ATE445158T1 - Toxizitätstypisierung unter verwendung von leberstammzellen - Google Patents
Toxizitätstypisierung unter verwendung von leberstammzellenInfo
- Publication number
- ATE445158T1 ATE445158T1 AT01946391T AT01946391T ATE445158T1 AT E445158 T1 ATE445158 T1 AT E445158T1 AT 01946391 T AT01946391 T AT 01946391T AT 01946391 T AT01946391 T AT 01946391T AT E445158 T1 ATE445158 T1 AT E445158T1
- Authority
- AT
- Austria
- Prior art keywords
- toxicity
- stem cells
- chemical compositions
- typing
- liver stem
- Prior art date
Links
- 230000001988 toxicity Effects 0.000 title abstract 5
- 231100000419 toxicity Toxicity 0.000 title abstract 5
- 210000004185 liver Anatomy 0.000 title 1
- 210000000130 stem cell Anatomy 0.000 title 1
- 239000000203 mixture Substances 0.000 abstract 4
- 239000000126 substance Substances 0.000 abstract 3
- 108090000623 proteins and genes Proteins 0.000 abstract 2
- 101150000157 ARHGEF1 gene Proteins 0.000 abstract 1
- 230000004075 alteration Effects 0.000 abstract 1
- 238000000506 liquid--solid chromatography Methods 0.000 abstract 1
- 101150055452 lsc gene Proteins 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 238000012216 screening Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6809—Methods for determination or identification of nucleic acids involving differential detection
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5014—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing toxicity
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Analytical Chemistry (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- General Health & Medical Sciences (AREA)
- Physics & Mathematics (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Microbiology (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Toxicology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- General Engineering & Computer Science (AREA)
- General Physics & Mathematics (AREA)
- Cell Biology (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Tropical Medicine & Parasitology (AREA)
- Pathology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
- Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US21160600P | 2000-06-14 | 2000-06-14 | |
| PCT/US2001/019187 WO2001096866A1 (en) | 2000-06-14 | 2001-06-14 | Toxicity typing using liver stem cells |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE445158T1 true ATE445158T1 (de) | 2009-10-15 |
Family
ID=22787620
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT01946391T ATE445158T1 (de) | 2000-06-14 | 2001-06-14 | Toxizitätstypisierung unter verwendung von leberstammzellen |
Country Status (12)
| Country | Link |
|---|---|
| US (3) | US20020012905A1 (de) |
| EP (1) | EP1290444B1 (de) |
| JP (1) | JP2004503256A (de) |
| KR (1) | KR100865664B1 (de) |
| AT (1) | ATE445158T1 (de) |
| AU (1) | AU2001268449A1 (de) |
| CA (1) | CA2412361C (de) |
| DE (1) | DE60140120D1 (de) |
| DK (1) | DK1290444T3 (de) |
| ES (1) | ES2334639T3 (de) |
| HK (1) | HK1054980A1 (de) |
| WO (1) | WO2001096866A1 (de) |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7555492B2 (en) * | 1999-11-05 | 2009-06-30 | The Board Of Trustees At The Leland Stanford Junior University | System and method for internet-accessible tools and knowledge base for protocol design, metadata capture and laboratory experiment management |
| HK1054980A1 (zh) | 2000-06-14 | 2003-12-19 | Vistagen, Inc. | 利用肝脏干细胞进行毒性分型 |
| US20050060102A1 (en) * | 2000-10-12 | 2005-03-17 | O'reilly David J. | Interactive correlation of compound information and genomic information |
| JP2005535285A (ja) * | 2002-01-31 | 2005-11-24 | ジーン ロジック インコーポレイテッド | 分子肝毒性モデリング |
| EP1578393A4 (de) * | 2002-02-04 | 2008-03-19 | Gene Logic Inc | Primäre ratten-hepatozyten-toxizitätsmodellierung |
| AU2003241418A1 (en) * | 2002-05-10 | 2003-11-11 | Phase-1 Molecular Toxicology, Inc. | Liver inflammation predictive genes |
| WO2004097585A2 (en) * | 2003-04-24 | 2004-11-11 | Stanford University | System and method for internet-accessible tools and knowledge base for protocol design, metadata capture and laboratory experiment management |
| EP1654536A4 (de) * | 2003-08-07 | 2008-07-30 | Ocimum Biosolutions Inc | Primäre ratten-hepatozyten-toxizitätsmodellierung |
| EP1697873A4 (de) * | 2003-11-24 | 2008-01-23 | Gene Logic Inc | Verfahren zur modellierung molekularer toxikologie |
| JPWO2005078070A1 (ja) * | 2004-02-13 | 2007-10-18 | 株式会社リプロセル | 胚性幹細胞用フィーダー細胞作成培地およびフィーダー細胞 |
| US20060035250A1 (en) * | 2004-06-10 | 2006-02-16 | Georges Natsoulis | Necessary and sufficient reagent sets for chemogenomic analysis |
| US7588892B2 (en) * | 2004-07-19 | 2009-09-15 | Entelos, Inc. | Reagent sets and gene signatures for renal tubule injury |
| US20060040338A1 (en) * | 2004-08-18 | 2006-02-23 | Odyssey Thera, Inc. | Pharmacological profiling of drugs with cell-based assays |
| US20060094059A1 (en) * | 2004-09-22 | 2006-05-04 | Odyssey Thera, Inc. | Methods for identifying new drug leads and new therapeutic uses for known drugs |
| WO2006077981A1 (ja) * | 2005-01-21 | 2006-07-27 | Miyazaki Prefecture | 高スループット機能性評価方法、プログラム、及び装置 |
| JP4721752B2 (ja) * | 2005-04-06 | 2011-07-13 | 独立行政法人科学技術振興機構 | 妊娠状態における薬物代謝予測法 |
| US7795390B2 (en) | 2005-06-24 | 2010-09-14 | Teijin Pharma Limited | Biological substance nesfatin and its related substances and uses thereof |
| US7983855B2 (en) | 2005-09-20 | 2011-07-19 | Micro Motion, Inc. | Meter electronics and methods for generating a drive signal for a vibratory flowmeter |
| US20070198653A1 (en) * | 2005-12-30 | 2007-08-23 | Kurt Jarnagin | Systems and methods for remote computer-based analysis of user-provided chemogenomic data |
| ATE459701T1 (de) * | 2005-12-30 | 2010-03-15 | Drugmode Aps | Bioreaktor für die zell- und gewebekultur |
| US20100021885A1 (en) * | 2006-09-18 | 2010-01-28 | Mark Fielden | Reagent sets and gene signatures for non-genotoxic hepatocarcinogenicity |
| AU2007304423A1 (en) * | 2006-10-02 | 2008-04-10 | Cellartis Ab | Novel toxicity assay based on human blastocyst-derived stem cells and progenitor cells |
| US8426807B2 (en) * | 2008-08-01 | 2013-04-23 | Brown University | System and methods for determining molecules using mass spectrometry and related techniques |
| GB201103828D0 (en) * | 2011-03-07 | 2011-04-20 | Dundee Cell Products Ltd | Evaluation of therapeutic agent |
| JP5820320B2 (ja) * | 2012-03-27 | 2015-11-24 | 株式会社東芝 | 情報処理端末及び方法、並びに、情報管理装置及び方法 |
| US20170273611A1 (en) * | 2014-08-22 | 2017-09-28 | The General Hospital Corporation | Systems and methods for discovery and characterization of neuroactive drugs |
| WO2016183231A1 (en) | 2015-05-12 | 2016-11-17 | Baker Group, LLP | Method and system for a bioartificial organ |
| US10303757B2 (en) | 2016-08-19 | 2019-05-28 | Cognex Corporation | Apparatuses, systems, and methods for providing a visual program for machine vision systems |
| KR102083408B1 (ko) * | 2017-04-28 | 2020-03-02 | 가천대학교 산학협력단 | 줄기세포 기반의 독성 물질 스크리닝 방법 |
| CN111549112A (zh) * | 2020-04-02 | 2020-08-18 | 中国农业大学 | 一种丙烯酰胺暴露检测的标志物及其应用 |
Family Cites Families (73)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CS191501B1 (en) * | 1976-04-02 | 1979-07-31 | Richard Jelinek | Method of testing the embryotoxicity on the chicken embryo |
| US4973493A (en) * | 1982-09-29 | 1990-11-27 | Bio-Metric Systems, Inc. | Method of improving the biocompatibility of solid surfaces |
| US5328695A (en) * | 1983-03-22 | 1994-07-12 | Massachusetts Institute Of Technology | Muscle morphogenic protein and use thereof |
| US5200313A (en) * | 1983-08-05 | 1993-04-06 | Miles Inc. | Nucleic acid hybridization assay employing detectable anti-hybrid antibodies |
| US4569774A (en) * | 1984-11-13 | 1986-02-11 | Mobil Oil Corporation | Polyglycol lubricants comprising trifluoromethane sulfonate |
| US5202231A (en) * | 1987-04-01 | 1993-04-13 | Drmanac Radoje T | Method of sequencing of genomes by hybridization of oligonucleotide probes |
| US6270961B1 (en) * | 1987-04-01 | 2001-08-07 | Hyseq, Inc. | Methods and apparatus for DNA sequencing and DNA identification |
| PT87133B (pt) * | 1987-04-02 | 1992-07-31 | Amrad Corp Ltd | Metodo de purificacao do factor inibidor da leucemia (lif) e de composicoes farmaceuticas contendo polipeptidos com actividade do lif |
| US5506131A (en) * | 1987-06-05 | 1996-04-09 | The United States Of America As Represented By The Department Of Health And Human Services | Immortalized human cell lines containing exogenous cytochrome P450 genes |
| GB8810400D0 (en) | 1988-05-03 | 1988-06-08 | Southern E | Analysing polynucleotide sequences |
| US5002867A (en) * | 1988-04-25 | 1991-03-26 | Macevicz Stephen C | Nucleic acid sequence determination by multiple mixed oligonucleotide probes |
| US5166065A (en) * | 1988-08-04 | 1992-11-24 | Amrad Corporation Limited | In vitro propagation of embryonic stem cells |
| SE463386B (sv) | 1989-03-17 | 1990-11-12 | Nilas Tore Nilsson | Anordning foer bildvisning |
| US6040138A (en) | 1995-09-15 | 2000-03-21 | Affymetrix, Inc. | Expression monitoring by hybridization to high density oligonucleotide arrays |
| AU8868091A (en) * | 1990-10-17 | 1992-05-20 | Jack Love | Identification and paternity determination by detecting presence or absence of multiple nucleic acid sequences |
| US5486359A (en) * | 1990-11-16 | 1996-01-23 | Osiris Therapeutics, Inc. | Human mesenchymal stem cells |
| US5197985A (en) * | 1990-11-16 | 1993-03-30 | Caplan Arnold I | Method for enhancing the implantation and differentiation of marrow-derived mesenchymal cells |
| WO1992010588A1 (en) | 1990-12-06 | 1992-06-25 | Affymax Technologies N.V. | Sequencing by hybridization of a target nucleic acid to a matrix of defined oligonucleotides |
| JPH06319535A (ja) | 1991-04-12 | 1994-11-22 | Bio Material Kenkyusho:Kk | 株化肝細胞 |
| US6069005A (en) * | 1991-08-07 | 2000-05-30 | Albert Einstein College Of Medicine Of Yeshwa University | Hapatoblasts and method of isolating same |
| JPH07501206A (ja) * | 1991-08-07 | 1995-02-09 | イェシバ・ユニバーシティ | 前駆肝細胞の増殖 |
| EP1382386A3 (de) | 1992-02-19 | 2004-12-01 | The Public Health Research Institute Of The City Of New York, Inc. | Neue Ordnungen für Oligonukleotide und ihr Nutzen zum Sortieren, Isolieren, Sequenzierung und Manipulieren von Nukleinsäuren |
| JPH08503600A (ja) * | 1992-05-29 | 1996-04-23 | アボツト・ラボラトリーズ | Rna配列で開始させるリガーゼ連鎖反応 |
| WO1994000484A1 (en) * | 1992-06-22 | 1994-01-06 | Young Henry E | Scar inhibitory factor and use thereof |
| US5453357A (en) * | 1992-10-08 | 1995-09-26 | Vanderbilt University | Pluripotential embryonic stem cells and methods of making same |
| US5690926A (en) * | 1992-10-08 | 1997-11-25 | Vanderbilt University | Pluripotential embryonic cells and methods of making same |
| JP3789930B2 (ja) * | 1992-10-09 | 2006-06-28 | アドバンスド ティシュー サイエンシズ,インコーポレーテッド | 肝予備細胞 |
| AU692434B2 (en) * | 1993-01-21 | 1998-06-11 | President And Fellows Of Harvard College | Methods and diagnostic kits utilizing mammalian stress promoters to determine toxicity of a compound |
| US6027880A (en) * | 1995-08-02 | 2000-02-22 | Affymetrix, Inc. | Arrays of nucleic acid probes and methods of using the same for detecting cystic fibrosis |
| US5459037A (en) * | 1993-11-12 | 1995-10-17 | The Scripps Research Institute | Method for simultaneous identification of differentially expressed mRNAs and measurement of relative concentrations |
| US5773213A (en) * | 1994-06-06 | 1998-06-30 | Brigham & Women's Hospital | Method for conducting sequential nucleic acid hybridization steps |
| RU2111254C1 (ru) * | 1994-07-11 | 1998-05-20 | Институт молекулярной биологии им.В.А.Энгельгардта РАН | СПОСОБ ДЕТЕКЦИИ ДИФФЕРЕНЦИАЛЬНО ЭКСПРЕССИРУЮЩИХСЯ МАТРИЧНЫХ РНК И КЛОНИРОВАНИЯ СООТВЕТСТВУЮЩИХ ИМ ФРАГМЕНТОВ кДНК |
| WO1997027317A1 (en) | 1996-01-23 | 1997-07-31 | Affymetrix, Inc. | Nucleic acid analysis techniques |
| US5914268A (en) | 1994-11-21 | 1999-06-22 | National Jewish Center For Immunology & Respiratory Medicine | Embryonic cell populations and methods to isolate such populations |
| US5830645A (en) | 1994-12-09 | 1998-11-03 | The Regents Of The University Of California | Comparative fluorescence hybridization to nucleic acid arrays |
| US5843780A (en) | 1995-01-20 | 1998-12-01 | Wisconsin Alumni Research Foundation | Primate embryonic stem cells |
| US5736396A (en) * | 1995-01-24 | 1998-04-07 | Case Western Reserve University | Lineage-directed induction of human mesenchymal stem cell differentiation |
| US5705365A (en) * | 1995-06-07 | 1998-01-06 | Gen-Probe Incorporated | Kits for determining pre-amplification levels of a nucleic acid target sequence from post-amplification levels of product |
| US5861313A (en) * | 1995-06-07 | 1999-01-19 | Ontogeny, Inc. | Method of isolating bile duct progenitor cells |
| DE19525285C2 (de) * | 1995-06-28 | 1999-04-15 | Inst Pflanzengenetik & Kultur | In vitro Testverfahren zum Nachweis Chemikalien-induzierter embryotoxischer/teratogener Effekte |
| WO1997013877A1 (en) * | 1995-10-12 | 1997-04-17 | Lynx Therapeutics, Inc. | Measurement of gene expression profiles in toxicity determination |
| US5972693A (en) | 1995-10-24 | 1999-10-26 | Curagen Corporation | Apparatus for identifying, classifying, or quantifying DNA sequences in a sample without sequencing |
| US5736332A (en) * | 1995-11-30 | 1998-04-07 | Mandecki; Wlodek | Method of determining the sequence of nucleic acids employing solid-phase particles carrying transponders |
| US6156502A (en) | 1995-12-21 | 2000-12-05 | Beattie; Kenneth Loren | Arbitrary sequence oligonucleotide fingerprinting |
| EP2573101B1 (de) | 1996-02-09 | 2016-04-20 | Cornell Research Foundation, Inc. | Erkennung von Nukleinsäurensequenz-Unterschieden mittels der Ligaseerkennungsreaktion mit adressierbaren Arrays |
| DE19606207A1 (de) * | 1996-02-21 | 1997-08-28 | Univ Duesseldorf H Heine | Verfahren zur Bestimmung der Phototoxizität und/oder Photosensibilität von Stoffen oder Stoffgemischen sowie dessen Verwendung |
| US5811297A (en) * | 1996-03-07 | 1998-09-22 | Amba Biosciences, Llc | Immortalized hematopoietic cell lines, cell system thereof with stromal cells, in vitro, ex vivo and in vivo uses, & in vitro generation of dendritic cells and macrophages |
| WO1997046313A1 (en) | 1996-06-07 | 1997-12-11 | Eos Biotechnology, Inc. | Immobilised linear oligonucleotide arrays |
| AU3392697A (en) | 1996-06-14 | 1998-01-07 | Regents Of The University Of California, The | (in vitro) derivation and culture of primate pluripotent stem cells and therapeutic uses thereof |
| US5800690A (en) * | 1996-07-03 | 1998-09-01 | Caliper Technologies Corporation | Variable control of electroosmotic and/or electrophoretic forces within a fluid-containing structure via electrical forces |
| US5827740A (en) * | 1996-07-30 | 1998-10-27 | Osiris Therapeutics, Inc. | Adipogenic differentiation of human mesenchymal stem cells |
| IL128348A (en) | 1996-08-19 | 2008-08-07 | Univ Massachusetts | Method of producing embryonic or stem like cell lines by transplantation of cell nuclei from animal or mammal, such cells and uses thereof |
| US6329140B1 (en) | 1996-09-19 | 2001-12-11 | Affymetrix, Inc. | Identification of molecular sequence signatures and methods involving the same |
| JPH10179150A (ja) | 1996-10-22 | 1998-07-07 | Sumitomo Bakelite Co Ltd | 肝細胞培養方法及び薬物代謝能測定方法 |
| US6133436A (en) * | 1996-11-06 | 2000-10-17 | Sequenom, Inc. | Beads bound to a solid support and to nucleic acids |
| US6060240A (en) | 1996-12-13 | 2000-05-09 | Arcaris, Inc. | Methods for measuring relative amounts of nucleic acids in a complex mixture and retrieval of specific sequences therefrom |
| AU9200298A (en) | 1997-08-22 | 1999-03-16 | Yale University | A process to study changes in gene expression in stem cells |
| US6033860A (en) * | 1997-10-31 | 2000-03-07 | Affymetrix, Inc. | Expression profiles in adult and fetal organs |
| CA2310621A1 (en) * | 1997-11-20 | 1999-06-03 | Smithkline Beecham Corporation | Methods for identifying the toxic/pathologic effect of environmental stimuli on gene transcription |
| ATE295899T1 (de) * | 1998-02-23 | 2005-06-15 | Phylonix Pharmaceuticals Inc | Screeningverfahren für die aktivität von agenzien unter verwendung von teleosten |
| ATE347102T1 (de) * | 1998-02-25 | 2006-12-15 | Us Health | Zellulare anordnungen für schnelle molekulare profilidentifizierung |
| US20020142976A1 (en) * | 1998-04-27 | 2002-10-03 | Icos Corporation | Materials and methods for modulating differentiation |
| US6129911A (en) | 1998-07-10 | 2000-10-10 | Rhode Island Hospital, A Lifespan Partner | Liver stem cell |
| US6406921B1 (en) * | 1998-07-14 | 2002-06-18 | Zyomyx, Incorporated | Protein arrays for high-throughput screening |
| WO2000018960A2 (en) * | 1998-09-25 | 2000-04-06 | Massachusetts Institute Of Technology | Methods and products related to genotyping and dna analysis |
| WO2000029002A2 (en) | 1998-11-13 | 2000-05-25 | Osiris Therapeutics, Inc. | In utero transplantation of human mesenchymal stem cells |
| AU778844B2 (en) * | 1998-12-09 | 2004-12-23 | Vistagen, Inc. | Toxicity typing using embryoid bodies |
| US7456017B2 (en) * | 1999-10-01 | 2008-11-25 | University Of North Carolina At Chapel Hill | Processes for clonal growth of hepatic progenitor cells |
| CA2392615A1 (en) * | 1999-12-06 | 2001-06-07 | The General Hospital Corporation | Pancreatic stem cells and their use in transplantation |
| US6458589B1 (en) * | 2000-04-27 | 2002-10-01 | Geron Corporation | Hepatocyte lineage cells derived from pluripotent stem cells |
| KR20030009531A (ko) | 2000-06-14 | 2003-01-29 | 비스타겐 인코포레이티드 | 중간엽 줄기 세포를 사용하는 독성 타이핑 |
| HK1054980A1 (zh) | 2000-06-14 | 2003-12-19 | Vistagen, Inc. | 利用肝脏干细胞进行毒性分型 |
| US20070111257A1 (en) * | 2005-07-07 | 2007-05-17 | Kohne David E | Improved protein expression comparison assay results and applications |
-
2001
- 2001-06-14 HK HK03106524.9A patent/HK1054980A1/zh unknown
- 2001-06-14 JP JP2002510944A patent/JP2004503256A/ja active Pending
- 2001-06-14 EP EP01946391A patent/EP1290444B1/de not_active Expired - Lifetime
- 2001-06-14 US US09/881,526 patent/US20020012905A1/en not_active Abandoned
- 2001-06-14 DK DK01946391.8T patent/DK1290444T3/da active
- 2001-06-14 DE DE60140120T patent/DE60140120D1/de not_active Expired - Lifetime
- 2001-06-14 AU AU2001268449A patent/AU2001268449A1/en not_active Abandoned
- 2001-06-14 ES ES01946391T patent/ES2334639T3/es not_active Expired - Lifetime
- 2001-06-14 WO PCT/US2001/019187 patent/WO2001096866A1/en not_active Ceased
- 2001-06-14 CA CA2412361A patent/CA2412361C/en not_active Expired - Fee Related
- 2001-06-14 KR KR1020027017109A patent/KR100865664B1/ko not_active Expired - Fee Related
- 2001-06-14 AT AT01946391T patent/ATE445158T1/de not_active IP Right Cessation
-
2006
- 2006-06-01 US US11/445,733 patent/US8143009B2/en not_active Expired - Fee Related
-
2012
- 2012-02-21 US US13/401,623 patent/US8512957B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| US8143009B2 (en) | 2012-03-27 |
| DE60140120D1 (de) | 2009-11-19 |
| EP1290444A1 (de) | 2003-03-12 |
| US8512957B2 (en) | 2013-08-20 |
| CA2412361C (en) | 2011-08-23 |
| US20020012905A1 (en) | 2002-01-31 |
| JP2004503256A (ja) | 2004-02-05 |
| AU2001268449A1 (en) | 2001-12-24 |
| KR100865664B1 (ko) | 2008-10-29 |
| US20120220469A1 (en) | 2012-08-30 |
| EP1290444B1 (de) | 2009-10-07 |
| WO2001096866A1 (en) | 2001-12-20 |
| US20070111195A1 (en) | 2007-05-17 |
| KR20030009532A (ko) | 2003-01-29 |
| CA2412361A1 (en) | 2001-12-20 |
| ES2334639T3 (es) | 2010-03-15 |
| DK1290444T3 (da) | 2010-01-18 |
| HK1054980A1 (zh) | 2003-12-19 |
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