DE3585969D1 - Protease-inhibitoren des alpha-1-antitrypsin typs mit modifizierter aktiever stelle und deren herstellung. - Google Patents
Protease-inhibitoren des alpha-1-antitrypsin typs mit modifizierter aktiever stelle und deren herstellung.Info
- Publication number
- DE3585969D1 DE3585969D1 DE8585107126T DE3585969T DE3585969D1 DE 3585969 D1 DE3585969 D1 DE 3585969D1 DE 8585107126 T DE8585107126 T DE 8585107126T DE 3585969 T DE3585969 T DE 3585969T DE 3585969 D1 DE3585969 D1 DE 3585969D1
- Authority
- DE
- Germany
- Prior art keywords
- antitrypsin
- alpha
- production
- type
- protease inhibitors
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
- C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/81—Protease inhibitors
- C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
- C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
- C07K14/8121—Serpins
- C07K14/8125—Alpha-1-antitrypsin
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Mycology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Biochemistry (AREA)
- Physics & Mathematics (AREA)
- Microbiology (AREA)
- Plant Pathology (AREA)
- Gastroenterology & Hepatology (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US06/620,408 US4732973A (en) | 1984-06-14 | 1984-06-14 | Active site modified protease α-1-antitrypsin inhibitors |
US06/620,662 US4752576A (en) | 1984-06-14 | 1984-06-14 | Expression of α-1 antitrypsin in yeast |
Publications (1)
Publication Number | Publication Date |
---|---|
DE3585969D1 true DE3585969D1 (de) | 1992-06-11 |
Family
ID=27088711
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE8585107126T Expired - Lifetime DE3585969D1 (de) | 1984-06-14 | 1985-06-10 | Protease-inhibitoren des alpha-1-antitrypsin typs mit modifizierter aktiever stelle und deren herstellung. |
Country Status (3)
Country | Link |
---|---|
EP (1) | EP0164719B1 (de) |
CA (1) | CA1341165C (de) |
DE (1) | DE3585969D1 (de) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ZA8410063B (en) * | 1984-01-30 | 1985-10-30 | Smith Kline Rit | Expression of human alpha-1-antitrypsin in yeast |
US4711848A (en) * | 1984-03-14 | 1987-12-08 | Zymogenetics, Inc. | Site specific mutagenesis in alpha-1-antitrypsin |
ATE102250T1 (de) * | 1984-05-11 | 1994-03-15 | Chiron Corp | Erhoehte hefetranskription unter verwendung einer hybridkonstruktion der promotorregion. |
WO1986000337A1 (fr) * | 1984-06-19 | 1986-01-16 | Transgene S.A. | DERIVES DE L'alpha1-ANTITRYPSINE HUMAINE ET PROCEDE POUR LEUR PREPARATION |
US4752585A (en) * | 1985-12-17 | 1988-06-21 | Cetus Corporation | Oxidation-resistant muteins |
FR2599752B1 (fr) * | 1986-06-10 | 1989-11-03 | Transgene Sa | Variants de l'alpha1- antitrypsine utiles notamment comme inhibiteurs de la kallikreine |
FR2601033B1 (fr) * | 1986-07-02 | 1990-01-19 | Transgene Sa | Variants de l'alpha-antitryspine humaine glycosylee et procede pour la preparation |
ATE72582T1 (de) * | 1986-09-05 | 1992-02-15 | Cetus Corp | Oxidationsresistente muteine von beta-interferon, deren herstellung und diese muteine enthaltende praeparate. |
DE58907373D1 (de) * | 1988-03-07 | 1994-05-11 | Ciba Geigy | Modifizierte Proteine. |
US5180667A (en) * | 1988-03-07 | 1993-01-19 | Ciba-Geigy Corporation | Genes encoding eglin C mutants |
GB8929110D0 (en) * | 1989-12-22 | 1990-02-28 | 3I Res Expl Ltd | Polypeptides and dna encoding therefor |
CN103804484B (zh) * | 2014-01-24 | 2016-03-16 | 南京必优康生物技术有限公司 | 一种网红细胞生长因子及其制备方法和应用 |
WO2023083859A1 (en) | 2021-11-09 | 2023-05-19 | Danmarks Tekniske Universitet | Variants of alpha-1-antitrypsin |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4711848A (en) * | 1984-03-14 | 1987-12-08 | Zymogenetics, Inc. | Site specific mutagenesis in alpha-1-antitrypsin |
WO1986000337A1 (fr) * | 1984-06-19 | 1986-01-16 | Transgene S.A. | DERIVES DE L'alpha1-ANTITRYPSINE HUMAINE ET PROCEDE POUR LEUR PREPARATION |
-
1985
- 1985-06-10 DE DE8585107126T patent/DE3585969D1/de not_active Expired - Lifetime
- 1985-06-10 EP EP85107126A patent/EP0164719B1/de not_active Expired - Lifetime
- 1985-06-13 CA CA 483838 patent/CA1341165C/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
CA1341165C (en) | 2001-01-16 |
EP0164719B1 (de) | 1992-05-06 |
EP0164719A2 (de) | 1985-12-18 |
EP0164719A3 (en) | 1986-08-06 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition |