RO86698B - Procedeu pentru prepararea unor (1-piperidinilalchil)-pirimidinone - Google Patents

Procedeu pentru prepararea unor (1-piperidinilalchil)-pirimidinone

Info

Publication number
RO86698B
RO86698B RO112446A RO11244683A RO86698B RO 86698 B RO86698 B RO 86698B RO 112446 A RO112446 A RO 112446A RO 11244683 A RO11244683 A RO 11244683A RO 86698 B RO86698 B RO 86698B
Authority
RO
Romania
Prior art keywords
methyl
hydrogen
general formula
bromine
methoxy
Prior art date
Application number
RO112446A
Other languages
English (en)
Other versions
RO86698A (ro
Inventor
Ludo Edmond Josephine Kennis
Jan Vandenberk
Carolus Josephus Martens
Original Assignee
Janssen Pharmaceutica N.V.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica N.V. filed Critical Janssen Pharmaceutica N.V.
Publication of RO86698A publication Critical patent/RO86698A/ro
Publication of RO86698B publication Critical patent/RO86698B/ro

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/30—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by doubly bound oxygen or sulfur atoms or by two oxygen or sulfur atoms singly bound to the same carbon atom
    • C07D211/32—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by doubly bound oxygen or sulfur atoms or by two oxygen or sulfur atoms singly bound to the same carbon atom by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D211/70—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D211/72—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D211/74—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/44—Radicals substituted by doubly-bound oxygen, sulfur, or nitrogen atoms, or by two such atoms singly-bound to the same carbon atom
    • C07D213/46—Oxygen atoms
    • C07D213/50—Ketonic radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

Inventia se refera la un procedeu pentru prepararea unor (1-piperidinilalchil)-pirimidinone cu formula generala I: (vezi formula) în care n este 1 sau 2, R este hidrogen, hidroxi sau metoxi, R1 este hidrogen sau metil, X este -S-, -CH2- sau -(R2)=C(R3) în care R2 si R3 sunt în mod independent alesi dintre hidrogen si metil, A este un radical bivalent cu formula -CH2-CH2-, CH2-CH2-CH2- sau (vezi formula) sunt independent alesi dintre hidrogen, clor, brom, metil si amino, grupele Ar1 si Ar2 sunt în mod independent alese dintre piridinil, tienil si fenil eventual substituit cu fluor, clor, brom, metil, trifluormetil, hidroxil si metoxi, constînd din aceea ca o pirimidin-5-ona cu formula generala II: (vezi formula) în care R1, A, X si n au semnificatiile de mai sus si W reprezinta clor sau brom, se trateaza cu o piperidina cu formila generala III: (vezi formula) în care R, Ar1 si Ar2 au semnificatiile de mai sus, la temperatura de reflux, în prezenta unui alcanol inferior sau cetone ca solvent, al unui carbonat sau bicarbonat de metal alcalin sau alcalino-teros ca acceptor de acid si eventual a unei iodusri de metal alcalin ca promotor al reactiei, dupa care compusul cu formula I obtinut poate fi transformat, daca se doreste, în saruri de aditie acida terapeutic utile sau în forme stereochimic izomere, prin procedee în sine cunoscute.
RO112446A 1982-11-01 1983-10-31 Procedeu pentru prepararea unor (1-piperidinilalchil)-pirimidinone RO86698B (ro)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US43807982A 1982-11-01 1982-11-01
US06/517,612 US4485107A (en) 1982-11-01 1983-07-27 [[Bis(aryl)methylene]-1-piperidinyl]alkyl-pyrimidinones

Publications (2)

Publication Number Publication Date
RO86698A RO86698A (ro) 1985-04-17
RO86698B true RO86698B (ro) 1985-05-02

Family

ID=27031541

Family Applications (1)

Application Number Title Priority Date Filing Date
RO112446A RO86698B (ro) 1982-11-01 1983-10-31 Procedeu pentru prepararea unor (1-piperidinilalchil)-pirimidinone

Country Status (26)

Country Link
US (1) US4485107A (ro)
EP (1) EP0110435B1 (ro)
KR (1) KR870000825B1 (ro)
AU (1) AU559176B2 (ro)
BG (2) BG51158A3 (ro)
CA (1) CA1211438A (ro)
CS (1) CS238396B2 (ro)
CY (1) CY1607A (ro)
DE (1) DE3378825D1 (ro)
DK (1) DK168919B1 (ro)
ES (1) ES8601965A1 (ro)
FI (1) FI77868C (ro)
GR (1) GR81277B (ro)
HK (1) HK52691A (ro)
IE (1) IE56180B1 (ro)
IL (1) IL70094A0 (ro)
IN (1) IN159576B (ro)
MA (1) MA19941A1 (ro)
NO (1) NO166133C (ro)
NZ (1) NZ205993A (ro)
PH (1) PH20483A (ro)
PT (1) PT77493B (ro)
RO (1) RO86698B (ro)
SG (1) SG46791G (ro)
SU (1) SU1313349A3 (ro)
ZW (1) ZW23283A1 (ro)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4529727A (en) * 1982-04-21 1985-07-16 Janssen Pharmaceutical, N.V. Pyrimido[2,1-b][1,3]-thiazines
US4581171A (en) * 1983-07-27 1986-04-08 Janssen Pharmaceutica, N.V. [[Bis(aryl)methylene]-1-piperidinyl]alkyl-pyrimidinones useful for treating psychotropic disorders
US4533665A (en) * 1983-07-27 1985-08-06 Janssen Pharmaceutica [[Bis(aryl)methylene]-1-piperidinyl]alkyl-pyrimidinones
US4888426A (en) * 1983-11-30 1989-12-19 Janssen Pharmaceutica N.V. 1-(5-methyl-furan-2-ylmethyl)-N-(4-piperidinyl)imidazo [4,5-6]pyridine-2-amine
US4695569A (en) * 1983-11-30 1987-09-22 Janssen Pharmaceutica N.V. Bicyclic heterocyclyl containing N-(bicyclic heterocyclyl)-4-piperidinamines
US4804663A (en) * 1985-03-27 1989-02-14 Janssen Pharmaceutica N.V. 3-piperidinyl-substituted 1,2-benzisoxazoles and 1,2-benzisothiazoles
US4874766A (en) * 1986-09-22 1989-10-17 Janssen Pharmaceutica N.V. Method of promoting wound-healing
US4921854A (en) * 1986-12-30 1990-05-01 Egis Gyogyszergyar Condensed thiazolopyrimidine, pyrimido-thiazine or thiazepine pyrimidine compounds
DE3738844A1 (de) * 1987-11-16 1989-05-24 Merck Patent Gmbh Analgetikum
IL90858A (en) * 1988-07-07 1994-08-26 Rhone Poulenc Sante History (Aza) Naftalensultam, their preparation and preparations containing them
IL90879A0 (en) * 1988-09-02 1990-02-09 Janssen Pharmaceutica Nv 3-piperidinyl-indazole derivatives,their preparation and antihypertensive compositions containing them
US5158952A (en) * 1988-11-07 1992-10-27 Janssen Pharmaceutica N.V. 3-[2-[4-(6-fluoro-1,2-benzisoxozol-3-yl)-1-piperidinyl]ethyl]-6,7,8,9 tetrahydro-9-hydroxy-2-methyl-4H-pyrido [1,2-a]pyrimidin-4-one, compositions and method of use
US5140029A (en) * 1989-01-09 1992-08-18 Janssen Pharmaceutica N.V. 2-aminopyrimidinone derivatives
GB8900382D0 (en) * 1989-01-09 1989-03-08 Janssen Pharmaceutica Nv 2-aminopyrimidinone derivatives
US5256659A (en) * 1989-01-09 1993-10-26 Janssen Pharmaceutica N.V. 2-aminopyrimidinone derivatives
FR2643373B1 (fr) * 1989-01-10 1993-12-31 Adir Cie Nouveaux derives des bisarylalcenes, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent
GB9008850D0 (en) * 1990-04-19 1990-06-13 Janssen Pharmaceutica Nv Novel 2,9-disubstituted-4h-pyridol(1,2-a)pyrimidin-4-ones
ES2050069B1 (es) * 1992-07-10 1994-12-16 Vita Invest Sa Procedimiento para la obtencion de 3-(2-(4-(6-fluoro-1,2-benzisoxazol-3-il)piperidino)etil)-2-metil-6,7,8,9-tetrahidro-4h-pirido(1,2-a) pirimidin-4-ona.
DK0729357T3 (da) 1993-11-19 2005-06-06 Janssen Pharmaceutica Nv Mikroindkapslede 1,2-benzazoler
IL122072A (en) * 1996-11-14 2001-03-19 Akzo Nobel Nv Piperidine derivatives their preparation and pharmaceutical compositions containing them
UA72189C2 (uk) 1997-11-17 2005-02-15 Янссен Фармацевтика Н.В. Фармацевтична композиція, що містить водну суспензію субмікронних ефірів 9-гідроксирисперидон жирних кислот
UA75051C2 (en) 1999-09-03 2006-03-15 Syngenta Participations Ag Tetrahydropiridines as pesticides, a composition, a method for the preparation thereof and a method of controlling pests
TW200400005A (en) * 2002-02-11 2004-01-01 Syngenta Participations Ag Derivatives of (1-benzyl-piperidine-4-yl)-diphenyl-methanol
KR20040034996A (ko) * 2002-10-18 2004-04-29 한미약품 주식회사 리스페리돈의 개선된 제조방법
AU2003296373A1 (en) * 2002-12-18 2004-07-29 Bayer Cropscience Ag N-(substituted arylmethyl)-4-(disubstituted methyl)piperidines and piperazines
EP1615924A1 (en) * 2003-04-22 2006-01-18 Synthon B.V. Water soluble salts of risperidone
CA2681267C (en) 2007-04-13 2013-11-19 Southern Research Institute Anti-angiogenic agents and methods of use
SI3231793T1 (sl) * 2014-12-12 2020-07-31 Japan Tobacco Inc. Spojine dihidropirimidin-2-ona in njihove medicinske uporabe
CN111741947B (zh) 2018-02-28 2024-06-11 日本烟草产业株式会社 4-甲基二氢嘧啶酮化合物及其药物用途
CN112724070B (zh) * 2021-01-08 2022-11-25 南京方生和医药科技有限公司 一种α，α-二苯基-4-哌啶甲醇的制备方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1252315A (ro) * 1969-06-05 1971-11-03
US3960863A (en) * 1974-06-25 1976-06-01 Sankyo Company Limited Pyrido[1,2-a]pyrimidinone derivatives
DE3000923A1 (de) * 1979-01-17 1980-07-31 Degussa Neue n-alkoxy-dithienylpiperidine
US4342870A (en) * 1980-03-28 1982-08-03 Janssen Pharmaceutica N.V. Novel 3-(1-piperidinylalkyl)-4H-pyrido[1,2-a]pyrimidin-4-one derivatives
US4443451A (en) * 1981-07-15 1984-04-17 Janssen Pharmaceutica N.V. Bicyclic pyrimidin-5-one derivatives

Also Published As

Publication number Publication date
CS238396B2 (en) 1985-11-13
BG60538B2 (bg) 1995-07-28
CA1211438A (en) 1986-09-16
ES526868A0 (es) 1985-11-01
AU2083483A (en) 1984-05-10
FI833995A (fi) 1984-05-02
BG51158A3 (en) 1993-02-15
NO166133B (no) 1991-02-25
MA19941A1 (fr) 1984-07-01
PH20483A (en) 1987-01-16
CS766383A2 (en) 1984-12-14
US4485107A (en) 1984-11-27
DK498483D0 (da) 1983-10-31
AU559176B2 (en) 1987-02-26
IE56180B1 (en) 1991-05-08
GR81277B (ro) 1984-12-11
IE832540L (en) 1984-05-01
SU1313349A3 (ru) 1987-05-23
DK168919B1 (da) 1994-07-11
FI77868C (fi) 1989-05-10
IL70094A0 (en) 1984-01-31
PT77493B (en) 1986-05-28
NO833956L (no) 1984-05-02
CY1607A (en) 1992-04-03
PT77493A (en) 1983-11-01
KR850000462A (ko) 1985-02-27
NO166133C (no) 1991-06-05
FI833995A0 (fi) 1983-10-31
DK498483A (da) 1984-05-02
DE3378825D1 (de) 1989-02-09
SG46791G (en) 1991-07-26
HK52691A (en) 1991-07-19
FI77868B (fi) 1989-01-31
IN159576B (ro) 1987-05-30
EP0110435A1 (en) 1984-06-13
NZ205993A (en) 1986-06-11
KR870000825B1 (ko) 1987-04-23
ES8601965A1 (es) 1985-11-01
ZW23283A1 (en) 1985-05-22
RO86698A (ro) 1985-04-17
EP0110435B1 (en) 1989-01-04

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