EA199801084A1 - Спосб получения фенилгетероциклических соединений, используемых в качестве ингибиторов циклооксигеназы-2 - Google Patents

Спосб получения фенилгетероциклических соединений, используемых в качестве ингибиторов циклооксигеназы-2

Info

Publication number
EA199801084A1
EA199801084A1 EA199801084A EA199801084A EA199801084A1 EA 199801084 A1 EA199801084 A1 EA 199801084A1 EA 199801084 A EA199801084 A EA 199801084A EA 199801084 A EA199801084 A EA 199801084A EA 199801084 A1 EA199801084 A1 EA 199801084A1
Authority
EA
Eurasian Patent Office
Prior art keywords
cyclooxygenase
inhibitors
compounds used
heterocyclic compounds
obtain phenyl
Prior art date
Application number
EA199801084A
Other languages
English (en)
Inventor
Кай Россен
Ральф П. Волант
Гуо-Джие Хо
Роджер Н. Фарр
Дэвид Дж. Матр
Original Assignee
Мерк Энд Ко., Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9613110.7A external-priority patent/GB9613110D0/en
Priority claimed from GBGB9622831.7A external-priority patent/GB9622831D0/en
Priority claimed from GBGB9622816.8A external-priority patent/GB9622816D0/en
Application filed by Мерк Энд Ко., Инк. filed Critical Мерк Энд Ко., Инк.
Publication of EA199801084A1 publication Critical patent/EA199801084A1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/26—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D307/30—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/32—Oxygen atoms
    • C07D307/33—Oxygen atoms in position 2, the oxygen atom being in its keto or unsubstituted enol form
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C315/00—Preparation of sulfones; Preparation of sulfoxides
    • C07C315/02—Preparation of sulfones; Preparation of sulfoxides by formation of sulfone or sulfoxide groups by oxidation of sulfides, or by formation of sulfone groups by oxidation of sulfoxides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C07C317/24—Sulfones; Sulfoxides having sulfone or sulfoxide groups and doubly-bound oxygen atoms bound to the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C319/00—Preparation of thiols, sulfides, hydropolysulfides or polysulfides
    • C07C319/14—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of sulfides
    • C07C319/20—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of sulfides by reactions not involving the formation of sulfide groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/125—Saturated compounds having only one carboxyl group and containing ether groups, groups, groups, or groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/48—Compounds containing oxirane rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/58—One oxygen atom, e.g. butenolide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/60—Two oxygen atoms, e.g. succinic anhydride

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Fertilizers (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Furan Compounds (AREA)

Abstract

Изобретение касается способа получения соединений формулы (I) или (IA), используемых для лечения заболеваний, опосредованных циклооксигеназой-2.Международная заявка была опубликована вместе с отчетом о международном поиске.
EA199801084A 1996-05-31 1997-05-27 Спосб получения фенилгетероциклических соединений, используемых в качестве ингибиторов циклооксигеназы-2 EA199801084A1 (ru)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US1864496P 1996-05-31 1996-05-31
GBGB9613110.7A GB9613110D0 (en) 1996-06-21 1996-06-21 Process for making phenyl heterocyclic useful as cox-2 inhibitors
US2810896P 1996-10-09 1996-10-09
US2810996P 1996-10-09 1996-10-09
GBGB9622831.7A GB9622831D0 (en) 1996-11-01 1996-11-01 Process for making phenyl heterocycles useful as cox-2 inhibitors
GBGB9622816.8A GB9622816D0 (en) 1996-11-01 1996-11-01 Process for making phenyl heterocycles useful as cox-2 inhibitors
PCT/US1997/009193 WO1997045420A1 (en) 1996-05-31 1997-05-27 Process for making phenyl heterocycles useful as cox-2 inhibitors

Publications (1)

Publication Number Publication Date
EA199801084A1 true EA199801084A1 (ru) 1999-04-29

Family

ID=27547262

Family Applications (1)

Application Number Title Priority Date Filing Date
EA199801084A EA199801084A1 (ru) 1996-05-31 1997-05-27 Спосб получения фенилгетероциклических соединений, используемых в качестве ингибиторов циклооксигеназы-2

Country Status (19)

