UY25127A1 - Metodo para preparar acidos 4-fenil-4-ciano-ciclohexanoicos sustituidos - Google Patents

Metodo para preparar acidos 4-fenil-4-ciano-ciclohexanoicos sustituidos

Info

Publication number
UY25127A1
UY25127A1 UY25127A UY25127A UY25127A1 UY 25127 A1 UY25127 A1 UY 25127A1 UY 25127 A UY25127 A UY 25127A UY 25127 A UY25127 A UY 25127A UY 25127 A1 UY25127 A1 UY 25127A1
Authority
UY
Uruguay
Prior art keywords
halogen
cyano
alkyl
phenyl
cr4r5
Prior art date
Application number
UY25127A
Other languages
English (en)
Inventor
Kevin Webb
Wilford Mendelson
Andrew Allen
Marie Diederich Ann
Li Lui
Original Assignee
Smithkline Beecham Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beecham Corp filed Critical Smithkline Beecham Corp
Publication of UY25127A1 publication Critical patent/UY25127A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00—Ethers; Compounds having groups, groups or groups
    • C07C43/02—Ethers
    • C07C43/20—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring
    • C07C43/21—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring containing rings other than six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/48—Compounds containing oxirane rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C253/00—Preparation of carboxylic acid nitriles
    • C07C253/30—Preparation of carboxylic acid nitriles by reactions not involving the formation of cyano groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
    • C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pulmonology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Epoxy Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Catalysts (AREA)

Abstract

Esta invención se refiere a compuestos intermedios y a una vía de síntesis para producir ácido 4-ciano-4-(3-ciclo-pentiloxi-4-metoxifenil)ciclohexanoico y sus análogos. Este ácido y sus análogos mencionados son selectivos respecto a la inhibición del sitio catalítico en la isoenzima de la clase de las fosfodiesterasas, los ácidos son útiles en el tratamiento de enfermedades que pueden ser moderadas por afectar la enzima PDE IV y subtipos. Esta invención se refiere a un método para producir un compuesto de fórmula (I) en la cual R1 es -(CR4R5)nC(O)O(CR4R5)mR6 donde los restos de alquilo pueden estar sustituídos con uno o mas halógenos; m es de 0a2; n es 1a 4, r es 0a6; R4 y R5 se seleccionan independientemente de H o alquilo C1-2;R6 es H , metilo, hidroxilo, arilo, arilo sustituído con halo, indanilo, indenilo, etc; X es YR2, halógeno, haloógeno, nitro, NH2, formilamina; X2 es O,; Y es O o S(O)m´; m´es 0,1 ó 2R3 es H, halógeno, alquilo C1-4; R´y R´´ son H o -C(O)OH. Ejemplo: Preparaciòn de 3-ciclopebtiloxi-4-metoxibenzaldehído
UY25127A 1997-02-12 1998-08-06 Metodo para preparar acidos 4-fenil-4-ciano-ciclohexanoicos sustituidos UY25127A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US3760897P 1997-02-12 1997-02-12
UY24882A UY24882A1 (es) 1997-02-12 1998-02-10 Ácidos 4-fenil-4-ciano-ciclohexanoicos sustituidos

Publications (1)

Publication Number Publication Date
UY25127A1 true UY25127A1 (es) 1998-11-27

Family

ID=21895265

Family Applications (2)

Application Number Title Priority Date Filing Date
UY24882A UY24882A1 (es) 1997-02-12 1998-02-10 Ácidos 4-fenil-4-ciano-ciclohexanoicos sustituidos
UY25127A UY25127A1 (es) 1997-02-12 1998-08-06 Metodo para preparar acidos 4-fenil-4-ciano-ciclohexanoicos sustituidos

Family Applications Before (1)

Application Number Title Priority Date Filing Date
UY24882A UY24882A1 (es) 1997-02-12 1998-02-10 Ácidos 4-fenil-4-ciano-ciclohexanoicos sustituidos

Country Status (38)

Country Link
US (1) US6337408B1 (es)
EP (1) EP1023279B8 (es)
JP (4) JP3786971B2 (es)
KR (1) KR100412008B1 (es)
CN (2) CN1301982C (es)
AP (1) AP1215A (es)
AR (2) AR012550A1 (es)
AT (2) ATE237603T1 (es)
AU (1) AU725484B2 (es)
BG (1) BG63541B1 (es)
BR (1) BR9808637A (es)
CA (1) CA2279951A1 (es)
CO (1) CO4950534A1 (es)
CY (1) CY2478B1 (es)
DE (3) DE69836928T2 (es)
DK (2) DK1524268T3 (es)
DZ (1) DZ2423A1 (es)
EA (1) EA001783B1 (es)
ES (3) ES2246373T3 (es)
HK (1) HK1037613A1 (es)
HU (1) HUP0001801A3 (es)
ID (1) ID23527A (es)
IL (7) IL131270A (es)
MA (1) MA24471A1 (es)
MY (1) MY118813A (es)
NO (1) NO993863L (es)
NZ (1) NZ337084A (es)
OA (1) OA11144A (es)
PL (1) PL193366B1 (es)
PT (2) PT1524268E (es)
SI (2) SI1524268T1 (es)
SK (1) SK108899A3 (es)
TR (1) TR199901920T2 (es)
TW (1) TW442455B (es)
UA (1) UA58533C2 (es)
UY (2) UY24882A1 (es)
WO (1) WO1998034584A2 (es)
ZA (1) ZA981125B (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UA67753C2 (uk) * 1997-10-10 2004-07-15 Смітклайн Бічам Корпорейшн Спосіб отримання заміщених 4-феніл-4-ціанциклогексанових кислот
US6452022B1 (en) * 1997-10-10 2002-09-17 Smithkline Beecham Corporation Method for preparing substituted 4-phenyl-4-cyanocyclohexanoic acids
US20040220424A1 (en) * 1999-08-06 2004-11-04 Smithkline Beecham Corporation Process for preparing acids via alpha-chloroepoxy esters
UY26268A1 (es) * 1999-08-06 2001-01-31 Smithkline Beecham Corp Procedimiento para preparar acidos a traves de alfa-cloroep xi- esteres ley 17164 art 127
GB9920152D0 (en) 1999-08-25 1999-10-27 Smithkline Beecham Plc Novel process
EP2258689A1 (en) 2000-03-16 2010-12-08 Biolipox AB Benzylated PDE4 inhibitors
CN102491959B (zh) * 2011-12-19 2015-03-25 江苏澄扬作物科技有限公司 一种环氧乙烷衍生物的制备方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8320943D0 (en) * 1983-08-03 1983-09-07 Lilly Industries Ltd Organic compounds
SK279958B6 (sk) * 1992-04-02 1999-06-11 Smithkline Beecham Corporation Zlúčeniny s protialergickým a protizápalovým účink
EP0634930A4 (en) * 1992-04-02 1995-02-22 Smithkline Beecham Corporation Compounds useful for treating allergic and inflammatory diseases.

Also Published As

Publication number Publication date
JP2004269546A (ja) 2004-09-30
JP4093967B2 (ja) 2008-06-04
HK1037613A1 (en) 2002-02-15
IL166184A0 (en) 2006-01-15
EP1023279A2 (en) 2000-08-02
IL150955A (en) 2006-07-05
IL131270A0 (en) 2001-01-28
IL166188A0 (en) 2006-01-15
DE69831022D1 (de) 2005-09-01
HUP0001801A3 (en) 2001-12-28
BG103651A (en) 2000-02-29
IL166186A0 (en) 2006-01-15
AR012550A1 (es) 2000-11-08
SI1524268T1 (sl) 2007-04-30
ES2280008T3 (es) 2007-09-01
IL131270A (en) 2005-05-17
NZ337084A (en) 2001-04-27
DE69813596T2 (de) 2004-02-12
PL193366B1 (pl) 2007-02-28
SI1295869T1 (sl) 2005-12-31
OA11144A (en) 2003-04-17
EA199900735A1 (ru) 2000-02-28
JP2001510482A (ja) 2001-07-31
EA001783B1 (ru) 2001-08-27
NO993863D0 (no) 1999-08-11
AU725484B2 (en) 2000-10-12
AP9901618A0 (en) 1999-09-30
PT1524268E (pt) 2007-03-30
KR100412008B1 (ko) 2003-12-24
AP1215A (en) 2003-10-14
EP1023279B1 (en) 2003-04-16
NO993863L (no) 1999-08-11
ATE300517T1 (de) 2005-08-15
DE69836928D1 (de) 2007-03-08
IL166185A0 (en) 2006-01-15
JP2004149546A (ja) 2004-05-27
WO1998034584A3 (en) 1998-11-19
BR9808637A (pt) 2000-07-04
US6337408B1 (en) 2002-01-08
CA2279951A1 (en) 1998-08-13
TW442455B (en) 2001-06-23
UY24882A1 (es) 2001-08-27
JP2004292460A (ja) 2004-10-21
DE69831022T2 (de) 2006-04-20
KR20000070927A (ko) 2000-11-25
ZA981125B (en) 1998-08-21
CN1246855A (zh) 2000-03-08
UA58533C2 (uk) 2003-08-15
MA24471A1 (fr) 1998-10-01
ES2246373T3 (es) 2006-02-16
MY118813A (en) 2005-01-31
PT1023279E (pt) 2003-08-29
EP1023279A4 (en) 2000-10-04
SK108899A3 (en) 2000-01-18
WO1998034584A2 (en) 1998-08-13
CN1854131A (zh) 2006-11-01
CY2478B1 (en) 2005-06-03
DE69813596D1 (de) 2003-05-22
DE69836928T2 (de) 2007-11-08
CO4950534A1 (es) 2000-09-01
CN1301982C (zh) 2007-02-28
DK1524268T3 (da) 2007-05-14
TR199901920T2 (xx) 1999-11-22
JP4053023B2 (ja) 2008-02-27
PL335031A1 (en) 2000-03-27
IL166187A0 (en) 2006-01-15
ID23527A (id) 2000-04-27
BG63541B1 (bg) 2002-04-30
DZ2423A1 (fr) 2003-01-04
EP1023279B8 (en) 2003-08-13
JP4053024B2 (ja) 2008-02-27
ES2196551T3 (es) 2003-12-16
JP3786971B2 (ja) 2006-06-21
HUP0001801A2 (hu) 2000-10-28
ATE237603T1 (de) 2003-05-15
AU6654498A (en) 1998-08-26
AR050308A2 (es) 2006-10-18
DK1023279T3 (da) 2003-07-21

