DE3786961D1 - Alpha-1-antitrypsin-varianten, besonders verwendbar als kallikrein-inhibitoren. - Google Patents

Alpha-1-antitrypsin-varianten, besonders verwendbar als kallikrein-inhibitoren.

Info

Publication number
DE3786961D1
DE3786961D1 DE8787401301T DE3786961T DE3786961D1 DE 3786961 D1 DE3786961 D1 DE 3786961D1 DE 8787401301 T DE8787401301 T DE 8787401301T DE 3786961 T DE3786961 T DE 3786961T DE 3786961 D1 DE3786961 D1 DE 3786961D1
Authority
DE
Germany
Prior art keywords
antitrypsin
callicine
versions
inhibitors
alpha
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE8787401301T
Other languages
English (en)
Other versions
DE3786961T2 (de
Inventor
Sophie Jallat
Michael Courtney
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Transgene SA
Original Assignee
Transgene SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Transgene SA filed Critical Transgene SA
Publication of DE3786961D1 publication Critical patent/DE3786961D1/de
Application granted granted Critical
Publication of DE3786961T2 publication Critical patent/DE3786961T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
    • C07K14/8121—Serpins
    • C07K14/8125—Alpha-1-antitrypsin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biotechnology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biophysics (AREA)
  • Cardiology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Virology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Plural Heterocyclic Compounds (AREA)
DE87401301T 1986-06-10 1987-06-10 Alpha-1-antitrypsin-Varianten, besonders verwendbar als Kallikrein-Inhibitoren. Expired - Fee Related DE3786961T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8608386A FR2599752B1 (fr) 1986-06-10 1986-06-10 Variants de l'alpha1- antitrypsine utiles notamment comme inhibiteurs de la kallikreine

Publications (2)

Publication Number Publication Date
DE3786961D1 true DE3786961D1 (de) 1993-09-16
DE3786961T2 DE3786961T2 (de) 1994-01-20

Family

ID=9336200

Family Applications (1)

Application Number Title Priority Date Filing Date
DE87401301T Expired - Fee Related DE3786961T2 (de) 1986-06-10 1987-06-10 Alpha-1-antitrypsin-Varianten, besonders verwendbar als Kallikrein-Inhibitoren.

Country Status (13)

Country Link
US (1) US4973668A (de)
EP (1) EP0253690B1 (de)
JP (1) JP2649804B2 (de)
KR (1) KR880000575A (de)
AT (1) ATE92960T1 (de)
AU (1) AU610500B2 (de)
CA (1) CA1328706C (de)
DE (1) DE3786961T2 (de)
DK (1) DK173131B1 (de)
FR (1) FR2599752B1 (de)
IE (1) IE61060B1 (de)
PT (1) PT85047B (de)
ZA (1) ZA874123B (de)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0401508B1 (de) * 1989-05-13 1994-11-23 Bayer Ag Proteinaseninhibitoren, Verfahren zu ihrer Herstellung sowie diese enthaltende Arzneimittel
WO1993018159A2 (en) 1992-03-09 1993-09-16 Chiron Corporation Compositions and methods for pace 4 and 4.1 gene and polypeptides in cells
WO1995002055A1 (en) * 1993-07-09 1995-01-19 Michael Laskowski Novel protein inhibitors of serine proteinases (e.g. furin) derived from turkey ovomucoid third domain
AU3479495A (en) * 1994-09-30 1996-04-26 Ppl Therapeutics (Scotland) Ltd Alpha-1-antitrypsin and antithrombine-iii variants
GB2318732A (en) 1996-11-01 1998-05-06 Johnson & Johnson Medical Wound healing compositions containing alpha-1-antitrypsin
EP2369930A4 (de) * 2008-12-02 2012-10-03 Joslin Diabetes Ct Verfahren zur senkung des blutdrucks anhand von plasma-kallikrein-hemmern
CA2838984A1 (en) 2011-06-10 2012-12-13 Isis Pharmaceuticals, Inc. Methods for modulating kallikrein (klkb1) expression
EP2726153B1 (de) 2011-06-29 2018-03-28 Ionis Pharmaceuticals, Inc. Verfahren zur modulierung der kallikrein (klkb1)-expression
EP3715457A3 (de) 2013-08-28 2020-12-16 Ionis Pharmaceuticals, Inc. Modulation der prekallikrein (pkk)-expression
GB201322091D0 (en) 2013-12-13 2014-01-29 Cambridge Entpr Ltd Modified serpins for the treatment of bleeding disorders
US10294477B2 (en) 2014-05-01 2019-05-21 Ionis Pharmaceuticals, Inc. Compositions and methods for modulating PKK expression
US11851474B2 (en) 2017-02-23 2023-12-26 Preclinics Gesellschaft Für Präklinische Forschung Mbh Modified serpins for the treatment of bradykinin-mediated disease
WO2018183705A1 (en) * 2017-03-29 2018-10-04 Cornell University Oxidation-resistant aat gene therapy

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3380848D1 (en) * 1982-08-04 1989-12-21 Nat Res Dev Molecular cloning of the gene for human anti-haemophilic factor ix
US4711848A (en) * 1984-03-14 1987-12-08 Zymogenetics, Inc. Site specific mutagenesis in alpha-1-antitrypsin
DE3585969D1 (de) * 1984-06-14 1992-06-11 Chiron Corp Protease-inhibitoren des alpha-1-antitrypsin typs mit modifizierter aktiever stelle und deren herstellung.
JP2599585B2 (ja) * 1984-06-19 1997-04-09 トランスジ−ン ソシエテ アノニム ヒトα▲下１▼−アンチトリプシン誘導体及びその製造法
CA1299120C (en) * 1984-10-22 1992-04-21 Glenn Kawasaki Stable dna constructs for expression of alpha-1-antitrypsin
DE3684947D1 (de) * 1985-03-15 1992-05-27 Nat Res Dev Faktor-ix-protein.
GR860984B (en) * 1985-04-17 1986-08-18 Zymogenetics Inc Expression of factor vii and ix activities in mammalian cells
ATE74164T1 (de) * 1985-04-22 1992-04-15 Genetics Inst Herstellung mit hoher leistung des aktivfaktors ix.
FR2601033B1 (fr) * 1986-07-02 1990-01-19 Transgene Sa Variants de l'alpha-antitryspine humaine glycosylee et procede pour la preparation

Also Published As

Publication number Publication date
CA1328706C (fr) 1994-04-19
FR2599752B1 (fr) 1989-11-03
US4973668A (en) 1990-11-27
EP0253690B1 (de) 1993-08-11
AU7362587A (en) 1987-12-17
PT85047A (fr) 1987-07-01
JPS6379899A (ja) 1988-04-09
DK173131B1 (da) 2000-01-31
ZA874123B (en) 1987-12-09
ATE92960T1 (de) 1993-08-15
KR880000575A (ko) 1988-03-26
DK285087D0 (da) 1987-06-03
DE3786961T2 (de) 1994-01-20
JP2649804B2 (ja) 1997-09-03
AU610500B2 (en) 1991-05-23
FR2599752A1 (fr) 1987-12-11
EP0253690A1 (de) 1988-01-20
IE871374L (en) 1987-12-10
PT85047B (pt) 1990-03-08
DK285087A (da) 1987-12-11
IE61060B1 (en) 1994-09-21

Similar Documents

Publication Publication Date Title
ES2148140T3 (es) Inhibidores de la biosintesis del oxido nitrico.
DK0810209T3 (da) Alpha - and beta-aminosyre-hydroxyethylaminosulfonamider til anvendelse som inhibitorer af retrovirale proteaser
ES2088839T3 (es) Compuestos que inhiben las proteasas retrovirales.
ATE165817T1 (de) Metalloproteinaseinhibitoren
AP9200410A0 (en) Retroviral protease inhibitors.
DE3786961D1 (de) Alpha-1-antitrypsin-varianten, besonders verwendbar als kallikrein-inhibitoren.
DK0607334T3 (da) Cycliske urinstoffer og analoger anvendelige som retrovirale proteasehæmmere
ES2036562T3 (es) Un procedimiento para produccion de un derivado de pirrolidinamida.
BR9810163B1 (pt) compostos liberadores de àxido nÍtricos.
ATE179169T1 (de) Prostaglandinanaloge
EA199800200A1 (ru) Ингибиторы пролилэндопептидазы
DE69728164D1 (de) Peptidomimetische inhibitoren von der protease des menschlichen cytomegalovirus
ES2051954T3 (es) 2-aminotiazoles substituidos.
DK0545582T3 (da) Forbedret fiskeproduktion
DK377687A (da) Triazol-fungicidpraeparater
FI930092A0 (fi) Indanopyrrolidinkarbamater
DE3677465D1 (de) N-glykolylneuraminsaeurederivat.
ES2060711T3 (es) 2-aminotiazoles substituidos.
PT878195E (pt) Utilizacao de um composto 2-aroil-3-arilbenzo(b)tiofeno para a reducao de fibrinogenio
SU1690242A1 (ru) Антифидант

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee