HK1054980A1 - 利用肝臟干細胞進行毒性分型 - Google Patents

利用肝臟干細胞進行毒性分型

Info

Publication number
HK1054980A1
HK1054980A1 HK03106524.9A HK03106524A HK1054980A1 HK 1054980 A1 HK1054980 A1 HK 1054980A1 HK 03106524 A HK03106524 A HK 03106524A HK 1054980 A1 HK1054980 A1 HK 1054980A1
Authority
HK
Hong Kong
Prior art keywords
toxicity
stem cells
chemical compositions
typing
liver stem
Prior art date
Application number
HK03106524.9A
Other languages
English (en)
Inventor
Ralph Snodgrass H
Original Assignee
Vistagen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vistagen Inc filed Critical Vistagen Inc
Publication of HK1054980A1 publication Critical patent/HK1054980A1/zh

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6809Methods for determination or identification of nucleic acids involving differential detection
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5014Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing toxicity

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Analytical Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Toxicology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pathology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
HK03106524.9A 2000-06-14 2003-09-11 利用肝臟干細胞進行毒性分型 HK1054980A1 (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US21160600P 2000-06-14 2000-06-14
PCT/US2001/019187 WO2001096866A1 (en) 2000-06-14 2001-06-14 Toxicity typing using liver stem cells

Publications (1)

Publication Number Publication Date
HK1054980A1 true HK1054980A1 (zh) 2003-12-19

Family

ID=22787620

Family Applications (1)

Application Number Title Priority Date Filing Date
HK03106524.9A HK1054980A1 (zh) 2000-06-14 2003-09-11 利用肝臟干細胞進行毒性分型

Country Status (12)

Country Link
US (3) US20020012905A1 (zh)
EP (1) EP1290444B1 (zh)
JP (1) JP2004503256A (zh)
KR (1) KR100865664B1 (zh)
AT (1) ATE445158T1 (zh)
AU (1) AU2001268449A1 (zh)
CA (1) CA2412361C (zh)
DE (1) DE60140120D1 (zh)
DK (1) DK1290444T3 (zh)
ES (1) ES2334639T3 (zh)
HK (1) HK1054980A1 (zh)
WO (1) WO2001096866A1 (zh)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7555492B2 (en) * 1999-11-05 2009-06-30 The Board Of Trustees At The Leland Stanford Junior University System and method for internet-accessible tools and knowledge base for protocol design, metadata capture and laboratory experiment management
EP1290444B1 (en) * 2000-06-14 2009-10-07 Vistagen, Inc. Toxicity typing using liver stem cells
US20050060102A1 (en) * 2000-10-12 2005-03-17 O'reilly David J. Interactive correlation of compound information and genomic information
CA2471661A1 (en) * 2002-01-31 2003-08-07 Gene Logic, Inc. Molecular hepatotoxicology modeling
EP1578393A4 (en) * 2002-02-04 2008-03-19 Gene Logic Inc MODELING THE TOXICITY OF PRIMARY RAT-BASED RAT CELLS
AU2003241418A1 (en) * 2002-05-10 2003-11-11 Phase-1 Molecular Toxicology, Inc. Liver inflammation predictive genes
WO2004097585A2 (en) * 2003-04-24 2004-11-11 Stanford University System and method for internet-accessible tools and knowledge base for protocol design, metadata capture and laboratory experiment management
JP2007501617A (ja) * 2003-08-07 2007-02-01 ジーン ロジック インコーポレイテッド 初代ラット肝細胞毒性モデリング
CA2546391A1 (en) * 2003-11-24 2005-06-09 Gene Logic, Inc. Methods for molecular toxicology modeling
CN1914313A (zh) * 2004-02-13 2007-02-14 旭科技玻璃股份有限公司 胚胎干细胞用喂食细胞培育培养基及喂食细胞
WO2005124650A2 (en) * 2004-06-10 2005-12-29 Iconix Pharmaceuticals, Inc. Sufficient and necessary reagent sets for chemogenomic analysis
US7588892B2 (en) * 2004-07-19 2009-09-15 Entelos, Inc. Reagent sets and gene signatures for renal tubule injury
US20060040338A1 (en) * 2004-08-18 2006-02-23 Odyssey Thera, Inc. Pharmacological profiling of drugs with cell-based assays
US20060094059A1 (en) * 2004-09-22 2006-05-04 Odyssey Thera, Inc. Methods for identifying new drug leads and new therapeutic uses for known drugs
WO2006077981A1 (ja) * 2005-01-21 2006-07-27 Miyazaki Prefecture 高スループット機能性評価方法、プログラム、及び装置
JP4721752B2 (ja) * 2005-04-06 2011-07-13 独立行政法人科学技術振興機構 妊娠状態における薬物代謝予測法
US7795390B2 (en) 2005-06-24 2010-09-14 Teijin Pharma Limited Biological substance nesfatin and its related substances and uses thereof
KR101206377B1 (ko) 2005-09-20 2012-11-29 마이크로 모우션, 인코포레이티드 진동 유량계에 대한 구동 신호를 생성하기 위한 방법 및 계측 전자장치
DK1966367T3 (da) * 2005-12-30 2010-05-03 Drugmode Aps Bioreaktor til celle- og vævskultur
US20070198653A1 (en) * 2005-12-30 2007-08-23 Kurt Jarnagin Systems and methods for remote computer-based analysis of user-provided chemogenomic data
US20100021885A1 (en) * 2006-09-18 2010-01-28 Mark Fielden Reagent sets and gene signatures for non-genotoxic hepatocarcinogenicity
GB2457832A (en) * 2006-10-02 2009-09-02 Cellartis Ab Novel toxicity assay based on human blastocyst-derived stem cells and progenitor cells
WO2010014235A1 (en) * 2008-08-01 2010-02-04 Brown University System and methods for determining molecules using mass spectrometry and related techniques
GB201103828D0 (en) * 2011-03-07 2011-04-20 Dundee Cell Products Ltd Evaluation of therapeutic agent
JP5820320B2 (ja) * 2012-03-27 2015-11-24 株式会社東芝 情報処理端末及び方法、並びに、情報管理装置及び方法
WO2016029211A1 (en) * 2014-08-22 2016-02-25 The General Hospital Corporation Systems and methods for discovery and characterization of neuroactive drugs
WO2016183231A1 (en) 2015-05-12 2016-11-17 Baker Group, LLP Method and system for a bioartificial organ
US10303757B2 (en) 2016-08-19 2019-05-28 Cognex Corporation Apparatuses, systems, and methods for providing a visual program for machine vision systems
KR102083408B1 (ko) * 2017-04-28 2020-03-02 가천대학교 산학협력단 줄기세포 기반의 독성 물질 스크리닝 방법
CN111549112A (zh) * 2020-04-02 2020-08-18 中国农业大学 一种丙烯酰胺暴露检测的标志物及其应用

