DE60140120D1 - Toxizitätstypisierung unter verwendung von leberstammzellen - Google Patents
Toxizitätstypisierung unter verwendung von leberstammzellenInfo
- Publication number
- DE60140120D1 DE60140120D1 DE60140120T DE60140120T DE60140120D1 DE 60140120 D1 DE60140120 D1 DE 60140120D1 DE 60140120 T DE60140120 T DE 60140120T DE 60140120 T DE60140120 T DE 60140120T DE 60140120 D1 DE60140120 D1 DE 60140120D1
- Authority
- DE
- Germany
- Prior art keywords
- toxicity
- chemical compositions
- typing
- toxicities
- molecular profiles
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6809—Methods for determination or identification of nucleic acids involving differential detection
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5014—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing toxicity
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US21160600P | 2000-06-14 | 2000-06-14 | |
PCT/US2001/019187 WO2001096866A1 (en) | 2000-06-14 | 2001-06-14 | Toxicity typing using liver stem cells |
Publications (1)
Publication Number | Publication Date |
---|---|
DE60140120D1 true DE60140120D1 (de) | 2009-11-19 |
Family
ID=22787620
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE60140120T Expired - Lifetime DE60140120D1 (de) | 2000-06-14 | 2001-06-14 | Toxizitätstypisierung unter verwendung von leberstammzellen |
Country Status (12)
Country | Link |
---|---|
US (3) | US20020012905A1 (de) |
EP (1) | EP1290444B1 (de) |
JP (1) | JP2004503256A (de) |
KR (1) | KR100865664B1 (de) |
AT (1) | ATE445158T1 (de) |
AU (1) | AU2001268449A1 (de) |
CA (1) | CA2412361C (de) |
DE (1) | DE60140120D1 (de) |
DK (1) | DK1290444T3 (de) |
ES (1) | ES2334639T3 (de) |
HK (1) | HK1054980A1 (de) |
WO (1) | WO2001096866A1 (de) |
Families Citing this family (30)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7555492B2 (en) * | 1999-11-05 | 2009-06-30 | The Board Of Trustees At The Leland Stanford Junior University | System and method for internet-accessible tools and knowledge base for protocol design, metadata capture and laboratory experiment management |
WO2001096866A1 (en) | 2000-06-14 | 2001-12-20 | Vistagen, Inc. | Toxicity typing using liver stem cells |
US20050060102A1 (en) * | 2000-10-12 | 2005-03-17 | O'reilly David J. | Interactive correlation of compound information and genomic information |
CA2471661A1 (en) * | 2002-01-31 | 2003-08-07 | Gene Logic, Inc. | Molecular hepatotoxicology modeling |
EP1578393A4 (de) * | 2002-02-04 | 2008-03-19 | Gene Logic Inc | Primäre ratten-hepatozyten-toxizitätsmodellierung |
US20040067507A1 (en) * | 2002-05-10 | 2004-04-08 | Nolan Timothy D. | Liver inflammation predictive genes |
WO2004097585A2 (en) * | 2003-04-24 | 2004-11-11 | Stanford University | System and method for internet-accessible tools and knowledge base for protocol design, metadata capture and laboratory experiment management |
CA2533922A1 (en) * | 2003-08-07 | 2005-02-17 | Gene Logic, Inc. | Primary rat hepatocyte toxicity modeling |
EP1697873A4 (de) * | 2003-11-24 | 2008-01-23 | Gene Logic Inc | Verfahren zur modellierung molekularer toxikologie |
CN1914313A (zh) * | 2004-02-13 | 2007-02-14 | 旭科技玻璃股份有限公司 | 胚胎干细胞用喂食细胞培育培养基及喂食细胞 |
WO2005124650A2 (en) * | 2004-06-10 | 2005-12-29 | Iconix Pharmaceuticals, Inc. | Sufficient and necessary reagent sets for chemogenomic analysis |
US7588892B2 (en) * | 2004-07-19 | 2009-09-15 | Entelos, Inc. | Reagent sets and gene signatures for renal tubule injury |
US20060040338A1 (en) * | 2004-08-18 | 2006-02-23 | Odyssey Thera, Inc. | Pharmacological profiling of drugs with cell-based assays |
US20060094059A1 (en) * | 2004-09-22 | 2006-05-04 | Odyssey Thera, Inc. | Methods for identifying new drug leads and new therapeutic uses for known drugs |
WO2006077981A1 (ja) * | 2005-01-21 | 2006-07-27 | Miyazaki Prefecture | 高スループット機能性評価方法、プログラム、及び装置 |
JP4721752B2 (ja) * | 2005-04-06 | 2011-07-13 | 独立行政法人科学技術振興機構 | 妊娠状態における薬物代謝予測法 |
US7795390B2 (en) | 2005-06-24 | 2010-09-14 | Teijin Pharma Limited | Biological substance nesfatin and its related substances and uses thereof |
KR20120005558A (ko) | 2005-09-20 | 2012-01-16 | 마이크로 모우션, 인코포레이티드 | 진동 유량계에 대한 구동 신호를 생성하기 위한 방법 및 계측 전자장치 |
US20070198653A1 (en) * | 2005-12-30 | 2007-08-23 | Kurt Jarnagin | Systems and methods for remote computer-based analysis of user-provided chemogenomic data |
DK1966367T3 (da) * | 2005-12-30 | 2010-05-03 | Drugmode Aps | Bioreaktor til celle- og vævskultur |
US20100021885A1 (en) * | 2006-09-18 | 2010-01-28 | Mark Fielden | Reagent sets and gene signatures for non-genotoxic hepatocarcinogenicity |
GB2457832A (en) * | 2006-10-02 | 2009-09-02 | Cellartis Ab | Novel toxicity assay based on human blastocyst-derived stem cells and progenitor cells |
EP2342359B1 (de) * | 2008-08-01 | 2015-03-04 | Brown University | System und verfahren zur bestimmung von molekülen anhand von massenspektrometrie sowie entsprechende verfahren |
GB201103828D0 (en) * | 2011-03-07 | 2011-04-20 | Dundee Cell Products Ltd | Evaluation of therapeutic agent |
JP5820320B2 (ja) * | 2012-03-27 | 2015-11-24 | 株式会社東芝 | 情報処理端末及び方法、並びに、情報管理装置及び方法 |
US20170273611A1 (en) * | 2014-08-22 | 2017-09-28 | The General Hospital Corporation | Systems and methods for discovery and characterization of neuroactive drugs |
WO2016183231A1 (en) | 2015-05-12 | 2016-11-17 | Baker Group, LLP | Method and system for a bioartificial organ |
US10303757B2 (en) | 2016-08-19 | 2019-05-28 | Cognex Corporation | Apparatuses, systems, and methods for providing a visual program for machine vision systems |
KR102083408B1 (ko) * | 2017-04-28 | 2020-03-02 | 가천대학교 산학협력단 | 줄기세포 기반의 독성 물질 스크리닝 방법 |
CN111549112A (zh) * | 2020-04-02 | 2020-08-18 | 中国农业大学 | 一种丙烯酰胺暴露检测的标志物及其应用 |
Family Cites Families (73)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CS191501B1 (en) | 1976-04-02 | 1979-07-31 | Richard Jelinek | Method of testing the embryotoxicity on the chicken embryo |
US4973493A (en) | 1982-09-29 | 1990-11-27 | Bio-Metric Systems, Inc. | Method of improving the biocompatibility of solid surfaces |
US5328695A (en) | 1983-03-22 | 1994-07-12 | Massachusetts Institute Of Technology | Muscle morphogenic protein and use thereof |
US5200313A (en) | 1983-08-05 | 1993-04-06 | Miles Inc. | Nucleic acid hybridization assay employing detectable anti-hybrid antibodies |
US4569774A (en) | 1984-11-13 | 1986-02-11 | Mobil Oil Corporation | Polyglycol lubricants comprising trifluoromethane sulfonate |
US5202231A (en) | 1987-04-01 | 1993-04-13 | Drmanac Radoje T | Method of sequencing of genomes by hybridization of oligonucleotide probes |
US6270961B1 (en) | 1987-04-01 | 2001-08-07 | Hyseq, Inc. | Methods and apparatus for DNA sequencing and DNA identification |
PT87133B (pt) | 1987-04-02 | 1992-07-31 | Amrad Corp Ltd | Metodo de purificacao do factor inibidor da leucemia (lif) e de composicoes farmaceuticas contendo polipeptidos com actividade do lif |
US5506131A (en) | 1987-06-05 | 1996-04-09 | The United States Of America As Represented By The Department Of Health And Human Services | Immortalized human cell lines containing exogenous cytochrome P450 genes |
GB8810400D0 (en) | 1988-05-03 | 1988-06-08 | Southern E | Analysing polynucleotide sequences |
US5002867A (en) | 1988-04-25 | 1991-03-26 | Macevicz Stephen C | Nucleic acid sequence determination by multiple mixed oligonucleotide probes |
AU623922B2 (en) | 1988-08-04 | 1992-05-28 | Amrad Operations Pty. Limited | In vitro propagation of embryonic stem cells |
SE463386B (sv) | 1989-03-17 | 1990-11-12 | Nilas Tore Nilsson | Anordning foer bildvisning |
US6040138A (en) | 1995-09-15 | 2000-03-21 | Affymetrix, Inc. | Expression monitoring by hybridization to high density oligonucleotide arrays |
EP0553258A4 (en) | 1990-10-17 | 1993-09-22 | Jack D. Love | Identification and paternity determination by detecting presence or absence of multiple nucleic acid sequences |
US5486359A (en) | 1990-11-16 | 1996-01-23 | Osiris Therapeutics, Inc. | Human mesenchymal stem cells |
US5197985A (en) | 1990-11-16 | 1993-03-30 | Caplan Arnold I | Method for enhancing the implantation and differentiation of marrow-derived mesenchymal cells |
EP0562047A4 (en) | 1990-12-06 | 1995-11-02 | Affymax Tech Nv | Sequencing by hybridization of a target nucleic acid to a matrix of defined oligonucleotides |
JPH06319535A (ja) | 1991-04-12 | 1994-11-22 | Bio Material Kenkyusho:Kk | 株化肝細胞 |
WO1993003142A1 (en) | 1991-08-07 | 1993-02-18 | Albert Einstein College Of Medicine | Proliferation of hepatocyte precursors |
US6069005A (en) | 1991-08-07 | 2000-05-30 | Albert Einstein College Of Medicine Of Yeshwa University | Hapatoblasts and method of isolating same |
DE69333650T2 (de) | 1992-02-19 | 2006-01-12 | The Public Health Research Institute Of The City Of New York, Inc. | Neue anordnungn von oligonukleotiden und ihr nutzen zum sortieren, isolieren, sequenzieren und manipulieren von nukleinsäuren |
AU4387193A (en) | 1992-05-29 | 1993-12-30 | Abbott Laboratories | Ligase chain reaction starting with rna sequences |
WO1994000484A1 (en) | 1992-06-22 | 1994-01-06 | Young Henry E | Scar inhibitory factor and use thereof |
US5453357A (en) | 1992-10-08 | 1995-09-26 | Vanderbilt University | Pluripotential embryonic stem cells and methods of making same |
US5690926A (en) | 1992-10-08 | 1997-11-25 | Vanderbilt University | Pluripotential embryonic cells and methods of making same |
DK0671923T3 (da) | 1992-10-09 | 2001-08-13 | Advanced Tissue Sciences Inc | Leverreserveceller |
AU692434B2 (en) | 1993-01-21 | 1998-06-11 | President And Fellows Of Harvard College | Methods and diagnostic kits utilizing mammalian stress promoters to determine toxicity of a compound |
US6027880A (en) | 1995-08-02 | 2000-02-22 | Affymetrix, Inc. | Arrays of nucleic acid probes and methods of using the same for detecting cystic fibrosis |
US5459037A (en) | 1993-11-12 | 1995-10-17 | The Scripps Research Institute | Method for simultaneous identification of differentially expressed mRNAs and measurement of relative concentrations |
US5773213A (en) | 1994-06-06 | 1998-06-30 | Brigham & Women's Hospital | Method for conducting sequential nucleic acid hybridization steps |
RU2111254C1 (ru) | 1994-07-11 | 1998-05-20 | Институт молекулярной биологии им.В.А.Энгельгардта РАН | СПОСОБ ДЕТЕКЦИИ ДИФФЕРЕНЦИАЛЬНО ЭКСПРЕССИРУЮЩИХСЯ МАТРИЧНЫХ РНК И КЛОНИРОВАНИЯ СООТВЕТСТВУЮЩИХ ИМ ФРАГМЕНТОВ кДНК |
US5914268A (en) | 1994-11-21 | 1999-06-22 | National Jewish Center For Immunology & Respiratory Medicine | Embryonic cell populations and methods to isolate such populations |
US5830645A (en) | 1994-12-09 | 1998-11-03 | The Regents Of The University Of California | Comparative fluorescence hybridization to nucleic acid arrays |
