ATE328862T1 - Verfahren zur industriellen herstellung von betulinsäuren - Google Patents

Verfahren zur industriellen herstellung von betulinsäuren

Info

Publication number
ATE328862T1
ATE328862T1 AT01942354T AT01942354T ATE328862T1 AT E328862 T1 ATE328862 T1 AT E328862T1 AT 01942354 T AT01942354 T AT 01942354T AT 01942354 T AT01942354 T AT 01942354T AT E328862 T1 ATE328862 T1 AT E328862T1
Authority
AT
Austria
Prior art keywords
betulin
acetate
dibenzoate
betulinic
industrial production
Prior art date
Application number
AT01942354T
Other languages
English (en)
Inventor
Pavel A Krasutsky
Robert M Carlson
Vitaliy V Nesterenko
Original Assignee
Univ Minnesota
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Minnesota filed Critical Univ Minnesota
Application granted granted Critical
Publication of ATE328862T1 publication Critical patent/ATE328862T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/347—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups
    • C07C51/367—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups by introduction of functional groups containing oxygen only in singly bound form
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/16—Preparation of carboxylic acids or their salts, halides or anhydrides by oxidation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C62/00—Compounds having carboxyl groups bound to carbon atoms of rings other than six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C62/30—Unsaturated compounds
    • C07C62/32—Unsaturated compounds containing hydroxy or O-metal groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/08—Preparation of carboxylic acid esters by reacting carboxylic acids or symmetrical anhydrides with the hydroxy or O-metal group of organic compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/14—Preparation of carboxylic acid esters from carboxylic acid halides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/28—Preparation of carboxylic acid esters by modifying the hydroxylic moiety of the ester, such modification not being an introduction of an ester group
    • C07C67/29—Preparation of carboxylic acid esters by modifying the hydroxylic moiety of the ester, such modification not being an introduction of an ester group by introduction of oxygen-containing functional groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/02—Ortho- or ortho- and peri-condensed systems
    • C07C2603/52—Ortho- or ortho- and peri-condensed systems containing five condensed rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Steroid Compounds (AREA)
AT01942354T 2000-01-11 2001-01-11 Verfahren zur industriellen herstellung von betulinsäuren ATE328862T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US09/480,406 US6232481B1 (en) 2000-01-11 2000-01-11 Method for manufacturing betulinic acid

Publications (1)

Publication Number Publication Date
ATE328862T1 true ATE328862T1 (de) 2006-06-15

Family

ID=23907841

Family Applications (1)

Application Number Title Priority Date Filing Date
AT01942354T ATE328862T1 (de) 2000-01-11 2001-01-11 Verfahren zur industriellen herstellung von betulinsäuren

Country Status (10)

Country Link
US (4) US6232481B1 (de)
EP (1) EP1248766B1 (de)
JP (1) JP2003519674A (de)
AT (1) ATE328862T1 (de)
AU (1) AU5789601A (de)
CA (1) CA2396574A1 (de)
DE (1) DE60120352T2 (de)
ES (1) ES2264694T3 (de)
NO (1) NO20023276L (de)
WO (1) WO2001051451A2 (de)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6232481B1 (en) * 2000-01-11 2001-05-15 Regents Of The University Of Minnesota Method for manufacturing betulinic acid
US7407480B2 (en) * 2001-07-27 2008-08-05 Ams Research Corporation Method and apparatus for correction of urinary and gynecological pathologies, including treatment of incontinence cystocele
US20090023698A1 (en) * 2005-03-29 2009-01-22 Krasutsky Pavel A Methods of manufacturing bioactive 3-esters of betulinic aldehyde and betulinic acid
WO2006105357A2 (en) * 2005-03-29 2006-10-05 Regents Of The University Of Minnesota Electrochemical method for the production of betulin aldehyde
WO2006105354A1 (en) * 2005-03-29 2006-10-05 Regents Of The University Of Minnesota Selective oxidation of triterpenes employing tempo
WO2006133314A2 (en) * 2005-06-08 2006-12-14 Regents Of The University Of Minnesota Synthesis of betulonic and betulinic aldehydes
CA2649704A1 (en) * 2006-04-18 2007-10-25 Regents Of The University Of Minnesota Depolymerization extraction of compounds from birch bark
KR100941595B1 (ko) * 2008-06-05 2010-02-11 주식회사 알앤엘바이오 바이러스 억제제로서 유용한 트리테르페노이드계 화합물
CN101302244B (zh) * 2008-06-06 2011-04-13 东北林业大学 一种桦木酸的生产方法
CN102399255B (zh) * 2010-09-09 2015-04-15 东北林业大学 一种桦木酸的制备方法
RU2560710C1 (ru) * 2014-10-30 2015-08-20 Федеральное Государственное Бюджетное Учреждение Науки Институт Химии И Химической Технологии Сибирского Отделения Российской Академии Наук (Иххт Со Ран) Способ получения производных 3-ацетата-28-сульфата бетулина
PL227790B1 (pl) 2015-08-13 2018-01-31 Slaski Univ Medyczny W Katowicach Fosfoniany acetylenowych pochodnych betuliny o działaniu przeciwnowotworowym, sposób ich wytwarzania i zastosowanie.
CN110577470B (zh) * 2019-10-09 2022-12-27 蚌埠学院 一种利用沸石分子筛催化2-萘甲醚选择性硝化的方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW212790B (de) 1991-10-15 1993-09-11 Ciba Geigy Ag
US5804575A (en) 1997-03-27 1998-09-08 The Board Of Trustees Of The University Of Illinois Methods of manufacturing betulinic acid
WO1999045025A1 (en) * 1998-03-02 1999-09-10 The University Of North Carolina At Chapel Hill Acylated betulin and dihydrobetulin derivatives, preparation thereof and use thereof
US6232481B1 (en) 2000-01-11 2001-05-15 Regents Of The University Of Minnesota Method for manufacturing betulinic acid

Also Published As

Publication number Publication date
JP2003519674A (ja) 2003-06-24
EP1248766A2 (de) 2002-10-16
US6407270B1 (en) 2002-06-18
US20020016482A1 (en) 2002-02-07
US6271405B2 (en) 2001-08-07
US6232481B1 (en) 2001-05-15
US20020028960A1 (en) 2002-03-07
CA2396574A1 (en) 2001-07-19
NO20023276D0 (no) 2002-07-05
WO2001051451A2 (en) 2001-07-19
NO20023276L (no) 2002-09-09
EP1248766B1 (de) 2006-06-07
US20010007908A1 (en) 2001-07-12
ES2264694T3 (es) 2007-01-16
WO2001051451A3 (en) 2002-03-07
DE60120352T2 (de) 2007-04-26
US6867314B2 (en) 2005-03-15
DE60120352D1 (de) 2006-07-20
AU5789601A (en) 2001-07-24

Similar Documents

Publication Publication Date Title
DE69530242D1 (de) Verfahren zur Herstellung von Glutaminsäure durch Fermentation
DE60110497D1 (de) Verfahren zur Herstellung von Acrylsäure
ATE328862T1 (de) Verfahren zur industriellen herstellung von betulinsäuren
DE69904405D1 (de) Verfahren zur Herstellung von Essigsäure
RS53562B1 (sr) Tripeptidi, inhibitori hepatitisa c
DE60230274D1 (de) Verfahren zur herstellung von l-aminosäuren durch enterobacteriaceae-stämmen mit verstärkter expression des pts-g
DE59810029D1 (de) Verfahren zur herstellung von esterweichmachern
DE19681532T1 (de) Verfahren zur Herstellung von L-Glutaminsäure durch Fermentation
DE69902139D1 (de) Verfahren zur Herstellung von Salpetersäure
HUP9901818A2 (hu) Előnyös adalékot tartalmazó szappanpehely, ilyen pehelytartalmú mosdószappan, valamint eljárás e szappanpehely előállítására
ATE276235T1 (de) Verfahren zur herstellung von thiocarbonsäuren
DE69011880D1 (de) Verfahren zur Herstellung von L-Aminosäuren durch Fermentation.
DE69903698D1 (de) Verfahren zur Herstellung von Acrylsäure
DE60038560D1 (de) Verfahren zur fermentativen Herstellung von L-Arginin
ATE327219T1 (de) Verfahren zur herstellung von hydroxymethylthiobuttersäure
DE50111897D1 (de) VERFAHREN ZUR HERSTELLUNG VON ESTERN alpha, beta -UNGESÄTTIGTER CARBONSÄUREN
DE69800312D1 (de) Verfahren zur Herstellung von Acrylsäuren aus Acrolein durch Redox-Reaktion
DE60117525D1 (de) Verfahren zur herstellung von laktonen
DE50101751D1 (de) Kontinuierliches isothermes Verfahren zur Herstellung von Mononitrotoluolen
DE60015563D1 (de) Verfahren zur herstellung von benzoperhydroisoindolen
DE69907607D1 (de) Verfahren zur Herstellung von Essigsäure
ATE212019T1 (de) Verfahren zur herstellung von phenylheterocyclen die als cox-2 inhibitoren verwendet werden können
ATE390400T1 (de) Verfahren zur herstellung von alpha'-chlorketonen
DE59807664D1 (de) Verfahren zur herstellung von 3-cyano-2,4-dihalogen-5-fluor-benzoesäuren
ATE155789T1 (de) Verfahren zur herstellung von aminomethanphosphonsäure

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification

Ref document number: 1248766

Country of ref document: EP

REN Ceased due to non-payment of the annual fee