ATE74164T1 - Herstellung mit hoher leistung des aktivfaktors ix. - Google Patents

Herstellung mit hoher leistung des aktivfaktors ix.

Info

Publication number
ATE74164T1
ATE74164T1 AT86902988T AT86902988T ATE74164T1 AT E74164 T1 ATE74164 T1 AT E74164T1 AT 86902988 T AT86902988 T AT 86902988T AT 86902988 T AT86902988 T AT 86902988T AT E74164 T1 ATE74164 T1 AT E74164T1
Authority
AT
Austria
Prior art keywords
pct
manufacturing
active factor
high performance
date
Prior art date
Application number
AT86902988T
Other languages
English (en)
Inventor
Randal J Kaufman
Charles B Shoemaker
Louise C Wasley
Original Assignee
Genetics Inst
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=24914546&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE74164(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Genetics Inst filed Critical Genetics Inst
Application granted granted Critical
Publication of ATE74164T1 publication Critical patent/ATE74164T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/644—Coagulation factor IXa (3.4.21.22)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21022—Coagulation factor IXa (3.4.21.22)

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
AT86902988T 1985-04-22 1986-04-17 Herstellung mit hoher leistung des aktivfaktors ix. ATE74164T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US72543685A 1985-04-22 1985-04-22
PCT/US1986/000817 WO1986006408A1 (en) 1985-04-22 1986-04-17 HIGH YIElD PRODUCTION OF ACTIVE FACTOR IX
EP86902988A EP0218713B1 (de) 1985-04-22 1986-04-17 Herstellung mit hoher leistung des aktivfaktors ix

Publications (1)

Publication Number Publication Date
ATE74164T1 true ATE74164T1 (de) 1992-04-15

Family

ID=24914546

Family Applications (1)

Application Number Title Priority Date Filing Date
AT86902988T ATE74164T1 (de) 1985-04-22 1986-04-17 Herstellung mit hoher leistung des aktivfaktors ix.

Country Status (8)

Country Link
US (1) US4770999A (de)
EP (1) EP0218713B1 (de)
JP (1) JP2584443B2 (de)
KR (1) KR880700060A (de)
AT (1) ATE74164T1 (de)
AU (1) AU5864086A (de)
DE (1) DE3684546D1 (de)
WO (1) WO1986006408A1 (de)

Families Citing this family (56)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4775624A (en) * 1985-02-08 1988-10-04 Eli Lilly And Company Vectors and compounds for expression of human protein C
US5171569A (en) * 1985-03-15 1992-12-15 National Research Development Corporation Factor IX preparations uncontaminated by plasma components or pox virus
US4959318A (en) * 1985-06-27 1990-09-25 Zymogenetics, Inc. Expression of protein C
US5516650A (en) * 1985-06-27 1996-05-14 Zymogenetics, Inc. Production of activated protein C
EP0245949B1 (de) * 1986-04-09 1997-10-29 Eli Lilly And Company Verfahren zur Anwendung von den BK-Virus-Verstärker enthaltenden eukaryotischen Expressionsvektoren
FR2599752B1 (fr) * 1986-06-10 1989-11-03 Transgene Sa Variants de l'alpha1- antitrypsine utiles notamment comme inhibiteurs de la kallikreine
FR2600334B1 (fr) * 1986-06-23 1989-05-12 Transgene Sa Vecteurs d'integration dans les cellules eucaryotes assurant l'expression du facteur ix, lignees celullaires obtenues et procede pour leur preparation
US5082774A (en) * 1988-08-30 1992-01-21 The General Hospital Corporation Recombinant human nerve growth factor
FR2638643B1 (fr) * 1988-11-09 1991-04-12 Transgene Sa Sequence d'adn codant pour le facteur ix humain ou une proteine analogue, vecteur d'expression, cellules transformees, procede de preparation du facteur ix et produits obtenus correspondants
US5047335A (en) * 1988-12-21 1991-09-10 The Regents Of The University Of Calif. Process for controlling intracellular glycosylation of proteins
US5225537A (en) * 1989-12-29 1993-07-06 Zymogenetics, Inc. Methods for producing hybrid phospholipid-binding proteins
JP3330932B2 (ja) * 1990-01-29 2002-10-07 ノボ ノルディスク ヘルス ケア アクチェンゲゼルシャフト 抗凝固剤タンパク質
JP4236698B2 (ja) * 1990-11-26 2009-03-11 ジェネティックス インスティチュート，リミテッド ライアビリティ カンパニー 宿主細胞でのｐａｃｅの発現およびその使用法
US5817788A (en) * 1991-02-28 1998-10-06 Zymogenetics, Inc. Modified factor VII
US5861374A (en) * 1991-02-28 1999-01-19 Novo Nordisk A/S Modified Factor VII
US5788965A (en) * 1991-02-28 1998-08-04 Novo Nordisk A/S Modified factor VII
US5833982A (en) 1991-02-28 1998-11-10 Zymogenetics, Inc. Modified factor VII
US5997864A (en) 1995-06-07 1999-12-07 Novo Nordisk A/S Modified factor VII
WO1992015324A1 (en) * 1991-03-01 1992-09-17 Rhone-Poulenc Rorer International (Holdings) Inc. Preparation of factor ix
US6039944A (en) * 1992-02-28 2000-03-21 Zymogenetics, Inc. Modified Factor VII
US6372716B1 (en) 1994-04-26 2002-04-16 Genetics Institute, Inc. Formulations for factor IX
AT403167B (de) * 1994-11-14 1997-11-25 Immuno Ag Selektion und expression von fremdproteinen mittels eines selektions-amplifikations-systems
US5770700A (en) * 1996-01-25 1998-06-23 Genetics Institute, Inc. Liquid factor IX formulations
US6475725B1 (en) * 1997-06-20 2002-11-05 Baxter Aktiengesellschaft Recombinant cell clones having increased stability and methods of making and using the same
BRPI0109494B8 (pt) * 2000-03-22 2021-05-25 Octagene Gmbh muteína de fator viii, sequência de dna, vetor, processo para produção da muteína de fator viii, composição farmacêutica e uso da muteína do fator viii
US7083787B2 (en) * 2000-11-15 2006-08-01 Globeimmune, Inc. Yeast-dendritic cell vaccines and uses thereof
US7220718B2 (en) 2001-08-03 2007-05-22 United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Oral treatment of hemophilia
ES2411007T3 (es) 2001-10-10 2013-07-04 Novo Nordisk A/S Remodelación y glicoconjugación de péptidos
CA2522345A1 (en) 2003-04-09 2004-11-18 Neose Technologies, Inc. Glycopegylation methods and proteins/peptides produced by the methods
WO2006127896A2 (en) 2005-05-25 2006-11-30 Neose Technologies, Inc. Glycopegylated factor ix
DK1842920T4 (da) 2003-09-23 2017-08-21 Univ North Carolina Chapel Hill Celler der co-udtrykker K-vitaminreduktase og K-vitaminafhængigt protein, samt anvendelse deraf til at forbedre produktiviteten af det K-vitaminafhængige protein
ATE489105T1 (de) 2004-03-19 2010-12-15 Baxter Int Faktor ixa zur behandlung von blutungsstörungen
KR101100059B1 (ko) * 2004-06-30 2011-12-29 넥타르 테라퓨틱스 중합체­인자 ｉｘ 부분의 접합체
CA2601574C (en) 2005-03-15 2014-12-02 University Of North Carolina At Chapel Hill Methods and compositions for producing active vitamin k-dependent proteins
EP1707634A1 (de) 2005-03-29 2006-10-04 Octapharma AG Verfahren zur Isolierung von rekombinant hergestellten Proteinen
DK1969127T4 (en) * 2005-12-21 2017-10-16 Cnj Holdings Inc Process for the preparation of biologically active vitamin K-dependent proteins by recombinant methods
US8383388B2 (en) 2006-06-19 2013-02-26 Catalyst Biosciences, Inc. Modified coagulation factor IX polypeptides and use thereof for treatment
US20110046060A1 (en) 2009-08-24 2011-02-24 Amunix Operating, Inc., Coagulation factor IX compositions and methods of making and using same
WO2011003153A1 (en) * 2009-07-10 2011-01-13 Csl Limited Method of increasing the expression yield of vitamin k-dependent proteins
WO2011095604A1 (en) 2010-02-04 2011-08-11 Octapharma Biopharmaceuticals Gmbh Half-life prolongation of proteins
TWI621625B (zh) 2010-09-17 2018-04-21 巴克斯歐塔公司 在弱酸性至中性ｐｈ中經由具有組胺酸的水性調配物穩定免疫球蛋白
EP2625262B1 (de) 2010-10-05 2015-09-23 Novo Nordisk Health Care AG Verfahren zur proteinherstellung
WO2012088222A2 (en) 2010-12-21 2012-06-28 The University Of North Carolina At Chapel Hill Methods and compositions for producing active vitamin k-dependent proteins
CN119192402A (zh) 2012-02-15 2024-12-27 比奥贝拉蒂治疗公司 因子viii组合物及其制备和使用方法
WO2013123457A1 (en) 2012-02-15 2013-08-22 Biogen Idec Ma Inc. Recombinant factor viii proteins
WO2015023891A2 (en) 2013-08-14 2015-02-19 Biogen Idec Ma Inc. Factor viii-xten fusions and uses thereof
CA2994547A1 (en) 2015-08-03 2017-02-09 Bioverativ Therapeutics Inc. Factor ix fusion proteins and methods of making and using same
CN110662770A (zh) 2016-11-23 2020-01-07 比奥维拉迪维治疗股份有限公司 结合凝血因子ix和凝血因子x的双特异性抗体
US12161696B2 (en) 2016-12-02 2024-12-10 Bioverativ Therapeutics Inc. Methods of treating hemophilic arthropathy using chimeric clotting factors
CR20190389A (es) 2017-01-31 2019-11-26 Bioverativ Therapeutics Inc Proteínas de fusión del factor ix y procedimientos de preparación y utilización de las mismas
US20210107994A1 (en) 2017-03-31 2021-04-15 Public University Corporation Nara Medical University Medicinal composition usable for preventing and/or treating blood coagulation factor ix abnormality, comprising multispecific antigen binding molecule replacing function of blood coagulation factor viii
JP7261739B2 (ja) 2017-04-27 2023-04-20 中外製薬株式会社 薬物動態が改善された血液凝固第ｉｘ因子
WO2019032898A1 (en) 2017-08-09 2019-02-14 Bioverativ Therapeutics Inc. NUCLEIC ACID MOLECULES AND USES THEREOF
TW202015723A (zh) 2018-05-18 2020-05-01 美商百歐維拉提夫治療公司 治療ａ型血友病的方法
SG11202101157VA (en) 2018-08-09 2021-03-30 Bioverativ Therapeutics Inc Nucleic acid molecules and uses thereof for non-viral gene therapy
EP3867380A2 (de) 2018-10-18 2021-08-25 Intellia Therapeutics, Inc. Zusammensetzungen und verfahren zur expression von faktor ix

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0107278B1 (de) * 1982-08-04 1989-11-15 National Research Development Corporation Molekulare Klonierung des Gens für menschlichen antihaemophilischen Faktor IX
GB2125409B (en) * 1982-08-04 1985-11-13 Nat Res Dev Genetic engineering
FR2564106B1 (fr) * 1984-05-09 1988-04-22 Transgene Sa Vecteurs d'expression du facteur ix, cellules transformees par ces vecteurs et procede de preparation du facteur ix.
JPH082307B2 (ja) * 1984-05-22 1996-01-17 トランスジ−ン ソシエテ アノニム 第▲ｉｘ▼因子の製造方法
US4775624A (en) * 1985-02-08 1988-10-04 Eli Lilly And Company Vectors and compounds for expression of human protein C
EP0195592B1 (de) * 1985-03-15 1992-04-22 Btg International Limited Faktor-IX-Protein
GR860984B (en) * 1985-04-17 1986-08-18 Zymogenetics Inc Expression of factor vii and ix activities in mammalian cells

Also Published As

Publication number Publication date
EP0218713B1 (de) 1992-03-25
WO1986006408A1 (en) 1986-11-06
EP0218713A1 (de) 1987-04-22
US4770999A (en) 1988-09-13
EP0218713A4 (de) 1987-04-28
JPS62502514A (ja) 1987-10-01
JP2584443B2 (ja) 1997-02-26
AU5864086A (en) 1986-11-18
KR880700060A (ko) 1988-02-15
DE3684546D1 (de) 1992-04-30

Similar Documents

Publication Publication Date Title
ATE74164T1 (de) Herstellung mit hoher leistung des aktivfaktors ix.
NL980031I2 (nl) Fenylcarbamaten.
DE59803845D1 (de) Sulfinsäurederivate und deren herstellung und verwendung
DE69231947D1 (de) Genherstellung zur produktion von transgenfisch
FI925005A0 (fi) Nya sulfonylfoereningar
ATE42316T1 (de) Phosphorsaeureesterverbindung.
ATE26982T1 (de) Herstellung von 6-alpha-bromo- und/oder 6,6dibromo-penicillansaeure 1,1-dioxiden.
ATE44028T1 (de) Kronenaether-derivate.
AR247483A1 (es) Nuevas metafenilendiaminas trialcoxi-sustituidas, procedimiento de preparacion, composiciones tintoreas para el tenido por oxidacion de fibras queratinicas y en particular de los cabellos humanos
DK67384A (da) N-iminopyridiniumbetainderivater
ATE47886T1 (de) Herstellung von stahllegierungen unter verwendung von chemisch hergestelltem v2o3 als vanadiumzusatz.
SE427288B (sv) Elektrolyscell av trekammartyp for elektrolys av en alkalemetallhalogenidlosning
FI870460A0 (fi) Foerfarande foer framstaellning av nya terapeutiskt anvaendbara 5-substituerade oktahydroindolizinderivat och vid foerfarandet anvaendbara mellanprodukter.
JPS5362515A (en) Magnetic head
ES2040226T3 (es) Procedimiento para preparar nuevos tetrahidro-benzotiazoles.
ES8706152A1 (es) Procedimiento para preparar un nuevo derivado de octahidroindol (2,3-a) quinolizina
ATE105286T1 (de) Herstellung von 3,3-diarylacrylsaeureamiden.
KR860003828A (ko) 맥반의왕석을 함유하는 세안용 조성물
SU823606A1 (ru) Турбоагрегат
SU1468978A1 (ru) Катодный узел дл получени хрома
ES429178A1 (es) Procedimiento para la preparacion de nuevos 1-(meta-acilo- xifenil)-1-hidroxi-2-n alcohilamino-etanos.
ES416221A1 (es) Procedimiento para la preparacion de nuevos derivados de difenilmetano farmacologicamente activos.
ATE36516T1 (de) Reinigung von 4-fluor-4'-hydroxy-benzophenon.
SU1018358A1 (ru) Способ получения ацетопропилхлорида
ES8504132A1 (es) Procedimiento de obtencion de nuevos derivados imidazolicos del acido 2-hidroxibenzoico

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties