WO2001009384A3 - Serial analysis of genetic alterations - Google Patents

Serial analysis of genetic alterations Download PDF

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Publication number
WO2001009384A3
WO2001009384A3 PCT/US2000/020557 US0020557W WO0109384A3 WO 2001009384 A3 WO2001009384 A3 WO 2001009384A3 US 0020557 W US0020557 W US 0020557W WO 0109384 A3 WO0109384 A3 WO 0109384A3
Authority
WO
WIPO (PCT)
Prior art keywords
genetic alterations
serial analysis
serial
analysis
alterations
Prior art date
Application number
PCT/US2000/020557
Other languages
French (fr)
Other versions
WO2001009384A2 (en
Inventor
James E Stefano
Original Assignee
Genzyme Corp
James E Stefano
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genzyme Corp, James E Stefano filed Critical Genzyme Corp
Priority to AU63870/00A priority Critical patent/AU6387000A/en
Publication of WO2001009384A2 publication Critical patent/WO2001009384A2/en
Publication of WO2001009384A3 publication Critical patent/WO2001009384A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844—Nucleic acid amplification reactions
    • C12Q1/6853—Nucleic acid amplification reactions using modified primers or templates
    • C12Q1/6855—Ligating adaptors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6809—Methods for determination or identification of nucleic acids involving differential detection

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Analytical Chemistry (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Genetics & Genomics (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)

Abstract

Methods and compositions for the rapid detection and identification of multiple genetic alterations are provided.
PCT/US2000/020557 1999-07-29 2000-07-28 Serial analysis of genetic alterations WO2001009384A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU63870/00A AU6387000A (en) 1999-07-29 2000-07-28 Serial analysis of genetic alterations

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US14643799P 1999-07-29 1999-07-29
US60/146,437 1999-07-29

Publications (2)

Publication Number Publication Date
WO2001009384A2 WO2001009384A2 (en) 2001-02-08
WO2001009384A3 true WO2001009384A3 (en) 2001-06-07

Family

ID=22517359

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2000/020557 WO2001009384A2 (en) 1999-07-29 2000-07-28 Serial analysis of genetic alterations

Country Status (2)

Country Link
AU (1) AU6387000A (en)
WO (1) WO2001009384A2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9499863B2 (en) 2007-12-05 2016-11-22 Complete Genomics, Inc. Reducing GC bias in DNA sequencing using nucleotide analogs

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004081225A2 (en) 2003-03-07 2004-09-23 Rubicon Genomics, Inc. Amplification and analysis of whole genome and whole transcriptome libraries generated by a dna polymerization process
US8206913B1 (en) 2003-03-07 2012-06-26 Rubicon Genomics, Inc. Amplification and analysis of whole genome and whole transcriptome libraries generated by a DNA polymerization process
WO2004081183A2 (en) * 2003-03-07 2004-09-23 Rubicon Genomics, Inc. In vitro dna immortalization and whole genome amplification using libraries generated from randomly fragmented dna
EP2290106B1 (en) 2004-03-08 2018-01-03 Rubicon Genomics, Inc. Method for generating and amplifying DNA libraries for sensitive detection and analysis of DNA methylation
EP3492602A1 (en) 2005-06-15 2019-06-05 Complete Genomics, Inc. Single molecule arrays for genetic and chemical analysis
WO2007018601A1 (en) 2005-08-02 2007-02-15 Rubicon Genomics, Inc. Compositions and methods for processing and amplification of dna, including using multiple enzymes in a single reaction
WO2007018602A1 (en) 2005-08-02 2007-02-15 Rubicon Genomics, Inc. Isolation of cpg islands by thermal segregation and enzymatic selection-amplification method
US8951731B2 (en) * 2007-10-15 2015-02-10 Complete Genomics, Inc. Sequence analysis using decorated nucleic acids
US8617811B2 (en) 2008-01-28 2013-12-31 Complete Genomics, Inc. Methods and compositions for efficient base calling in sequencing reactions
US8415099B2 (en) 2007-11-05 2013-04-09 Complete Genomics, Inc. Efficient base determination in sequencing reactions
US9524369B2 (en) 2009-06-15 2016-12-20 Complete Genomics, Inc. Processing and analysis of complex nucleic acid sequence data
KR101372947B1 (en) * 2012-02-24 2014-03-13 삼성에스디에스 주식회사 System and method for processing reference sequence for analyzing genome sequence

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995029258A1 (en) * 1994-04-27 1995-11-02 St. James' And Seacroft University Hospitals Nhs Trust Nucleic acid mutation assays
WO1996041002A2 (en) * 1995-06-07 1996-12-19 Genzyme Corporation Methods for the identification of genetic modification of dna involving dna sequencing and positional cloning
EP0761822A2 (en) * 1995-09-12 1997-03-12 The Johns Hopkins University School Of Medicine Method for serial analysis of gene expression
WO1997029211A1 (en) * 1996-02-09 1997-08-14 The Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services RESTRICTION DISPLAY (RD-PCR) OF DIFFERENTIALLY EXPRESSED mRNAs
US5750335A (en) * 1992-04-24 1998-05-12 Massachusetts Institute Of Technology Screening for genetic variation
WO1999023256A1 (en) * 1997-10-30 1999-05-14 Cold Spring Harbor Laboratory Probe arrays and methods of using probe arrays for distinguishing dna
WO1999039003A1 (en) * 1998-01-30 1999-08-05 Genzyme Corporation Method for detecting and identifying mutations

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5750335A (en) * 1992-04-24 1998-05-12 Massachusetts Institute Of Technology Screening for genetic variation
WO1995029258A1 (en) * 1994-04-27 1995-11-02 St. James' And Seacroft University Hospitals Nhs Trust Nucleic acid mutation assays
WO1996041002A2 (en) * 1995-06-07 1996-12-19 Genzyme Corporation Methods for the identification of genetic modification of dna involving dna sequencing and positional cloning
EP0761822A2 (en) * 1995-09-12 1997-03-12 The Johns Hopkins University School Of Medicine Method for serial analysis of gene expression
WO1997029211A1 (en) * 1996-02-09 1997-08-14 The Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services RESTRICTION DISPLAY (RD-PCR) OF DIFFERENTIALLY EXPRESSED mRNAs
WO1999023256A1 (en) * 1997-10-30 1999-05-14 Cold Spring Harbor Laboratory Probe arrays and methods of using probe arrays for distinguishing dna
WO1999039003A1 (en) * 1998-01-30 1999-08-05 Genzyme Corporation Method for detecting and identifying mutations

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
COTTIN R: "Current methods of mutation research", MUTATION RESEARCH, vol. 285, 1993, pages 125 - 144, XP000443992 *
ELLIS L A ET AL: "MUTS BINDING PROTECTS HETERODUPLEX DNA FROM EXONUCLEASE DIGESTION IN VITRO: A SIMPLE METHOD FOR DETECTING MUTATIONS", NUCLEIC ACIDS RESEARCH,GB,OXFORD UNIVERSITY PRESS, SURREY, vol. 22, no. 13, 11 July 1994 (1994-07-11), pages 2710 - 2711, XP000606262, ISSN: 0305-1048 *
PARSONS B L ET AL: "EVALUATION OF MUTS AS A TOOL FOR DIRECT MEASUREMENT OF POINT MUTATIONS IN GENOMIC DNA", MUTATION RESEARCH,NL,AMSTERDAM, vol. 374, no. 2, 21 March 1997 (1997-03-21), pages 277 - 285, XP002914507, ISSN: 0027-5107 *
VELCULESCU V E ET AL: "SERIAL ANALYSIS OF GENE EXPRESSION", SCIENCE,US,AMERICAN ASSOCIATION FOR THE ADVANCEMENT OF SCIENCE,, vol. 270, 20 October 1995 (1995-10-20), pages 484 - 487, XP002053721, ISSN: 0036-8075 *
WHITE M J ET AL: "CONCATEMER CHAIN REACTION: A TAQ DNA POLYMERASE-MEDIATED MECHANISM FOR GENERATING LONG TANDEMLY REPETITIVE DNA SEQUENCES", ANALYTICAL BIOCHEMISTRY,US,ACADEMIC PRESS, SAN DIEGO, CA, vol. 199, no. 2, 1 December 1991 (1991-12-01), pages 184 - 190, XP000236491, ISSN: 0003-2697 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9499863B2 (en) 2007-12-05 2016-11-22 Complete Genomics, Inc. Reducing GC bias in DNA sequencing using nucleotide analogs

Also Published As

Publication number Publication date
AU6387000A (en) 2001-02-19
WO2001009384A2 (en) 2001-02-08

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