Similar Documents

Publication Publication Date Title
ES2058396T3 (es) N-isopropilanilidas de acido heteroariloxiacetico.
AR039778A1 (es) Moduladores alostericos positivos del receptor nicotinico de la acetilcolina
DK0657428T3 (da) Fremstilling af 3,4,4-trisubstituerede-piperidinyl-N-alkylcarboxylater og mellemprodukter, der er egnede som opioidantagonister
AR000039A2 (es) Compuestos de piridinosulfonamida sustituidos, composiciones herbicidas que los contienen, metodo para preparar estos compuestos y compuestosintermediarios.
ES2032749T3 (es) Acidos oxoftalazinil-aceticos heterociclicos.
RO86698B (ro) Procedeu pentru prepararea unor (1-piperidinilalchil)-pirimidinone
DOP2002000399A (es) Nuevos derivados de acido sulfonico
ES2026669T3 (es) Procedimiento para la preparacion y el uso terapeutico de los beta-d-fenil tioxilosidos.
UY25127A1 (es) Metodo para preparar acidos 4-fenil-4-ciano-ciclohexanoicos sustituidos
PA8572001A1 (es) Derivados de isoquinolina
PT82368B (pt) Processo para a preparacao de n-{(4-piperidinil)-alquil}-oxazolaminas e n-{(4-piepridinil)-alquil}-tiazolaminas biciclicas condensadas substituidas
ES2044981T3 (es) Un proceso para la preparacion de nuevos derivados de 4(3h)-quinazolinona.
BR0209950A (pt) Composição estabilizadora finamente distribuìda para polìmeros contendo halogênio
GT199900011A (es) Nuevos derivados del acido dihidroxihexanoico
AR247380A1 (es) Procedimiento para preparar derivados de n-aminobutil n-fenil arilamidas
ATE179169T1 (de) Prostaglandinanaloge
DE60228724D1 (de) Verfahren zur herstellung von beraprost und dessen salzen
AR027559A1 (es) Metodo para la preparacion de citalopram
AR240859A2 (es) Composicion herbicida que contiene un derivado de difenil eter, dicho compuesto y procedimiento paraprepararlo
UY25524A1 (es) Método para preparar ácidos 4-fenil4-cianociclohexanoicos sustituidos
DE50309260D1 (de) Verfahren zur herstellung von bicalutamid
AR034861A1 (es) Un compuesto de indenoindolona, un procedimiento para su preparacion y una composicion farmaceutica que lo comprende
AR016522A1 (es) Produccion de compuestos de avermectina
ES2057441T3 (es) Derivados de piridina, procesos para su preparacion y composiciones farmaceuticas de los mismos.
DK1015415T3 (da) Nye stereoselektive fremgangsmåder til fremstilling af gabapentin-analoger

Legal Events

Date Code Title Description
VENC Patent expired

Effective date: 20180806