HUP0001801A2 - Eljárás szubsztituált 4-ciano-4-fenil-ciklohexánkarbonsavak előállítására és az eljárás intermedierei - Google Patents
Eljárás szubsztituált 4-ciano-4-fenil-ciklohexánkarbonsavak előállítására és az eljárás intermediereiInfo
- Publication number
- HUP0001801A2 HUP0001801A2 HU0001801A HUP0001801A HUP0001801A2 HU P0001801 A2 HUP0001801 A2 HU P0001801A2 HU 0001801 A HU0001801 A HU 0001801A HU P0001801 A HUP0001801 A HU P0001801A HU P0001801 A2 HUP0001801 A2 HU P0001801A2
- Authority
- HU
- Hungary
- Prior art keywords
- cr4r5
- group
- optionally substituted
- hydrogen atom
- compounds
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 4
- XWFKZQVEYDVFTA-UHFFFAOYSA-N 4-cyano-4-phenylcyclohexane-1-carboxylic acid Chemical class C1CC(C(=O)O)CCC1(C#N)C1=CC=CC=C1 XWFKZQVEYDVFTA-UHFFFAOYSA-N 0.000 title 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 5
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 150000002367 halogens Chemical class 0.000 abstract 2
- AMXOYNBUYSYVKV-UHFFFAOYSA-M lithium bromide Chemical compound [Li+].[Br-] AMXOYNBUYSYVKV-UHFFFAOYSA-M 0.000 abstract 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 2
- 125000004430 oxygen atom Chemical group O* 0.000 abstract 2
- 125000000547 substituted alkyl group Chemical group 0.000 abstract 2
- YBYIRNPNPLQARY-UHFFFAOYSA-N 1H-indene Natural products C1=CC=C2CC=CC2=C1 YBYIRNPNPLQARY-UHFFFAOYSA-N 0.000 abstract 1
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 abstract 1
- 125000005160 aryl oxy alkyl group Chemical group 0.000 abstract 1
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 abstract 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 1
- 229910052731 fluorine Inorganic materials 0.000 abstract 1
- 239000011737 fluorine Substances 0.000 abstract 1
- 125000002541 furyl group Chemical group 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 125000003392 indanyl group Chemical group C1(CCC2=CC=CC=C12)* 0.000 abstract 1
- 125000003454 indenyl group Chemical group C1(C=CC2=CC=CC=C12)* 0.000 abstract 1
- 239000002798 polar solvent Substances 0.000 abstract 1
- 125000005592 polycycloalkyl group Polymers 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 125000004309 pyranyl group Chemical group O1C(C=CC=C1)* 0.000 abstract 1
- 125000003107 substituted aryl group Chemical group 0.000 abstract 1
- 125000003718 tetrahydrofuranyl group Chemical group 0.000 abstract 1
- 125000001412 tetrahydropyranyl group Chemical group 0.000 abstract 1
- 125000005958 tetrahydrothienyl group Chemical group 0.000 abstract 1
- 125000004632 tetrahydrothiopyranyl group Chemical group S1C(CCCC1)* 0.000 abstract 1
- 125000001544 thienyl group Chemical group 0.000 abstract 1
- -1 thiopyranyl Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C43/00—Ethers; Compounds having groups, groups or groups
- C07C43/02—Ethers
- C07C43/20—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring
- C07C43/21—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring containing rings other than six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
- C07D303/02—Compounds containing oxirane rings
- C07D303/48—Compounds containing oxirane rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms, e.g. ester or nitrile radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C253/00—Preparation of carboxylic acid nitriles
- C07C253/30—Preparation of carboxylic acid nitriles by reactions not involving the formation of cyano groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
- C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pulmonology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Catalysts (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
A találmány tárgya eljárás (I) általános képletű vegyületek - amelyekképletében Rl -(CR4R5)nC(O)O(CR4R5)m 6, -(CR4R5)nO(CR4R5)mR6<I*U ^*X*O*A*>, -(CR4R5)nC(O)NR4(CR4R5)m I*U*^*X*O*A*>R6 vagy -(CR4R5)rR6 csoport, ame-lyekben az alkilcsoportok adott esetben egy vagy több halogénatommalszubsztituáltak, m 0, l vagy 2; n 0, l, 2, 3 vagy 4; r 0, l, 2, 3, 4, 5 vagy 6; R4 és R5 hidrogénatom vagy alkilcsoport, R6 hidrogénatom, metil-, hidroxi-, adott esetben szubsztituált aril-,aril-oxi-alkil-, indanil-, indenil-, policikloalkil-,tetrahidrofuril-, furil-, tetrahidropiranil-, piranil-,tetrahidrotienil-, tienil-, tetra- hidrotiopiranil-, tiopiranil-,cikloalkil- és egy vagy két telítetlen kötést tartalmazócikloalkilcsoport, bizonyos megkötésekkel, X YR2, halogénatom, amino- vagy formil-amino-csoport; X2 oxigénatom vagy NR8 csoport; Y oxigénatom vagy S(O)m, csoport; m' 0, 1 vagy 2; R2 adott esetben szubsztituált metil- vagy etilcsoport; R3 hidrogén-, halogénatom, adott esetben szubsztituált alkil-,CH2NHC(O)C(O)NH2, -CH=CR8'R8' vagy ciklopropilcsoport; R8 hidrogénatom, adott esetben szubsztituált alkilcsoport; R8' R8 vagy fluoratom; R' és R'' jelentése egymástól függetlenül hidrogénatom vagykarboxicsoport - előállítására, amelynek során egy (II) általánosképletű vegyületet - ahol Rl, R3, X2 és X jelentése az (I) általánosképletnél meghatározott - poláris oldószerben, körülbelül 60 °C és 100°C közötti hőmérséklet-tartományban, adott esetben inert atmoszféraalatt, a reakció teljes lejátszódásához elegendő ideig lítium-bromiddal reagáltatnak. A találmány tárgyát képezik maguk a (II)általános képletű vegyületek is. Ó
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US3760897P | 1997-02-12 | 1997-02-12 | |
PCT/US1998/002749 WO1998034584A2 (en) | 1997-02-12 | 1998-02-12 | Compounds and method for preparing substituted 4-phenyl-4-cyanocyclohexanoic acids |
Publications (2)
Publication Number | Publication Date |
---|---|
HUP0001801A2 true HUP0001801A2 (hu) | 2000-10-28 |
HUP0001801A3 HUP0001801A3 (en) | 2001-12-28 |
Family
ID=21895265
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HU0001801A HUP0001801A3 (en) | 1997-02-12 | 1998-02-12 | Compounds and method for preparing substituted 4-phenyl-4-cyanocyclohexanoic acids |
Country Status (38)
Country | Link |
---|---|
US (1) | US6337408B1 (hu) |
EP (1) | EP1023279B8 (hu) |
JP (4) | JP3786971B2 (hu) |
KR (1) | KR100412008B1 (hu) |
CN (2) | CN1854131A (hu) |
AP (1) | AP1215A (hu) |
AR (2) | AR012550A1 (hu) |
AT (2) | ATE300517T1 (hu) |
AU (1) | AU725484B2 (hu) |
BG (1) | BG63541B1 (hu) |
BR (1) | BR9808637A (hu) |
CA (1) | CA2279951A1 (hu) |
CO (1) | CO4950534A1 (hu) |
CY (1) | CY2478B1 (hu) |
DE (3) | DE69831022T2 (hu) |
DK (2) | DK1524268T3 (hu) |
DZ (1) | DZ2423A1 (hu) |
EA (1) | EA001783B1 (hu) |
ES (3) | ES2196551T3 (hu) |
HK (1) | HK1037613A1 (hu) |
HU (1) | HUP0001801A3 (hu) |
ID (1) | ID23527A (hu) |
IL (7) | IL131270A (hu) |
MA (1) | MA24471A1 (hu) |
MY (1) | MY118813A (hu) |
NO (1) | NO993863L (hu) |
NZ (1) | NZ337084A (hu) |
OA (1) | OA11144A (hu) |
PL (1) | PL193366B1 (hu) |
PT (2) | PT1023279E (hu) |
SI (2) | SI1524268T1 (hu) |
SK (1) | SK108899A3 (hu) |
TR (1) | TR199901920T2 (hu) |
TW (1) | TW442455B (hu) |
UA (1) | UA58533C2 (hu) |
UY (2) | UY24882A1 (hu) |
WO (1) | WO1998034584A2 (hu) |
ZA (1) | ZA981125B (hu) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6452022B1 (en) * | 1997-10-10 | 2002-09-17 | Smithkline Beecham Corporation | Method for preparing substituted 4-phenyl-4-cyanocyclohexanoic acids |
UA67753C2 (uk) * | 1997-10-10 | 2004-07-15 | Смітклайн Бічам Корпорейшн | Спосіб отримання заміщених 4-феніл-4-ціанциклогексанових кислот |
US20040220424A1 (en) * | 1999-08-06 | 2004-11-04 | Smithkline Beecham Corporation | Process for preparing acids via alpha-chloroepoxy esters |
ECSP003599A (es) * | 1999-08-06 | 2002-03-25 | Smithkline Beecham Corp | Procedimiento para preparar acidos a traves de alfa-coroepoxi-esteres |
GB9920152D0 (en) * | 1999-08-25 | 1999-10-27 | Smithkline Beecham Plc | Novel process |
EP1265861A2 (en) | 2000-03-16 | 2002-12-18 | Inflazyme Pharmaceuticals, Ltd. | Benzylated pde4 inhibitors |
CN102491959B (zh) * | 2011-12-19 | 2015-03-25 | 江苏澄扬作物科技有限公司 | 一种环氧乙烷衍生物的制备方法 |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB8320943D0 (en) * | 1983-08-03 | 1983-09-07 | Lilly Industries Ltd | Organic compounds |
AU677776B2 (en) * | 1992-04-02 | 1997-05-08 | Smithkline Beecham Corporation | Compounds useful for treating allergic and inflammatory diseases |
AU3738293A (en) * | 1992-04-02 | 1993-11-08 | Smithkline Beecham Corporation | Compounds useful for treating allergic and inflammatory diseases |
-
1998
- 1998-02-10 UY UY24882A patent/UY24882A1/es not_active IP Right Cessation
- 1998-02-10 AR ARP980100587A patent/AR012550A1/es unknown
- 1998-02-10 MY MYPI98000536A patent/MY118813A/en unknown
- 1998-02-11 ZA ZA981125A patent/ZA981125B/xx unknown
- 1998-02-12 DK DK04078092T patent/DK1524268T3/da active
- 1998-02-12 WO PCT/US1998/002749 patent/WO1998034584A2/en active IP Right Grant
- 1998-02-12 ES ES98908534T patent/ES2196551T3/es not_active Expired - Lifetime
- 1998-02-12 CA CA002279951A patent/CA2279951A1/en not_active Abandoned
- 1998-02-12 AT AT02078056T patent/ATE300517T1/de not_active IP Right Cessation
- 1998-02-12 DE DE69831022T patent/DE69831022T2/de not_active Expired - Lifetime
- 1998-02-12 CO CO98007356A patent/CO4950534A1/es unknown
- 1998-02-12 HU HU0001801A patent/HUP0001801A3/hu unknown
- 1998-02-12 PT PT98908534T patent/PT1023279E/pt unknown
- 1998-02-12 TR TR1999/01920T patent/TR199901920T2/xx unknown
- 1998-02-12 MA MA24962A patent/MA24471A1/fr unknown
- 1998-02-12 EA EA199900735A patent/EA001783B1/ru not_active IP Right Cessation
- 1998-02-12 DK DK98908534T patent/DK1023279T3/da active
- 1998-02-12 AT AT98908534T patent/ATE237603T1/de not_active IP Right Cessation
- 1998-02-12 BR BR9808637-5A patent/BR9808637A/pt not_active Application Discontinuation
- 1998-02-12 AU AU66544/98A patent/AU725484B2/en not_active Ceased
- 1998-02-12 ES ES04078092T patent/ES2280008T3/es not_active Expired - Lifetime
- 1998-02-12 ID IDW990806A patent/ID23527A/id unknown
- 1998-02-12 CN CNA2006100819583A patent/CN1854131A/zh active Pending
- 1998-02-12 KR KR10-1999-7007192A patent/KR100412008B1/ko not_active IP Right Cessation
- 1998-02-12 PT PT04078092T patent/PT1524268E/pt unknown
- 1998-02-12 DZ DZ980033A patent/DZ2423A1/xx active
- 1998-02-12 DE DE69813596T patent/DE69813596T2/de not_active Expired - Lifetime
- 1998-02-12 EP EP98908534A patent/EP1023279B8/en not_active Expired - Lifetime
- 1998-02-12 AP APAP/P/1999/001618A patent/AP1215A/en active
- 1998-02-12 IL IL13127098A patent/IL131270A/xx not_active IP Right Cessation
- 1998-02-12 PL PL335031A patent/PL193366B1/pl not_active IP Right Cessation
- 1998-02-12 NZ NZ337084A patent/NZ337084A/en unknown
- 1998-02-12 SI SI9830872T patent/SI1524268T1/sl unknown
- 1998-02-12 JP JP53506598A patent/JP3786971B2/ja not_active Expired - Fee Related
- 1998-02-12 DE DE69836928T patent/DE69836928T2/de not_active Expired - Lifetime
- 1998-02-12 SI SI9830794T patent/SI1295869T1/sl unknown
- 1998-02-12 SK SK1088-99A patent/SK108899A3/sk unknown
- 1998-02-12 ES ES02078056T patent/ES2246373T3/es not_active Expired - Lifetime
- 1998-02-12 CN CNB988023776A patent/CN1301982C/zh not_active Expired - Fee Related
- 1998-07-20 TW TW087101889A patent/TW442455B/zh active
- 1998-08-06 UY UY25127A patent/UY25127A1/es not_active IP Right Cessation
- 1998-12-02 UA UA99084524A patent/UA58533C2/uk unknown
-
1999
- 1999-08-10 BG BG103651A patent/BG63541B1/bg unknown
- 1999-08-11 NO NO993863A patent/NO993863L/no unknown
- 1999-08-12 OA OA9900176A patent/OA11144A/en unknown
-
2000
- 2000-03-22 US US09/533,368 patent/US6337408B1/en not_active Expired - Fee Related
-
2001
- 2001-01-30 HK HK01100673A patent/HK1037613A1/xx not_active IP Right Cessation
-
2002
- 2002-07-29 IL IL150955A patent/IL150955A/en not_active IP Right Cessation
-
2004
- 2004-01-05 JP JP2004000418A patent/JP4093967B2/ja not_active Expired - Fee Related
- 2004-06-09 JP JP2004171348A patent/JP4053024B2/ja not_active Expired - Fee Related
- 2004-06-09 JP JP2004171346A patent/JP4053023B2/ja not_active Expired - Fee Related
- 2004-09-08 CY CY0400070A patent/CY2478B1/xx unknown
-
2005
- 2005-01-06 IL IL16618505A patent/IL166185A0/xx unknown
- 2005-01-06 IL IL16618405A patent/IL166184A0/xx unknown
- 2005-01-06 IL IL16618705A patent/IL166187A0/xx unknown
- 2005-01-06 IL IL16618605A patent/IL166186A0/xx unknown
- 2005-01-06 IL IL16618805A patent/IL166188A0/xx unknown
-
2006
- 2006-04-05 AR ARP060101344A patent/AR050308A2/es not_active Application Discontinuation
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FD9A | Lapse of provisional protection due to non-payment of fees |