PT2380985E - Células que expressam a vitamina k epóxido reductase e sua utilização - Google Patents

Células que expressam a vitamina k epóxido reductase e sua utilização Download PDF

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Publication number
PT2380985E
PT2380985E PT111569794T PT11156979T PT2380985E PT 2380985 E PT2380985 E PT 2380985E PT 111569794 T PT111569794 T PT 111569794T PT 11156979 T PT11156979 T PT 11156979T PT 2380985 E PT2380985 E PT 2380985E
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PT
Portugal
Prior art keywords
cells expressing
epoxide reductase
warfarin
increased
expressing vitamin
Prior art date
Application number
PT111569794T
Other languages
English (en)
Inventor
Darrel W Stafford
Tao Li
Original Assignee
Univ North Carolina
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
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Application filed by Univ North Carolina filed Critical Univ North Carolina
Publication of PT2380985E publication Critical patent/PT2380985E/pt

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1137—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against enzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0006—Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/172—Haplotypes

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  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Analytical Chemistry (AREA)
  • Virology (AREA)
  • Plant Pathology (AREA)
  • Pathology (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
PT111569794T 2003-09-23 2004-09-23 Células que expressam a vitamina k epóxido reductase e sua utilização PT2380985E (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US50552703P 2003-09-23 2003-09-23

Publications (1)

Publication Number Publication Date
PT2380985E true PT2380985E (pt) 2014-03-26

Family

ID=34393028

Family Applications (1)

Application Number Title Priority Date Filing Date
PT111569794T PT2380985E (pt) 2003-09-23 2004-09-23 Células que expressam a vitamina k epóxido reductase e sua utilização

Country Status (13)

Country Link
US (6) US7687233B2 (pt)
EP (4) EP2380985B1 (pt)
JP (4) JP2007506433A (pt)
AT (1) ATE455174T1 (pt)
AU (2) AU2004275828B2 (pt)
CA (1) CA2539434C (pt)
DE (1) DE602004025157D1 (pt)
DK (2) DK1842920T4 (pt)
ES (2) ES2453895T3 (pt)
HK (1) HK1093223A1 (pt)
PL (1) PL1842920T5 (pt)
PT (1) PT2380985E (pt)
WO (1) WO2005030039A2 (pt)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2380985B1 (en) 2003-09-23 2014-01-01 University of North Carolina at Chapel Hill Cells expressing vitamin K epoxide reductase and use thereof
DE602004026897D1 (de) * 2003-10-14 2010-06-10 Baxter Healthcare Sa Vkorc1 (vitamin k epoxide recycling polypeptide), ein therapeutisches ziel für coumarin und deren derivate
GB0324044D0 (en) 2003-10-14 2003-11-19 Astrazeneca Ab Protein
WO2006012902A2 (en) * 2004-08-02 2006-02-09 Novozymes A/S Creation of diversity in polypeptides
US7445896B2 (en) * 2004-10-18 2008-11-04 University Of Washington Methods and compositions for detecting VKORC1 single nucleotide polymorphisms
CA2583904C (en) * 2004-10-18 2018-01-09 University Of Washington Methods and compositions for predicting drug responses
MX2007007568A (es) * 2004-12-21 2008-03-11 Academia Sinica Variantes geneticas de vkorci que predicen la sensibilidad a la warfarina.
CN103396998A (zh) * 2005-02-28 2013-11-20 巴克斯特国际公司 重组共表达维生素k环氧化物还原酶亚基1以提高依赖维生素k的蛋白质表达
AU2005329450A1 (en) * 2005-03-15 2006-09-28 University Of North Carolina At Chapel Hill Methods and compositions for producing active Vitamin K-dependent proteins
US7989193B2 (en) * 2005-04-13 2011-08-02 Medimmune Limited Compositions and methods for producing gamma-carboxylated proteins
US8500720B2 (en) * 2005-05-09 2013-08-06 Medtronic, Inc Method and apparatus for treatment of cardiac disorders
EP1969127B8 (en) * 2005-12-21 2017-12-13 Aptevo BioTherapeutics LLC Method of producing biologically active vitamin k dependent proteins by recombinant methods
US20070298426A1 (en) * 2006-06-02 2007-12-27 Academia Sinica Warfarin dosage prediction
US8206967B2 (en) 2007-07-06 2012-06-26 Medimmune Limited Method for production of recombinant human thrombin
CN102046205A (zh) 2008-04-24 2011-05-04 凯尔特药物Peg有限公司 具有延长的半衰期的因子ix缀合物
US20110243958A1 (en) * 2008-10-15 2011-10-06 President And Fellows Of Harvard College Antimicrobial agents that target bacterial vkor
ES2475718T3 (es) 2009-07-10 2014-07-11 Csl Limited Método para incrementar el rendimiento de la expresión de proteínas dependientes de vitamina K
EP2655607A4 (en) 2010-12-21 2014-05-14 Univ North Carolina METHOD AND COMPOSITIONS FOR PRODUCING ACTIVE VITAMIN K-DEPENDENT PROTEINS
JP2012139232A (ja) * 2012-03-15 2012-07-26 Univ Of North Carolina At Chapel Hill 活性ビタミンｋ依存性タンパク質を生産するための方法及び組成物
JP2014221048A (ja) * 2014-06-16 2014-11-27 ユニヴァーシティ・オヴ・ノース・キャロライナ・アト・チャペル・ヒル 活性ビタミンｋ依存性タンパク質を生産するための方法及び組成物
BR102015012334A2 (pt) 2015-05-27 2016-11-29 Fundação Hemoct De Ribeirão Preto Fundherp processo de produção do fator vii de coagulação sanguínea e fator vii de coagulação sanguínea
EP4252629A3 (en) 2016-12-07 2023-12-27 Biora Therapeutics, Inc. Gastrointestinal tract detection methods, devices and systems
EP3554541B1 (en) 2016-12-14 2023-06-07 Biora Therapeutics, Inc. Treatment of a disease of the gastrointestinal tract with a chemokine/chemokine receptor inhibitor
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EP4309722A2 (en) 2019-12-13 2024-01-24 Biora Therapeutics, Inc. Ingestible device for delivery of therapeutic agent to the gastrointestinal tract

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GB0324044D0 (en) 2003-10-14 2003-11-19 Astrazeneca Ab Protein
DE602004026897D1 (de) 2003-10-14 2010-06-10 Baxter Healthcare Sa Vkorc1 (vitamin k epoxide recycling polypeptide), ein therapeutisches ziel für coumarin und deren derivate
US7445896B2 (en) 2004-10-18 2008-11-04 University Of Washington Methods and compositions for detecting VKORC1 single nucleotide polymorphisms
CA2583904C (en) 2004-10-18 2018-01-09 University Of Washington Methods and compositions for predicting drug responses
MX2007007568A (es) 2004-12-21 2008-03-11 Academia Sinica Variantes geneticas de vkorci que predicen la sensibilidad a la warfarina.
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AU2005329450A1 (en) * 2005-03-15 2006-09-28 University Of North Carolina At Chapel Hill Methods and compositions for producing active Vitamin K-dependent proteins
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EP1969127B8 (en) 2005-12-21 2017-12-13 Aptevo BioTherapeutics LLC Method of producing biologically active vitamin k dependent proteins by recombinant methods
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Also Published As

Publication number Publication date
JP2010268803A (ja) 2010-12-02
WO2005030039A3 (en) 2005-07-21
CA2539434A1 (en) 2005-04-07
JP2007506433A (ja) 2007-03-22
AU2004275828B2 (en) 2010-04-29
EP1842920B2 (en) 2017-06-21
US20110124000A1 (en) 2011-05-26
EP1842920B1 (en) 2010-01-13
HK1093223A1 (en) 2007-02-23
US20070190614A1 (en) 2007-08-16
CA2539434C (en) 2014-03-18
US7858318B2 (en) 2010-12-28
US20090215045A1 (en) 2009-08-27
US20090215061A1 (en) 2009-08-27
US7687233B2 (en) 2010-03-30
JP2015180205A (ja) 2015-10-15
EP2380985A1 (en) 2011-10-26
DK1842920T3 (da) 2010-05-03
ES2339710T5 (es) 2017-10-05
US7524665B2 (en) 2009-04-28
WO2005030039A2 (en) 2005-04-07
AU2004275828A1 (en) 2005-04-07
ES2453895T3 (es) 2014-04-08
US20070009950A1 (en) 2007-01-11
ES2339710T3 (es) 2010-05-24
DE602004025157D1 (de) 2010-03-04
DK2380985T3 (en) 2014-03-17
EP1842920A1 (en) 2007-10-10
EP1670947A4 (en) 2008-11-05
EP1670947B1 (en) 2015-04-01
DK1842920T4 (da) 2017-08-21
US8097410B2 (en) 2012-01-17
JP5840539B2 (ja) 2016-01-06
US7482141B2 (en) 2009-01-27
JP5094920B2 (ja) 2012-12-12
EP2380985B1 (en) 2014-01-01
EP2336360A1 (en) 2011-06-22
US8426128B2 (en) 2013-04-23
JP2012161315A (ja) 2012-08-30
US20060240440A1 (en) 2006-10-26
AU2010203318A1 (en) 2010-08-12
AU2010203318B2 (en) 2012-07-12
EP1670947A2 (en) 2006-06-21
PL1842920T5 (pl) 2018-04-30
ATE455174T1 (de) 2010-01-15
PL1842920T3 (pl) 2010-06-30

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