US5843780A (en) | 1995-01-20 | 1998-12-01 | Wisconsin Alumni Research Foundation | Primate embryonic stem cells |
US5736396A (en) | 1995-01-24 | 1998-04-07 | Case Western Reserve University | Lineage-directed induction of human mesenchymal stem cell differentiation |
US5861313A (en) | 1995-06-07 | 1999-01-19 | Ontogeny, Inc. | Method of isolating bile duct progenitor cells |
US5705365A (en) | 1995-06-07 | 1998-01-06 | Gen-Probe Incorporated | Kits for determining pre-amplification levels of a nucleic acid target sequence from post-amplification levels of product |
DE19525285C2 (de) | 1995-06-28 | 1999-04-15 | Inst Pflanzengenetik & Kultur | In vitro Testverfahren zum Nachweis Chemikalien-induzierter embryotoxischer/teratogener Effekte |
WO1997013877A1 (en) * | 1995-10-12 | 1997-04-17 | Lynx Therapeutics, Inc. | Measurement of gene expression profiles in toxicity determination |
US5972693A (en) | 1995-10-24 | 1999-10-26 | Curagen Corporation | Apparatus for identifying, classifying, or quantifying DNA sequences in a sample without sequencing |
US5736332A (en) | 1995-11-30 | 1998-04-07 | Mandecki; Wlodek | Method of determining the sequence of nucleic acids employing solid-phase particles carrying transponders |
US6156502A (en) | 1995-12-21 | 2000-12-05 | Beattie; Kenneth Loren | Arbitrary sequence oligonucleotide fingerprinting |
JP2002515738A (ja) | 1996-01-23 | 2002-05-28 | アフィメトリックス,インコーポレイティド | 核酸分析法 |
AU735440B2 (en) | 1996-02-09 | 2001-07-05 | Cornell Research Foundation Inc. | Detection of nucleic acid sequence differences using the ligase detection reaction with addressable arrays |
DE19606207A1 (de) | 1996-02-21 | 1997-08-28 | Univ Duesseldorf H Heine | Verfahren zur Bestimmung der Phototoxizität und/oder Photosensibilität von Stoffen oder Stoffgemischen sowie dessen Verwendung |
US5811297A (en) | 1996-03-07 | 1998-09-22 | Amba Biosciences, Llc | Immortalized hematopoietic cell lines, cell system thereof with stromal cells, in vitro, ex vivo and in vivo uses, & in vitro generation of dendritic cells and macrophages |
WO1997046313A1 (en) | 1996-06-07 | 1997-12-11 | Eos Biotechnology, Inc. | Immobilised linear oligonucleotide arrays |
AU3392697A (en) | 1996-06-14 | 1998-01-07 | Regents Of The University Of California, The | (in vitro) derivation and culture of primate pluripotent stem cells and therapeutic uses thereof |
US5800690A (en) | 1996-07-03 | 1998-09-01 | Caliper Technologies Corporation | Variable control of electroosmotic and/or electrophoretic forces within a fluid-containing structure via electrical forces |
US5827740A (en) | 1996-07-30 | 1998-10-27 | Osiris Therapeutics, Inc. | Adipogenic differentiation of human mesenchymal stem cells |
CN1230989A (zh) | 1996-08-19 | 1999-10-06 | 马萨诸塞大学 | 通过种间核移植制备胚胎细胞或干细胞样细胞系 |
AU4495497A (en) | 1996-09-19 | 1998-04-14 | Affymetrix, Inc. | Identification of molecular sequence signatures and methods involving the same |
JPH10179150A (ja) | 1996-10-22 | 1998-07-07 | Sumitomo Bakelite Co Ltd | 肝細胞培養方法及び薬物代謝能測定方法 |
US6133436A (en) | 1996-11-06 | 2000-10-17 | Sequenom, Inc. | Beads bound to a solid support and to nucleic acids |
US6060240A (en) | 1996-12-13 | 2000-05-09 | Arcaris, Inc. | Methods for measuring relative amounts of nucleic acids in a complex mixture and retrieval of specific sequences therefrom |
AU9200298A (en) | 1997-08-22 | 1999-03-16 | Yale University | A process to study changes in gene expression in stem cells |
WO1999023254A1 (en) * | 1997-10-31 | 1999-05-14 | Affymetrix, Inc. | Expression profiles in adult and fetal organs |
CA2310621A1 (en) * | 1997-11-20 | 1999-06-03 | Smithkline Beecham Corporation | Methods for identifying the toxic/pathologic effect of environmental stimuli on gene transcription |
JP4383533B2 (ja) | 1998-02-23 | 2009-12-16 | フィロニクス ファーマシューティカルズ, インコーポレイテッド | 真骨魚類を使用する、活性についての薬剤のスクリーニング方法 |
AU756731C (en) * | 1998-02-25 | 2004-07-29 | Canton Of Basel-Stadt | Cellular arrays for rapid molecular profiling |
US20020142976A1 (en) * | 1998-04-27 | 2002-10-03 | Icos Corporation | Materials and methods for modulating differentiation |
US6129911A (en) | 1998-07-10 | 2000-10-10 | Rhode Island Hospital, A Lifespan Partner | Liver stem cell |
US6406921B1 (en) * | 1998-07-14 | 2002-06-18 | Zyomyx, Incorporated | Protein arrays for high-throughput screening |
WO2000018960A2 (en) * | 1998-09-25 | 2000-04-06 | Massachusetts Institute Of Technology | Methods and products related to genotyping and dna analysis |
EP1128836A2 (de) | 1998-11-13 | 2001-09-05 | Osiris Therapeutics, Inc. | Transplantation von menschlichen mesenchymalen stamzellen in der gebärmutter |
KR20010080722A (ko) | 1998-12-09 | 2001-08-22 | 추후제출 | 배형체를 사용한 독성 타이핑 |
US7456017B2 (en) * | 1999-10-01 | 2008-11-25 | University Of North Carolina At Chapel Hill | Processes for clonal growth of hepatic progenitor cells |
EP1257282A4 (de) * | 1999-12-06 | 2003-05-02 | Gen Hospital Corp | Pankreatische stammzellen und deren verwendung in transplantation |
US6458589B1 (en) | 2000-04-27 | 2002-10-01 | Geron Corporation | Hepatocyte lineage cells derived from pluripotent stem cells |
JP2004503255A (ja) | 2000-06-14 | 2004-02-05 | ビスタジェン インコーポレイテッド | 間葉幹細胞を使用する毒性の分類 |
WO2001096866A1 (en) | 2000-06-14 | 2001-12-20 | Vistagen, Inc. | Toxicity typing using liver stem cells |
US20070111257A1 (en) * | 2005-07-07 | 2007-05-17 | Kohne David E | Improved protein expression comparison assay results and applications |
-
2001
- 2001-06-14 WO PCT/US2001/019187 patent/WO2001096866A1/en active Application Filing
- 2001-06-14 DK DK01946391.8T patent/DK1290444T3/da active
- 2001-06-14 US US09/881,526 patent/US20020012905A1/en not_active Abandoned
- 2001-06-14 AT AT01946391T patent/ATE445158T1/de not_active IP Right Cessation
- 2001-06-14 DE DE60140120T patent/DE60140120D1/de not_active Expired - Lifetime
- 2001-06-14 ES ES01946391T patent/ES2334639T3/es not_active Expired - Lifetime
- 2001-06-14 AU AU2001268449A patent/AU2001268449A1/en not_active Abandoned
- 2001-06-14 KR KR1020027017109A patent/KR100865664B1/ko not_active IP Right Cessation
- 2001-06-14 EP EP01946391A patent/EP1290444B1/de not_active Expired - Lifetime
- 2001-06-14 CA CA2412361A patent/CA2412361C/en not_active Expired - Fee Related
- 2001-06-14 JP JP2002510944A patent/JP2004503256A/ja active Pending
-
2003
- 2003-09-11 HK HK03106524.9A patent/HK1054980A1/zh unknown
-
2006
- 2006-06-01 US US11/445,733 patent/US8143009B2/en not_active Expired - Lifetime
-
2012
- 2012-02-21 US US13/401,623 patent/US8512957B2/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
EP1290444A1 (de) | 2003-03-12 |
AU2001268449A1 (en) | 2001-12-24 |
US20020012905A1 (en) | 2002-01-31 |
EP1290444B1 (de) | 2009-10-07 |
ES2334639T3 (es) | 2010-03-15 |
ATE445158T1 (de) | 2009-10-15 |
CA2412361C (en) | 2011-08-23 |
US8143009B2 (en) | 2012-03-27 |
DK1290444T3 (da) | 2010-01-18 |
US8512957B2 (en) | 2013-08-20 |
US20120220469A1 (en) | 2012-08-30 |
KR100865664B1 (ko) | 2008-10-29 |
KR20030009532A (ko) | 2003-01-29 |
JP2004503256A (ja) | 2004-02-05 |
US20070111195A1 (en) | 2007-05-17 |
WO2001096866A1 (en) | 2001-12-20 |
HK1054980A1 (zh) | 2003-12-19 |
CA2412361A1 (en) | 2001-12-20 |
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