DE60120352D1 - Verfahren zur industriellen herstellung von betulinsäuren - Google Patents

Verfahren zur industriellen herstellung von betulinsäuren

Info

Publication number
DE60120352D1
DE60120352D1 DE60120352T DE60120352T DE60120352D1 DE 60120352 D1 DE60120352 D1 DE 60120352D1 DE 60120352 T DE60120352 T DE 60120352T DE 60120352 T DE60120352 T DE 60120352T DE 60120352 D1 DE60120352 D1 DE 60120352D1
Authority
DE
Germany
Prior art keywords
betulin
acetate
dibenzoate
acids
betulinic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE60120352T
Other languages
English (en)
Other versions
DE60120352T2 (de
Inventor
A Krasutsky
M Carlson
Vitaliy V Nesterenko
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Minnesota
Original Assignee
University of Minnesota
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Minnesota filed Critical University of Minnesota
Publication of DE60120352D1 publication Critical patent/DE60120352D1/de
Application granted granted Critical
Publication of DE60120352T2 publication Critical patent/DE60120352T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/347—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups
    • C07C51/367—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups by introduction of functional groups containing oxygen only in singly bound form
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/16—Preparation of carboxylic acids or their salts, halides or anhydrides by oxidation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C62/00—Compounds having carboxyl groups bound to carbon atoms of rings other than six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C62/30—Unsaturated compounds
    • C07C62/32—Unsaturated compounds containing hydroxy or O-metal groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/08—Preparation of carboxylic acid esters by reacting carboxylic acids or symmetrical anhydrides with the hydroxy or O-metal group of organic compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/14—Preparation of carboxylic acid esters from carboxylic acid halides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/28—Preparation of carboxylic acid esters by modifying the hydroxylic moiety of the ester, such modification not being an introduction of an ester group
    • C07C67/29—Preparation of carboxylic acid esters by modifying the hydroxylic moiety of the ester, such modification not being an introduction of an ester group by introduction of oxygen-containing functional groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/02—Ortho- or ortho- and peri-condensed systems
    • C07C2603/52—Ortho- or ortho- and peri-condensed systems containing five condensed rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Steroid Compounds (AREA)
DE60120352T 2000-01-11 2001-01-11 Verfahren zur industriellen herstellung von betulinsäuren Expired - Fee Related DE60120352T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US480406 2000-01-11
US09/480,406 US6232481B1 (en) 2000-01-11 2000-01-11 Method for manufacturing betulinic acid
PCT/US2001/000991 WO2001051451A2 (en) 2000-01-11 2001-01-11 Methods for manufacturing betulinic acid

Publications (2)

Publication Number Publication Date
DE60120352D1 true DE60120352D1 (de) 2006-07-20
DE60120352T2 DE60120352T2 (de) 2007-04-26

Family

ID=23907841

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60120352T Expired - Fee Related DE60120352T2 (de) 2000-01-11 2001-01-11 Verfahren zur industriellen herstellung von betulinsäuren

Country Status (10)

Country Link
US (4) US6232481B1 (de)
EP (1) EP1248766B1 (de)
JP (1) JP2003519674A (de)
AT (1) ATE328862T1 (de)
AU (1) AU5789601A (de)
CA (1) CA2396574A1 (de)
DE (1) DE60120352T2 (de)
ES (1) ES2264694T3 (de)
NO (1) NO20023276L (de)
WO (1) WO2001051451A2 (de)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6232481B1 (en) * 2000-01-11 2001-05-15 Regents Of The University Of Minnesota Method for manufacturing betulinic acid
US7407480B2 (en) * 2001-07-27 2008-08-05 Ams Research Corporation Method and apparatus for correction of urinary and gynecological pathologies, including treatment of incontinence cystocele
WO2006105357A2 (en) * 2005-03-29 2006-10-05 Regents Of The University Of Minnesota Electrochemical method for the production of betulin aldehyde
CA2603124A1 (en) * 2005-03-29 2006-10-05 Regents Of The University Of Minnesota Selective oxidation of triterpenes employing tempo
US20090023698A1 (en) * 2005-03-29 2009-01-22 Krasutsky Pavel A Methods of manufacturing bioactive 3-esters of betulinic aldehyde and betulinic acid
US20090131714A1 (en) * 2005-06-08 2009-05-21 Krasutsky Pavel A Synthesis of betulonic and betulinic aldehydes
CA2649704A1 (en) * 2006-04-18 2007-10-25 Regents Of The University Of Minnesota Depolymerization extraction of compounds from birch bark
KR100941595B1 (ko) * 2008-06-05 2010-02-11 주식회사 알앤엘바이오 바이러스 억제제로서 유용한 트리테르페노이드계 화합물
CN101302244B (zh) * 2008-06-06 2011-04-13 东北林业大学 一种桦木酸的生产方法
CN102399255B (zh) * 2010-09-09 2015-04-15 东北林业大学 一种桦木酸的制备方法
RU2560710C1 (ru) * 2014-10-30 2015-08-20 Федеральное Государственное Бюджетное Учреждение Науки Институт Химии И Химической Технологии Сибирского Отделения Российской Академии Наук (Иххт Со Ран) Способ получения производных 3-ацетата-28-сульфата бетулина
PL227790B1 (pl) 2015-08-13 2018-01-31 Slaski Univ Medyczny W Katowicach Fosfoniany acetylenowych pochodnych betuliny o działaniu przeciwnowotworowym, sposób ich wytwarzania i zastosowanie.
CN110577470B (zh) * 2019-10-09 2022-12-27 蚌埠学院 一种利用沸石分子筛催化2-萘甲醚选择性硝化的方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW212790B (de) * 1991-10-15 1993-09-11 Ciba Geigy Ag
US5804575A (en) * 1997-03-27 1998-09-08 The Board Of Trustees Of The University Of Illinois Methods of manufacturing betulinic acid
PT1068219E (pt) * 1998-03-02 2007-03-30 Univ North Carolina Derivados acilados de betulina e de di-hidrobetulina, sua preparação e sua utilização
US6232481B1 (en) * 2000-01-11 2001-05-15 Regents Of The University Of Minnesota Method for manufacturing betulinic acid

Also Published As

Publication number Publication date
US6407270B1 (en) 2002-06-18
US20020016482A1 (en) 2002-02-07
ES2264694T3 (es) 2007-01-16
CA2396574A1 (en) 2001-07-19
ATE328862T1 (de) 2006-06-15
EP1248766A2 (de) 2002-10-16
US20020028960A1 (en) 2002-03-07
JP2003519674A (ja) 2003-06-24
WO2001051451A3 (en) 2002-03-07
NO20023276D0 (no) 2002-07-05
US6232481B1 (en) 2001-05-15
WO2001051451A2 (en) 2001-07-19
US20010007908A1 (en) 2001-07-12
DE60120352T2 (de) 2007-04-26
US6271405B2 (en) 2001-08-07
AU5789601A (en) 2001-07-24
US6867314B2 (en) 2005-03-15
NO20023276L (no) 2002-09-09
EP1248766B1 (de) 2006-06-07

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee