KR850000462A - [[비스(아릴)메틸렌]-1-피페리디닐]알킬-피리미딘온의 제조방법 - Google Patents
[[비스(아릴)메틸렌]-1-피페리디닐]알킬-피리미딘온의 제조방법 Download PDFInfo
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- KR850000462A KR850000462A KR1019830004656A KR830004656A KR850000462A KR 850000462 A KR850000462 A KR 850000462A KR 1019830004656 A KR1019830004656 A KR 1019830004656A KR 830004656 A KR830004656 A KR 830004656A KR 850000462 A KR850000462 A KR 850000462A
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- general formula
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- lower alkyl
- acid addition
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- 125000003118 aryl group Chemical group 0.000 title 1
- 125000000325 methylidene group Chemical group [H]C([H])=* 0.000 title 1
- 150000001875 compounds Chemical group 0.000 claims 10
- 239000002253 acid Substances 0.000 claims 9
- 239000003814 drug Substances 0.000 claims 7
- 125000000217 alkyl group Chemical group 0.000 claims 6
- 150000003839 salts Chemical class 0.000 claims 6
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 5
- 125000003545 alkoxy group Chemical group 0.000 claims 4
- 239000003153 chemical reaction reagent Substances 0.000 claims 4
- 125000001475 halogen functional group Chemical group 0.000 claims 4
- 229910052739 hydrogen Inorganic materials 0.000 claims 4
- 239000001257 hydrogen Substances 0.000 claims 4
- 125000004356 hydroxy functional group Chemical group O* 0.000 claims 4
- 238000000034 method Methods 0.000 claims 4
- 239000008194 pharmaceutical composition Substances 0.000 claims 3
- 125000001255 4-fluorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C([H])=C1F 0.000 claims 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 2
- NQRYJNQNLNOLGT-UHFFFAOYSA-N Piperidine Chemical compound C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 claims 2
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 2
- 150000002431 hydrogen Chemical group 0.000 claims 2
- 230000003340 mental effect Effects 0.000 claims 2
- 125000001570 methylene group Chemical group [H]C([H])([*:1])[*:2] 0.000 claims 2
- 208000020016 psychiatric disease Diseases 0.000 claims 2
- 238000007126 N-alkylation reaction Methods 0.000 claims 1
- 102000001708 Protein Isoforms Human genes 0.000 claims 1
- 108010029485 Protein Isoforms Proteins 0.000 claims 1
- 150000001412 amines Chemical class 0.000 claims 1
- 239000002552 dosage form Substances 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 150000002825 nitriles Chemical class 0.000 claims 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 1
- 208000024335 physical disease Diseases 0.000 claims 1
- 125000004076 pyridyl group Chemical group 0.000 claims 1
- 238000007363 ring formation reaction Methods 0.000 claims 1
- 238000010561 standard procedure Methods 0.000 claims 1
- 238000007910 systemic administration Methods 0.000 claims 1
- 125000001544 thienyl group Chemical group 0.000 claims 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/30—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by doubly bound oxygen or sulfur atoms or by two oxygen or sulfur atoms singly bound to the same carbon atom
- C07D211/32—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by doubly bound oxygen or sulfur atoms or by two oxygen or sulfur atoms singly bound to the same carbon atom by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D211/70—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D211/72—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D211/74—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/44—Radicals substituted by doubly-bound oxygen, sulfur, or nitrogen atoms, or by two such atoms singly-bound to the same carbon atom
- C07D213/46—Oxygen atoms
- C07D213/50—Ketonic radicals
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Hydrogenated Pyridines (AREA)
Abstract
내용 없음.
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
Claims (7)
- 투약단위당 약제로 사용할 수 있는 캐리어와 심신장애로 고통을 받고 있는 환자를 치료하는데 유효 한 양의 일반식 :의 있을 수 있는 입체화학적 이성질형 및 이것의 약제로 사용할 수 있는 산부가염을 가진 화합물을 적어도 하나를 함유한 단위투약형의 약제조성물, 상기 식에서, R은 수소, 히드록시 또는 저급알킬록시이며; R1은 수소와 저급알킬로 구성된 그룹으로 부터 선택된 일원이며; X는-S-,-CH2- 및-C(R2)=C(R3)-로 구성된 그룹으로 부터 선택된 일원인데, 상기 R2와 R3는 각각 독립적으로 수소 또는 저급알킬이다; 그리고 A는 R4와 R5가 각각 수소, 할로, 아미노 및 저급알킬로 구성된 그룹으로 부터 독립적으로 선택된 일원인 일반식-CH2-CH2-,-CH2-CH2-CH2- 또는를 가지는 2가 라디칼이고; Ar1및 Ar2는 피리디닐, 티에닐 및 페닐로 된 그룹으로 부터 각각 독립적으로 선택되는데 할로, 히드록시, 저급알킬록시, 저급알킬 및 트리플루오로메틸로 임의로 치환된다.
- 제1항에서, Alk가 1,2-에탄디일라디칼인 약제조성물.
- 제1항에서, 일반식(I)의 화합물이 6-[2-[4-[비스(4-플루오로페닐)메틸렌]-1-피페리디닐]에틸]-7-메틸-5H-티아졸로 [3,2-a] 피리미딘-5- 또는 이것의 약제로 사용할 수 있는 산부가염인 약제조성물.
- 약제로 사용할 수 있는 양의 일반식 :의 있을 수 있는 입체화학적 이성질형 및 이것의 약제로 사용할 수 있는 산부가염을 가진 화합물의 적어도 하나를 환자에 전신투약하는 것으로 된 심신장애로 고통을 받고 있는 환자를 치료하는 방법, 위 식에서 R,R1,Alk,X,A,Ar1및 Ar2들을 제1항에서 정의한 바와 같다.
- 제4항에서 Alk가 1,2-에탄디일라디칼인 방법.
- 제4항에서 일반식(I)의 화합물이 6-[2-[4-[비스(4-플루오로페닐)메틸렌]-1-피페리디닐]에틸]-7-메틸-5H-티아졸로 [3,2-a] 피리미딘-5- 또는 이것의 약제로 사용할 수 있는 산부가염인 방법.
- a) N-알킬화 방법에 따라서, 일반식 :의 시약을 일반식 :의 피페리딘과 반응시키거나; 또는b) 일반식 :의 아민을 일반식 :의 α-카르보닐카르복시산 유도체와 반응시키거나, 또는c) 일반식 :의 시약을 일반식 :의 α-아미노카르복시산 유도체로 고리화시키거나; 또는d) 일반식 :의 니트릴을 일반식 :의 α-아민카르복시산 유도체로 고리화시키거나; 또는e) 일반식 :의 2-메르캅토피리미딘온을 일반식 :의 시약으로 고리화시켜서로 표시되는 일반식(I)의 화합물을 제조하거나; 또는f) 일반식 :의 2-메르캅토피리미딘온을 일반식 :의 시약으로 고리화하여 X가 S이고 또 A가인로 표시되는 일반식(I)의 화합물을 제조하는 것을 특징으로 하는 일반식 :을 가진 화합물, 있을 수 있는 입체화학적 이성질형 및 이것의 약제로 사용할 수 있는 산부가염을 제조하고 또 만일 필요하다면 적당한 산과 반응시켜서 전술과 같이 하여서 얻은 화합물(I)의 치료적으로 유용한 산부가염을 제조하며; 또 더욱 필요하면 표준방법으로 전술한 생성물의 입체화학적 이성질형을 제조하는 방법, 위 식들에서 R,R1,Alk,A,X,Ar1및 Ar2들은 제1항에서 정의한 바와 같고, L은 예컨데 저급알킬록시, 히드록시, 할로, 아미노, 모노-및 디(저급알킬) 아미노 및 기타와 같은 적당한 이탈기를 표시하며, L1은 예컨데 저급알킬록시, 히드록시, 할로, 아미노, 모노-및 디(저급알킬)아미노 및 기타와 같은 적당한 이탈기를 각각 독립적으로 표시한다.※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US43807982A | 1982-11-01 | 1982-11-01 | |
| US438079 | 1982-11-01 | ||
| US06/517,612 US4485107A (en) | 1982-11-01 | 1983-07-27 | [[Bis(aryl)methylene]-1-piperidinyl]alkyl-pyrimidinones |
| US517612 | 1983-07-27 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| KR850000462A true KR850000462A (ko) | 1985-02-27 |
| KR870000825B1 KR870000825B1 (ko) | 1987-04-23 |
Family
ID=27031541
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1019830004656A KR870000825B1 (ko) | 1982-11-01 | 1983-12-30 | [[비스(아릴)메틸렌]-1-피페리디닐]알킬-피리미딘온의 제조방법 |
Country Status (26)
| Country | Link |
|---|---|
| US (1) | US4485107A (ko) |
| EP (1) | EP0110435B1 (ko) |
| KR (1) | KR870000825B1 (ko) |
| AU (1) | AU559176B2 (ko) |
| BG (2) | BG51158A3 (ko) |
| CA (1) | CA1211438A (ko) |
| CS (1) | CS238396B2 (ko) |
| CY (1) | CY1607A (ko) |
| DE (1) | DE3378825D1 (ko) |
| DK (1) | DK168919B1 (ko) |
| ES (1) | ES8601965A1 (ko) |
| FI (1) | FI77868C (ko) |
| GR (1) | GR81277B (ko) |
| HK (1) | HK52691A (ko) |
| IE (1) | IE56180B1 (ko) |
| IL (1) | IL70094A0 (ko) |
| IN (1) | IN159576B (ko) |
| MA (1) | MA19941A1 (ko) |
| NO (1) | NO166133C (ko) |
| NZ (1) | NZ205993A (ko) |
| PH (1) | PH20483A (ko) |
| PT (1) | PT77493B (ko) |
| RO (1) | RO86698B (ko) |
| SG (1) | SG46791G (ko) |
| SU (1) | SU1313349A3 (ko) |
| ZW (1) | ZW23283A1 (ko) |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4529727A (en) * | 1982-04-21 | 1985-07-16 | Janssen Pharmaceutical, N.V. | Pyrimido[2,1-b][1,3]-thiazines |
| US4533665A (en) * | 1983-07-27 | 1985-08-06 | Janssen Pharmaceutica | [[Bis(aryl)methylene]-1-piperidinyl]alkyl-pyrimidinones |
| US4581171A (en) * | 1983-07-27 | 1986-04-08 | Janssen Pharmaceutica, N.V. | [[Bis(aryl)methylene]-1-piperidinyl]alkyl-pyrimidinones useful for treating psychotropic disorders |
| US4695569A (en) * | 1983-11-30 | 1987-09-22 | Janssen Pharmaceutica N.V. | Bicyclic heterocyclyl containing N-(bicyclic heterocyclyl)-4-piperidinamines |
| US4888426A (en) * | 1983-11-30 | 1989-12-19 | Janssen Pharmaceutica N.V. | 1-(5-methyl-furan-2-ylmethyl)-N-(4-piperidinyl)imidazo [4,5-6]pyridine-2-amine |
| US4804663A (en) * | 1985-03-27 | 1989-02-14 | Janssen Pharmaceutica N.V. | 3-piperidinyl-substituted 1,2-benzisoxazoles and 1,2-benzisothiazoles |
| US4874766A (en) * | 1986-09-22 | 1989-10-17 | Janssen Pharmaceutica N.V. | Method of promoting wound-healing |
| US4921854A (en) * | 1986-12-30 | 1990-05-01 | Egis Gyogyszergyar | Condensed thiazolopyrimidine, pyrimido-thiazine or thiazepine pyrimidine compounds |
| DE3738844A1 (de) * | 1987-11-16 | 1989-05-24 | Merck Patent Gmbh | Analgetikum |
| IL90858A (en) * | 1988-07-07 | 1994-08-26 | Rhone Poulenc Sante | History (Aza) Naftalensultam, their preparation and preparations containing them |
| IL90879A0 (en) * | 1988-09-02 | 1990-02-09 | Janssen Pharmaceutica Nv | 3-piperidinyl-indazole derivatives,their preparation and antihypertensive compositions containing them |
| US5158952A (en) * | 1988-11-07 | 1992-10-27 | Janssen Pharmaceutica N.V. | 3-[2-[4-(6-fluoro-1,2-benzisoxozol-3-yl)-1-piperidinyl]ethyl]-6,7,8,9 tetrahydro-9-hydroxy-2-methyl-4H-pyrido [1,2-a]pyrimidin-4-one, compositions and method of use |
| US5256659A (en) * | 1989-01-09 | 1993-10-26 | Janssen Pharmaceutica N.V. | 2-aminopyrimidinone derivatives |
| US5140029A (en) * | 1989-01-09 | 1992-08-18 | Janssen Pharmaceutica N.V. | 2-aminopyrimidinone derivatives |
| GB8900382D0 (en) * | 1989-01-09 | 1989-03-08 | Janssen Pharmaceutica Nv | 2-aminopyrimidinone derivatives |
| FR2643373B1 (fr) * | 1989-01-10 | 1993-12-31 | Adir Cie | Nouveaux derives des bisarylalcenes, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent |
| GB9008850D0 (en) * | 1990-04-19 | 1990-06-13 | Janssen Pharmaceutica Nv | Novel 2,9-disubstituted-4h-pyridol(1,2-a)pyrimidin-4-ones |
| ES2050069B1 (es) * | 1992-07-10 | 1994-12-16 | Vita Invest Sa | Procedimiento para la obtencion de 3-(2-(4-(6-fluoro-1,2-benzisoxazol-3-il)piperidino)etil)-2-metil-6,7,8,9-tetrahidro-4h-pirido(1,2-a) pirimidin-4-ona. |
| KR100354270B1 (ko) | 1993-11-19 | 2003-02-11 | 알커메스 컨트롤드 테라포이틱스 인코퍼레이티드 Ii | 마이크로캡슐화된3-피페리디닐-치환된1,2-벤즈이속사졸및1,2-벤즈이소티아졸 |
| IL122072A (en) * | 1996-11-14 | 2001-03-19 | Akzo Nobel Nv | Piperidine derivatives their preparation and pharmaceutical compositions containing them |
| UA72189C2 (uk) | 1997-11-17 | 2005-02-15 | Янссен Фармацевтика Н.В. | Фармацевтична композиція, що містить водну суспензію субмікронних ефірів 9-гідроксирисперидон жирних кислот |
| UA75051C2 (en) * | 1999-09-03 | 2006-03-15 | Syngenta Participations Ag | Tetrahydropiridines as pesticides, a composition, a method for the preparation thereof and a method of controlling pests |
| TW200400005A (en) * | 2002-02-11 | 2004-01-01 | Syngenta Participations Ag | Derivatives of (1-benzyl-piperidine-4-yl)-diphenyl-methanol |
| KR20040034996A (ko) * | 2002-10-18 | 2004-04-29 | 한미약품 주식회사 | 리스페리돈의 개선된 제조방법 |
| BR0316747A (pt) * | 2002-12-18 | 2005-10-18 | Fmc Corp | Piperidinas n-(arilmetil substituìdas)-4-(metil dissubstituìdas) e piperazinas |
| WO2004094415A1 (en) * | 2003-04-22 | 2004-11-04 | Synthon B.V. | Risperidone monohydrochloride |
| CA2874595A1 (en) | 2007-04-13 | 2009-02-19 | Southern Research Institute | Use of terfenadine for treating breast and ovarian tumors |
| KR102551018B1 (ko) * | 2014-12-12 | 2023-07-05 | 니뽄 다바코 산교 가부시키가이샤 | 디히드로피리미딘-2-온 화합물 및 그의 의약 용도 |
| EP3760616A4 (en) | 2018-02-28 | 2021-11-03 | Japan Tobacco Inc. | 4-METHYLDIHYDROPYRIMIDINONE COMPOUND AND ITS MEDICINAL USE |
| CN112724070B (zh) * | 2021-01-08 | 2022-11-25 | 南京方生和医药科技有限公司 | 一种α，α-二苯基-4-哌啶甲醇的制备方法 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1252315A (ko) * | 1969-06-05 | 1971-11-03 | ||
| US3960863A (en) * | 1974-06-25 | 1976-06-01 | Sankyo Company Limited | Pyrido[1,2-a]pyrimidinone derivatives |
| DE3000923A1 (de) * | 1979-01-17 | 1980-07-31 | Degussa | Neue n-alkoxy-dithienylpiperidine |
| US4342870A (en) * | 1980-03-28 | 1982-08-03 | Janssen Pharmaceutica N.V. | Novel 3-(1-piperidinylalkyl)-4H-pyrido[1,2-a]pyrimidin-4-one derivatives |
| US4443451A (en) * | 1981-07-15 | 1984-04-17 | Janssen Pharmaceutica N.V. | Bicyclic pyrimidin-5-one derivatives |
-
1983
- 1983-07-27 US US06/517,612 patent/US4485107A/en not_active Expired - Lifetime
- 1983-09-06 IN IN1090/CAL/83A patent/IN159576B/en unknown
- 1983-09-15 CA CA000436799A patent/CA1211438A/en not_active Expired
- 1983-09-29 DE DE8383201393T patent/DE3378825D1/de not_active Expired
- 1983-09-29 EP EP83201393A patent/EP0110435B1/en not_active Expired
- 1983-10-13 PT PT77493A patent/PT77493B/pt not_active IP Right Cessation
- 1983-10-18 NZ NZ205993A patent/NZ205993A/en unknown
- 1983-10-19 CS CS837663A patent/CS238396B2/cs unknown
- 1983-10-21 PH PH29745A patent/PH20483A/en unknown
- 1983-10-27 GR GR72809A patent/GR81277B/el unknown
- 1983-10-27 SU SU833656351A patent/SU1313349A3/ru active
- 1983-10-28 IE IE2540/83A patent/IE56180B1/en not_active IP Right Cessation
- 1983-10-28 ES ES526868A patent/ES8601965A1/es not_active Expired
- 1983-10-28 ZW ZW232/83A patent/ZW23283A1/xx unknown
- 1983-10-28 MA MA20161A patent/MA19941A1/fr unknown
- 1983-10-31 DK DK498483A patent/DK168919B1/da not_active IP Right Cessation
- 1983-10-31 FI FI833995A patent/FI77868C/fi not_active IP Right Cessation
- 1983-10-31 NO NO833956A patent/NO166133C/no unknown
- 1983-10-31 AU AU20834/83A patent/AU559176B2/en not_active Expired
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- 1983-10-31 IL IL70094A patent/IL70094A0/xx not_active IP Right Cessation
- 1983-11-01 BG BG62872A patent/BG51158A3/xx unknown
- 1983-12-30 KR KR1019830004656A patent/KR870000825B1/ko not_active IP Right Cessation
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1991
- 1991-06-18 SG SG467/91A patent/SG46791G/en unknown
- 1991-07-11 HK HK526/91A patent/HK52691A/xx not_active IP Right Cessation
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1992
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1993
- 1993-06-16 BG BG97874A patent/BG60538B2/bg unknown
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