ATE514755T1 - Fluoreszenzfarbstoffe zur verwendung bei der glukoseerfassung - Google Patents

Fluoreszenzfarbstoffe zur verwendung bei der glukoseerfassung

Info

Publication number
ATE514755T1
ATE514755T1 AT07799791T AT07799791T ATE514755T1 AT E514755 T1 ATE514755 T1 AT E514755T1 AT 07799791 T AT07799791 T AT 07799791T AT 07799791 T AT07799791 T AT 07799791T AT E514755 T1 ATE514755 T1 AT E514755T1
Authority
AT
Austria
Prior art keywords
fluorescent dyes
glucose detection
cys
hpts
class
Prior art date
Application number
AT07799791T
Other languages
English (en)
Inventor
Jeff Suri
Original Assignee
Glumetrics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glumetrics Inc filed Critical Glumetrics Inc
Application granted granted Critical
Publication of ATE514755T1 publication Critical patent/ATE514755T1/de

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C09DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09BORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B57/00Other synthetic dyes of known constitution
    • C09B57/001Pyrene dyes
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/54Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving glucose or galactose
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/52Use of compounds or compositions for colorimetric, spectrophotometric or fluorometric investigation, e.g. use of reagent paper and including single- and multilayer analytical elements
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/531Production of immunochemical test materials
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/66Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood sugars, e.g. galactose
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10TTECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00Chemistry: analytical and immunological testing
    • Y10T436/14Heterocyclic carbon compound [i.e., O, S, N, Se, Te, as only ring hetero atom]
    • Y10T436/142222Hetero-O [e.g., ascorbic acid, etc.]
    • Y10T436/143333Saccharide [e.g., DNA, etc.]
    • Y10T436/144444Glucose

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Food Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Cell Biology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Emergency Medicine (AREA)
  • Diabetes (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
AT07799791T 2006-07-25 2007-07-24 Fluoreszenzfarbstoffe zur verwendung bei der glukoseerfassung ATE514755T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US83308106P 2006-07-25 2006-07-25
PCT/US2007/074255 WO2008014280A2 (en) 2006-07-25 2007-07-24 Flourescent dyes for use in glucose sensing

Publications (1)

Publication Number Publication Date
ATE514755T1 true ATE514755T1 (de) 2011-07-15

Family

ID=38896105

Family Applications (1)

Application Number Title Priority Date Filing Date
AT07799791T ATE514755T1 (de) 2006-07-25 2007-07-24 Fluoreszenzfarbstoffe zur verwendung bei der glukoseerfassung

Country Status (7)

Country Link
US (2) US7417164B2 (de)
EP (1) EP2054476B9 (de)
JP (1) JP5159778B2 (de)
AT (1) ATE514755T1 (de)
AU (1) AU2007276777A1 (de)
CA (1) CA2652025A1 (de)
WO (1) WO2008014280A2 (de)

Families Citing this family (98)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7899511B2 (en) 2004-07-13 2011-03-01 Dexcom, Inc. Low oxygen in vivo analyte sensor
US7192450B2 (en) 2003-05-21 2007-03-20 Dexcom, Inc. Porous membranes for use with implantable devices
US8527026B2 (en) 1997-03-04 2013-09-03 Dexcom, Inc. Device and method for determining analyte levels
US7885697B2 (en) 2004-07-13 2011-02-08 Dexcom, Inc. Transcutaneous analyte sensor
US6001067A (en) * 1997-03-04 1999-12-14 Shults; Mark C. Device and method for determining analyte levels
US6862465B2 (en) 1997-03-04 2005-03-01 Dexcom, Inc. Device and method for determining analyte levels
US9155496B2 (en) 1997-03-04 2015-10-13 Dexcom, Inc. Low oxygen in vivo analyte sensor
US6949816B2 (en) 2003-04-21 2005-09-27 Motorola, Inc. Semiconductor component having first surface area for electrically coupling to a semiconductor chip and second surface area for electrically coupling to a substrate, and method of manufacturing same
US6175752B1 (en) 1998-04-30 2001-01-16 Therasense, Inc. Analyte monitoring device and methods of use
US8974386B2 (en) 1998-04-30 2015-03-10 Abbott Diabetes Care Inc. Analyte monitoring device and methods of use
US8346337B2 (en) 1998-04-30 2013-01-01 Abbott Diabetes Care Inc. Analyte monitoring device and methods of use
US8465425B2 (en) 1998-04-30 2013-06-18 Abbott Diabetes Care Inc. Analyte monitoring device and methods of use
US9066695B2 (en) 1998-04-30 2015-06-30 Abbott Diabetes Care Inc. Analyte monitoring device and methods of use
US8688188B2 (en) 1998-04-30 2014-04-01 Abbott Diabetes Care Inc. Analyte monitoring device and methods of use
US8480580B2 (en) 1998-04-30 2013-07-09 Abbott Diabetes Care Inc. Analyte monitoring device and methods of use
US7470420B2 (en) * 2000-12-05 2008-12-30 The Regents Of The University Of California Optical determination of glucose utilizing boronic acid adducts
US6560471B1 (en) 2001-01-02 2003-05-06 Therasense, Inc. Analyte monitoring device and methods of use
US20030032874A1 (en) 2001-07-27 2003-02-13 Dexcom, Inc. Sensor head for use with implantable devices
US6702857B2 (en) 2001-07-27 2004-03-09 Dexcom, Inc. Membrane for use with implantable devices
US8260393B2 (en) 2003-07-25 2012-09-04 Dexcom, Inc. Systems and methods for replacing signal data artifacts in a glucose sensor data stream
US9247901B2 (en) 2003-08-22 2016-02-02 Dexcom, Inc. Systems and methods for replacing signal artifacts in a glucose sensor data stream
US9282925B2 (en) 2002-02-12 2016-03-15 Dexcom, Inc. Systems and methods for replacing signal artifacts in a glucose sensor data stream
US8010174B2 (en) 2003-08-22 2011-08-30 Dexcom, Inc. Systems and methods for replacing signal artifacts in a glucose sensor data stream
US7828728B2 (en) 2003-07-25 2010-11-09 Dexcom, Inc. Analyte sensor
US7134999B2 (en) 2003-04-04 2006-11-14 Dexcom, Inc. Optimized sensor geometry for an implantable glucose sensor
US8423113B2 (en) 2003-07-25 2013-04-16 Dexcom, Inc. Systems and methods for processing sensor data
EP1648298A4 (de) 2003-07-25 2010-01-13 Dexcom Inc Sauerstoffverbessernde membransysteme für implantierbare vorrichtungen
US8761856B2 (en) 2003-08-01 2014-06-24 Dexcom, Inc. System and methods for processing analyte sensor data
US7591801B2 (en) 2004-02-26 2009-09-22 Dexcom, Inc. Integrated delivery device for continuous glucose sensor
US8676287B2 (en) 2003-08-01 2014-03-18 Dexcom, Inc. System and methods for processing analyte sensor data
US20080119703A1 (en) 2006-10-04 2008-05-22 Mark Brister Analyte sensor
US9135402B2 (en) 2007-12-17 2015-09-15 Dexcom, Inc. Systems and methods for processing sensor data
US7276029B2 (en) 2003-08-01 2007-10-02 Dexcom, Inc. System and methods for processing analyte sensor data
US8886273B2 (en) 2003-08-01 2014-11-11 Dexcom, Inc. Analyte sensor
US20190357827A1 (en) 2003-08-01 2019-11-28 Dexcom, Inc. Analyte sensor
US8369919B2 (en) 2003-08-01 2013-02-05 Dexcom, Inc. Systems and methods for processing sensor data
US7774145B2 (en) 2003-08-01 2010-08-10 Dexcom, Inc. Transcutaneous analyte sensor
US20140121989A1 (en) 2003-08-22 2014-05-01 Dexcom, Inc. Systems and methods for processing analyte sensor data
US8233959B2 (en) 2003-08-22 2012-07-31 Dexcom, Inc. Systems and methods for processing analyte sensor data
US7920906B2 (en) 2005-03-10 2011-04-05 Dexcom, Inc. System and methods for processing analyte sensor data for sensor calibration
US9247900B2 (en) 2004-07-13 2016-02-02 Dexcom, Inc. Analyte sensor
WO2005051170A2 (en) 2003-11-19 2005-06-09 Dexcom, Inc. Integrated receiver for continuous analyte sensor
US8615282B2 (en) 2004-07-13 2013-12-24 Dexcom, Inc. Analyte sensor
US8287453B2 (en) 2003-12-05 2012-10-16 Dexcom, Inc. Analyte sensor
US8423114B2 (en) 2006-10-04 2013-04-16 Dexcom, Inc. Dual electrode system for a continuous analyte sensor
US8364231B2 (en) 2006-10-04 2013-01-29 Dexcom, Inc. Analyte sensor
US11633133B2 (en) 2003-12-05 2023-04-25 Dexcom, Inc. Dual electrode system for a continuous analyte sensor
WO2005057168A2 (en) 2003-12-05 2005-06-23 Dexcom, Inc. Calibration techniques for a continuous analyte sensor
EP3263032B1 (de) 2003-12-09 2024-01-24 Dexcom, Inc. Signalverarbeitung in einem durchgehenden analytsensor
US8808228B2 (en) 2004-02-26 2014-08-19 Dexcom, Inc. Integrated medicament delivery device for use with continuous analyte sensor
US8792955B2 (en) 2004-05-03 2014-07-29 Dexcom, Inc. Transcutaneous analyte sensor
US8277713B2 (en) 2004-05-03 2012-10-02 Dexcom, Inc. Implantable analyte sensor
US8452368B2 (en) 2004-07-13 2013-05-28 Dexcom, Inc. Transcutaneous analyte sensor
WO2006127694A2 (en) 2004-07-13 2006-11-30 Dexcom, Inc. Analyte sensor
US8565848B2 (en) 2004-07-13 2013-10-22 Dexcom, Inc. Transcutaneous analyte sensor
US20060016700A1 (en) 2004-07-13 2006-01-26 Dexcom, Inc. Transcutaneous analyte sensor
US7783333B2 (en) 2004-07-13 2010-08-24 Dexcom, Inc. Transcutaneous medical device with variable stiffness
US8133178B2 (en) 2006-02-22 2012-03-13 Dexcom, Inc. Analyte sensor
US8744546B2 (en) 2005-05-05 2014-06-03 Dexcom, Inc. Cellulosic-based resistance domain for an analyte sensor
US8060174B2 (en) 2005-04-15 2011-11-15 Dexcom, Inc. Analyte sensing biointerface
US9757061B2 (en) 2006-01-17 2017-09-12 Dexcom, Inc. Low oxygen in vivo analyte sensor
US7831287B2 (en) 2006-10-04 2010-11-09 Dexcom, Inc. Dual electrode system for a continuous analyte sensor
US7751863B2 (en) 2007-02-06 2010-07-06 Glumetrics, Inc. Optical determination of ph and glucose
US8838195B2 (en) 2007-02-06 2014-09-16 Medtronic Minimed, Inc. Optical systems and methods for ratiometric measurement of blood glucose concentration
CA2684511A1 (en) 2007-05-01 2008-11-13 Glumetrics, Inc. Pyridinium boronic acid quenchers for use in analyte sensors
WO2008141243A2 (en) * 2007-05-10 2008-11-20 Glumetrics, Inc. Device and methods for calibrating analyte sensors
EP2162057A1 (de) * 2007-05-10 2010-03-17 Glumetrics, Inc. Verschleissbeständiger gleichgewichtsfluoreszenzsensor für intravaskuläre echtzeit-glukosemessung
US20080306434A1 (en) 2007-06-08 2008-12-11 Dexcom, Inc. Integrated medicament delivery device for use with continuous analyte sensor
EP3078714A1 (de) * 2007-08-06 2016-10-12 Medtronic Minimed, Inc. Polymerisierbare, fluoreszente hpts-mono- und -bis-cys-ma-farbstoffe zur verwendung in analytsensoren
EP4159114B1 (de) 2007-10-09 2024-04-10 DexCom, Inc. Integriertes insulin-abgabesystem mit kontinuierlichem glucosesensor
US8417312B2 (en) 2007-10-25 2013-04-09 Dexcom, Inc. Systems and methods for processing sensor data
EP2217316A4 (de) 2007-11-21 2013-01-16 Glumetrics Inc Verwendung eines intravaskulären equilibrium-sensors für enge glykämische kontrolle
US8290559B2 (en) 2007-12-17 2012-10-16 Dexcom, Inc. Systems and methods for processing sensor data
CA2715624A1 (en) * 2008-02-20 2009-08-27 Dexcom, Inc. Continuous medicament sensor system for in vivo use
US11730407B2 (en) 2008-03-28 2023-08-22 Dexcom, Inc. Polymer membranes for continuous analyte sensors
US8583204B2 (en) 2008-03-28 2013-11-12 Dexcom, Inc. Polymer membranes for continuous analyte sensors
US8682408B2 (en) 2008-03-28 2014-03-25 Dexcom, Inc. Polymer membranes for continuous analyte sensors
WO2009129186A2 (en) * 2008-04-17 2009-10-22 Glumetrics, Inc. Sensor for percutaneous intravascular deployment without an indwelling cannula
WO2010005398A1 (en) * 2008-07-09 2010-01-14 Agency For Science, Technology And Research Trapping glucose probe in pores of polymer
WO2010033724A2 (en) 2008-09-19 2010-03-25 Dexcom, Inc. Particle-containing membrane and particulate electrode for analyte sensors
WO2010111660A1 (en) 2009-03-27 2010-09-30 Dexcom, Inc. Methods and systems for promoting glucose management
EP2438152A4 (de) * 2009-06-05 2012-12-12 Glumetrics Inc Algorithmen zur kalibrierung eines analytsensors
EP2483679A4 (de) 2009-09-30 2013-04-24 Glumetrics Inc Sensoren mit thrombenresistenter beschichtung
US8467843B2 (en) 2009-11-04 2013-06-18 Glumetrics, Inc. Optical sensor configuration for ratiometric correction of blood glucose measurement
JP2013519101A (ja) 2010-02-08 2013-05-23 グルメトリクス, インコーポレイテッド 化学センサーの抗酸化剤保護
US8473222B2 (en) * 2010-03-11 2013-06-25 Glumetrics, Inc. Measurement devices and methods for measuring analyte concentration incorporating temperature and pH correction
ES2847578T3 (es) 2011-04-15 2021-08-03 Dexcom Inc Calibración avanzada de sensor de analito y detección de errores
KR101952468B1 (ko) * 2011-04-18 2019-02-26 노비오센스 비.브이. 할로우 코일에 기반한 전기화학적 바이오센서
CA2857493C (en) 2011-07-15 2019-06-11 Glumetrics, Inc. Combinations of fluorphores and pyridinium boronic acid quenchers for use in analyte sensors
DK2760432T3 (da) 2011-09-27 2019-06-11 Medtronic Minimed Inc Fremgangsmåde til funktionalisering af en porøs membranafdækning på en optisk sensor til fremme af kobling af et antitrombogent middel
CN108852368B (zh) 2013-03-14 2024-01-12 普罗菲尤萨股份有限公司 氧传感器
CN105820810B (zh) * 2016-04-27 2018-03-30 中南大学 一种识别半胱氨酸和同型半胱氨酸新型荧光探针的合成与应用
CN115505280A (zh) 2016-12-21 2022-12-23 普罗菲尤萨股份有限公司 可聚合的近红外染料
JOP20190161A1 (ar) 2016-12-27 2017-06-16 Profusa Inc مستشعرات جلوكوز بطيف قريب من الأشعة تحت الحمراء
WO2019083939A1 (en) 2017-10-24 2019-05-02 Dexcom, Inc. PRECONNECTED ANALYTE SENSORS
US11331022B2 (en) 2017-10-24 2022-05-17 Dexcom, Inc. Pre-connected analyte sensors
CN112601491B (zh) 2018-06-27 2025-08-19 普罗菲尤萨股份有限公司 近红外葡萄糖传感器
WO2025134799A1 (ja) * 2023-12-19 2025-06-26 富士フイルム株式会社 樹脂組成物、膜、光学フィルタ、固体撮像素子および画像表示装置

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5512246A (en) 1989-09-21 1996-04-30 Anthony P. Russell Method and means for detecting polyhydroxyl compounds
US5137833A (en) 1989-09-21 1992-08-11 Russell Anthony P Method for detecting polyhydroxyl compounds
GB2284809B (en) 1993-11-07 1998-04-29 Japan Res Dev Corp A fluorescent phenylboronic acid suitable for use in the detection of saccharides
JP2799837B2 (ja) 1995-03-03 1998-09-21 科学技術振興事業団 ビナフチル基を有するボロン酸化合物
US6002954A (en) 1995-11-22 1999-12-14 The Regents Of The University Of California Detection of biological molecules using boronate-based chemical amplification and optical sensors
EP0862648B1 (de) 1995-11-22 2004-10-06 Medtronic MiniMed, Inc. Detektion von biologischen molekülen unter verwendung von chemischer amplifikation und optischem sensor
US6766183B2 (en) 1995-11-22 2004-07-20 Medtronic Minimed, Inc. Long wave fluorophore sensor compounds and other fluorescent sensor compounds in polymers
EP2292626B1 (de) 2000-08-04 2014-05-21 Senseonics, Incorporated Nachweis von Analyten in wässrigen Medien
US6627177B2 (en) 2000-12-05 2003-09-30 The Regents Of The University Of California Polyhydroxyl-substituted organic molecule sensing optical in vivo method utilizing a boronic acid adduct and the device thereof
US6653141B2 (en) 2000-12-05 2003-11-25 The Regents Of The University Of California Polyhydroxyl-substituted organic molecule sensing method and device
US7470420B2 (en) 2000-12-05 2008-12-30 The Regents Of The University Of California Optical determination of glucose utilizing boronic acid adducts
US6800451B2 (en) 2001-01-05 2004-10-05 Sensors For Medicine And Science, Inc. Detection of glucose in solutions also containing an alpha-hydroxy acid or a beta-diketone

Also Published As

Publication number Publication date
EP2054476B1 (de) 2011-06-29
JP5159778B2 (ja) 2013-03-13
CA2652025A1 (en) 2008-01-31
EP2054476A2 (de) 2009-05-06
US7767846B2 (en) 2010-08-03
JP2009544729A (ja) 2009-12-17
US20080027245A1 (en) 2008-01-31
EP2054476B9 (de) 2012-03-14
WO2008014280A3 (en) 2008-09-18
AU2007276777A1 (en) 2008-01-31
US20080305506A1 (en) 2008-12-11
WO2008014280A2 (en) 2008-01-31
US7417164B2 (en) 2008-08-26

Similar Documents

Publication Publication Date Title
ATE514755T1 (de) Fluoreszenzfarbstoffe zur verwendung bei der glukoseerfassung
TW200622950A (en) Methods of monitoring the concentration of an analyte
WO2009073201A3 (en) Alternate labeling strategies for single molecule sequencing
DE602008006382D1 (de) Pyridin-boronsäure-quencher zur verwendung in analytsensoren
EA200702643A1 (ru) Антитела, связывающие tweak
ATE497984T1 (de) Dimercaptanterminierte polythioetherpolymere und verfahren zu ihrer herstellung und verwendung
HUE042561T2 (hu) Anti-IL-23-ellenanyagok, készítmények, eljárások és alkalmazások
NL1034464A1 (nl) Raman-en fotoluminescentiespectroscopie.
ATE375518T1 (de) Diagnoseverfahren für erkrankungen unter verwendung von copeptin
ATE512366T1 (de) Ms-verfahren zur evaluierung von glycanen
CO6241120A2 (es) (DIHIDRO)PIRROLO[2,1-á]ISOQUINOLINAS.
WO2008017074A3 (en) Dyes and precursors and conjugates thereof
EP1903334A4 (de) Biosensor
ATE500503T1 (de) Cd86- und cd80-rezeptorkonkurrenztests
ATE504836T1 (de) Verfahren zur identifizierung von trpv2- modulatoren
DK2118666T3 (da) Fremgangsmåde til normalisering af koncentrationen af analytter i en urinprøve
EP1909098A4 (de) Biosensor
ATE495243T1 (de) Verfahren zur herstellung von hochempfindlichen endonukleasen, neuartige zubereitungen von nukleasen und ihre verwendung
ATE456666T1 (de) Verfahren zur auswertung von ribonukleotidsequenzen
DE602006010400D1 (de) Olanzapin-analoga und verfahren zu ihrer verwendung
DE602006009980D1 (de) Biosensor
DE602006018708D1 (de) Polymer, vernetztes polymer, zusammensetzung für elektrolyt und klebstoffzusammensetzung
ATE507222T1 (de) 1,1-dioxo-thiomorpholinyl-indolyl-methanon- derivate zur verwendung als h3-modulatoren
WO2010062499A3 (en) Anthraquinone based near ir emitting compounds and uses thereof
NO20091386L (no) Fenyloksyanilinderivater

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties