ZA874123B - Variants of alpha1-antitrypsin which are useful,in particular,as kallikrein inhibitors - Google Patents

Variants of alpha1-antitrypsin which are useful,in particular,as kallikrein inhibitors

Info

Publication number
ZA874123B
ZA874123B ZA874123A ZA874123A ZA874123B ZA 874123 B ZA874123 B ZA 874123B ZA 874123 A ZA874123 A ZA 874123A ZA 874123 A ZA874123 A ZA 874123A ZA 874123 B ZA874123 B ZA 874123B
Authority
ZA
South Africa
Prior art keywords
alpha1
antitrypsin
useful
variants
kallikrein inhibitors
Prior art date
Application number
ZA874123A
Other languages
English (en)
Inventor
Jallat Sophie
Courtney Michael
Original Assignee
Transgene S.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Transgene S.A. filed Critical Transgene S.A.
Publication of ZA874123B publication Critical patent/ZA874123B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
    • C07K14/8121—Serpins
    • C07K14/8125—Alpha-1-antitrypsin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biotechnology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biophysics (AREA)
  • Cardiology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Virology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Plural Heterocyclic Compounds (AREA)
ZA874123A 1986-06-10 1987-06-09 Variants of alpha1-antitrypsin which are useful,in particular,as kallikrein inhibitors ZA874123B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8608386A FR2599752B1 (fr) 1986-06-10 1986-06-10 Variants de l'alpha1- antitrypsine utiles notamment comme inhibiteurs de la kallikreine

Publications (1)

Publication Number Publication Date
ZA874123B true ZA874123B (en) 1987-12-09

Family

ID=9336200

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA874123A ZA874123B (en) 1986-06-10 1987-06-09 Variants of alpha1-antitrypsin which are useful,in particular,as kallikrein inhibitors

Country Status (13)

Country Link
US (1) US4973668A (de)
EP (1) EP0253690B1 (de)
JP (1) JP2649804B2 (de)
KR (1) KR880000575A (de)
AT (1) ATE92960T1 (de)
AU (1) AU610500B2 (de)
CA (1) CA1328706C (de)
DE (1) DE3786961T2 (de)
DK (1) DK173131B1 (de)
FR (1) FR2599752B1 (de)
IE (1) IE61060B1 (de)
PT (1) PT85047B (de)
ZA (1) ZA874123B (de)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK0401508T3 (da) * 1989-05-13 1995-05-15 Bayer Ag Proteaseinhibitorer, fremgangsmåde til deres fremstilling samt lægemidler med indhold deraf
WO1993018159A2 (en) 1992-03-09 1993-09-16 Chiron Corporation Compositions and methods for pace 4 and 4.1 gene and polypeptides in cells
WO1995002055A1 (en) * 1993-07-09 1995-01-19 Michael Laskowski Novel protein inhibitors of serine proteinases (e.g. furin) derived from turkey ovomucoid third domain
WO1996010638A1 (en) * 1994-09-30 1996-04-11 Ppl Therapeutics (Scotland) Ltd. Alpha-1-antitrypsin and antithrombine-iii variants
GB2318732A (en) 1996-11-01 1998-05-06 Johnson & Johnson Medical Wound healing compositions containing alpha-1-antitrypsin
US20110318359A1 (en) * 2008-12-02 2011-12-29 Feener Edward P Method for reducing blood pressure using inhibitors of plasma kallikrein
US9315811B2 (en) 2011-06-10 2016-04-19 Ionis Pharmaceuticals, Inc. Methods for modulating kallikrein (KLKB1) expression
US9322021B2 (en) 2011-06-29 2016-04-26 Ionis Pharmaceuticals, Inc. Methods for modulating kallikrein (KLKB1) expression
US9670492B2 (en) 2013-08-28 2017-06-06 Ionis Pharmaceuticals, Inc. Modulation of prekallikrein (PKK) expression
GB201322091D0 (en) 2013-12-13 2014-01-29 Cambridge Entpr Ltd Modified serpins for the treatment of bleeding disorders
EP3137091B1 (de) 2014-05-01 2020-12-02 Ionis Pharmaceuticals, Inc. Konjugate von antisens-oligonukleotiden und deren verwendung zur modulation der pkk-expression
EP3585808B1 (de) 2017-02-23 2021-11-10 Preclinics Gesellschaft für präklinische Forschung mbH Modifizierte serpin zur behandlung von bradykininvermittelten erkrankungen
WO2018183705A1 (en) * 2017-03-29 2018-10-04 Cornell University Oxidation-resistant aat gene therapy

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2625412B2 (ja) * 1982-08-04 1997-07-02 ブリティッシュ・テクノロジー・グループ・リミテッド ヒト第９因子ポリペプチドをコードするｃｄｎａ
US4711848A (en) * 1984-03-14 1987-12-08 Zymogenetics, Inc. Site specific mutagenesis in alpha-1-antitrypsin
EP0164719B1 (de) * 1984-06-14 1992-05-06 Chiron Corporation Protease-Inhibitoren des Alpha-1-Antitrypsin Typs mit modifizierter aktiever Stelle und deren Herstellung
WO1986000337A1 (fr) * 1984-06-19 1986-01-16 Transgene S.A. DERIVES DE L'alpha1-ANTITRYPSINE HUMAINE ET PROCEDE POUR LEUR PREPARATION
CA1299120C (en) * 1984-10-22 1992-04-21 Glenn Kawasaki Stable dna constructs for expression of alpha-1-antitrypsin
EP0430930B1 (de) * 1985-03-15 1993-09-01 Btg International Limited Faktor IX-Protein
GR860984B (en) * 1985-04-17 1986-08-18 Zymogenetics Inc Expression of factor vii and ix activities in mammalian cells
ATE74164T1 (de) * 1985-04-22 1992-04-15 Genetics Inst Herstellung mit hoher leistung des aktivfaktors ix.
FR2601033B1 (fr) * 1986-07-02 1990-01-19 Transgene Sa Variants de l'alpha-antitryspine humaine glycosylee et procede pour la preparation

Also Published As

Publication number Publication date
EP0253690A1 (de) 1988-01-20
FR2599752A1 (fr) 1987-12-11
JP2649804B2 (ja) 1997-09-03
CA1328706C (fr) 1994-04-19
AU610500B2 (en) 1991-05-23
DK285087A (da) 1987-12-11
EP0253690B1 (de) 1993-08-11
PT85047B (pt) 1990-03-08
IE61060B1 (en) 1994-09-21
DE3786961T2 (de) 1994-01-20
DE3786961D1 (de) 1993-09-16
KR880000575A (ko) 1988-03-26
AU7362587A (en) 1987-12-17
ATE92960T1 (de) 1993-08-15
PT85047A (fr) 1987-07-01
JPS6379899A (ja) 1988-04-09
DK285087D0 (da) 1987-06-03
IE871374L (en) 1987-12-10
US4973668A (en) 1990-11-27
DK173131B1 (da) 2000-01-31
FR2599752B1 (fr) 1989-11-03

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