ATE486128T1 - Zusammensetzungen und verfahren zur erhöhung der produktion rekombinanter gamma-carboxylierter proteine - Google Patents

Zusammensetzungen und verfahren zur erhöhung der produktion rekombinanter gamma-carboxylierter proteine

Info

Publication number
ATE486128T1
ATE486128T1 AT06840107T AT06840107T ATE486128T1 AT E486128 T1 ATE486128 T1 AT E486128T1 AT 06840107 T AT06840107 T AT 06840107T AT 06840107 T AT06840107 T AT 06840107T AT E486128 T1 ATE486128 T1 AT E486128T1
Authority
AT
Austria
Prior art keywords
methods
compositions
production
increase
carboxylated proteins
Prior art date
Application number
AT06840107T
Other languages
English (en)
Inventor
Reidar Wallin
Original Assignee
Univ Wake Forest Health Sciences
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Wake Forest Health Sciences filed Critical Univ Wake Forest Health Sciences
Application granted granted Critical
Publication of ATE486128T1 publication Critical patent/ATE486128T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6437—Coagulation factor VIIa (3.4.21.21)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6432—Coagulation factor Xa (3.4.21.6)

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
AT06840107T 2005-12-02 2006-12-04 Zusammensetzungen und verfahren zur erhöhung der produktion rekombinanter gamma-carboxylierter proteine ATE486128T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US74207605P 2005-12-02 2005-12-02
US78205606P 2006-03-14 2006-03-14
PCT/US2006/061575 WO2007065173A2 (en) 2005-12-02 2006-12-04 Compositions and methods for increasing production of recombinant gamma-carboxylated proteins

Publications (1)

Publication Number Publication Date
ATE486128T1 true ATE486128T1 (de) 2010-11-15

Family

ID=38092974

Family Applications (1)

Application Number Title Priority Date Filing Date
AT06840107T ATE486128T1 (de) 2005-12-02 2006-12-04 Zusammensetzungen und verfahren zur erhöhung der produktion rekombinanter gamma-carboxylierter proteine

Country Status (7)

Country Link
US (2) US8647868B2 (de)
EP (1) EP1963506B1 (de)
AT (1) ATE486128T1 (de)
AU (1) AU2006320168B2 (de)
CA (1) CA2632794C (de)
DE (1) DE602006017882D1 (de)
WO (1) WO2007065173A2 (de)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2539434C (en) 2003-09-23 2014-03-18 University Of North Carolina At Chapel Hill Methods and compositions for the correlation of single nucleotide polymorphisms in the vitamin k epoxide reductase gene and warfarin dosage
ATE466074T1 (de) 2003-10-14 2010-05-15 Baxter Int Vkorc1 (vitamin k epoxide recycling polypeptide), ein therapeutisches ziel für coumarin und deren derivate
GB0324044D0 (en) 2003-10-14 2003-11-19 Astrazeneca Ab Protein
AU2005329450A1 (en) 2005-03-15 2006-09-28 University Of North Carolina At Chapel Hill Methods and compositions for producing active Vitamin K-dependent proteins
CA2602793C (en) 2005-04-13 2016-11-22 Astrazeneca Ab A host cell comprising a vector for production of proteins requiring gamma-carboxylation
US8206967B2 (en) 2007-07-06 2012-06-26 Medimmune Limited Method for production of recombinant human thrombin
PL2451963T3 (pl) * 2009-07-10 2014-09-30 Csl Ltd Sposób zwiększania wydajności ekspresji białek zależnych od witaminy K
US9896677B2 (en) 2010-01-18 2018-02-20 Novo Nordisk Health Care Ag Purification of blood coagulation factors
US9631002B2 (en) 2010-12-21 2017-04-25 The University Of North Carolina At Chapel Hill Methods and compositions for producing active vitamin K-dependent proteins
BR102015012334A2 (pt) 2015-05-27 2016-11-29 Fundação Hemoct De Ribeirão Preto Fundherp processo de produção do fator vii de coagulação sanguínea e fator vii de coagulação sanguínea
EP3305810A4 (de) * 2015-05-27 2018-04-25 Fundacao Hemocentro de Ribeirao Preto Verfahren zur herstellung von blutgerinnungsfaktor vii sowie blutgerinnungsfaktor vii

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2003276430A1 (en) * 2002-06-14 2003-12-31 Stowers Institute For Medical Research Wise/sost nucleic acid sequences and amino acid sequences
CN1926242B (zh) * 2004-02-13 2013-01-16 格莱克托普有限公司 高活性糖蛋白加工条件及其有效生产方法
US20060073117A1 (en) * 2004-10-01 2006-04-06 Stowers Institute For Medical Research Methods and compositions for controlling hair follicle stem cell fate
EP1819832A2 (de) * 2004-11-23 2007-08-22 K.U.Leuven Research & Development Autismusgene und regulierte sekretion
JP2008523837A (ja) 2004-12-21 2008-07-10 ノボ ノルディスク ヘルス ケア アクチェンゲゼルシャフト ガンマ―カルボキシル化に欠陥のある宿主系におけるガンマ―カルボキシル化ポリペプチドの発現
PL1853700T3 (pl) * 2005-02-28 2013-05-31 Baxalta Inc Koekspresja przez rekombinowanie podjednostki 1 reduktazy epoksydu witaminy K w celu poprawy ekspresji białka zależnego od witaminy K
CA2602793C (en) * 2005-04-13 2016-11-22 Astrazeneca Ab A host cell comprising a vector for production of proteins requiring gamma-carboxylation

Also Published As

Publication number Publication date
US20140227248A1 (en) 2014-08-14
US20100331255A1 (en) 2010-12-30
WO2007065173A2 (en) 2007-06-07
EP1963506B1 (de) 2010-10-27
CA2632794C (en) 2015-04-07
US8647868B2 (en) 2014-02-11
CA2632794A1 (en) 2007-06-07
DE602006017882D1 (de) 2010-12-09
AU2006320168A1 (en) 2007-06-07
WO2007065173A3 (en) 2008-07-03
AU2006320168B2 (en) 2012-02-23
EP1963506A2 (de) 2008-09-03
EP1963506A4 (de) 2009-01-07

Similar Documents

Publication Publication Date Title
NL301145I2 (nl) Tirbanibulin
CO6501191A2 (es) Medio de cultivo celular para expresión de la proteina adamts
SG10201405377XA (en) Compositions and methods for antibodies targeting complement protein c5
MX2009005655A (es) Composiciones y usos de un polipeptido alfa-amilasa del bacilo de la especie 195.
WO2011047087A3 (en) Protein detection via nanoreporters
MY146352A (en) Adipose derived adult stem cells in hepatic regeneration
MX2009013170A (es) Particulas de silice y metodos para prepararlas y utilizarlas.
DE602006016735D1 (de) Verfahren zur proliferation von stammzellen
SG165339A1 (en) Incorporation of non-naturally encoded amino acids into proteins
MX341064B (es) Variantes de la familia il-1.
ATE486128T1 (de) Zusammensetzungen und verfahren zur erhöhung der produktion rekombinanter gamma-carboxylierter proteine
MX2008001538A (es) Aril piridinas y metodos para su uso.
WO2006069719A3 (en) Lyophilization of virosomes
ATE501268T1 (de) Vorrichtungen und verfahren zur bestimmung von proteaseaktivität
TW200738752A (en) Modulation of MDL-1 activity for treatment of inflammatory disease
ATE497779T1 (de) Enzyme zur reduzierung von immunologischem stress
DE602007012412D1 (de) Rekombinante produktion heparinbindender proteine
MX2009012643A (es) Particulas de alumina y metodos para fabricar las mismas.
WO2010123885A3 (en) Iga1 protease polypeptide agents and uses thereof
TW200728205A (en) Alumina particles and methods of making the same
ATE420162T1 (de) Verfahren und zusammensetzungen zum targeting sekretorischer lysosomen
EP1885867A4 (de) Neue verfahren
TW200504218A (en) Methods for preventing gluconoylation of proteins
WO2007095256A3 (en) Methods of promoting cardiac cell proliferation
ATE449863T1 (de) Verwendung von lepa zur verbesserung der genauigkeit der in-vitro-proteinsynthese

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification

Ref document number: 1963506

Country of ref document: EP