EA199800675A1 - Дифенилстильбены как пролекарства к ингибиторам циклооксигеназы(сох-2) - Google Patents

Дифенилстильбены как пролекарства к ингибиторам циклооксигеназы(сох-2)

Info

Publication number
EA199800675A1
EA199800675A1 EA199800675A EA199800675A EA199800675A1 EA 199800675 A1 EA199800675 A1 EA 199800675A1 EA 199800675 A EA199800675 A EA 199800675A EA 199800675 A EA199800675 A EA 199800675A EA 199800675 A1 EA199800675 A1 EA 199800675A1
Authority
EA
Eurasian Patent Office
Prior art keywords
procaraces
diphenylstylbenes
soh
cyclooxygenase inhibitors
cyclooxygenase
Prior art date
Application number
EA199800675A
Other languages
English (en)
Inventor
Кэмерон Блэк
Марио Жирар
Дэниэл Гай
Заоин Ванг
Original Assignee
Мерк Фросст Кэнада Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9605647.8A external-priority patent/GB9605647D0/en
Application filed by Мерк Фросст Кэнада Инк. filed Critical Мерк Фросст Кэнада Инк.
Publication of EA199800675A1 publication Critical patent/EA199800675A1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182—Radicals derived from carboxylic acids
    • C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/095—Sulfur, selenium, or tellurium compounds, e.g. thiols
    • A61K31/10—Sulfides; Sulfoxides; Sulfones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C311/16—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/22—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms
    • C07C311/29—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C07C317/16—Sulfones; Sulfoxides having sulfone or sulfoxide groups and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C317/22—Sulfones; Sulfoxides having sulfone or sulfoxide groups and singly-bound oxygen atoms bound to the same carbon skeleton with sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C07C317/24—Sulfones; Sulfoxides having sulfone or sulfoxide groups and doubly-bound oxygen atoms bound to the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C07C317/44—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof

Abstract

Изобретение включает новое соединение формулы (I), используемое в лечении заболеваний, опосредованных циклооксигеназой СОХ-2. Изобретение также включает фармацевтические композиции для лечения заболеваний, опосредованных циклооксигеназой-2, включающие соединения формулы (I).Международная заявка была опубликована вместе с отчетом о международном поиске.
EA199800675A 1996-02-01 1997-01-29 Дифенилстильбены как пролекарства к ингибиторам циклооксигеназы(сох-2) EA199800675A1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US1095096P 1996-02-01 1996-02-01
GBGB9605647.8A GB9605647D0 (en) 1996-03-18 1996-03-18 Diphenyl stilbenes as prodrugs to cox-2 inhibitors
PCT/CA1997/000063 WO1997028120A1 (en) 1996-02-01 1997-01-29 Diphenyl stilbenes as prodrugs to cox-2 inhibitors

Publications (1)

Publication Number Publication Date
EA199800675A1 true EA199800675A1 (ru) 1999-02-25

Family

ID=26308949

Family Applications (1)

Application Number Title Priority Date Filing Date
EA199800675A EA199800675A1 (ru) 1996-02-01 1997-01-29 Дифенилстильбены как пролекарства к ингибиторам циклооксигеназы(сох-2)

Country Status (19)

Country Link
EP (1) EP0882015B1 (ru)
JP (1) JP3662936B2 (ru)
KR (1) KR19990082260A (ru)
CN (1) CN1214677A (ru)
AT (1) ATE198323T1 (ru)
AU (1) AU707199B2 (ru)
CA (1) CA2244134C (ru)
CZ (1) CZ241698A3 (ru)
DE (1) DE69703791T2 (ru)
EA (1) EA199800675A1 (ru)
EE (1) EE9800230A (ru)
ES (1) ES2152648T3 (ru)
HU (1) HUP9902119A3 (ru)
IL (1) IL125441A0 (ru)
NO (1) NO983511L (ru)
NZ (1) NZ326283A (ru)
PL (1) PL328225A1 (ru)
SK (1) SK102698A3 (ru)
WO (1) WO1997028120A1 (ru)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6635417B1 (en) 1996-07-31 2003-10-21 California Institute Of Technology Complex formation between DSDNA and oligomer of cyclic heterocycles
US5998140A (en) * 1996-07-31 1999-12-07 The Scripps Research Institute Complex formation between dsDNA and oligomer of cyclic heterocycles
IL150368A0 (en) 1999-12-23 2002-12-01 Nitromed Inc Nitrosated and nitrosylated cyclooxygenase-2-inhibitors, compositions and methods of use
AR038957A1 (es) 2001-08-15 2005-02-02 Pharmacia Corp Terapia de combinacion para el tratamiento del cancer
US7199154B2 (en) 2002-07-26 2007-04-03 Merck Frosst Company Nitric oxide releasing prodrugs of diaryl-2-(5h)-furanones as cyclooxygenase-2 inhibitors
AU2003261281A1 (en) 2002-07-29 2004-02-16 Nicox S.A. Cyclooxygenase- 2 selective inhibitors, compositions and methods of use
US7169809B2 (en) 2003-03-05 2007-01-30 Merck Frosst Company Nitric oxide releasing prodrugs of diaryl-2-(5H)-furanones as cyclooxygenase-2 inhibitors
JP2007520483A (ja) 2004-01-27 2007-07-26 メルク フロスト カンパニー シクロオキシゲナーゼ−２インヒビターとしてのジアリール−２−（５ｈ）−フラノンの一酸化窒素放出プロドラッグ
JP2007520484A (ja) * 2004-01-27 2007-07-26 メルク フロスト カンパニー シクロオキシゲナーゼ−２インヒビターとしてのジアリール−２−（５ｈ）−フラノンの一酸化窒素放出プロドラッグ
WO2006029436A1 (de) * 2004-09-17 2006-03-23 Universität Wien Cox-ii-inhibitorverbindungen
WO2022195579A1 (en) 2021-03-15 2022-09-22 Saul Yedgar Hyaluronic acid-conjugated dipalmitoyl phosphatidyl ethanolamine in combination with non-steroidal anti-inflammatory drugs (nsaids) for treating or alleviating inflammatory diseases

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR920700198A (ko) * 1989-04-24 1992-02-19 오오쓰까 아끼히꼬 3-할로게노-2, 3-디페닐아크릴알데히드 유도체, 그의 제조방법 및 고지방혈증을 치료하기 위한 의약 조성물
US5474995A (en) * 1993-06-24 1995-12-12 Merck Frosst Canada, Inc. Phenyl heterocycles as cox-2 inhibitors
US5393790A (en) * 1994-02-10 1995-02-28 G.D. Searle & Co. Substituted spiro compounds for the treatment of inflammation

Also Published As

Publication number Publication date
AU1434697A (en) 1997-08-22
PL328225A1 (en) 1999-01-18
NO983511D0 (no) 1998-07-30
DE69703791T2 (de) 2001-06-21
NO983511L (no) 1998-09-30
ATE198323T1 (de) 2001-01-15
HUP9902119A2 (hu) 2001-04-28
EP0882015A1 (en) 1998-12-09
CA2244134C (en) 2005-04-26
CN1214677A (zh) 1999-04-21
CA2244134A1 (en) 1997-08-07
ES2152648T3 (es) 2001-02-01
WO1997028120A1 (en) 1997-08-07
JP2000504332A (ja) 2000-04-11
AU707199B2 (en) 1999-07-08
EE9800230A (et) 1998-12-15
HUP9902119A3 (en) 2001-08-28
EP0882015B1 (en) 2000-12-27
SK102698A3 (en) 1999-04-13
CZ241698A3 (cs) 1998-12-16
DE69703791D1 (de) 2001-02-01
JP3662936B2 (ja) 2005-06-22
NZ326283A (en) 1998-12-23
KR19990082260A (ko) 1999-11-25
MX9806213A (es) 1998-12-31
IL125441A0 (en) 1999-03-12

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