ATE486128T1 - Zusammensetzungen und verfahren zur erhöhung der produktion rekombinanter gamma-carboxylierter proteine - Google Patents

Zusammensetzungen und verfahren zur erhöhung der produktion rekombinanter gamma-carboxylierter proteine

Info

Publication number
ATE486128T1
ATE486128T1 AT06840107T AT06840107T ATE486128T1 AT E486128 T1 ATE486128 T1 AT E486128T1 AT 06840107 T AT06840107 T AT 06840107T AT 06840107 T AT06840107 T AT 06840107T AT E486128 T1 ATE486128 T1 AT E486128T1
Authority
AT
Austria
Prior art keywords
methods
compositions
production
increase
carboxylated proteins
Prior art date
Application number
AT06840107T
Other languages
English (en)
Inventor
Reidar Wallin
Original Assignee
Univ Wake Forest Health Sciences
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Wake Forest Health Sciences filed Critical Univ Wake Forest Health Sciences
Application granted granted Critical
Publication of ATE486128T1 publication Critical patent/ATE486128T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6437—Coagulation factor VIIa (3.4.21.21)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6432—Coagulation factor Xa (3.4.21.6)

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Hematology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Toxicology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
AT06840107T 2005-12-02 2006-12-04 Zusammensetzungen und verfahren zur erhöhung der produktion rekombinanter gamma-carboxylierter proteine ATE486128T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US74207605P 2005-12-02 2005-12-02
US78205606P 2006-03-14 2006-03-14
PCT/US2006/061575 WO2007065173A2 (en) 2005-12-02 2006-12-04 Compositions and methods for increasing production of recombinant gamma-carboxylated proteins

Publications (1)

Publication Number Publication Date
ATE486128T1 true ATE486128T1 (de) 2010-11-15

Family

ID=38092974

Family Applications (1)

Application Number Title Priority Date Filing Date
AT06840107T ATE486128T1 (de) 2005-12-02 2006-12-04 Zusammensetzungen und verfahren zur erhöhung der produktion rekombinanter gamma-carboxylierter proteine

Country Status (7)

Country Link
US (2) US8647868B2 (de)
EP (1) EP1963506B1 (de)
AT (1) ATE486128T1 (de)
AU (1) AU2006320168B2 (de)
CA (1) CA2632794C (de)
DE (1) DE602006017882D1 (de)
WO (1) WO2007065173A2 (de)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE455174T1 (de) 2003-09-23 2010-01-15 Univ North Carolina Zellen, die vitamin-k-reduktase und vitamin-k- abhängiges protein coexprimieren und deren anwendung zur verbesserung der produktivität von diesem vitamin-k-abhängigen protein
GB0324044D0 (en) 2003-10-14 2003-11-19 Astrazeneca Ab Protein
PL2189523T3 (pl) 2003-10-14 2012-05-31 Baxalta Inc Polipeptyd przekształcający epoksyd witaminy K VKORC1, obiekt działania leczniczego kumaryny i jej pochodnych
US20090325226A1 (en) 2005-03-15 2009-12-31 Stafford Darrel W Methods and Compositions for Producing Active Vitamin K-Dependent Proteins
KR20130140221A (ko) 2005-04-13 2013-12-23 아스트라제네카 아베 감마 카르복실화를 필요로 하는 단백질 생산용 벡터를 포함하는 숙주 세포
US8206967B2 (en) 2007-07-06 2012-06-26 Medimmune Limited Method for production of recombinant human thrombin
WO2011003153A1 (en) 2009-07-10 2011-01-13 Csl Limited Method of increasing the expression yield of vitamin k-dependent proteins
EP2526115B1 (de) 2010-01-18 2018-08-01 Novo Nordisk Health Care AG Reinigung von blutgerinnungsfaktoren
WO2012088222A2 (en) 2010-12-21 2012-06-28 The University Of North Carolina At Chapel Hill Methods and compositions for producing active vitamin k-dependent proteins
EP3305810A4 (de) * 2015-05-27 2018-04-25 Fundacao Hemocentro de Ribeirao Preto Verfahren zur herstellung von blutgerinnungsfaktor vii sowie blutgerinnungsfaktor vii
BR102015012334A2 (pt) 2015-05-27 2016-11-29 Fundação Hemoct De Ribeirão Preto Fundherp processo de produção do fator vii de coagulação sanguínea e fator vii de coagulação sanguínea

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003106657A2 (en) * 2002-06-14 2003-12-24 Stowers Institute For Medical Research Wise/sost nucleic acid sequences and amino acid sequences
EP1725673A1 (de) * 2004-02-13 2006-11-29 Glycotope Gmbh Verfahrensbedingungen für sialytierte glykoproteine und effizientes verfahren zu deren produktion
US20060073117A1 (en) * 2004-10-01 2006-04-06 Stowers Institute For Medical Research Methods and compositions for controlling hair follicle stem cell fate
WO2006056028A2 (en) * 2004-11-23 2006-06-01 K.U. Leuven Research & Development Autism genes and regulated secretion
US20090100533A1 (en) 2004-12-21 2009-04-16 Novo Nordisk Health Care Ag Expression of gamma-carboxylated polypeptides in gamma-carboxylation deficient host sytems
CN103396998A (zh) * 2005-02-28 2013-11-20 巴克斯特国际公司 重组共表达维生素k环氧化物还原酶亚基1以提高依赖维生素k的蛋白质表达
KR20130140221A (ko) 2005-04-13 2013-12-23 아스트라제네카 아베 감마 카르복실화를 필요로 하는 단백질 생산용 벡터를 포함하는 숙주 세포

Also Published As

Publication number Publication date
CA2632794A1 (en) 2007-06-07
WO2007065173A2 (en) 2007-06-07
WO2007065173A3 (en) 2008-07-03
CA2632794C (en) 2015-04-07
EP1963506B1 (de) 2010-10-27
DE602006017882D1 (de) 2010-12-09
AU2006320168B2 (en) 2012-02-23
US8647868B2 (en) 2014-02-11
EP1963506A4 (de) 2009-01-07
US20140227248A1 (en) 2014-08-14
AU2006320168A1 (en) 2007-06-07
EP1963506A2 (de) 2008-09-03
US20100331255A1 (en) 2010-12-30

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