UY24882A1 - Ácidos 4-fenil-4-ciano-ciclohexanoicos sustituidos - Google Patents

Ácidos 4-fenil-4-ciano-ciclohexanoicos sustituidos

Info

Publication number
UY24882A1
UY24882A1 UY24882A UY24882A UY24882A1 UY 24882 A1 UY24882 A1 UY 24882A1 UY 24882 A UY24882 A UY 24882A UY 24882 A UY24882 A UY 24882A UY 24882 A1 UY24882 A1 UY 24882A1
Authority
UY
Uruguay
Prior art keywords
substituted
4alkyl
phenyl
nr8r10
ciano
Prior art date
Application number
UY24882A
Other languages
English (en)
Inventor
Kevin Webb
Wilford Mendelson
Li Lui
Ann Marie Diederich
Andrew Allen
Original Assignee
Smithkline Beecham Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beecham Corp filed Critical Smithkline Beecham Corp
Priority to UY25127A priority Critical patent/UY25127A1/es
Publication of UY24882A1 publication Critical patent/UY24882A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00—Ethers; Compounds having groups, groups or groups
    • C07C43/02—Ethers
    • C07C43/20—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring
    • C07C43/21—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring containing rings other than six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/48—Compounds containing oxirane rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C253/00—Preparation of carboxylic acid nitriles
    • C07C253/30—Preparation of carboxylic acid nitriles by reactions not involving the formation of cyano groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
    • C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pulmonology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Catalysts (AREA)

Abstract

Compuesto de fórmula general (II) representada en la figura 1, donde: R3 es hidrógeno, halógeno, alquilo C1-4, CH2NHC(O)C(O)-NH2, alquilo C1-4 sustituido con halo, -CH=CR8, R8, ciclopropilo sustituido opcionalmente con R8, CN, OR8, CH2OR8, NR8R10, CH2NR8R10, C(Z')H, C(O)OR8, C(O)NR8R10, Cabono enlazado por enlace triple con CRT8, donde R8 es hidrógeno o alquilo C1-4 sustituido opcionalmente con 1 a 3 átomos de fúor. X es YR2, halógeno, nitro, NH2 o formilamida, donde Y es O u S(O)m, con m de 0 a 2; X2 es O u NR8; T es CN o SO2R es alquilo o alquil-fenilo. Ejemplos no limitantes de compuestos fórmula general (II): Alcohol 3-ciclopentiloxi-4-metoxibencílico; 4-clorometil-2-ciclopentoxi-1-metoxibenceno. Estos compuestos son útiles en el tratamiento de cirto número de enfermedades que pueden ser moderadas por afectar la enzima PDE IV y sus subtipos (enfermedades como asma bronquial).
UY24882A 1997-02-12 1998-02-10 Ácidos 4-fenil-4-ciano-ciclohexanoicos sustituidos UY24882A1 (es)

Priority Applications (1)

Application Number Priority Date Filing Date Title
UY25127A UY25127A1 (es) 1997-02-12 1998-08-06 Metodo para preparar acidos 4-fenil-4-ciano-ciclohexanoicos sustituidos

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US3760897P 1997-02-12 1997-02-12

Publications (1)

Publication Number Publication Date
UY24882A1 true UY24882A1 (es) 2001-08-27

Family

ID=21895265

Family Applications (2)

Application Number Title Priority Date Filing Date
UY24882A UY24882A1 (es) 1997-02-12 1998-02-10 Ácidos 4-fenil-4-ciano-ciclohexanoicos sustituidos
UY25127A UY25127A1 (es) 1997-02-12 1998-08-06 Metodo para preparar acidos 4-fenil-4-ciano-ciclohexanoicos sustituidos

Family Applications After (1)

Application Number Title Priority Date Filing Date
UY25127A UY25127A1 (es) 1997-02-12 1998-08-06 Metodo para preparar acidos 4-fenil-4-ciano-ciclohexanoicos sustituidos

Country Status (38)

Country Link
US (1) US6337408B1 (es)
EP (1) EP1023279B8 (es)
JP (4) JP3786971B2 (es)
KR (1) KR100412008B1 (es)
CN (2) CN1854131A (es)
AP (1) AP1215A (es)
AR (2) AR012550A1 (es)
AT (2) ATE237603T1 (es)
AU (1) AU725484B2 (es)
BG (1) BG63541B1 (es)
BR (1) BR9808637A (es)
CA (1) CA2279951A1 (es)
CO (1) CO4950534A1 (es)
CY (1) CY2478B1 (es)
DE (3) DE69813596T2 (es)
DK (2) DK1023279T3 (es)
DZ (1) DZ2423A1 (es)
EA (1) EA001783B1 (es)
ES (3) ES2246373T3 (es)
HK (1) HK1037613A1 (es)
HU (1) HUP0001801A3 (es)
ID (1) ID23527A (es)
IL (7) IL131270A (es)
MA (1) MA24471A1 (es)
MY (1) MY118813A (es)
NO (1) NO993863D0 (es)
NZ (1) NZ337084A (es)
OA (1) OA11144A (es)
PL (1) PL193366B1 (es)
PT (2) PT1524268E (es)
SI (2) SI1524268T1 (es)
SK (1) SK108899A3 (es)
TR (1) TR199901920T2 (es)
TW (1) TW442455B (es)
UA (1) UA58533C2 (es)
UY (2) UY24882A1 (es)
WO (1) WO1998034584A2 (es)
ZA (1) ZA981125B (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UA67753C2 (uk) * 1997-10-10 2004-07-15 Смітклайн Бічам Корпорейшн Спосіб отримання заміщених 4-феніл-4-ціанциклогексанових кислот
US6452022B1 (en) * 1997-10-10 2002-09-17 Smithkline Beecham Corporation Method for preparing substituted 4-phenyl-4-cyanocyclohexanoic acids
ECSP003599A (es) * 1999-08-06 2002-03-25 Smithkline Beecham Corp Procedimiento para preparar acidos a traves de alfa-coroepoxi-esteres
US20040220424A1 (en) * 1999-08-06 2004-11-04 Smithkline Beecham Corporation Process for preparing acids via alpha-chloroepoxy esters
GB9920152D0 (en) * 1999-08-25 1999-10-27 Smithkline Beecham Plc Novel process
CA2402384A1 (en) 2000-03-16 2001-09-20 Inflazyme Pharmaceuticals Ltd. Benzylated pde4 inhibitors
CN102491959B (zh) * 2011-12-19 2015-03-25 江苏澄扬作物科技有限公司 一种环氧乙烷衍生物的制备方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8320943D0 (en) * 1983-08-03 1983-09-07 Lilly Industries Ltd Organic compounds
US5552438A (en) * 1992-04-02 1996-09-03 Smithkline Beecham Corporation Compounds useful for treating allergic and inflammatory diseases
MX9301903A (es) * 1992-04-02 1994-08-31 Smithkline Beecham Corp Compuestos.

Also Published As

Publication number Publication date
BG103651A (en) 2000-02-29
AP9901618A0 (en) 1999-09-30
ES2280008T3 (es) 2007-09-01
CN1246855A (zh) 2000-03-08
DE69813596T2 (de) 2004-02-12
IL150955A (en) 2006-07-05
OA11144A (en) 2003-04-17
JP4093967B2 (ja) 2008-06-04
BG63541B1 (bg) 2002-04-30
SI1295869T1 (sl) 2005-12-31
CN1301982C (zh) 2007-02-28
WO1998034584A3 (en) 1998-11-19
SK108899A3 (en) 2000-01-18
PT1023279E (pt) 2003-08-29
EP1023279A4 (en) 2000-10-04
NZ337084A (en) 2001-04-27
US6337408B1 (en) 2002-01-08
AU6654498A (en) 1998-08-26
KR20000070927A (ko) 2000-11-25
ID23527A (id) 2000-04-27
TR199901920T2 (xx) 1999-11-22
AR012550A1 (es) 2000-11-08
DE69831022T2 (de) 2006-04-20
UA58533C2 (uk) 2003-08-15
IL166186A0 (en) 2006-01-15
PL335031A1 (en) 2000-03-27
EA001783B1 (ru) 2001-08-27
HUP0001801A2 (hu) 2000-10-28
ATE237603T1 (de) 2003-05-15
DE69836928T2 (de) 2007-11-08
NO993863L (no) 1999-08-11
AU725484B2 (en) 2000-10-12
IL166184A0 (en) 2006-01-15
MA24471A1 (fr) 1998-10-01
AR050308A2 (es) 2006-10-18
DE69836928D1 (de) 2007-03-08
JP3786971B2 (ja) 2006-06-21
AP1215A (en) 2003-10-14
WO1998034584A2 (en) 1998-08-13
DE69813596D1 (de) 2003-05-22
DK1524268T3 (da) 2007-05-14
IL131270A0 (en) 2001-01-28
IL166185A0 (en) 2006-01-15
JP2004149546A (ja) 2004-05-27
TW442455B (en) 2001-06-23
CO4950534A1 (es) 2000-09-01
DE69831022D1 (de) 2005-09-01
ES2196551T3 (es) 2003-12-16
HUP0001801A3 (en) 2001-12-28
JP4053023B2 (ja) 2008-02-27
IL166187A0 (en) 2006-01-15
DK1023279T3 (da) 2003-07-21
KR100412008B1 (ko) 2003-12-24
PT1524268E (pt) 2007-03-30
EP1023279B1 (en) 2003-04-16
SI1524268T1 (sl) 2007-04-30
DZ2423A1 (fr) 2003-01-04
EP1023279B8 (en) 2003-08-13
ATE300517T1 (de) 2005-08-15
NO993863D0 (no) 1999-08-11
PL193366B1 (pl) 2007-02-28
EP1023279A2 (en) 2000-08-02
UY25127A1 (es) 1998-11-27
JP2004292460A (ja) 2004-10-21
JP2001510482A (ja) 2001-07-31
JP2004269546A (ja) 2004-09-30
MY118813A (en) 2005-01-31
CN1854131A (zh) 2006-11-01
CY2478B1 (en) 2005-06-03
IL131270A (en) 2005-05-17
BR9808637A (pt) 2000-07-04
JP4053024B2 (ja) 2008-02-27
EA199900735A1 (ru) 2000-02-28
CA2279951A1 (en) 1998-08-13
ZA981125B (en) 1998-08-21
HK1037613A1 (en) 2002-02-15
ES2246373T3 (es) 2006-02-16
IL166188A0 (en) 2006-01-15

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Legal Events

Date Code Title Description
VENC Patent expired

Effective date: 20180210