ATE212019T1 - Verfahren zur herstellung von phenylheterocyclen die als cox-2 inhibitoren verwendet werden können - Google Patents
Verfahren zur herstellung von phenylheterocyclen die als cox-2 inhibitoren verwendet werden könnenInfo
- Publication number
- ATE212019T1 ATE212019T1 AT97927840T AT97927840T ATE212019T1 AT E212019 T1 ATE212019 T1 AT E212019T1 AT 97927840 T AT97927840 T AT 97927840T AT 97927840 T AT97927840 T AT 97927840T AT E212019 T1 ATE212019 T1 AT E212019T1
- Authority
- AT
- Austria
- Prior art keywords
- phenylheterocycles
- cox
- inhibitors
- producing
- cyclooxygenase
- Prior art date
Links
- 229940111134 coxibs Drugs 0.000 title 1
- 239000003255 cyclooxygenase 2 inhibitor Substances 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- 102000010907 Cyclooxygenase 2 Human genes 0.000 abstract 1
- 108010037462 Cyclooxygenase 2 Proteins 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 230000001404 mediated effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/60—Two oxygen atoms, e.g. succinic anhydride
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/26—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D307/30—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/32—Oxygen atoms
- C07D307/33—Oxygen atoms in position 2, the oxygen atom being in its keto or unsubstituted enol form
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C315/00—Preparation of sulfones; Preparation of sulfoxides
- C07C315/02—Preparation of sulfones; Preparation of sulfoxides by formation of sulfone or sulfoxide groups by oxidation of sulfides, or by formation of sulfone groups by oxidation of sulfoxides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C317/00—Sulfones; Sulfoxides
- C07C317/24—Sulfones; Sulfoxides having sulfone or sulfoxide groups and doubly-bound oxygen atoms bound to the same carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C319/00—Preparation of thiols, sulfides, hydropolysulfides or polysulfides
- C07C319/14—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of sulfides
- C07C319/20—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of sulfides by reactions not involving the formation of sulfide groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/125—Saturated compounds having only one carboxyl group and containing ether groups, groups, groups, or groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
- C07D303/02—Compounds containing oxirane rings
- C07D303/48—Compounds containing oxirane rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/58—One oxygen atom, e.g. butenolide
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Furan Compounds (AREA)
- Indole Compounds (AREA)
- Epoxy Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Plural Heterocyclic Compounds (AREA)
- Fertilizers (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US1864496P | 1996-05-31 | 1996-05-31 | |
| GBGB9613110.7A GB9613110D0 (en) | 1996-06-21 | 1996-06-21 | Process for making phenyl heterocyclic useful as cox-2 inhibitors |
| US2810896P | 1996-10-09 | 1996-10-09 | |
| US2810996P | 1996-10-09 | 1996-10-09 | |
| GBGB9622831.7A GB9622831D0 (en) | 1996-11-01 | 1996-11-01 | Process for making phenyl heterocycles useful as cox-2 inhibitors |
| GBGB9622816.8A GB9622816D0 (en) | 1996-11-01 | 1996-11-01 | Process for making phenyl heterocycles useful as cox-2 inhibitors |
| PCT/US1997/009193 WO1997045420A1 (en) | 1996-05-31 | 1997-05-27 | Process for making phenyl heterocycles useful as cox-2 inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE212019T1 true ATE212019T1 (de) | 2002-02-15 |
Family
ID=27547262
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT97927840T ATE212019T1 (de) | 1996-05-31 | 1997-05-27 | Verfahren zur herstellung von phenylheterocyclen die als cox-2 inhibitoren verwendet werden können |
Country Status (19)
| Country | Link |
|---|---|
| EP (1) | EP0906300B1 (de) |
| JP (1) | JP3149192B2 (de) |
| KR (1) | KR20000016043A (de) |
| CN (1) | CN1219931A (de) |
| AT (1) | ATE212019T1 (de) |
| AU (1) | AU713380B2 (de) |
| BR (1) | BR9709264A (de) |
| CA (1) | CA2255635A1 (de) |
| CZ (1) | CZ391498A3 (de) |
| DE (1) | DE69709639T2 (de) |
| EA (1) | EA199801084A1 (de) |
| ES (1) | ES2169399T3 (de) |
| HR (1) | HRP970289A2 (de) |
| HU (1) | HUP9902443A3 (de) |
| NZ (1) | NZ332637A (de) |
| PL (1) | PL330227A1 (de) |
| SK (1) | SK164698A3 (de) |
| WO (1) | WO1997045420A1 (de) |
| YU (1) | YU53998A (de) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2201466T3 (es) * | 1997-03-14 | 2004-03-16 | MERCK FROSST CANADA & CO. | `(metilsulfonil)fenil-2-(5h)-furanonas con enlace con oxigeno como inhibidores de cox-2`. |
| US6071954A (en) * | 1997-03-14 | 2000-06-06 | Merk Frosst Canada, Inc. | (methylsulfonyl)phenyl-2-(5H)-furanones with oxygen link as COX-2 inhibitors |
| GB2330833A (en) * | 1997-10-29 | 1999-05-05 | Merck & Co Inc | PREPARATION OF 4-(4-Methylsulfonylphenyl)-2-furanones USEFUL AS COX-2 INHIBITORS |
| CA2322824A1 (en) * | 1998-03-13 | 1999-09-16 | Merck & Co., Inc. | Combination therapy and composition for acute coronary ischemic syndrome and related conditions |
| FR2799462B1 (fr) * | 1999-10-08 | 2004-05-28 | Merial Sas | Procede de preparation d'inhibiteurs cox-2 |
| PL2266585T3 (pl) | 2003-05-07 | 2013-10-31 | Osteologix As | Rozpuszczalne w wodzie sole stronktu do stosowania w leczeniu chorób chrząstki i/lub kości |
| CN106255676B (zh) | 2014-05-15 | 2019-04-30 | 富士胶片株式会社 | α-溴代苯乙酮化合物的制造方法 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE9422447U1 (de) * | 1993-01-15 | 2002-10-17 | G.D. Searle LLC, Chicago, Ill. | 3,4-Diarylthiophene und Analoga davon, sowie deren Verwendung als entzündungshemmende Mittel |
| AU6718494A (en) * | 1993-05-13 | 1994-12-12 | Merck Frosst Canada Inc. | 2-substituted-3,4-diarylthiophene derivatives as inhibitors of cyclooxygenase |
| US5474995A (en) * | 1993-06-24 | 1995-12-12 | Merck Frosst Canada, Inc. | Phenyl heterocycles as cox-2 inhibitors |
| US5585504A (en) * | 1994-09-16 | 1996-12-17 | Merck & Co., Inc. | Process of making cox-2 inhibitors having a lactone bridge |
| DE69529690T2 (de) * | 1994-12-21 | 2003-11-13 | Merck Frosst Canada & Co., Halifax | Diaryl-2(5h)-fuaranone als cox-2-inhibitoren |
| US5789413A (en) | 1996-02-01 | 1998-08-04 | Merck Frosst Canada, Inc. | Alkylated styrenes as prodrugs to COX-2 inhibitors |
-
1997
- 1997-05-26 HR HR9622816.8A patent/HRP970289A2/xx not_active Application Discontinuation
- 1997-05-27 AU AU32203/97A patent/AU713380B2/en not_active Ceased
- 1997-05-27 ES ES97927840T patent/ES2169399T3/es not_active Expired - Lifetime
- 1997-05-27 NZ NZ332637A patent/NZ332637A/en unknown
- 1997-05-27 WO PCT/US1997/009193 patent/WO1997045420A1/en not_active Ceased
- 1997-05-27 EA EA199801084A patent/EA199801084A1/ru unknown
- 1997-05-27 CA CA002255635A patent/CA2255635A1/en not_active Abandoned
- 1997-05-27 JP JP54295397A patent/JP3149192B2/ja not_active Expired - Fee Related
- 1997-05-27 KR KR1019980709608A patent/KR20000016043A/ko not_active Ceased
- 1997-05-27 CN CN97194963A patent/CN1219931A/zh active Pending
- 1997-05-27 DE DE69709639T patent/DE69709639T2/de not_active Expired - Fee Related
- 1997-05-27 SK SK1646-98A patent/SK164698A3/sk unknown
- 1997-05-27 EP EP97927840A patent/EP0906300B1/de not_active Expired - Lifetime
- 1997-05-27 CZ CZ983914A patent/CZ391498A3/cs unknown
- 1997-05-27 BR BR9709264A patent/BR9709264A/pt unknown
- 1997-05-27 AT AT97927840T patent/ATE212019T1/de not_active IP Right Cessation
- 1997-05-27 HU HU9902443A patent/HUP9902443A3/hu unknown
- 1997-05-27 PL PL97330227A patent/PL330227A1/xx unknown
-
1998
- 1998-11-27 YU YU53998A patent/YU53998A/sr unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JP3149192B2 (ja) | 2001-03-26 |
| CZ391498A3 (cs) | 1999-04-14 |
| ES2169399T3 (es) | 2002-07-01 |
| BR9709264A (pt) | 1999-08-10 |
| PL330227A1 (en) | 1999-05-10 |
| YU53998A (en) | 1999-11-22 |
| HRP970289A2 (en) | 1998-04-30 |
| EP0906300A1 (de) | 1999-04-07 |
| WO1997045420A1 (en) | 1997-12-04 |
| DE69709639T2 (de) | 2002-08-08 |
| EA199801084A1 (ru) | 1999-04-29 |
| AU713380B2 (en) | 1999-12-02 |
| HUP9902443A3 (en) | 2001-05-28 |
| JPH11511753A (ja) | 1999-10-12 |
| NZ332637A (en) | 2000-06-23 |
| SK164698A3 (en) | 1999-07-12 |
| KR20000016043A (ko) | 2000-03-25 |
| HUP9902443A2 (hu) | 2001-04-28 |
| AU3220397A (en) | 1998-01-05 |
| EP0906300B1 (de) | 2002-01-16 |
| CN1219931A (zh) | 1999-06-16 |
| DE69709639D1 (de) | 2002-02-21 |
| CA2255635A1 (en) | 1997-12-04 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |