DK1842920T4 - Celler der co-udtrykker K-vitaminreduktase og K-vitaminafhængigt protein, samt anvendelse deraf til at forbedre produktiviteten af det K-vitaminafhængige protein - Google Patents
Celler der co-udtrykker K-vitaminreduktase og K-vitaminafhængigt protein, samt anvendelse deraf til at forbedre produktiviteten af det K-vitaminafhængige protein Download PDFInfo
- Publication number
- DK1842920T4 DK1842920T4 DK07109353.8T DK07109353T DK1842920T4 DK 1842920 T4 DK1842920 T4 DK 1842920T4 DK 07109353 T DK07109353 T DK 07109353T DK 1842920 T4 DK1842920 T4 DK 1842920T4
- Authority
- DK
- Denmark
- Prior art keywords
- vitamin
- dependent protein
- reductase
- productivity
- cells
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
- C12N15/1137—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against enzymes
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0006—Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/156—Polymorphic or mutational markers
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/158—Expression markers
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/172—Haplotypes
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US50552703P | 2003-09-23 | 2003-09-23 | |
EP04789039.7A EP1670947B1 (en) | 2003-09-23 | 2004-09-23 | Methods and compositions for the correlation of single nucleotide polymorphisms in the vitamin k epoxide reductase gene and warfarin dosage |
Publications (2)
Publication Number | Publication Date |
---|---|
DK1842920T3 DK1842920T3 (da) | 2010-05-03 |
DK1842920T4 true DK1842920T4 (da) | 2017-08-21 |
Family
ID=34393028
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK07109353.8T DK1842920T4 (da) | 2003-09-23 | 2004-09-23 | Celler der co-udtrykker K-vitaminreduktase og K-vitaminafhængigt protein, samt anvendelse deraf til at forbedre produktiviteten af det K-vitaminafhængige protein |
DK11156979.4T DK2380985T3 (da) | 2003-09-23 | 2004-09-23 | Celler, der udtrykker vitamin K-epoxid-reduktase, samt deres anvendelse |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK11156979.4T DK2380985T3 (da) | 2003-09-23 | 2004-09-23 | Celler, der udtrykker vitamin K-epoxid-reduktase, samt deres anvendelse |
Country Status (13)
Country | Link |
---|---|
US (6) | US7687233B2 (da) |
EP (4) | EP2336360A1 (da) |
JP (4) | JP2007506433A (da) |
AT (1) | ATE455174T1 (da) |
AU (2) | AU2004275828B2 (da) |
CA (1) | CA2539434C (da) |
DE (1) | DE602004025157D1 (da) |
DK (2) | DK1842920T4 (da) |
ES (2) | ES2339710T5 (da) |
HK (1) | HK1093223A1 (da) |
PL (1) | PL1842920T5 (da) |
PT (1) | PT2380985E (da) |
WO (1) | WO2005030039A2 (da) |
Families Citing this family (25)
Publication number | Priority date | Publication date | Assignee | Title |
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ES2339710T5 (es) | 2003-09-23 | 2017-10-05 | University Of North Carolina At Chapel Hill | Células que coexpresan vitamina K reductasa y proteína dependiente de vitamina K y uso de las mismas para mejorar la productividad de dicha proteína dependiente de vitamina K |
EP1673450B1 (en) * | 2003-10-14 | 2010-04-28 | Baxter International Inc. | Vitamin k epoxide recycling polypeptide vkorc1, a therapeutic target of coumarin and their derivatives |
GB0324044D0 (en) | 2003-10-14 | 2003-11-19 | Astrazeneca Ab | Protein |
CA2575878A1 (en) * | 2004-08-02 | 2006-02-09 | Novozymes A/S | Creation of diversity in polypeptides |
US7445896B2 (en) | 2004-10-18 | 2008-11-04 | University Of Washington | Methods and compositions for detecting VKORC1 single nucleotide polymorphisms |
EP1809767B1 (en) * | 2004-10-18 | 2011-09-07 | University of Washington | Methods and compositions for predicting response to warfarin |
NZ556461A (en) * | 2004-12-21 | 2009-12-24 | Academia Sinica | Genetic variants of vkorc1 predicting warfarin sensitivity |
WO2006089613A1 (en) | 2005-02-28 | 2006-08-31 | Baxter International Inc. | Recombinant co-expression of vitamin k epoxide reductase subunit 1 to improve vitamin k dependent protein expression |
US20090325226A1 (en) | 2005-03-15 | 2009-12-31 | Stafford Darrel W | Methods and Compositions for Producing Active Vitamin K-Dependent Proteins |
EP1874928A1 (en) * | 2005-04-13 | 2008-01-09 | AstraZeneca AB | A host cell comprising a vector for production of proteins requiring gamma-carboxylation |
US8500720B2 (en) * | 2005-05-09 | 2013-08-06 | Medtronic, Inc | Method and apparatus for treatment of cardiac disorders |
US20080045453A1 (en) * | 2005-12-21 | 2008-02-21 | Drohan William N | Method of producing biologically active vitamin K dependent proteins by recombinant methods |
TW200808976A (en) * | 2006-06-02 | 2008-02-16 | Pharmigene Inc | Warfarin dosage prediction |
US8206967B2 (en) | 2007-07-06 | 2012-06-26 | Medimmune Limited | Method for production of recombinant human thrombin |
MX2010011672A (es) | 2008-04-24 | 2011-03-02 | Celtic Pharma Peg Ltd | Conjugados del factor ix con vidas medias extendidas. |
WO2010045381A2 (en) * | 2008-10-15 | 2010-04-22 | President And Fellows Of Harvard College | Antimicrobial agents that target bacterial vkor |
CN102471794B (zh) | 2009-07-10 | 2014-10-29 | Csl有限公司 | 提高维生素k依赖性蛋白质的表达产量的方法 |
US9631002B2 (en) | 2010-12-21 | 2017-04-25 | The University Of North Carolina At Chapel Hill | Methods and compositions for producing active vitamin K-dependent proteins |
JP2012139232A (ja) * | 2012-03-15 | 2012-07-26 | Univ Of North Carolina At Chapel Hill | 活性ビタミンk依存性タンパク質を生産するための方法及び組成物 |
JP2014221048A (ja) * | 2014-06-16 | 2014-11-27 | ユニヴァーシティ・オヴ・ノース・キャロライナ・アト・チャペル・ヒル | 活性ビタミンk依存性タンパク質を生産するための方法及び組成物 |
BR102015012334A2 (pt) * | 2015-05-27 | 2016-11-29 | Fundação Hemoct De Ribeirão Preto Fundherp | processo de produção do fator vii de coagulação sanguínea e fator vii de coagulação sanguínea |
WO2018106959A1 (en) | 2016-12-07 | 2018-06-14 | Progenity Inc. | Gastrointestinal tract detection methods, devices and systems |
WO2018112264A1 (en) | 2016-12-14 | 2018-06-21 | Progenity Inc. | Treatment of a disease of the gastrointestinal tract with a chemokine/chemokine receptor inhibitor |
WO2020106757A1 (en) | 2018-11-19 | 2020-05-28 | Progenity, Inc. | Ingestible device for delivery of therapeutic agent to the gastrointestinal tract |
US11707610B2 (en) | 2019-12-13 | 2023-07-25 | Biora Therapeutics, Inc. | Ingestible device for delivery of therapeutic agent to the gastrointestinal tract |
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ES2339710T5 (es) * | 2003-09-23 | 2017-10-05 | University Of North Carolina At Chapel Hill | Células que coexpresan vitamina K reductasa y proteína dependiente de vitamina K y uso de las mismas para mejorar la productividad de dicha proteína dependiente de vitamina K |
EP1673450B1 (en) | 2003-10-14 | 2010-04-28 | Baxter International Inc. | Vitamin k epoxide recycling polypeptide vkorc1, a therapeutic target of coumarin and their derivatives |
GB0324044D0 (en) * | 2003-10-14 | 2003-11-19 | Astrazeneca Ab | Protein |
US7445896B2 (en) * | 2004-10-18 | 2008-11-04 | University Of Washington | Methods and compositions for detecting VKORC1 single nucleotide polymorphisms |
EP1809767B1 (en) | 2004-10-18 | 2011-09-07 | University of Washington | Methods and compositions for predicting response to warfarin |
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WO2006089613A1 (en) * | 2005-02-28 | 2006-08-31 | Baxter International Inc. | Recombinant co-expression of vitamin k epoxide reductase subunit 1 to improve vitamin k dependent protein expression |
US20090325226A1 (en) * | 2005-03-15 | 2009-12-31 | Stafford Darrel W | Methods and Compositions for Producing Active Vitamin K-Dependent Proteins |
EP1874928A1 (en) | 2005-04-13 | 2008-01-09 | AstraZeneca AB | A host cell comprising a vector for production of proteins requiring gamma-carboxylation |
US8647868B2 (en) | 2005-12-02 | 2014-02-11 | Wake Forest University Health Sciences | Compositions and methods for increasing production of recombinant gamma-carboxylated proteins |
US20080045453A1 (en) | 2005-12-21 | 2008-02-21 | Drohan William N | Method of producing biologically active vitamin K dependent proteins by recombinant methods |
TW200808976A (en) * | 2006-06-02 | 2008-02-16 | Pharmigene Inc | Warfarin dosage prediction |
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2004
- 2004-09-23 ES ES07109353.8T patent/ES2339710T5/es active Active
- 2004-09-23 CA CA2539434A patent/CA2539434C/en active Active
- 2004-09-23 ES ES11156979.4T patent/ES2453895T3/es active Active
- 2004-09-23 DK DK07109353.8T patent/DK1842920T4/da active
- 2004-09-23 JP JP2006528251A patent/JP2007506433A/ja not_active Withdrawn
- 2004-09-23 US US10/573,131 patent/US7687233B2/en not_active Expired - Fee Related
- 2004-09-23 EP EP10178665A patent/EP2336360A1/en not_active Withdrawn
- 2004-09-23 PT PT111569794T patent/PT2380985E/pt unknown
- 2004-09-23 AT AT07109353T patent/ATE455174T1/de not_active IP Right Cessation
- 2004-09-23 PL PL07109353T patent/PL1842920T5/pl unknown
- 2004-09-23 EP EP04789039.7A patent/EP1670947B1/en not_active Not-in-force
- 2004-09-23 DK DK11156979.4T patent/DK2380985T3/da active
- 2004-09-23 DE DE602004025157T patent/DE602004025157D1/de active Active
- 2004-09-23 AU AU2004275828A patent/AU2004275828B2/en active Active
- 2004-09-23 WO PCT/US2004/031481 patent/WO2005030039A2/en active Application Filing
- 2004-09-23 EP EP07109353.8A patent/EP1842920B2/en active Active
- 2004-09-23 EP EP11156979.4A patent/EP2380985B1/en active Active
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2006
- 2006-09-06 US US11/516,229 patent/US7524665B2/en active Active
- 2006-12-20 HK HK06114003.0A patent/HK1093223A1/xx not_active IP Right Cessation
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2007
- 2007-01-30 US US11/699,930 patent/US7482141B2/en active Active
- 2007-10-26 US US11/924,707 patent/US8097410B2/en not_active Expired - Fee Related
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2009
- 2009-01-28 US US12/361,053 patent/US7858318B2/en not_active Expired - Fee Related
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2010
- 2010-07-02 JP JP2010151738A patent/JP5094920B2/ja not_active Expired - Fee Related
- 2010-07-26 AU AU2010203318A patent/AU2010203318B2/en not_active Ceased
- 2010-12-17 US US12/971,574 patent/US8426128B2/en not_active Expired - Fee Related
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2012
- 2012-03-12 JP JP2012054537A patent/JP5840539B2/ja active Active
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2015
- 2015-05-07 JP JP2015094928A patent/JP2015180205A/ja active Pending
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