Country Link
EP (1) EP0906300B1 (ru)
JP (1) JP3149192B2 (ru)
KR (1) KR20000016043A (ru)
CN (1) CN1219931A (ru)
AT (1) ATE212019T1 (ru)
AU (1) AU713380B2 (ru)
BR (1) BR9709264A (ru)
CA (1) CA2255635A1 (ru)
CZ (1) CZ391498A3 (ru)
DE (1) DE69709639T2 (ru)
EA (1) EA199801084A1 (ru)
ES (1) ES2169399T3 (ru)
HR (1) HRP970289A2 (ru)
HU (1) HUP9902443A3 (ru)
NZ (1) NZ332637A (ru)
PL (1) PL330227A1 (ru)
SK (1) SK164698A3 (ru)
WO (1) WO1997045420A1 (ru)
YU (1) YU53998A (ru)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6071954A (en) * 1997-03-14 2000-06-06 Merk Frosst Canada, Inc. (methylsulfonyl)phenyl-2-(5H)-furanones with oxygen link as COX-2 inhibitors
EP0970067B1 (en) * 1997-03-14 2003-07-02 Merck Frosst Canada & Co. (methylsulfonyl)phenyl-2-(5h)-furanones with oxygen link as cox-2 inhibitors
GB2330833A (en) * 1997-10-29 1999-05-05 Merck & Co Inc PREPARATION OF 4-(4-Methylsulfonylphenyl)-2-furanones USEFUL AS COX-2 INHIBITORS
EP1061908A4 (en) * 1998-03-13 2007-01-24 Merck & Co Inc COMBINATION THERAPY AND COMPOSITION FOR ACUTE CORONARY MIXING SYNDROME AND ASSOCIATED CONDITIONS
FR2799462B1 (fr) * 1999-10-08 2004-05-28 Merial Sas Procede de preparation d'inhibiteurs cox-2
ES2275218T3 (es) 2003-05-07 2007-06-01 Osteologix A/S Sales de estroncio hidrosolubles para el tratamiento de afecciones de cartilagos y/o huesos.
JP6204583B2 (ja) * 2014-05-15 2017-09-27 富士フイルム株式会社 α−ブロモアセトフェノン化合物の製造方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2152792C (en) * 1993-01-15 2000-02-15 Stephen R. Bertenshaw Novel 3,4-diaryl thiophenes and analogs thereof having use as antiinflammatory agents
CA2161789A1 (en) * 1993-05-13 1994-11-24 Jacques Yves Gauthier 2-substituted-3,4-diarylthiophene derivatives as inhibitors of cyclooxygenase
US5474995A (en) * 1993-06-24 1995-12-12 Merck Frosst Canada, Inc. Phenyl heterocycles as cox-2 inhibitors
US5585504A (en) * 1994-09-16 1996-12-17 Merck & Co., Inc. Process of making cox-2 inhibitors having a lactone bridge
DE69529690T2 (de) * 1994-12-21 2003-11-13 Merck Frosst Canada Inc Diaryl-2(5h)-fuaranone als cox-2-inhibitoren

Also Published As

Publication number Publication date
CA2255635A1 (en) 1997-12-04
JPH11511753A (ja) 1999-10-12
AU3220397A (en) 1998-01-05
HRP970289A2 (en) 1998-04-30
JP3149192B2 (ja) 2001-03-26
AU713380B2 (en) 1999-12-02
KR20000016043A (ko) 2000-03-25
PL330227A1 (en) 1999-05-10
YU53998A (en) 1999-11-22
BR9709264A (pt) 1999-08-10
EP0906300A1 (en) 1999-04-07
ATE212019T1 (de) 2002-02-15
DE69709639T2 (de) 2002-08-08
CN1219931A (zh) 1999-06-16
SK164698A3 (en) 1999-07-12
HUP9902443A3 (en) 2001-05-28
EP0906300B1 (en) 2002-01-16
DE69709639D1 (de) 2002-02-21
CZ391498A3 (cs) 1999-04-14
NZ332637A (en) 2000-06-23
WO1997045420A1 (en) 1997-12-04
ES2169399T3 (es) 2002-07-01
HUP9902443A2 (hu) 2001-04-28

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