DE3882593D1 - Polypeptid und dessen herstellung. - Google Patents

Polypeptid und dessen herstellung.

Info

Publication number
DE3882593D1
DE3882593D1 DE8888108570T DE3882593T DE3882593D1 DE 3882593 D1 DE3882593 D1 DE 3882593D1 DE 8888108570 T DE8888108570 T DE 8888108570T DE 3882593 T DE3882593 T DE 3882593T DE 3882593 D1 DE3882593 D1 DE 3882593D1
Authority
DE
Germany
Prior art keywords
polypeptide
production
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE8888108570T
Other languages
English (en)
Other versions
DE3882593T2 (de
Inventor
Kumao Toyoshima
Ryuya Horiuchi
Kiyoshi Yamauchi
Tadashi Yamamoto
Koichi Igarashi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Takeda Pharmaceutical Co Ltd
Original Assignee
Takeda Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Chemical Industries Ltd filed Critical Takeda Chemical Industries Ltd
Publication of DE3882593D1 publication Critical patent/DE3882593D1/de
Application granted granted Critical
Publication of DE3882593T2 publication Critical patent/DE3882593T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
    • C07K1/113—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure
    • C07K1/1133—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure by redox-reactions involving cystein/cystin side chains
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/55—IL-2
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C12N9/22—Ribonucleases RNAses, DNAses
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/90—Isomerases (5.)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y503/00—Intramolecular oxidoreductases (5.3)
    • C12Y503/04—Intramolecular oxidoreductases (5.3) transposing S-S bonds (5.3.4)
    • C12Y503/04001—Protein disulfide-isomerase (5.3.4.1), i.e. disufide bond-forming enzyme
DE88108570T 1987-06-01 1988-05-28 Polypeptid und dessen Herstellung. Expired - Fee Related DE3882593T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP13862887 1987-06-01
JP23549287 1987-09-18
JP25114487 1987-10-05

Publications (2)

Publication Number Publication Date
DE3882593D1 true DE3882593D1 (de) 1993-09-02
DE3882593T2 DE3882593T2 (de) 1993-11-18

Family

ID=27317710

Family Applications (1)

Application Number Title Priority Date Filing Date
DE88108570T Expired - Fee Related DE3882593T2 (de) 1987-06-01 1988-05-28 Polypeptid und dessen Herstellung.

Country Status (9)

Country Link
US (2) US5700678A (de)
EP (1) EP0293793B1 (de)
JP (1) JP2803089B2 (de)
CA (1) CA1341390C (de)
DE (1) DE3882593T2 (de)
FI (1) FI882516A (de)
HU (1) HU204566B (de)
IL (1) IL86455A0 (de)
NO (1) NO882385L (de)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0509841A3 (en) * 1991-04-18 1993-08-18 Tonen Corporation Co-expression system of protein disulfide isomerase gene and useful polypeptide gene and process for producing the polypeptide using its system
DE4113750A1 (de) 1991-04-26 1992-10-29 Boehringer Mannheim Gmbh Verbesserung der renaturierung bei der sekretion von disulfidverbrueckten proteinen
US5496719A (en) * 1992-05-27 1996-03-05 Kabushiki Kaisha Toyota Chuo Kenkyusho Polypeptide from Humicola insolens possessing protein disulfide isomerase activity gene encoding the same
US6291205B1 (en) * 1992-06-12 2001-09-18 Merck & Co., Inc. Method of increasing production of disulfide bonded recombinant proteins by saccharomyces cerevisiae
DK76893D0 (de) * 1993-06-28 1993-06-28 Novo Nordisk As
US5663304A (en) * 1993-08-20 1997-09-02 Genentech, Inc. Refolding of misfolded insulin-like growth factor-I
US5639635A (en) * 1994-11-03 1997-06-17 Genentech, Inc. Process for bacterial production of polypeptides
US5789199A (en) * 1994-11-03 1998-08-04 Genentech, Inc. Process for bacterial production of polypeptides
WO1997038123A1 (en) * 1996-04-05 1997-10-16 Board Of Regents, The University Of Texas System Methods for producing soluble, biologically-active disulfide bond-containing eukaryotic proteins in bacterial cells
US6083715A (en) * 1997-06-09 2000-07-04 Board Of Regents, The University Of Texas System Methods for producing heterologous disulfide bond-containing polypeptides in bacterial cells
ATE426670T1 (de) * 1997-07-16 2009-04-15 Genencor Int Erhíhung der produktion von proteinen in gram- positiven mikroorganismen
US6521421B1 (en) 1997-07-16 2003-02-18 Genencor International, Inc. Expression vectors encoding Bacillus subtilis disulfide bond isomerase and methods of secreting proteins in gram-positive microorganisms using the same
EP2050762A3 (de) 1998-03-10 2009-07-08 Genentech, Inc. Neue Polypeptide und für diese kodierende Nukleinsäuren
US20030059884A1 (en) * 1998-04-01 2003-03-27 Genentech, Inc. Secreted and transmembrane polypeptides and nucleic acids encoding the same
US20020127618A1 (en) 1998-09-21 2002-09-12 Jeff Gray Diagnostic assays for detection of cryptosporidium parvum
WO2000040746A1 (en) * 1999-01-08 2000-07-13 Medical Analysis Systems, Inc. Compositions and methods for stabilizing thiol-containing biomolecules
JP3734634B2 (ja) * 1999-03-03 2006-01-11 ヒゲタ醤油株式会社 タンパク質の活性化方法及び該装置
KR100414182B1 (ko) * 2001-07-02 2004-01-07 대한민국 누에 배양세포로부터 분리한 프로테인 디설피드이소머레이즈를 코딩하는 ｃＤＮＡ 유전자의 염기서열 및그의 연역 아미노산
GB0329722D0 (en) 2003-12-23 2004-01-28 Delta Biotechnology Ltd Modified plasmid and use thereof
GB0329681D0 (en) 2003-12-23 2004-01-28 Delta Biotechnology Ltd Gene expression technique
AU2005317828A1 (en) 2004-12-23 2006-06-29 Novozymes Delta Limited Gene expression technique
US8637435B2 (en) * 2007-11-16 2014-01-28 Merck Sharp & Dohme Corp. Eukaryotic cell display systems
JP2011514157A (ja) * 2008-02-20 2011-05-06 グライコフィ， インコーポレイテッド 蛋白質生産用ベクター及び酵母株
US8877686B2 (en) * 2008-03-03 2014-11-04 Glycofi, Inc. Surface display of recombinant proteins in lower eukaryotes
US8067339B2 (en) 2008-07-09 2011-11-29 Merck Sharp & Dohme Corp. Surface display of whole antibodies in eukaryotes
CA2739568C (en) * 2008-10-31 2015-12-01 Shujun Sun Purification of acidic proteins using ceramic hydroxyapatite chromatography

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4904602A (en) * 1985-11-27 1990-02-27 Repligen Corporation Thioredoxin shufflease and use thereof
EP0509841A3 (en) * 1991-04-18 1993-08-18 Tonen Corporation Co-expression system of protein disulfide isomerase gene and useful polypeptide gene and process for producing the polypeptide using its system

Also Published As

Publication number Publication date
HUT47974A (en) 1989-04-28
EP0293793B1 (de) 1993-07-28
EP0293793A2 (de) 1988-12-07
CA1341390C (en) 2002-10-01
JPH02460A (ja) 1990-01-05
FI882516A (fi) 1988-12-02
DE3882593T2 (de) 1993-11-18
IL86455A0 (en) 1988-11-15
NO882385L (no) 1988-12-02
NO882385D0 (no) 1988-05-31
HU204566B (en) 1992-01-28
EP0293793A3 (en) 1990-05-16
JP2803089B2 (ja) 1998-09-24
US5874247A (en) 1999-02-23
FI882516A0 (fi) 1988-05-27
US5700678A (en) 1997-12-23

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee