
ES (3) ES2196551T3 (ru)
HK (1) HK1037613A1 (ru)
HU (1) HUP0001801A3 (ru)
ID (1) ID23527A (ru)
IL (7) IL131270A (ru)
MA (1) MA24471A1 (ru)
MY (1) MY118813A (ru)
NO (1) NO993863L (ru)
NZ (1) NZ337084A (ru)
OA (1) OA11144A (ru)
PL (1) PL193366B1 (ru)
PT (2) PT1023279E (ru)
SI (2) SI1524268T1 (ru)
SK (1) SK108899A3 (ru)
TR (1) TR199901920T2 (ru)
TW (1) TW442455B (ru)
UA (1) UA58533C2 (ru)
UY (2) UY24882A1 (ru)
WO (1) WO1998034584A2 (ru)
ZA (1) ZA981125B (ru)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6452022B1 (en) * 1997-10-10 2002-09-17 Smithkline Beecham Corporation Method for preparing substituted 4-phenyl-4-cyanocyclohexanoic acids
UA67753C2 (ru) * 1997-10-10 2004-07-15 Смітклайн Бічам Корпорейшн Способ получения замещенной цианоциклогексановой кислоты
US20040220424A1 (en) * 1999-08-06 2004-11-04 Smithkline Beecham Corporation Process for preparing acids via alpha-chloroepoxy esters
ECSP003599A (es) * 1999-08-06 2002-03-25 Smithkline Beecham Corp Procedimiento para preparar acidos a traves de alfa-coroepoxi-esteres
GB9920152D0 (en) * 1999-08-25 1999-10-27 Smithkline Beecham Plc Novel process
EP1265861A2 (en) 2000-03-16 2002-12-18 Inflazyme Pharmaceuticals, Ltd. Benzylated pde4 inhibitors
CN102491959B (zh) * 2011-12-19 2015-03-25 江苏澄扬作物科技有限公司 一种环氧乙烷衍生物的制备方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8320943D0 (en) * 1983-08-03 1983-09-07 Lilly Industries Ltd Organic compounds
AU677776B2 (en) * 1992-04-02 1997-05-08 Smithkline Beecham Corporation Compounds useful for treating allergic and inflammatory diseases
AU3738293A (en) * 1992-04-02 1993-11-08 Smithkline Beecham Corporation Compounds useful for treating allergic and inflammatory diseases

Also Published As

Publication number Publication date
SI1295869T1 (sl) 2005-12-31
IL131270A (en) 2005-05-17
BG103651A (en) 2000-02-29
CN1301982C (zh) 2007-02-28
DE69836928T2 (de) 2007-11-08
IL131270A0 (en) 2001-01-28
MY118813A (en) 2005-01-31
TR199901920T2 (xx) 1999-11-22
NZ337084A (en) 2001-04-27
IL166184A0 (en) 2006-01-15
DE69831022T2 (de) 2006-04-20
UY25127A1 (es) 1998-11-27
ATE300517T1 (de) 2005-08-15
NO993863D0 (no) 1999-08-11
IL150955A (en) 2006-07-05
EP1023279A4 (en) 2000-10-04
ES2280008T3 (es) 2007-09-01
BG63541B1 (bg) 2002-04-30
WO1998034584A3 (en) 1998-11-19
DE69813596D1 (de) 2003-05-22
ID23527A (id) 2000-04-27
US6337408B1 (en) 2002-01-08
AU725484B2 (en) 2000-10-12
EP1023279B1 (en) 2003-04-16
JP4093967B2 (ja) 2008-06-04
JP3786971B2 (ja) 2006-06-21
TW442455B (en) 2001-06-23
DK1524268T3 (da) 2007-05-14
EA001783B1 (ru) 2001-08-27
UA58533C2 (ru) 2003-08-15
AU6654498A (en) 1998-08-26
IL166187A0 (en) 2006-01-15
PL193366B1 (pl) 2007-02-28
IL166188A0 (en) 2006-01-15
ES2246373T3 (es) 2006-02-16
KR20000070927A (ko) 2000-11-25
DE69836928D1 (de) 2007-03-08
PT1524268E (pt) 2007-03-30
AR050308A2 (es) 2006-10-18
HUP0001801A2 (hu) 2000-10-28
UY24882A1 (es) 2001-08-27
JP2004269546A (ja) 2004-09-30
JP2001510482A (ja) 2001-07-31
WO1998034584A2 (en) 1998-08-13
DE69831022D1 (de) 2005-09-01
IL166185A0 (en) 2006-01-15
CN1246855A (zh) 2000-03-08
SI1524268T1 (sl) 2007-04-30
HUP0001801A3 (en) 2001-12-28
OA11144A (en) 2003-04-17
PL335031A1 (en) 2000-03-27
SK108899A3 (en) 2000-01-18
EP1023279A2 (en) 2000-08-02
KR100412008B1 (ko) 2003-12-24
MA24471A1 (fr) 1998-10-01
BR9808637A (pt) 2000-07-04
JP4053024B2 (ja) 2008-02-27
AP1215A (en) 2003-10-14
DZ2423A1 (fr) 2003-01-04
EP1023279B8 (en) 2003-08-13
CN1854131A (zh) 2006-11-01
CY2478B1 (en) 2005-06-03
ZA981125B (en) 1998-08-21
DE69813596T2 (de) 2004-02-12
DK1023279T3 (da) 2003-07-21
ATE237603T1 (de) 2003-05-15
PT1023279E (pt) 2003-08-29
JP2004292460A (ja) 2004-10-21
AP9901618A0 (en) 1999-09-30
AR012550A1 (es) 2000-11-08
ES2196551T3 (es) 2003-12-16
JP2004149546A (ja) 2004-05-27
NO993863L (no) 1999-08-11
JP4053023B2 (ja) 2008-02-27
IL166186A0 (en) 2006-01-15
CO4950534A1 (es) 2000-09-01
CA2279951A1 (en) 1998-08-13
HK1037613A1 (en) 2002-02-15

Similar Documents

Publication Publication Date Title
EA200000539A1 (ru) Способ получения производных класса таксоидов
EA200401540A1 (ru) Спироиндолинпиперидиновые производные
RU94042903A (ru) 3,4,4-трехзамещенные пиперидинил-n-алкилкарбоксилаты и промежуточные соединения, способ их получения, фармкомпозиция
EA199900079A1 (ru) Способ получения фенильных гетероциклов, пригодных в качестве ингибиторов цог-2
EA200200481A1 (ru) Способ получения производных 4-трифторметилсульфинилпиразола
EA200200900A1 (ru) Способ получения циталопрама
EA199900141A1 (ru) Цветообразующая композиция, содержащая реагент, включающий пирогаллольные структурные фрагменты, соль железа (ii) и органическую кислоту
EA200400129A1 (ru) Способ получения периндоприла, его аналогов и солей с использованием 2,5-диоксооксазолидиновых промежуточных соединений
EA199800792A1 (ru) Способы получения промежуточных соединений для пестицидов
EA199900334A1 (ru) Циклопентеноны, способы их получения и применение
EA200000094A1 (ru) Способ получения замещенного пергидроизоиндола
EA199800123A1 (ru) Способ получения n-замещенных 3-гидроксипиразолов
EA199900735A1 (ru) Соединения и способ получения замещенных 4-фенил-4-цианоциклогексановых кислот
EA199900948A1 (ru) Способ получения 2-арил-3-арил-5-галогенпиридинов, используемых в качестве ингибиторов cox-2
EA199900821A1 (ru) Способ получения производных пиразола
EA200000910A1 (ru) Азабициклические лиганды рецепторов 5нт1
BR9408223A (pt) Composto derivado de 4-benzoilisoxazol processo de preparação composição herbicida método de controle herbicida e compostos intermediarios
EA200200939A1 (ru) Способ получения циталопрама
EA199900235A1 (ru) Аморфные бензотиофены, способы получения и способы применения
EA200200101A1 (ru) Получение замещенных пиперидин-4-онов
EA199900741A1 (ru) Способ получения эпросартана
EA200000069A1 (ru) Способ получения 4-замещенных-1h-индол-3-глиоксамидов
EA200000406A1 (ru) Способ получения замещенных 4-фенил-4-цианоциклогексановых кислот
EA199900740A1 (ru) Способ получения эпросартана (варианты)
EA199801084A1 (ru) Спосб получения фенилгетероциклических соединений, используемых в качестве ингибиторов циклооксигеназы-2

Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM RU