WO2003054166A3 - Nucleotide polymorphisms associated with osteoarthritis - Google Patents

Nucleotide polymorphisms associated with osteoarthritis Download PDF

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Publication number
WO2003054166A3
WO2003054166A3 PCT/US2002/041225 US0241225W WO03054166A3 WO 2003054166 A3 WO2003054166 A3 WO 2003054166A3 US 0241225 W US0241225 W US 0241225W WO 03054166 A3 WO03054166 A3 WO 03054166A3
Authority
WO
WIPO (PCT)
Prior art keywords
osteoarthritis
nucleotide polymorphisms
polymorphisms associated
development
provides methods
Prior art date
Application number
PCT/US2002/041225
Other languages
French (fr)
Other versions
WO2003054166A2 (en
Inventor
Karen Anne Jones
Alan Schafer
Original Assignee
Incyte Genomics Inc
Karen Anne Jones
Alan Schafer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Incyte Genomics Inc, Karen Anne Jones, Alan Schafer filed Critical Incyte Genomics Inc
Priority to AU2002366713A priority Critical patent/AU2002366713A1/en
Publication of WO2003054166A2 publication Critical patent/WO2003054166A2/en
Publication of WO2003054166A3 publication Critical patent/WO2003054166A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Pathology (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

The invention relates to novel polynucleotides associated with human disease, and in particular to osteoarthritis. The invention further relates to polymorphic polynucleotides associated with osteoarthritis. The invention provides methods of determining if a particular polymorphism predisposes an individual to or is associated with the development of osteoarthritis. The invention also provides methods of detecting the presence of one or more polymorphism as an indicator of osteoarthritis, and provides for use of novel polynucleotides of the invention in the development of drugs and in disease treatment.
PCT/US2002/041225 2001-12-20 2002-12-19 Nucleotide polymorphisms associated with osteoarthritis WO2003054166A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2002366713A AU2002366713A1 (en) 2001-12-20 2002-12-19 Nucleotide polymorphisms associated with osteoarthritis

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US34260301P 2001-12-20 2001-12-20
US60/342,603 2001-12-20

Publications (2)

Publication Number Publication Date
WO2003054166A2 WO2003054166A2 (en) 2003-07-03
WO2003054166A3 true WO2003054166A3 (en) 2004-03-18

Family

ID=23342513

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2002/041225 WO2003054166A2 (en) 2001-12-20 2002-12-19 Nucleotide polymorphisms associated with osteoarthritis

Country Status (2)

Country Link
AU (1) AU2002366713A1 (en)
WO (1) WO2003054166A2 (en)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1448600A4 (en) 2001-09-07 2004-12-22 Bristol Myers Squibb Co Polynucleotide encoding a novel human g-protein coupled receptor, hgprbmy39
US20060211774A1 (en) * 2003-04-29 2006-09-21 Bennett Simon T Method of diagnosins a genetic susceptibility for bone damage
WO2005097421A2 (en) * 2004-04-01 2005-10-20 Sequenom, Inc. Methods for identifying risk of osteoarthritis and treatments thereof
GB0425197D0 (en) * 2004-11-15 2004-12-15 Ares Trading Sa Leucine-rich repeat (LRR) motif containing proteins
WO2007028212A1 (en) * 2005-09-08 2007-03-15 Apollo Life Sciences Limited Noggin and chimeric molecules thereof
FR2908654B1 (en) * 2006-11-20 2014-04-04 Oreal COSMETIC USE OF CHITINASE PROTEINS
EP2162747B1 (en) * 2007-06-20 2014-04-30 Galapagos N.V. Molecular targets and methods to identify compounds for treating bone and joint degenerative diseases
EP2245459A1 (en) 2008-01-23 2010-11-03 Herlev Hospital Ykl-40 as a general marker for non-specific disease
NZ592241A (en) 2008-09-15 2012-11-30 Herlev Hospital Ykl-40 as a marker for gastrointestinal cancers
EP3483288B1 (en) 2011-11-30 2022-03-16 Children's Hospital Medical Center Personalized pain management and anesthesia: preemptive risk identification
DK3019619T3 (en) 2013-07-11 2021-10-11 Modernatx Inc COMPOSITIONS INCLUDING SYNTHETIC POLYNUCLEOTIDES CODING CRISPR-RELATED PROTEINS, SYNTHETIC SGRNAs, AND USES OF USE
JP6581117B2 (en) 2014-02-24 2019-09-25 チルドレンズ ホスピタル メディカル センター Methods and compositions for personalized pain management
EP3571309A4 (en) 2017-01-20 2020-11-25 Children's Hospital Medical Center Methods and compositions relating to oprm1 dna methylation for personalized pain management
CN111088369B (en) * 2020-01-17 2022-11-15 天津奥群牧业有限公司 Detection method, primer pair and application of sheep RORA gene insertion/deletion polymorphism

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6265157B1 (en) * 1991-12-03 2001-07-24 Allegheny University Of The Health Sciences Compositions and methods for detecting altered COL1A1 gene sequences

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6265157B1 (en) * 1991-12-03 2001-07-24 Allegheny University Of The Health Sciences Compositions and methods for detecting altered COL1A1 gene sequences

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
AHERN H.: "Biochemical, reagent kits offer scientists good return on investment", THE SCIENTIST, vol. 9, no. 15, July 1995 (1995-07-01), pages 1 - 5, XP002921157 *
THUR ET AL.: "Mutations in cartilage oligomeric matrix protein causing pseudoachondroplasia and multiple epiphyseal dysplasia affect binding of calcium and collagen I, II and IX", THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 276, no. 9, 2 March 2001 (2001-03-02), pages 6083 - 6092, XP002965461 *

Also Published As

Publication number Publication date
WO2003054166A2 (en) 2003-07-03
AU2002366713A1 (en) 2003-07-09
AU2002366713A8 (en) 2003-07-09

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