DK1842920T3 - Celler der co-udtrykker K-vitaminreduktase og K-vitaminafhængigt protein, samt anvendelse deraf til at forbedre produktiviteten af det K-vitaminafhængige protein - Google Patents

Celler der co-udtrykker K-vitaminreduktase og K-vitaminafhængigt protein, samt anvendelse deraf til at forbedre produktiviteten af det K-vitaminafhængige protein

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Publication number
DK1842920T3
DK1842920T3 DK07109353.8T DK07109353T DK1842920T3 DK 1842920 T3 DK1842920 T3 DK 1842920T3 DK 07109353 T DK07109353 T DK 07109353T DK 1842920 T3 DK1842920 T3 DK 1842920T3
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DK
Denmark
Prior art keywords
vitamin
dependent protein
reductase
productivity
cells
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Application number
DK07109353.8T
Other languages
English (en)
Other versions
DK1842920T4 (da
Inventor
Darrel Stafford
Tao Li
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Univ North Carolina
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Application filed by Univ North Carolina filed Critical Univ North Carolina
Publication of DK1842920T3 publication Critical patent/DK1842920T3/da
Application granted granted Critical
Publication of DK1842920T4 publication Critical patent/DK1842920T4/da

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1137—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against enzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0006—Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/172—Haplotypes

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Analytical Chemistry (AREA)
  • Immunology (AREA)
  • Virology (AREA)
  • Pathology (AREA)
  • Plant Pathology (AREA)
  • Medicinal Chemistry (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
DK07109353.8T 2003-09-23 2004-09-23 Celler der co-udtrykker K-vitaminreduktase og K-vitaminafhængigt protein, samt anvendelse deraf til at forbedre produktiviteten af det K-vitaminafhængige protein DK1842920T4 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US50552703P 2003-09-23 2003-09-23
EP04789039.7A EP1670947B1 (en) 2003-09-23 2004-09-23 Methods and compositions for the correlation of single nucleotide polymorphisms in the vitamin k epoxide reductase gene and warfarin dosage

Publications (2)

Publication Number Publication Date
DK1842920T3 true DK1842920T3 (da) 2010-05-03
DK1842920T4 DK1842920T4 (da) 2017-08-21

Family

ID=34393028

Family Applications (2)

Application Number Title Priority Date Filing Date
DK11156979.4T DK2380985T3 (da) 2003-09-23 2004-09-23 Celler, der udtrykker vitamin K-epoxid-reduktase, samt deres anvendelse
DK07109353.8T DK1842920T4 (da) 2003-09-23 2004-09-23 Celler der co-udtrykker K-vitaminreduktase og K-vitaminafhængigt protein, samt anvendelse deraf til at forbedre produktiviteten af det K-vitaminafhængige protein

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DK11156979.4T DK2380985T3 (da) 2003-09-23 2004-09-23 Celler, der udtrykker vitamin K-epoxid-reduktase, samt deres anvendelse

Country Status (13)

Country Link
US (6) US7687233B2 (da)
EP (4) EP1842920B2 (da)
JP (4) JP2007506433A (da)
AT (1) ATE455174T1 (da)
AU (2) AU2004275828B2 (da)
CA (1) CA2539434C (da)
DE (1) DE602004025157D1 (da)
DK (2) DK2380985T3 (da)
ES (2) ES2453895T3 (da)
HK (1) HK1093223A1 (da)
PL (1) PL1842920T5 (da)
PT (1) PT2380985E (da)
WO (1) WO2005030039A2 (da)

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US7445896B2 (en) * 2004-10-18 2008-11-04 University Of Washington Methods and compositions for detecting VKORC1 single nucleotide polymorphisms
EP1809767B1 (en) * 2004-10-18 2011-09-07 University of Washington Methods and compositions for predicting response to warfarin
EP1831402B1 (en) * 2004-12-21 2010-06-09 Academia Sinica Genetic variants of vkorc1 predicting warfarin sensitivity
EP2295547B1 (en) * 2005-02-28 2017-09-20 Baxalta GmbH Recombinant co-expression of vitamin K epoxide reductase subunit 1 to improve vitamin K dependant protein expression
US20090325226A1 (en) * 2005-03-15 2009-12-31 Stafford Darrel W Methods and Compositions for Producing Active Vitamin K-Dependent Proteins
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CN115666704A (zh) 2019-12-13 2023-01-31 比奥拉治疗股份有限公司 用于将治疗剂递送至胃肠道的可摄取装置

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Also Published As

Publication number Publication date
JP2010268803A (ja) 2010-12-02
AU2004275828B2 (en) 2010-04-29
ES2453895T3 (es) 2014-04-08
EP1842920A1 (en) 2007-10-10
AU2010203318A1 (en) 2010-08-12
ES2339710T5 (es) 2017-10-05
US20110124000A1 (en) 2011-05-26
US7524665B2 (en) 2009-04-28
US20060240440A1 (en) 2006-10-26
US20090215045A1 (en) 2009-08-27
US7482141B2 (en) 2009-01-27
EP1670947A2 (en) 2006-06-21
EP2380985B1 (en) 2014-01-01
EP1670947B1 (en) 2015-04-01
US7858318B2 (en) 2010-12-28
JP2007506433A (ja) 2007-03-22
PL1842920T3 (pl) 2010-06-30
AU2010203318B2 (en) 2012-07-12
JP2012161315A (ja) 2012-08-30
EP1842920B2 (en) 2017-06-21
EP1670947A4 (en) 2008-11-05
US8426128B2 (en) 2013-04-23
ES2339710T3 (es) 2010-05-24
CA2539434C (en) 2014-03-18
US7687233B2 (en) 2010-03-30
PL1842920T5 (pl) 2018-04-30
EP2336360A1 (en) 2011-06-22
US20070009950A1 (en) 2007-01-11
DK1842920T4 (da) 2017-08-21
DK2380985T3 (da) 2014-03-17
US20090215061A1 (en) 2009-08-27
WO2005030039A3 (en) 2005-07-21
HK1093223A1 (en) 2007-02-23
ATE455174T1 (de) 2010-01-15
EP2380985A1 (en) 2011-10-26
US8097410B2 (en) 2012-01-17
US20070190614A1 (en) 2007-08-16
EP1842920B1 (en) 2010-01-13
DE602004025157D1 (de) 2010-03-04
PT2380985E (pt) 2014-03-26
JP5840539B2 (ja) 2016-01-06
JP2015180205A (ja) 2015-10-15
AU2004275828A1 (en) 2005-04-07
CA2539434A1 (en) 2005-04-07
WO2005030039A2 (en) 2005-04-07
JP5094920B2 (ja) 2012-12-12

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