Family Cites Families (73)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CS191501B1 (en) * 1976-04-02 1979-07-31 Richard Jelinek Method of testing the embryotoxicity on the chicken embryo
US4973493A (en) * 1982-09-29 1990-11-27 Bio-Metric Systems, Inc. Method of improving the biocompatibility of solid surfaces
US5328695A (en) * 1983-03-22 1994-07-12 Massachusetts Institute Of Technology Muscle morphogenic protein and use thereof
US5200313A (en) * 1983-08-05 1993-04-06 Miles Inc. Nucleic acid hybridization assay employing detectable anti-hybrid antibodies
US4569774A (en) * 1984-11-13 1986-02-11 Mobil Oil Corporation Polyglycol lubricants comprising trifluoromethane sulfonate
US5202231A (en) * 1987-04-01 1993-04-13 Drmanac Radoje T Method of sequencing of genomes by hybridization of oligonucleotide probes
US6270961B1 (en) * 1987-04-01 2001-08-07 Hyseq, Inc. Methods and apparatus for DNA sequencing and DNA identification
PT87133B (pt) * 1987-04-02 1992-07-31 Amrad Corp Ltd Metodo de purificacao do factor inibidor da leucemia (lif) e de composicoes farmaceuticas contendo polipeptidos com actividade do lif
US5506131A (en) * 1987-06-05 1996-04-09 The United States Of America As Represented By The Department Of Health And Human Services Immortalized human cell lines containing exogenous cytochrome P450 genes
GB8810400D0 (en) 1988-05-03 1988-06-08 Southern E Analysing polynucleotide sequences
US5002867A (en) * 1988-04-25 1991-03-26 Macevicz Stephen C Nucleic acid sequence determination by multiple mixed oligonucleotide probes
US5166065A (en) * 1988-08-04 1992-11-24 Amrad Corporation Limited In vitro propagation of embryonic stem cells
SE463386B (sv) 1989-03-17 1990-11-12 Nilas Tore Nilsson Anordning foer bildvisning
US6040138A (en) * 1995-09-15 2000-03-21 Affymetrix, Inc. Expression monitoring by hybridization to high density oligonucleotide arrays
AU8868091A (en) * 1990-10-17 1992-05-20 Jack Love Identification and paternity determination by detecting presence or absence of multiple nucleic acid sequences
US5197985A (en) * 1990-11-16 1993-03-30 Caplan Arnold I Method for enhancing the implantation and differentiation of marrow-derived mesenchymal cells
US5486359A (en) * 1990-11-16 1996-01-23 Osiris Therapeutics, Inc. Human mesenchymal stem cells
DK0834575T3 (da) 1990-12-06 2002-04-02 Affymetrix Inc A Delaware Corp Identifikation af nucleinsyrer i prøver
JPH06319535A (ja) 1991-04-12 1994-11-22 Bio Material Kenkyusho:Kk 株化肝細胞
US6069005A (en) * 1991-08-07 2000-05-30 Albert Einstein College Of Medicine Of Yeshwa University Hapatoblasts and method of isolating same
EP0597964A4 (en) * 1991-08-07 1994-11-30 Einstein Coll Med PROLIFERATION OF HEPATOCYTE PRECURSORS.
EP1382386A3 (en) 1992-02-19 2004-12-01 The Public Health Research Institute Of The City Of New York, Inc. Novel oligonucleotide arrays and their use for sorting, isolating, sequencing, and manipulating nucleic acids
EP1262560A2 (en) * 1992-05-29 2002-12-04 Abbott Laboratories Method of forming cDNA from an RNA target sequence present in a sample
AU4543193A (en) * 1992-06-22 1994-01-24 Henry E. Young Scar inhibitory factor and use thereof
US5690926A (en) * 1992-10-08 1997-11-25 Vanderbilt University Pluripotential embryonic cells and methods of making same
US5453357A (en) * 1992-10-08 1995-09-26 Vanderbilt University Pluripotential embryonic stem cells and methods of making same
DK0671923T3 (da) * 1992-10-09 2001-08-13 Advanced Tissue Sciences Inc Leverreserveceller
WO1994017208A1 (en) * 1993-01-21 1994-08-04 President And Fellows Of Harvard College Methods and diagnostic kits utilizing mammalian stress promoters to determine toxicity of a compound
US6027880A (en) * 1995-08-02 2000-02-22 Affymetrix, Inc. Arrays of nucleic acid probes and methods of using the same for detecting cystic fibrosis
US5459037A (en) * 1993-11-12 1995-10-17 The Scripps Research Institute Method for simultaneous identification of differentially expressed mRNAs and measurement of relative concentrations
US5773213A (en) * 1994-06-06 1998-06-30 Brigham & Women's Hospital Method for conducting sequential nucleic acid hybridization steps
RU2111254C1 (ru) * 1994-07-11 1998-05-20 Институт молекулярной биологии им.В.А.Энгельгардта РАН СПОСОБ ДЕТЕКЦИИ ДИФФЕРЕНЦИАЛЬНО ЭКСПРЕССИРУЮЩИХСЯ МАТРИЧНЫХ РНК И КЛОНИРОВАНИЯ СООТВЕТСТВУЮЩИХ ИМ ФРАГМЕНТОВ кДНК
WO1997027317A1 (en) 1996-01-23 1997-07-31 Affymetrix, Inc. Nucleic acid analysis techniques
US5914268A (en) 1994-11-21 1999-06-22 National Jewish Center For Immunology & Respiratory Medicine Embryonic cell populations and methods to isolate such populations
US5830645A (en) 1994-12-09 1998-11-03 The Regents Of The University Of California Comparative fluorescence hybridization to nucleic acid arrays
US5843780A (en) 1995-01-20 1998-12-01 Wisconsin Alumni Research Foundation Primate embryonic stem cells
US5736396A (en) * 1995-01-24 1998-04-07 Case Western Reserve University Lineage-directed induction of human mesenchymal stem cell differentiation
US5861313A (en) * 1995-06-07 1999-01-19 Ontogeny, Inc. Method of isolating bile duct progenitor cells
US5705365A (en) * 1995-06-07 1998-01-06 Gen-Probe Incorporated Kits for determining pre-amplification levels of a nucleic acid target sequence from post-amplification levels of product
DE19525285C2 (de) * 1995-06-28 1999-04-15 Inst Pflanzengenetik & Kultur In vitro Testverfahren zum Nachweis Chemikalien-induzierter embryotoxischer/teratogener Effekte
WO1997013877A1 (en) * 1995-10-12 1997-04-17 Lynx Therapeutics, Inc. Measurement of gene expression profiles in toxicity determination
US5972693A (en) 1995-10-24 1999-10-26 Curagen Corporation Apparatus for identifying, classifying, or quantifying DNA sequences in a sample without sequencing
US5736332A (en) * 1995-11-30 1998-04-07 Mandecki; Wlodek Method of determining the sequence of nucleic acids employing solid-phase particles carrying transponders
US6156502A (en) 1995-12-21 2000-12-05 Beattie; Kenneth Loren Arbitrary sequence oligonucleotide fingerprinting
EP2332958B1 (en) 1996-02-09 2016-04-20 Cornell Research Foundation, Inc. Detection of nucleic and sequence differences using the ligase detection reaction with addressable arrays
DE19606207A1 (de) * 1996-02-21 1997-08-28 Univ Duesseldorf H Heine Verfahren zur Bestimmung der Phototoxizität und/oder Photosensibilität von Stoffen oder Stoffgemischen sowie dessen Verwendung
US5811297A (en) * 1996-03-07 1998-09-22 Amba Biosciences, Llc Immortalized hematopoietic cell lines, cell system thereof with stromal cells, in vitro, ex vivo and in vivo uses, & in vitro generation of dendritic cells and macrophages
US6057100A (en) 1996-06-07 2000-05-02 Eos Biotechnology, Inc. Oligonucleotide arrays
AU3392697A (en) 1996-06-14 1998-01-07 Regents Of The University Of California, The (in vitro) derivation and culture of primate pluripotent stem cells and therapeutic uses thereof
US5800690A (en) * 1996-07-03 1998-09-01 Caliper Technologies Corporation Variable control of electroosmotic and/or electrophoretic forces within a fluid-containing structure via electrical forces
US5827740A (en) * 1996-07-30 1998-10-27 Osiris Therapeutics, Inc. Adipogenic differentiation of human mesenchymal stem cells
NZ334016A (en) 1996-08-19 2000-08-25 Univ Massachusetts Embryonic stem cell lines produced by cross species nuclear transplantation
CA2266745A1 (en) 1996-09-19 1998-03-26 Affymetrix, Inc. Identification of molecular sequence signatures and methods involving the same
JPH10179150A (ja) 1996-10-22 1998-07-07 Sumitomo Bakelite Co Ltd 肝細胞培養方法及び薬物代謝能測定方法
US6133436A (en) * 1996-11-06 2000-10-17 Sequenom, Inc. Beads bound to a solid support and to nucleic acids
US6060240A (en) 1996-12-13 2000-05-09 Arcaris, Inc. Methods for measuring relative amounts of nucleic acids in a complex mixture and retrieval of specific sequences therefrom
AU9200298A (en) 1997-08-22 1999-03-16 Yale University A process to study changes in gene expression in stem cells
ATE291097T1 (de) * 1997-10-31 2005-04-15 Affymetrix Inc A Delaware Corp Expressionsprofile in adulten und fötalen organen
WO1999027090A1 (en) * 1997-11-20 1999-06-03 Smithkline Beecham Corporation Methods for identifying the toxic/pathologic effect of environmental stimuli on gene transcription
JP4383533B2 (ja) * 1998-02-23 2009-12-16 フィロニクス ファーマシューティカルズ, インコーポレイテッド 真骨魚類を使用する、活性についての薬剤のスクリーニング方法
AU756731C (en) * 1998-02-25 2004-07-29 Canton Of Basel-Stadt Cellular arrays for rapid molecular profiling
US20020142976A1 (en) * 1998-04-27 2002-10-03 Icos Corporation Materials and methods for modulating differentiation
US6129911A (en) 1998-07-10 2000-10-10 Rhode Island Hospital, A Lifespan Partner Liver stem cell
US6406921B1 (en) * 1998-07-14 2002-06-18 Zyomyx, Incorporated Protein arrays for high-throughput screening
EP1056889B1 (en) * 1998-09-25 2007-06-27 Massachusetts Institute Of Technology Methods related to genotyping and dna analysis
WO2000029002A2 (en) 1998-11-13 2000-05-25 Osiris Therapeutics, Inc. In utero transplantation of human mesenchymal stem cells
JP2002531852A (ja) * 1998-12-09 2002-09-24 ビスタジェン インコーポレイテッド 胚様体を用いる毒性の分類
US7456017B2 (en) * 1999-10-01 2008-11-25 University Of North Carolina At Chapel Hill Processes for clonal growth of hepatic progenitor cells
WO2001039784A1 (en) * 1999-12-06 2001-06-07 The General Hospital Corporation Pancreatic stem cells and their use in transplantation
US6458589B1 (en) * 2000-04-27 2002-10-01 Geron Corporation Hepatocyte lineage cells derived from pluripotent stem cells
KR20030009531A (ko) * 2000-06-14 2003-01-29 비스타겐 인코포레이티드 중간엽 줄기 세포를 사용하는 독성 타이핑
EP1290444B1 (en) * 2000-06-14 2009-10-07 Vistagen, Inc. Toxicity typing using liver stem cells
EP1904845A4 (en) * 2005-07-07 2009-11-25 David E Kohne IMPROVED RESULTS AND APPLICATION OF COMPARISON EXAMPLES OF PROTEIN EXPRESSIONS

Also Published As

Publication number Publication date
US20070111195A1 (en) 2007-05-17
EP1290444A1 (en) 2003-03-12
EP1290444B1 (en) 2009-10-07
CA2412361A1 (en) 2001-12-20
ES2334639T3 (es) 2010-03-15
JP2004503256A (ja) 2004-02-05
AU2001268449A1 (en) 2001-12-24
CA2412361C (en) 2011-08-23
US20020012905A1 (en) 2002-01-31
KR100865664B1 (ko) 2008-10-29
US8512957B2 (en) 2013-08-20
DK1290444T3 (da) 2010-01-18
WO2001096866A1 (en) 2001-12-20
US20120220469A1 (en) 2012-08-30
US8143009B2 (en) 2012-03-27
DE60140120D1 (de) 2009-11-19
ATE445158T1 (de) 2009-10-15
KR20030009532A (ko) 2003-01-29

Similar Documents

Publication Publication Date Title
HK1054980A1 (zh) 利用肝臟干細胞進行毒性分型
WO2000034525A8 (en) Toxicity typing using embryoid bodies
HK1152378A1 (zh) 在稀有細胞檢測分析中用作內部功能控制的標記細胞
AU6152301A (en) Detection of nucleic acid hybridization by fluorescence polarization
WO2004029219A3 (en) Cell-based rna interference and related methods and compositions
DE69942459D1 (de) Isolierte nukleinsäuremoleküle die t-zellen induzierbare faktoren kodieren (tif), kodierte proteine und ihre anwendung
WO2003048300A3 (en) Methods of identifying cellular target molecules
WO2006012507A3 (en) Methods and compositions for risk stratification
AU5794498A (en) Releasable nonvolatile mass-label molecules
ATE419388T1 (de) Nukleinsäureanreicherung
AU2003241311A1 (en) Simple catalytic dna biosensors for ions based on color changes
WO2003087390A3 (en) Methods for detecting abnormally methylated nucleic acid in heterogeneous biological samples
MXPA03002572A (es) Secuencias de nucleotidos que intervienen en la fertilidad de los machos y metodo de su uso.
ATE336591T1 (de) Nachweisverfahren für kurze sequenzvarianten
EA200300880A1 (ru) Способ детекции нуклеотидного полиморфизма
WO2006048262A3 (en) Classification of acute myeloid leukemia
MXPA02001307A (es) Deteccion de micro-organismos.
AU1728001A (en) Oligonucleotides and assemblies thereof useful in the detection of the presence or absence of target nucleic acid sequences in a sample
DK1179183T3 (da) Fremgangsmåde til identifikation af præneoplastiske og/eller neoplastiske tilstande hos pattedyr
WO2006099537A3 (en) The use of antibody-surrogate antigen systems for detection of analytes
WO2001009384A3 (en) Serial analysis of genetic alterations
WO2004023098A3 (en) Method for detecting transferase enzymatic activity
WO2005074522A3 (en) Detection of ruminant dna via pcr
WO2005028621A3 (en) Assays with primary cells
WO2003035889A3 (en) Compositions and methods for bacteria detection