DK285087A - Human alfa1-antitrypsinvariant - Google Patents

Human alfa1-antitrypsinvariant

Info

Publication number
DK285087A
DK285087A DK285087A DK285087A DK285087A DK 285087 A DK285087 A DK 285087A DK 285087 A DK285087 A DK 285087A DK 285087 A DK285087 A DK 285087A DK 285087 A DK285087 A DK 285087A
Authority
DK
Denmark
Prior art keywords
human
alfa1
inventory
dry
dry inventory
Prior art date
Application number
DK285087A
Other languages
English (en)
Other versions
DK285087D0 (da
DK173131B1 (da
Inventor
Sophie Jallat
Michael Courtney
Original Assignee
Transgene Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Transgene Sa filed Critical Transgene Sa
Publication of DK285087D0 publication Critical patent/DK285087D0/da
Publication of DK285087A publication Critical patent/DK285087A/da
Application granted granted Critical
Publication of DK173131B1 publication Critical patent/DK173131B1/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
    • C07K14/8121—Serpins
    • C07K14/8125—Alpha-1-antitrypsin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Virology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
DK198702850A 1986-06-10 1987-06-03 Human alfa1-antitrypsinvariant og præparat omfattende en sådan variant DK173131B1 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR8608386 1986-06-10
FR8608386A FR2599752B1 (fr) 1986-06-10 1986-06-10 Variants de l'alpha1- antitrypsine utiles notamment comme inhibiteurs de la kallikreine

Publications (3)

Publication Number Publication Date
DK285087D0 DK285087D0 (da) 1987-06-03
DK285087A true DK285087A (da) 1987-12-11
DK173131B1 DK173131B1 (da) 2000-01-31

Family

ID=9336200

Family Applications (1)

Application Number Title Priority Date Filing Date
DK198702850A DK173131B1 (da) 1986-06-10 1987-06-03 Human alfa1-antitrypsinvariant og præparat omfattende en sådan variant

Country Status (13)

Country Link
US (1) US4973668A (da)
EP (1) EP0253690B1 (da)
JP (1) JP2649804B2 (da)
KR (1) KR880000575A (da)
AT (1) ATE92960T1 (da)
AU (1) AU610500B2 (da)
CA (1) CA1328706C (da)
DE (1) DE3786961T2 (da)
DK (1) DK173131B1 (da)
FR (1) FR2599752B1 (da)
IE (1) IE61060B1 (da)
PT (1) PT85047B (da)
ZA (1) ZA874123B (da)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2066033T3 (es) * 1989-05-13 1995-03-01 Bayer Ag Inhibidores de las proteinasas, procedimiento para su preparacion y composiciones farmaceuticas que los contienen.
JPH07504818A (ja) 1992-03-09 1995-06-01 カイロン　コーポレイション 細胞内ｐａｃｅ４およびｐａｃｅ４．１遺伝子ならびにポリペプチドに関する組成物および方法
AU7257994A (en) * 1993-07-09 1995-02-06 Michael Laskowski Novel protein inhibitors of serine proteinases (e.g. furin) derived from turkey ovomucoid third domain
WO1996010638A1 (en) * 1994-09-30 1996-04-11 Ppl Therapeutics (Scotland) Ltd. Alpha-1-antitrypsin and antithrombine-iii variants
GB2318732A (en) 1996-11-01 1998-05-06 Johnson & Johnson Medical Wound healing compositions containing alpha-1-antitrypsin
EP2369930A4 (en) * 2008-12-02 2012-10-03 Joslin Diabetes Ct METHOD OF REDUCING BLOOD PRESSURE FROM PLASMA CALLICINE INHIBITORS
EP3320922A1 (en) 2011-06-10 2018-05-16 Ionis Pharmaceuticals, Inc. Methods for modulating kallikrein (klkb1) expression
AU2012275096B2 (en) 2011-06-29 2016-02-04 Ionis Pharmaceuticals, Inc. Methods for modulating kallikrein (KLKB1) expression
WO2015031679A2 (en) 2013-08-28 2015-03-05 Isis Pharmaceuticals, Inc. Modulation of prekallikrein (pkk) expression
GB201322091D0 (en) 2013-12-13 2014-01-29 Cambridge Entpr Ltd Modified serpins for the treatment of bleeding disorders
DK3137091T3 (da) 2014-05-01 2021-01-25 Ionis Pharmaceuticals Inc Konjugater af modificerede antisense-oligonukleotider og anvendelse deraf til modulation af pkk-ekspression
US11851474B2 (en) 2017-02-23 2023-12-26 Preclinics Gesellschaft Für Präklinische Forschung Mbh Modified serpins for the treatment of bradykinin-mediated disease
US12031144B2 (en) 2017-03-29 2024-07-09 Cornell University Oxidation-resistant AAT gene therapy

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1984000560A1 (en) * 1982-08-04 1984-02-16 Nat Res Dev Molecular cloning of the gene for human anti-haemophilic factor ix
US4711848A (en) * 1984-03-14 1987-12-08 Zymogenetics, Inc. Site specific mutagenesis in alpha-1-antitrypsin
EP0164719B1 (en) * 1984-06-14 1992-05-06 Chiron Corporation Active site modified protease alpha-1-antitrypsin inhibitors and their production
JP2599585B2 (ja) * 1984-06-19 1997-04-09 トランスジ−ン ソシエテ アノニム ヒトα▲下１▼−アンチトリプシン誘導体及びその製造法
CA1299120C (en) * 1984-10-22 1992-04-21 Glenn Kawasaki Stable dna constructs for expression of alpha-1-antitrypsin
EP0430930B1 (en) * 1985-03-15 1993-09-01 Btg International Limited Factor ix protein
GR860984B (en) * 1985-04-17 1986-08-18 Zymogenetics Inc Expression of factor vii and ix activities in mammalian cells
ATE74164T1 (de) * 1985-04-22 1992-04-15 Genetics Inst Herstellung mit hoher leistung des aktivfaktors ix.
FR2601033B1 (fr) * 1986-07-02 1990-01-19 Transgene Sa Variants de l'alpha-antitryspine humaine glycosylee et procede pour la preparation

Also Published As

Publication number Publication date
ZA874123B (en) 1987-12-09
JPS6379899A (ja) 1988-04-09
DK285087D0 (da) 1987-06-03
DE3786961T2 (de) 1994-01-20
AU7362587A (en) 1987-12-17
ATE92960T1 (de) 1993-08-15
EP0253690A1 (fr) 1988-01-20
AU610500B2 (en) 1991-05-23
EP0253690B1 (fr) 1993-08-11
US4973668A (en) 1990-11-27
DK173131B1 (da) 2000-01-31
PT85047B (pt) 1990-03-08
IE871374L (en) 1987-12-10
JP2649804B2 (ja) 1997-09-03
FR2599752B1 (fr) 1989-11-03
CA1328706C (fr) 1994-04-19
KR880000575A (ko) 1988-03-26
PT85047A (fr) 1987-07-01
FR2599752A1 (fr) 1987-12-11
IE61060B1 (en) 1994-09-21
DE3786961D1 (de) 1993-09-16

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B1 Patent granted (law 1993)
PBP Patent lapsed

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